Clinical trials: SMC
Malaria, Anemia
Optimization of Seasonal Malaria Chemoprevention (SMC) Delivery
Based in part on the pivotal studies conducted in Mali, SMC was approved by WHO as a policy for malaria control in countries with seasonal malaria transmission such as Mali in March 2012.
- Trial name
- SMC (NCT02646410)
- Testing
- FPD+NDOT, FPD+DOT, DDD+NDOT
- Where
- Mali
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Bamako
Radiotherapy Side Effect
SMC Radiation Oncology Breast Cancer Cohort Study
The goal of this observational study is to learn about toxicities and cosmetic outcomes in breast cancer patients treated with hypofractionated radiotherapy.
- Trial name
- RASCO (NCT05775757)
- Testing
- Hypofractionated radiation therapy
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center
Sanfilippo Syndrome A
Natural History Observational Study of MPS IIIa in SMC
To characterize the clinical course of mucopolysaccharidosis type IIIA (MPS IIIA), and identify potential endpoints for future treatment trials.
- Trial name
- NCT04918641
- Testing
- assessment
- Volunteers
- 25 people
- Sponsor
- Samsung Medical Center
Renal Failure
Renal Allograft Tolerance Through Mixed Chimerism - SMC/MGH
The goal is to investigate the safety of the conditioning regimen, and its ability to induce donor/recipient lymphohematopoietic chimerism without Chimerism Transition Syndrome (CTS), which may result in donor-specific…
- Trial name
- NCT04540380
- Testing
- Rituximab, Fludarabine, Cyclophosphamide, Thymic irradiation and Siplizumab, Combined bone marrow and kidney transplant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Endothelial Dysfunction, Disorder of Smooth Muscle
The Effect of a Diabetic- and a Kidney-like Environment on Gene and Protein Expression in Cultured EC and SMC
This research is NOT part of an interventional trial, however the investigators use umbilical cord after birth for isolating endothelial and smooth muscle cells for academic research.
- Trial name
- NCT01423279
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Malaria, Malaria Prophylaxis
Boosting the Impact of SMC Through Simultaneous Screening and Treatment of Roommates
Malaria represents a major public health concern in sub-Sahara Africa. Seasonal malaria chemoprevention (SMC) is one of the largest preventive measures.
- Conditions
- Malaria, Malaria Prophylaxis, Mass Testing and Treatment
- Trial name
- SMC-RST (NCT04816461)
- Testing
- Amodiaquine Sulfadoxine-Pyrimethamin administration, Dihydroartemisinin-Piperaquine, Standard HRP2-RDT
- Where
- Burkina Faso
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso
Subjective Memory Complaint
Lifestyle Remodeling in Subjective Memory Complaint (SMC): Brain Imaging and Blood Biochemistry Study
The specific study aims: 1. To investigate whether the brain function is affected by the past life experiences, such as lifestyle and physiology-related factors in SMC. 2.
- Trial name
- NCT04162990
- Testing
- Lifestyle remodeling Intervention, Does Comparator: regular treatment
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Persistent Physical Symptoms (PPS)
CBT Plus SMC Compared to SMC for Persistent Physical Symptoms in Secondary Care (PRINCE)
Brief Summary: Persistent Physical Symptoms (PPS), also known as medically unexplained symptoms (MUS) is a term used to describe a range of persistent bodily symptoms for which the exact cause is unclear.
- Trial name
- PRINCE (NCT02426788)
- Testing
- Cognitive behavioural therapy (CBT)
- Where
- 7 sites in United Kingdom
- Volunteers
- 324 people
- Sponsor
- King's College London
Cardiovascular Diseases
A Comparison Study of the Perclose Proglide (TM) SMC System Versus Figure-of-8- Suture Technique for Closure of Large-bore Femoral Venous Access.
This study aims to compare the efficacy and safety of two strategies for closing large caliber venous access in patients undergoing percutaneous procedures: compression with figure-of-8 suture versus closure with the…
- Trial name
- NCT05859503
- Testing
- Closure Strategy with Perclose-Proglide system, Closure Strategy with figure-of-8
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Malaria,Falciparum
Seasonal Malaria Chemoprevention With Dihydroartemisin Piperaquin vs. Sulfadoxine-pyrimethamin+Amodiaquin
Seasonal Malaria Chemoprevention (SMC) for children less than five years old is one the high impact interventions against malaria in sub-Saharan Africa (SSA).
- Trial name
- NCT04149106
- Testing
- Sulfadoxine pyrimethamine + Amodiaquin, Dihydroartemisinin piperaquin
- Where
- Mali
- Volunteers
- 4,556 people, healthy volunteers welcome
- Sponsor
- University Clinical Research Center, Mali
Malaria, Falciparum, Malaria, Asymptomatic Parasitaemia
MDA and Targeted Control Against Plasmodium Carriage in the Sahel
Strategies implemented since 2010 by the Senegalese National Malaria Control Program (NMCP) enabled a reduction of malaria transmission.
- Trial name
- AMARETI (NCT07281443)
- Testing
- MDA with DHAp and SLD Primaquine, Targeted control (10-24 years) during the malaria high tranmission season: behaviour, Targeted control (15-24 years) during the malaria high tranmission season: test and treat
- Where
- Senegal
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Cerebral Palsy, Balance
The Relationship of Forward and Backward Walking with SMC, Trunk Control and Balance in Children with Cerebral Palsy
Children aged between 6-18 years old, diagnosed with cerebral palsy and meeting the inclusion criteria, will be included in this study.
- Conditions
- Cerebral Palsy, Balance, Gait Disorders in Children
- Trial name
- NCT05962749
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Alanya Alaaddin Keykubat University
Memory Deficits, tACS
tACS Improves Memory in Elders With Subjective Memory Complaints
Subjective memory complaints (SMC), the main cognitive component of which is event memory, is a predictor of Alzheimer's disease in elderly people.
- Trial name
- NCT05569902
- Testing
- active tACS
- Where
- Iran
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Tehran
Cerebral Small Vessel Diseases, CADASIL (Diagnosis)
Establishment of a CSF Bank for the Development of Biomarkers of Smooth Muscle Cell (SMC) Damage in Monogenic Cerebral Small Vessel Disease
The main objective of this research is to obtain biological markers of smooth muscle cells dysfunction or degeneration in cerebral small vessel diseases.
- Trial name
- CSF-cSVD (NCT05793424)
- Testing
- Cerebrospinal fluid (CSF) sample and additional blood samples
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Malaria, Malaria,Falciparum
Understanding and Maximizing the Community Impact of Antimalarial Treatment (INDIE-SMC)
Seasonal Malaria Chemoprophylaxis (SMC) is a fundamental component of malaria control. The SMC program involves that sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) is given to children below the age of 5 years during the peak…
- Trial name
- INDIE-SMC (NCT05878366)
- Testing
- Seasonal Malaria Chemoprophylaxis (under 5 year old) implemented by the MoH without DOT, Seasonal Malaria Chemoprophylaxis (under 5 years old) with DOT, Seasonal Malaria Chemoprophylaxis (under 10 years old) with DOT
- Where
- Burkina Faso
- Volunteers
- 2,978 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Stomach Neoplasms
The Screening Protocol for The VIKTORY Trial
This protocol is a screening protocol only. No drug intervention study will be included in this protocol. However, based on the molecular profiling, patients may be eligible for targeted agents.
- Trial name
- NCT02299648
- Testing
- Molecular profiling
- Where
- 2 sites in South Korea
- Volunteers
- 651 people
- Sponsor
- Samsung Medical Center
Mild Cognitive Impairment, Memory Disorders
Prospective Research on Identification of Dementia in Early Stages (P.R.I.D.E)
PRIDE Study - Brief Summary The PRIDE Study (Prospective Research on Identification of Dementia in Early Stages) is a multicenter, prospective, observational study designed to estimate the prevalence of Mild Cognitive Impairment…
- Conditions
- Mild Cognitive Impairment, Memory Disorders, Dementia
- Trial name
- PRIDE (NCT07918638)
- Volunteers
- 1,000 people
- Sponsor
- Don Mottola Medical Center
Malaria, Soil Transmitted Helminths
Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children
Malaria remains a major health problem, especially in sub-Saharan Africa where more than 90% of the disease and deaths occur in children.
- Conditions
- Malaria, Soil Transmitted Helminths, Schistosomiasis, Integrated Control
- Trial name
- MALHELMIN (NCT05354258)
- Testing
- Albendazole, Praziquantel, Amodiaquine
- Where
- Senegal
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Stereotactic Body Radiation Therapy (SBRT), Oligometastasis
SMC Radiation Oncology SABR Cohort for Oligometastasis
The goal of this observational study is to evaluate the efficacy and safety of stereotactic body radiotherapy (SABR) in patients with oligometastatic or oligoprogressive cancer. The main questions it aims to answer are: 1.
- Conditions
- Stereotactic Body Radiation Therapy (SBRT), Oligometastasis, Oligoprogression, ctDNA
- Trial name
- SABR-OMOP (NCT07121335)
- Testing
- Stereotactic body radiotherapy (SBRT)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Arrhythmia
Perclose Multi-Access Duplex Ultrasound (DUS) Study
The aim of this prospective, single-arm, United States (US) multi-center, descriptive clinical study is to evaluate the safety of multiple access site closure in a single vein with the SMC System by scheduled DUS at discharge and…
- Trial name
- NCT04904809
- Testing
- Perclose ProGlide SMC System and/or Perclose ProStyle SMCR System
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Abbott Medical Devices