Clinical trials: Rigidity, Muscle
Dementia, Paratonia
Safety and Effectiveness of Botulinum Toxin in Elderly Patients With Dementia and Muscle Stiffness
Aim of the study is to perform a pilot study to assess the impact of Botulinum toxin on muscle tone, and caregiver burden in individuals who are cognitively impaired and who are fully dependent.
- Trial name
- NCT02212119
- Testing
- Botulinum Toxin, Saline
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Assistive Technology Clinic, Canada
Refractive Errors
Clinical Evaluation of Acuity 200 (Fluoroxyfocon A) RGP Contact Lens
The objective of this clinical investigation is to collect valid scientific safety and effectiveness data on the Acuity 200 (fluoroxyfocon A) Rigid Gas Permeable Contact Lens, manufactured from a newly developed rigid gas…
- Trial name
- Acuity 200 (NCT03971227)
- Testing
- Acuity 200 (Fluoroxyfocon A) contact lens, Acuity 100 (Hexafocon A) contact lens
- Where
- 3 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Acuity Polymers, Inc.
Parkinson Disease
Modified Exercise Programme in Individuals With Parkinson's Disease
A feasibility study using measures of turning function derived from Inertial Measurement Unit sensory before, and after, a modified exercise programme approach.
- Trial name
- NCT03473834
- Testing
- Modified exercise programme, Medication
- Where
- Thailand
- Volunteers
- 22 people
- Sponsor
- Mahidol University
Erectile Dysfunction
SAR407899 Single-dose in Treatment of Mild to Moderate Erectile Dysfunction
The primary objective of this clinical trial is to study the ability of SAR407899 to increase the duration of penile erection in male patients with mild-moderate Erectile Dysfunction.
- Trial name
- RHOKET (NCT00914277)
- Testing
- SAR407899, Sildenafil
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Sanofi
Substance Use Disorder (SUD), Anxiety
Behavioral Rigidity in Residential Treatment for Substance Use Disorder (RIG-TD)
Behavioral rigidity, the tendency to maintain inflexible patterns of thinking and acting despite changing circumstances, is a common feature in substance use disorders, depression, and anxiety.
- Conditions
- Substance Use Disorder (SUD), Anxiety, Depression Anxiety Disorder
- Trial name
- RIG-TD (NCT07590115)
- Testing
- No intervention
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- Lauro Gutiérrez Castro
Glaucoma
The Effect of Selective Laser Trabeculoplasty (SLT) on Ocular Rigidity
The purpose of this study is to examine the influence of selective laser trabeculoplasty (SLT) on ocular rigidity in glaucoma patients.
- Trial name
- SLT/ORA (NCT01247831)
- Testing
- Selective Laser Trabeculoplasty
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Technische Universität Dresden
PARKINSON DISEASE (Disorder)
Virtual tES Device Treatment for Parkinson's Disease Motor Symptoms
This study tests a new, non-invasive brain stimulation device called Sphere V3.0 to help improve movement problems in people with Parkinson's disease.
- Trial name
- NCT07182058
- Testing
- Transcranial Electrical Stimulation Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- U: The Mind Company
Stiff-Person Syndrome
Stem Cell Transplantation for Stiff Person Syndrome (SPS)
Non-myeloablative regimens (as the investigators use herein) are designed to maximally suppress the immune system without destruction of the bone marrow stem cell compartment.
- Trial name
- SPS (NCT02282514)
- Testing
- Autologous Hematopoietic Stem Cells, Cyclophosphamide, Mesna
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Northwestern University
Parkinson's Disease
Measures of Motor Impairment in Early Parkinson's Disease
This study will test the accuracy of a new home-use electronic device that measures and records small changes in Parkinson's disease symptoms, such as tremor and impaired movement and speech.
- Trial name
- NCT00291265
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Kidney Disease Requiring Chronic Dialysis, Cardiovascular Calcification
The Intravenous Amino Acid Therapy for Vascular Rigidity in End Stage Renal Disease
The goal of this study is to learn if giving amino acids through the dialysis machine can help protect the blood vessels and heart in people with kidney failure.
- Trial name
- NASCAR (NCT07392697)
- Testing
- Amino Acid Supplementation, Sterile Saline Arm
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Haukeland University Hospital
Erectile Dysfunction
TRIP-patch vs Duplex
To measure saturation and desaturation of the cavernosal tissue with a cutaneous placed penile sensor, before and during full rigidity.
- Trial name
- NCT06402097
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- St. Antonius Hospital
Central Core Disease, Centronuclear Myopathy
Molecular and Genetic Studies of Congenital Myopathies
In the Congenital Myopathy Research Program at Boston Children's Hospital and Harvard Medical School, the researchers are studying the congenital myopathies (neuromuscular diseases present from birth), including central core…
- Conditions
- Central Core Disease, Centronuclear Myopathy, Congenital Fiber Type Disproportion, Multiminicore Disease
- Trial name
- NCT00272883
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- Boston Children's Hospital
Erectile Dysfunction
A Randomized, Open-Label, Crossover, Multicenter, Single Dose Comparator Study Evaluating Onset Of Penile Rigidity In Men With Erectile Dysfunction Who Are Treated With Sildenafil And Tadalafil
The objective of this study was to determine and compare the minimum time required to achieve penile rigidity greater than or equal to 60% at the base of the penis that is sustained for at least 3 minutes measured by Rigiscan®…
- Trial name
- NCT00644956
- Testing
- tadalafil, sildenafil
- Where
- 2 sites in Norway, United Kingdom
- Volunteers
- 56 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Age-related Macular Degeneration
Association Between Laser Interferometric Measurement of Fundus Pulsation and Pneumotonometric Measurement of Pulsatile Ocular Blood Flow in Patients With Age-related Macular Degeneration
Several methods have been proposed for the measurement of pulsatile ocular blood flow (POBF). The pneumatic tonometer, which is commercially available, assesses POBF by measurement of intraocular pressure (IOP) changes during the…
- Trial name
- NCT00991666
- Testing
- blood flow measurement
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Flatfoot
Foot Positions Affect Knee and Ankle Proprioception, Balance, Vertical Jump, and Muscle Activity in Individuals With Flexible and Rigid Flatfoot and Chronic Ankle Instability
To investigate the effect of various foot positions affect knee and ankle proprioception, balance, vertical jump, and muscle activity in individuals with flexible and rigid flatfoot and chronic ankle instability
- Trial name
- NCT05899855
- Testing
- No intervention
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Peripheral Arterial Disease
Effects of Exercise in the Functional Capacity, Central Artery and Rigidity Ankle Brachial Index
The Peripheral Arterial Disease prevalence is around 3-10 % of the world population. Exercise plays an important role in treating these patients.
- Trial name
- NCT02729090
- Testing
- Device: treadmill, Device: treadmill Train_Comb_aerobic
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Dementia, Gait
Fine and Gross Motor Function and Relationship With Muscle Tone in Older Adults With and Without Dementia
The purpose of this study was (1) to investigate changes in gait, balance, fine motor function, and muscle tone, and (2) to find out if there is a correlation between muscle tone/presence of paratonia and motor function (gross…
- Conditions
- Dementia, Gait, Balance, Muscle Tone
- Trial name
- NCT03479567
- Testing
- Gait accelerometry, balance accelerometry, Fine motor skill test
- Where
- Belgium
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University Ghent
Depression
Cognitive and Affective Processes Online
This study will provide data for evaluating the psychometric characteristics of the tests assessing cognitive flexibility, including their (1) internal consistency, (2) feasibility and tolerability, their (3) convergent and…
- Trial name
- NCT05736471
- Testing
- Computational dissociation of the causes of cognitive rigidity in depression
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Osteoporosis
Arteos II Study: Relationship Between Osteoporosis and Arterial Rigidity Within Fractured Patients Cohort
The investigators planned to study relationship between osteoporosis and arterial rigidity within fractured patients cohort.
- Trial name
- ARTEOS2 (NCT01587456)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Dental Trauma
Evaluation of the Periotest Method in Dental Traumatology
Background/Aims: The Periotest® method represents a technique for objective tooth mobility assessment. The aims of this study were: 1.
- Trial name
- NCT00904930
- Testing
- Wire Composite Splint (Dentaflex 0.45 mm), Wire Composite Splint (Denture Strengtheners)
- Where
- Germany
- Sponsor
- University of Erlangen-Nürnberg Medical School