Clinical trials: SANS
Covid19
Phytomedicines Versus Hydroxychloroquine as an Add on Therapy to Azythromycin in Asymptomatic Covid-19 Patients
Our previous work on plants has indicated significant antimalarial and antiviral activities. Of these plants, two recipes are proposed for evaluation for COVID-19.
- Trial name
- PHYTCOVID-19 (NCT04501965)
- Testing
- Hydroxychloroquine/Azithromycine, Quinquina-Stevia/Azythromycin, 4Plants/Azythromycin
- Where
- Guinea
- Volunteers
- 231 people
- Sponsor
- Institute for Research and Development of Medicinal and Food Plants of Guinea
Schizophrenia Disorders, Bipolar Disorders
MonPsy&Moi: A Digital Platform for Collecting Patient-Reported Experience and Outcome Measures in Psychiatry
Mental health disorders, with a 30% annual prevalence rate, are a leading cause of disability and reduced life expectancy. Despite their impact, patient-reported experience measures (PREMs) and outcome measures (PROMs) are…
- Conditions
- Schizophrenia Disorders, Bipolar Disorders, Major Depression
- Trial name
- Mon Psy & Moi (NCT06818227)
- Where
- France
- Volunteers
- 23,660 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Spaceflight Associated Neuro-Ocular Syndrome, SANS
The Eye in Orbit: UCF Adaption
The goal of this study is to understand the impact of space travel on the eyes. Space flight impacts numerous aspects of ocular anatomy and physiology.
- Trial name
- NCT06092359
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Central Florida
Aorto-ostial Coronary Lesions, Coronary Angioplasty
The OSTIAL Study (Optimization of Stent Placement in Aorto-ostial Lesions)
Aorto-ostial coronary lesions present a significant challenge during coronary angioplasty. This is due to the difficulty of precisely identifying the aorto-ostial plane and the frequent instability of the guiding catheter during…
- Conditions
- Aorto-ostial Coronary Lesions, Coronary Angioplasty, Floating Balloon" (FB) Technique
- Trial name
- OSTIAL (NCT07835048)
- Testing
- Coronary angioplasty using the floating balloon technique, Coronary angioplasty without the floating-balloon technique
- Where
- 6 sites in France
- Volunteers
- 75 people
- Sponsor
- Centre Cardiologique du Nord
Chest Pain
Interest of CARE Rule to Exclude the Hypothesis of an Acute Coronary Syndrome Without Bioassay - ICARE
Acute coronary syndrome (ACS) is a major health problem and its diagnosis remains a challenge for the emergency physician. The management of a suspected ACS is well codified, based on troponin assays, renewed if necessary.
- Trial name
- ICARE (NCT02813499)
- Testing
- CARE Rule
- Where
- 6 sites in Belgium, France
- Volunteers
- 1,453 people
- Sponsor
- University Hospital, Angers
HIV Seropositivity, HIV Testing
Free HIV Testing in Private Biological Laboratories: A New Offer to Encourage HIV Testing
The program " Au labo sans ordo " aims to increase HIV testing coverage, in order to improve the first stage of the HIV care cascade in Paris and the Alpes-Maritimes, areas facing a much higher HIV epidemic than the other regions…
- Trial name
- ALSO (NCT04030689)
- Testing
- data collected from patient file
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Schizophrenia
Low and High Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Resistant Auditory Hallucination in Schizophrenia
Auditory Hallucinations (AH) are experienced by 50 to 70% of subjects with schizophrenia. Almost a quarter of patients are medication resistant to such symptoms.
- Trial name
- rTMS (NCT02175251)
- Testing
- high frequency (20Hz), low frequency (1Hz)
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Type 2 Diabetes
EndoBarrier® SANS™ in Over-weight or Obese Type 2 Diabetic Subjects
This study will evaluate the safety and efficacy of the EndoBarrier® SANS™ in overweight and obese subjects with type 2 diabetes.
- Trial name
- NCT02443753
- Testing
- EndoBarrier SANS
- Where
- Malaysia
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Morphic Medical Inc.
Heart Disease
Diagnostic Efficacy of Connected WAtch ECG Versus External Holter ECG
Palpitations are a frequent reason for consultation (16% of total volume) and management in the emergency department. Conventional diagnostic management in our establishment is based on a 48-hour external ECG holter, combined…
- Trial name
- WAHOE (NCT06420960)
- Testing
- Wearing the connected watch
- Where
- France
- Volunteers
- 81 people
- Sponsor
- L'hôpital Nord-Ouest - Villefranche Villefranche sur Saône
Total Hip Arthroplasty (THA)
Comparison Between Opioid-sparing Anesthesia Guided by the CARDEAN® Index and Opioid-free Anesthesia During Total Hip Arthroplasty
The proposed study compares two anesthesia techniques; the hypothesis being tested is that titrating sufentanil based on the CARDEAN® index (titrated OSA) does not increase post-operative morphine consumption compared to…
- Trial name
- NCT07747142
- Testing
- Titrated Opioid Sparing Anesthesia, opioid free anesthesia
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Pole Sante Oreliance, Polyclinique des Longues Allees
OESOPHAGO-GASTRIC CARCINOMA
PHASE III RANDOMISED TRIAL to EVALUATE FOLFOX with or WITHOUT DOCETAXEL (TFOX) AS 1st LINE CHEMOTHERAPY for LOCALLY ADVANCED or METASTATIC OESOPHAGO-GASTRIC CARCINOMA
Gastric cancer is the fourth commonest cancer and the second largest cause of mortality from cancer. Surgical resection of localised forms of gastric cancer offers the only chance of a cure.
- Trial name
- GASTFOX (NCT03006432)
- Testing
- Oxaliplatin, 5Fluorouracil bolus, 5Fluorouracil continu
- Where
- 134 sites in France, Martinique
- Volunteers
- 507 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Digestive System Disease
Improvement of Lower Digestive Endoscopy Without Anesthesia : Evaluation of the Virtual Reality Mask
90% of colonoscopies are performed with general anesthesia (GA). GA carries risks and requires a prior anesthesia consultation, a dedicated team and technical platform on the day of the examination.
- Trial name
- REVENDO (NCT06414239)
- Testing
- Use of a VR mask, Standard of care
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ADHD
Impact of Ostracism on Prospective Memory in ADHD Children With or Without Emotional Dysregulation
Assess the effect of exposure to a situation of social exclusion or ostracism on the prospective memory of children with ADHD
- Trial name
- IOM-ADHD (NCT05520996)
- Testing
- Cyberball
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Rouen
Colorectal Cancer
Trial of Direct Home Delivery of Colorectal Cancer Screening Kit Without Pre-ordering
The effect of mailing FIT with the invitation on participation and colonoscopy rates will be evaluated in a randomized controlled trial conducted in the Centre-Val de Loire (CVL) region, involving 64,000 people from the…
- Trial name
- EXPEDIT (NCT06032338)
- Testing
- CRC screening invitation not including the screening test., Mailing of FIT with invitation, Information letter before invitation
- Where
- France
- Volunteers
- 64,000 people
- Sponsor
- University Hospital, Caen
Covid19
Add on to Azythromycine, Phytomedicine and/or Antimalarial Drug vs Hydroxychloroquine in Uncomplicated COVID-19 Patients
The phase II clinical trial, with three arms and at rate of 10 patients per arm, received the approval of the National Committee for Ethics and Health Research.
- Trial name
- CANCOVID-19 (NCT04502342)
- Testing
- Hydroxycloroquine and Azythromycine, Cospherunate/Azythromycine, Cospherunate/Phytomedicine/Azythromycien
- Where
- Guinea
- Volunteers
- 30 people
- Sponsor
- Institute for Research and Development of Medicinal and Food Plants of Guinea
Multidrug Resistant Tuberculosis
Effectiveness of a Simplified Short Regimen for Multidrug Resistant Tuberculosis in Uzbekistan
Multidrug resistant tuberculosis (MDR TB) is a growing problem and few people have access to adequate diagnosis and treatment. The current recommended treatment regimen for MDR TB has a minimum of 20 months duration with high…
- Trial name
- NCT02496572
- Testing
- Short course MDR-TB treatment regimen
- Where
- Uzbekistan
- Volunteers
- 110 people
- Sponsor
- Medecins Sans Frontieres, Netherlands
Schizophrenia
Antipsychotic Augmentation With L-Dopa
Dopamine, a chemical in the brain, has been linked to schizophrenia for a number of years. More recently, there is evidence that certain areas affected in schizophrenia (e.g.
- Trial name
- NCT01636037
- Testing
- levodopa/carbidopa (generic version of Sinemet)
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Centre for Addiction and Mental Health
Delivery Uterine
Use of Normal Saline With or Without Dextrose During Induction of Labor in Nulliparous
The objective of this study is to compare the effects of use of normal saline (250 cc / h), with or without dextrose supplement, on the evolution of labor in nulliparous.
- Trial name
- DEXTRONS (NCT02655783)
- Testing
- 5% dextrose, normal saline
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Université de Sherbrooke
Borderline Personality Disorder
NEUROIMAGING OF ADOLESCENT BORDERLINE PERSONALITY DISORDER WITH AND WITHOUT POST-TRAUMATIC STRESS DISORDER
Borderline personality disorder (BPD) is a common mental disorder in adolescents with significant individual and societal repercussions, characterized over the long term by emotional hyperresponsiveness, relational instability…
- Trial name
- BorderStress (NCT04852744)
- Testing
- Brain MRI
- Where
- France
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Cystitis
Use of a Share Decision Making Tool in the Care of Acute Cystitis Without Risk of Complication in Primary Care
the aim of this trial is to demonstrate that when caring women with symptoms of acute cystitis without any risk of complication, general practitioner may use share decision making tool to help patients better understand the…
- Trial name
- ARIBO (NCT04272281)
- Testing
- medical shared decision, Standard medical care
- Where
- France
- Volunteers
- 169 people
- Sponsor
- University Hospital, Bordeaux