Clinical trials: Root Canal
Three Canal Irrigation Methods and Their Comparison, Penetration of Irrigant in the Root Canal
Effectiveness of Three Different Irrigation Methods During a Root Canal Treatment
This study aims to compare the effectiveness of three root canal irrigation techniques-Conventional Needle Irrigation (CNI), Side-Vented Needle (SVN), and Ultrasonic Irrigation (UI)-in achieving irrigant penetration into the…
- Trial name
- NCT07731594
- Testing
- Conventional Needle, Side Vented Needle, Ultrasonic Irrigation
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Root Canal Infection
Postoperative Pain After Using a Minimally Invasive Reciprocating Single-file System in Mandibular Molars With Symptomatic Irreversible Pulpitis
The aim of the present study is to assess the incidence and severity of postoperative pain after root canal preparation of mandibular molars with symptomatic irreversible pulpitis using a minimally invasive reciprocating…
- Trial name
- NCT07718607
- Testing
- Reciprocating rotary single-file system, Wave One Gold rotary file system
- Volunteers
- 56 people
- Sponsor
- Minia University
C-shaped Root Canal
Deep Learning Framework for Classification, 3D Segmentation & Visualization of C-shaped Canals
The goal of this retrospective diagnostic accuracy study is to develop and validate a deep learning framework for the automated classification, three-dimensional (3D) segmentation, and visualization of C-shaped root canal anatomy…
- Trial name
- AI (NCT07697378)
- Volunteers
- 112 people
- Sponsor
- Cairo University
Root Canal Treatment, Postoperative Pain
Different Kinematics Within a Single-File System and Postoperative Pain
The goal of this clinical trial is to evaluating the influence of single file rotary system for root canal instrumentation using different kinematics on postoperative pain, the primary purpose: measuring post-operative pain by…
- Conditions
- Root Canal Treatment, Postoperative Pain, Apical Periodontitis
- Trial name
- NCT07699432
- Testing
- Twisted Adaptive motion (TFA), canal pro jeni, forward reciprocation
- Where
- Jordan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Root Canal Treatment, Obturation Quality
Diagnostic Accuracy of a Deep Learning Framework for Automated Evaluation of Root Canal Obturation Quality From Periapical Radiographs
This study aims to develop and evaluate an artificial intelligence (AI)-based system that can automatically assess the quality of root canal fillings using dental X-ray images.
- Trial name
- NCT07684482
- Testing
- Deep learning model
- Volunteers
- 490 people
- Sponsor
- Cairo University
Periapical Periodontitis, Root Canal Infection
Antibacterial Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments
This study evaluates the antibacterial effectiveness of two different intracanal medicaments, Bio-C Temp and UltraCal XS , in mandibular molar teeth with chronic apical periodontitis.
- Conditions
- Periapical Periodontitis, Root Canal Infection, Intracanal Medicaments
- Trial name
- NCT07671326
- Testing
- Root canal treatment with Bio-C Temp, a calcium silicate-based bioceramic intracanal medicament, Root canal treatment with UltraCal XS, a calcium hydroxide-based intracanal medicament
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medipol University
Postoperative Dental Pain, Root Canal Sealers
Effect of Different Root Canal Sealers on Postoperative Pain
This randomized clinical trial aimed to evaluate postoperative pain following the use of bioceramic and epoxy resin-based root canal sealers in combination with the continuous wave of condensation technique (CWCT), addressing a…
- Conditions
- Postoperative Dental Pain, Root Canal Sealers, Asymptomatic Irreversible Pulpitis
- Trial name
- NCT06726837
- Testing
- Postoperative pain - 6th hour, Postoperative pain - 24th hour, Postoperative pain - 48th hour
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Dicle University
Primary Apical Periodontitis, Root Canal Infection
Bacterial Profiles in Primary Apical Periodontitis Using 16S rRNA PCR
This pilot randomized clinical study aims to compare bacterial profiles in symptomatic and asymptomatic primary apical periodontitis using 16S rRNA polymerase chain reaction sequencing.
- Conditions
- Primary Apical Periodontitis, Root Canal Infection, Endodontic Infection
- Trial name
- NCT07637305
- Testing
- 3% Sodium Hypochlorite Irrigation with Ultrasonic Activation, 5.25% Sodium Hypochlorite Irrigation with Ultrasonic Activation
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- Hasanuddin University
Root Canal Obturation
Root Canal Obturation With a Ready-to-use Root Canal Sealer (PA1704) Versus BioRoot™ RCS: a Randomized Controlled Trial
The study design is a multicentric randomized controlled non-inferiority trial. 160 subjects (teeth) requiring a primary or a secondary root canal treatment will be enrolled in 2 groups (80 in each group).
- Trial name
- OPTIFILL (NCT04757753)
- Testing
- ready-to-use root canal sealer: PA1704, root canal sealer: BioRoot™ RCS
- Where
- 5 sites in Belgium, France
- Volunteers
- 160 people
- Sponsor
- Septodont
Chronic Apical Abscess, Root Canal Infection
Bacterial Profile Changes During Different Sodium Hypochlorite Irrigation Regimens and Calcium Hydroxide Medicament in Root Canal Treatment
The goal of this clinical trial is to learn how the bacterial profile in infected root canals changes during different phases of routine root canal treatment in adults with chronic apical abscess.
- Trial name
- BactProfil-RCT (NCT07623278)
- Testing
- Root canal treatment with 5.25% sodium hypochlorite irrigation, Root canal treatment with 3% sodium hypochlorite irrigation
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- Hasanuddin University
Root Canal Therapy
Prospective Evaluation of Clinical Endodontic Performance Assessment Methods
This prospective cohort study evaluates dental students' self-assessment of clinical endodontic performance and compares it with independent evaluations conducted in a dental education clinical setting.
- Trial name
- NCT07413276
- Testing
- Not applicable- observational study
- Where
- Greece
- Volunteers
- 201 people
- Sponsor
- Aristotle University Of Thessaloniki
Root Canal Infection, Periapical Diseases
Calcium Silicate Sealer-based Obturation in Root Canal Retreatment
This study will evaluate the outcome of calcium silicate sealer-based obturations in root canal retreatment.
- Trial name
- NCT05714384
- Testing
- CeraSeal (Calcium Silicate-based Root Canal Sealer)
- Where
- Kuwait
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Kuwait
Pulp Necrosis, Root Canal Infection
Comparison of Ultrasonic vs 980-nm Diode Laser Irrigant Activation for Reducing Residual Bacterial DNA in Necrotic Teeth
This randomized clinical trial aimed to compare residual oral bacterial DNA detection after ultrasonic irrigant activation and 980-nm diode laser irrigant activation during root canal treatment of necrotic single-rooted teeth.
- Trial name
- NCT07607028
- Testing
- Ultrasonic Activation, 980-nm Diode Laser Activation
- Where
- Indonesia
- Volunteers
- 16 people
- Sponsor
- Hasanuddin University
Accuracy of Root Canal Curvature Analysis
Development and Diagnostic Accuracy of a Deep Learning Model for Root Canal Curvature Analysis in Mandibular Molars Using CBCT Scans: A Diagnostic Accuracy Study
Root canal preparation in endodontics poses significant challenges, particularly in curved canals of mandibular molars, where accurate preoperative assessment using CBCT imaging is crucial to avoid iatrogenic errors and improve…
- Trial name
- NCT07587060
- Where
- Egypt
- Volunteers
- 207 people
- Sponsor
- Cairo University
Root Canal Treatment, Irreversible Acute Pulpitis
Postoperative Pain Following Root Canal Treatment With Bioceramic Sealers
To evaluate and compare postoperative pain and extrusion of sealers following root canal treatment using NeoSealer Flo and CeraSeal bioceramic sealers
- Trial name
- NCT07574801
- Testing
- root canal treatment
- Volunteers
- 30 people
- Sponsor
- Cairo University
Root Canal Obturation
Endodontic Post-operative Pain Evaluation of Patients After Using Endomethasone N or Endomethasone SP (EndoPOP)
The study is a post-marketing performance and safety study, designed as a comparative, prospective, multicenter, simple-blind, randomized clinical trial.
- Trial name
- EndoPOP (NCT04885686)
- Testing
- Endomethasone N RCS, Endomethasone SP RCS
- Where
- 15 sites in France
- Volunteers
- 300 people
- Sponsor
- Septodont
Dental Root Canal Obturation
Tooth Retention After Root Canal Treatment With Endomethasone N
The aim of root canal treatment, or endodontic treatment, is to treat pulpal or periapical diseases and thus transform a pathological tooth into a healthy, asymptomatic and functional entity on the dental arch.
- Trial name
- ENDO2021-02 (NCT04945993)
- Testing
- Endomethasone N
- Where
- 5 sites in France
- Volunteers
- 179 people
- Sponsor
- Septodont
Root Canal Obturation
Measurement of the Clinical and Radiological Performance Impact of the Root Canal Treatment With BioRootTM RCS.
The aim of this retro-prospective Post-Market Clinical Follow-Up (PMCF) study is to collect long term clinical and safety data on root canal obturation after treatment, or retreatment, by BioRootTM RCS.
- Trial name
- BioRoot RCS (NCT05247138)
- Testing
- BioRootTM RCS
- Where
- 9 sites in France
- Volunteers
- 142 people
- Sponsor
- Septodont
Irreversible Pulpitis, Post-endodontic Pain
Comparative Evaluation of Diclofenac Sodium and Ibuprofen for Post-Endodontic Pain Management
This randomized controlled trial aims to compare the effectiveness of Diclofenac sodium and Ibuprofen in reducing pain after root canal treatment.
- Conditions
- Irreversible Pulpitis, Post-endodontic Pain, Root Canal Treatment
- Trial name
- DIPI-PEP (NCT07565012)
- Testing
- Ibuprofen, Diclofenac sodium
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Periapical Diseases, Root Canal Therapy
Mineral Trioxide Aggregate (MTA) vs Gutta-Percha for Non-Surgical Endodontic Retreatment in Teeth With Apical Lesions
The main objective of this study is to compare the healing rate of periapical lesions after non-surgical endodontic retreatment in teeth obturated with gutta-percha versus those obturated with mineral trioxide aggregate (MTA)…
- Conditions
- Periapical Diseases, Root Canal Therapy, Mineral Trioxide Aggregate (MTA)
- Trial name
- NCT07477171
- Testing
- Mineral trioxide aggregate (MTA) group, Gutta-percha group
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- University of Santiago de Compostela