Root Canal TreatmentNCT07574801
Postoperative Pain Following Root Canal Treatment With Bioceramic Sealers
A study testing root canal treatment in people with Root Canal Treatment and Irreversible Acute Pulpitis, run by Cairo University.
Trial summary
To evaluate and compare postoperative pain and extrusion of sealers following root canal treatment using NeoSealer Flo and CeraSeal bioceramic sealers Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Root Canal Treatment, Irreversible Acute Pulpitis
- What is being tested?
- root canal treatment
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- No sites listed yet
- Study dates
- 1 May 2026to 8 Sep 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Molar teeth requiring root canal treatment
- Diagnosed with symptomatic irreversible pulpitis,
- Patients able to understand and use the VAS scale
Who cannot join
- Patients with systemic diseases affecting pain perception
- Use of analgesics within 12 hours before treatment
- Previously treated teeth
- Teeth with periapical abscess or swelling
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
Heba ibrahim Mohammady contact
About this study
Official title: Postoperative Pain and Sealer Extrusion Following Root Canal Treatment With Neosealer Flo and Ceraseal Bioceramic Sealers; a Randomized Clinical Trial
To evaluate and compare postoperative pain and extrusion of sealers following root canal treatment using NeoSealer Flo and CeraSeal bioceramic sealers
- Conditions
- Root Canal Treatment, Irreversible Acute Pulpitis
- Being tested
- root canal treatment
- Keywords
- postoperative pain, bioceramic sealer, extrusion, root canal treatment
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
root canal treatmentProcedure or surgery
nanosealer flo bioceramic root canal sealer
root canal treatmentProcedure or surgery
cerseral bioceramic root canal sealer
| Study group | Role | What they receive |
|---|---|---|
| nanosealer flo | Experimental | bioceramic sealer Receives: Procedure: root canal treatment |
| ceraseal | Active comparator | bioceramic sealer Receives: Procedure: root canal treatment |
What is being measured
The primary outcome is the main question the study is designed to answer.
postoperative pain
postoperative pain will be measured using a visual analogue scale ( after being introduced and discussed with the patient) at 2 time points, pain will be categorized as no pain, moderate and severe.
Measured: 24 and 48 hours
Secondary outcomes (1)
sealer extrusion
sealer extrusion will be measured radiographically using standardized digital periapical posttreatment radiographs via a blinded examiner and recorded as binary outcome: present/ absent.
Measured: immediate postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 May 2026
- Study start1 May 2026 (estimated)
- Primary completion1 Sep 2026 (estimated)
- Study completion8 Sep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Root Canal TreatmentStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, sara Gamal Ahmed, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07574801
- Sponsor's protocol ID
- NewENDO3.3.3
- Status last verified
- May 2026
- First submitted
- 26 Apr 2026
- Last updated
- 8 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 8 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Postoperative Pain and Sealer Extrusion Following Root Canal Treatment With Neosealer Flo and Ceraseal Bioceramic Sealers; a Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT07574801
- Acronym / sponsor ID
- NewENDO3.3.3
- Conditions
- Root Canal Treatment, Irreversible Acute Pulpitis
- Keywords
- postoperative pain, bioceramic sealer, extrusion, root canal treatment
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 May 2026 (estimated)
- Primary completion
- 1 Sep 2026 (estimated)
- Study completion
- 8 Sep 2026 (estimated)
- First posted
- 8 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To evaluate and compare postoperative pain and extrusion of sealers following root canal treatment using NeoSealer Flo and CeraSeal bioceramic sealers
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| nanosealer flo | Experimental | Procedure: root canal treatmentbioceramic sealer |
| ceraseal | Active comparator | Procedure: root canal treatmentbioceramic sealer |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Molar teeth requiring root canal treatment
- Diagnosed with symptomatic irreversible pulpitis,
- Patients able to understand and use the VAS scale
Key exclusion criteria (4 listed)
- Patients with systemic diseases affecting pain perception
- Use of analgesics within 12 hours before treatment
- Previously treated teeth
- Teeth with periapical abscess or swelling
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| root canal treatmentnanosealer flo bioceramic root canal sealer | Procedure or surgery | nanosealer flo |
| root canal treatmentcerseral bioceramic root canal sealer | Procedure or surgery | ceraseal |
Primary outcome
postoperative pain
Time frame: 24 and 48 hours
postoperative pain will be measured using a visual analogue scale ( after being introduced and discussed with the patient) at 2 time points, pain will be categorized as no pain, moderate and severe.
1 secondary outcome
sealer extrusion
Time frame: immediate postoperatively
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 May 2026.
- Related InfoLink provided by the sponsor.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Heba ibrahim Mohammady contact
Questions about this trial
What is this clinical trial studying?
A study testing root canal treatment in people with Root Canal Treatment and Irreversible Acute Pulpitis, run by Cairo University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 8 May 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Sara Gamal Elgamal (00201094557105, sara.elgamal@dentistry.cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
postoperative pain (time frame: 24 and 48 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 May 2026.