Clinical trials: SUDEP
Sleep Disordered Breathing, Apnea of Prematurity
The PARS Study: Paediatric Advanced Respiratory Service Study - An Observational Diagnostic Feasibility Study
Diagnostic investigations in paediatric respiratory and sleep medicine are often challenging due to patient size (due to prematurity), tolerability, and compliance with "gold standard equipment".
- Conditions
- Sleep Disordered Breathing, Apnea of Prematurity, Respiratory Rate, Sudden Unexpected Death in Epilepsy
- Trial name
- PARS (NCT06292299)
- Testing
- Pneumowave
- Where
- 2 sites in United Kingdom
- Volunteers
- 225 people
- Sponsor
- NHS Greater Clyde and Glasgow
Epilepsy, Sudden Unexpected Death in Epilepsy
Effect of Rose Odor Exposure on Ictal Apnea
This study will investigate the potential benefits of rose scent in reducing the risk of Sudden Unexpected Death in Epilepsy (SUDEP) in patients with epilepsy.
- Trial name
- NCT07116421
- Testing
- 2-phenylethanol rose scent
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Focal Epilepsy
Breathing Rescue for SUDEP Prevention
The purpose of this study is to precisely delineate human brain networks that modulate respiration and identify specific brain areas and stimulation techniques that can be used to prevent seizure-induced breathing failure.
- Trial name
- BreatheS (NCT05981755)
- Testing
- Breathing tasks, Brain mapping with stimulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
Epilepsy
Caracterization of the Combined Alterations in Respiration and aROUSal in Patients With Drug-resistant EpiLepsy
30% of patients with epilepsy suffer from drug-resistant seizures and are at risk of epilepsy-related complications, from cognitive dysfunctions to premature mortality.
- Trial name
- CARROUSEL (NCT06545214)
- Testing
- Video-EEG monitoring, Respiratory monitoring and polysomnography, 1 Hypercapnic challenge while participant is awake
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Epilepsy, Dravet Syndrome
A PET-MRI Study of Serotoninergic Brainstem Pathway in Patients With Dravet Syndrome
Dravet Syndrome (DS) is a severe neurodevelopmental disease, which is predominantly caused by mutations of SCN1A, the gene coding for Nav1.1 voltage-gated sodium channels.
- Conditions
- Epilepsy, Dravet Syndrome, Drug Resistant Epilepsy, Healthy Controls
- Trial name
- DRAPETONINE (NCT07013331)
- Testing
- [18F]MPPF PET-MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Epilepsy, Hypothalamus
Study of the Link Between Structural Alterations in the Hypothalamus and Cardiac Dysautonomia in Drug-resistant Epilepsy
Patients with drug-resistant epilepsy may have cardiac dysautonomia, with reduced heart rate variability and increased sympathetic tone.
- Conditions
- Epilepsy, Hypothalamus, Seizures- Cardiac Dysautonomia, SUDEP
- Trial name
- HYPOLEPSIE (NCT07888543)
- Testing
- MRI scan, electrocardiogram
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Temporal Lobe Epilepsy
Autonomic Dysfunction in Temporal Lobe Epilepsy and SUDEP
The study aimed at detection of autonomic dysfunction among cases with temporal lobe epilepsy; using different electrophysiological techniques.
- Trial name
- NCT06269822
- Testing
- Sympathetic skin response, heart rate variability test, quantitative EEG
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sudden Unexpected Death in Epilepsy, Near-Sudden Unexpected Death in Epilepsy
Electroclinical Features of Sudden Unexpected Death in Epilepsy (SUDEP) : a Multi-center Observational Study
Sudden unexpected death in epilepsy (SUDEP) is regarded as a leading cause of premature death in epilepsy patients. We aim to capture the whole process of SUDEP and near-SUDEP occurrence in patients with epilepsy, and expolre…
- Trial name
- NCT05423990
- Testing
- Video-Electroencephalography
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Liu Yonghong
Epilepsy
Cardiac Arrhythmias in Dravet Syndrome
SUMMARY Rationale: People with Dravet Syndrome (DS), a rare epilepsy syndrome, have a high risk of Sudden Unexpected Death in Epilepsy (SUDEP).
- Trial name
- NCT02415686
- Where
- 3 sites in Germany, Netherlands and 1 more
- Volunteers
- 59 people
- Sponsor
- Stichting Epilepsie Instellingen Nederland
SUDEP, Epilepsy
Improving Patient Communication About SUDEP
Children with generalized tonic-clonic seizures (GTCS) have about a 1 in 4500 of succumbing to sudden unexpected death in epilepsy (SUDEP).
- Trial name
- NCT03502759
- Testing
- CHICA SUDEP module
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Indiana University
Sudden Unexpected Death in Epilepsy (SUDEP)
Serotoninergic Pathways in Sudden and Unexpted Death in Epilepsy (SUDEP)
The mortality rate is increased in patients with epilepsy, and especially among patients with drug-resistant epilepsy. This increased mortality is mainly related to the risk of SUDEP whose incidence is between 3.5 and 9 per 1,000…
- Trial name
- SUDEP (NCT02788318)
- Testing
- Brain samples, Skin samples
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Hospices Civils de Lyon
Epilepsy, Seizures
Neural Circulatory Control and SUDEP Risk.
The investigators believe epilepsy alters the way the body controls blood pressure, heart rate and breathing, and these changes increase the risk of sudden unexpected death in patients with epilepsy (SUDEP).
- Trial name
- NC-SUDEP (NCT02813980)
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic
Epilepsy
Risk Factors of SUDEP
Numerous studies over the past decade have shown without any doubt that there is a higher mortality risk in patients with epilepsy than in the general population.
- Trial name
- PRERIES (NCT03074279)
- Testing
- Interview with a psychologist and self-reported questionnaires
- Where
- France
- Volunteers
- 408 people
- Sponsor
- University Hospital, Montpellier
Drug-resistant Partial Epilepsy
National Network for the Study of Predictors and Prevention of Sudden Unexpected Death in Drug-resistant Partial Epilepsies
Sudden unexpected death in epilepsy (SUDEP) is the main concern of professionals and patient associations involved in epilepsy. These represent a priority for the Ligue Française Contre l'Epilepsie (LFCE).
- Trial name
- REPOMSE (NCT02572297)
- Testing
- video-EEG
- Where
- France
- Volunteers
- 1,072 people
- Sponsor
- Hospices Civils de Lyon
Epilepsy, SUDEP
Carbon Dioxide (CO2) Chemosensitivity and SUDEP
The purpose of this research study is to better understand what causes Sudden Unexpected Death in Epilepsy (SUDEP). This study will enroll subjects from the University of Iowa Hospitals and Clinics (UIHC) Epilepsy Monitoring Unit…
- Trial name
- NCT04134754
- Testing
- 6% Carbon dioxide/50% oxygen/balance nitrogen mixture
- Where
- United States
- Volunteers
- 335 people
- Sponsor
- University of Iowa
Epilepsy
A Device to Prevent Sudden Unexpected Death in Epilepsy: Detecting Peri-Ictal Body Position
The goal of this study is to assess the performance of a commercial sheet sensor in determining body position after generalized tonic-clonic (GTC) seizures.
- Trial name
- NCT06135285
- Testing
- Study Subjects
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Dravet Syndrome
The FINTEPLA as an Anti-SUDEP Therapy in Dravet Syndrome Project
This study investigates cerebrovascular reactivity (CVR) and functional brain connectivity in Dravet Syndrome (DS) patients with convulsive seizures.
- Trial name
- FAST-DS (NCT07112365)
- Testing
- Fenfluramine treatment (Fintepla), Hypercapnia Challenge using the device (RespirAct)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The University of Texas Health Science Center, Houston
Epilepsy, SUDEP
Intracranial CArtography of Cortical Contribution to Respiratory Load Compensation in Epilepsy
30% of patients with epilepsy suffer from drug-resistant seizures and have a greater risk of premature mortality than the general population.
- Trial name
- ICARE (NCT07599150)
- Testing
- SEEG monitoring, Comprehensive respiratory monitoring, Cardio-respiratory monitoring
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Epilepsy, SUDEP
Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI
Sudden unexpected death in epilepsy patients (SUDEP) is devastating outcome for some patients with epilepsy. It ranks second only to stroke among neurological diseases in years of potential life lost.
- Trial name
- NCT02929667
- Testing
- Fluoxetine
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Rup Kamal Sainju
SUDEP
Risk Factors for Sudden Unexplained Death in Epilepsy
The main purpose of this study is to develop a North American registry for SUDEP cases; requesting family members of epilepsy patients who died suddenly of unclear causes (SUDEP) to contact the study team.
- Trial name
- SUDEP (NCT01662453)
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health