Clinical trials: STAT1
Hematologic Tests
Evaluation of Potassium (K) and Ionized Calcium (iCa) Tests Using Capillary Specimens
The objective of this study is to compare the performance of blood tests using the i-STAT 1 System against a comparator blood analysis system.
- Trial name
- NCT07287618
- Testing
- Blood draw
- Where
- 3 sites in United States
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Abbott Point of Care
Primary Immunodeficiency Diseases (PID)
Ex Vivo Evaluation of JAK-inhibitor and Gene Therapeutical Approach in JAK-STAT Related Disorders
The investigators want to study the JAK-inhibitors and their impact on the immune system and evaluate the potential of a gene-therapeutic strategy
- Trial name
- JAKarta (NCT07261891)
- Testing
- blood sampling
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- prof. dr. Rik Schrijvers
Activated Clotting Time
Clinical Evaluation of the i-STAT ACTpro Cartridge in an Adult Population
Measuring Activated Clotting Time (ACT) using the i-STAT ACTpro cartridge on the i-STAT 1 analyzer compared to a comparator device.
- Trial name
- ACT (NCT07382076)
- Testing
- Blood draw
- Where
- 11 sites in United States
- Volunteers
- 500 people
- Sponsor
- Abbott Point of Care
Atypical Nevi, Melanoma
Pilot Study Evaluating Sulforaphane in Atypical Nevi-Precursor Lesions
This is a pilot study to see if oral administration of freeze dried, powdered broccoli sprouts have any effect on whether moles end up becoming melanoma.
- Trial name
- NCT01568996
- Testing
- broccoli sprout extract - sulforaphane (BSE-SFN)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- John Kirkwood
Candidiasis, Chronic Mucocutaneous
CAMB/MAT2203 in Patients With Mucocutaneous Candidiasis
This is an open-label, dose-titration trial to study the efficacy, safety, and pharmacokinetics of oral cochleate amphotericin B (CAMB) in the treatment of mucocutaneous candidiasis infections in patients who are refractory or…
- Trial name
- CAMB (NCT02629419)
- Testing
- Amphotericin B
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Matinas BioPharma Nanotechnologies, Inc.
Colorectal Cancer Metastatic, Advanced Non-Small Cell Lung Carcinoma
The Oncopanel Pilot (TOP) Study
The BCCA Oncopanel is a clinical assay being developed to determine genotype status of a prospectively defined set of genes. The purpose of this pilot study is to assess the feasibility and effect on clinical-decision-making of…
- Conditions
- Colorectal Cancer Metastatic, Advanced Non-Small Cell Lung Carcinoma, Advanced Melanoma, Gastrointestinal Stromal Tumors
- Trial name
- NCT02171286
- Where
- 5 sites in Canada
- Volunteers
- 432 people
- Sponsor
- British Columbia Cancer Agency
Warts
Gene Expression Of Suppressor Of Cytokines in In Cutaneous Warts
Warts are common epidermal growths caused by various strains of human papilloma virus (HPV). Viral warts are common with a prevalence rate of 7-12%.
- Trial name
- NCT05781841
- Testing
- Detection of expression of SOCS3 gene, Detection of expression of IFN-α gene, Detection of expression of IFN-β gene
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Precision of Potassium (K) Test in Capillary Whole Blood
Precision Study Measuring Potassium (K) in Capillary Specimens
Assessing precision of i-STAT K test using the IUO i-STAT CG8+ cartridge on the i-STAT 1 Analyzer.
- Trial name
- NCT06291493
- Testing
- Fingerstick blood draw
- Where
- 4 sites in United States, Canada
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Abbott Point of Care
Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)
This is a research protocol that will examine Hematopoietic Stem Cell Transplantation (HSCT) using a reduced conditioning regimen (RIC) with total body Irradiation (TBI) in those diagnosed with Common Variable Immunodeficiency…
- Conditions
- Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder, Immune Dysregulation, DiGeorge Syndrome
- Trial name
- CVID/PIRD (NCT07284641)
- Testing
- Hematopoietic stem cell transplant (HSCT)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Paul Szabolcs
STAT1 Gain-of-Function Disease
Expanded Access Use of Itacitinib to Treat a Single Patient With STAT1 Gain of Function (GOF) Disease
Expanded access use of Itacitinib to treat a single patient with aplastic anemia.
- Trial name
- NCT05561985
- Testing
- Itacitinib
- Sponsor
- Incyte Corporation
DOK 8, STAT1
Genetic Analysis of Immune Disorders
The purposes of this study are to 1) identify the genes responsible for certain immune disorders, 2) learn about the medical problems they cause, and 3) learn how to predict who is likely to develop these disorders and what the…
- Conditions
- DOK 8, STAT1, GATA2, Immunodeficiency
- Trial name
- NCT00001467
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Potassium (K) & Ionized Calcium (iCa) in Capillary Whole Blood
Method Comparison Study for Measuring Potassium (K) and Ionized Calcium (iCa) in Blood
Method comparison study for Potassium (K) and ionized calcium (iCa).
- Trial name
- NCT06295835
- Testing
- Fingerstick blood draw
- Where
- 4 sites in United States, Canada
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Abbott Point of Care
Hematologic Tests
Clinical Evaluation of Precision for the Potassium and Ionized Calcium Tests in Capillary Specimens
Assess precision of the i-STAT potassium (K) and ionized calcium (iCa) tests using i-STAT CG8+ cartridge on the i-STAT 1 analyzer.
- Trial name
- NCT07287631
- Testing
- Capillary blood draw
- Where
- 3 sites in United States
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Abbott Point of Care
JAK1 GOF, STAT1 GOF
Upadacitinib in Treatment of JAK/STAT Pathway Disorders With Activating Mutations
This study focuses on a genetic condition that affects the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) immune signaling pathway.
- Conditions
- JAK1 GOF, STAT1 GOF, STAT3 GOF, STAT5B GOF
- Trial name
- SAFE-JAKi (NCT07670156)
- Testing
- Upadacitinib
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Lisa Satter