Clinical trials: Right Ventricular Failure
Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication
Definition and Management of Right Ventricular Injury in Adult Patients Receiving Extracorporeal Membrane Oxygenation
The aim of this study is to identify existing definitions and therapeutic approaches for acute right ventricular injury (RVI) in patients receiving extracorporeal membrane oxygenation (ECMO) for respiratory support.
- Conditions
- Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication, Right Heart Failure, Right Ventricular Dysfunction
- Trial name
- NCT05948332
- Testing
- Delphi Rounds to generate consensus opinions among Experts
- Where
- United Arab Emirates
- Volunteers
- 52 people
- Sponsor
- Prashant Nasa
Multi Organ Failure, Left Ventricular Dysfunction
Acute Cardiac Dysfunction in Critical Illnes
The overall aim of the study is to establish the clinical importance of cardiac dysfunction, by estimating its incidence and impact on short- and long-term outcomes, in a mixed population of critically ill patients with…
- Conditions
- Multi Organ Failure, Left Ventricular Dysfunction, Right Ventricular Dysfunction, Tako Tsubo Cardiomyopathy
- Trial name
- NCT05860504
- Testing
- Echocardiography, Cardiac magnetic resonance imaging, Coronary CT
- Where
- Sweden
- Volunteers
- 592 people
- Sponsor
- Sahlgrenska University Hospital
Carcinoid Heart Disease, Neuroendocrine Tumors
CardioNETPOL National Registry of Carcinoid Heart Disease
Carcinoid tumors are neuroendocrine tumors (NETs), most commonly originating from the gastrointestinal tract, that may secrete bioactive substances such as serotonin.
- Conditions
- Carcinoid Heart Disease, Neuroendocrine Tumors, Carcinoid Syndrome, Valvular Heart Disease Patients
- Trial name
- CardioNETPOL (NCT07450287)
- Testing
- Observational Registry of Carcinoid Heart Disease
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Lung Cancer, Ventricular Failure
Right Ventricular Inflammation After Lung Resection
The purpose of this study is explore the impact of lung cancer surgery on inflammation and function of the right side of the heart.
- Trial name
- NCT03523611
- Testing
- Lung Resection
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Glasgow
Heart Failure
Percutaneous RVAD to Preemptively Treat Right Heart Failure Post-LVAD
Prior studies have shown that left ventricular assist device (LVAD) implantation commonly results in right ventricular failure (RVF).
- Trial name
- NCT04458103
- Testing
- Percutaneous RVAD
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- Massachusetts General Hospital
Right Heart Failure
Predictive Value of Vasodilator Challenge for Right Heart Failure After LVAD Implantation
Prospective evaluation of the predictive value for post-LVAD right ventricular failure (RHF) of pulmonary vasodilator challenge, in addition to current laboratory, echocardiographic and haemodynamic parameters.
- Trial name
- PREVV-RHF-LVAD (NCT05836233)
- Testing
- Pulmonary Vasodilators
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- San Camillo Hospital, Rome
Heart Failure
Hemodynamic Testing Strategies to Assess Pulmonary Hypertension in Heart Failure
The goal of this observational study is to learn about heart function and high lung blood pressure in patients with heart failure.
- Trial name
- NCT05672719
- Testing
- Right Heart Catheterization
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- Mount Sinai Hospital, Canada
Heart Failure
Right Ventricular (RV) Pacing in Early Post-operative Continuous Flow Left Ventricular Assist Device (LVAD)
Continuous right ventricular (RV) pacing demonstrates harm in patients with normal left ventricular (LV) function as well as in patients with cardiomyopathy and clinical heart failure.
- Trial name
- NCT01446796
- Testing
- Implantable Cardioverter-Defibrillator (subject's pre-existing ICD)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Duke University
Arrhythmogenic Right Ventricular Cardiomyopathy
Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC
This first-in-human study is designed to evaluate the safety, and preliminary efficacy (PD) of TN-401 gene therapy in adult patients with symptomatic PKP2 mutation-associated ARVC.
- Trial name
- RIDGE-1 (NCT06228924)
- Testing
- TN-401
- Where
- 7 sites in United States
- Volunteers
- 15 people
- Sponsor
- Tenaya Therapeutics
Heart Failure, Cardiac Resynchronization Therapy
LVSP Based CRT vs. RVAP Based CRT
To find out whether left ventricular septal pacing (LVSP)-based cardiac resynchronization therapy (CRT) is superior to right ventricular apical pacing (RVAP)-based CRT in patients with failed left bundle branch pacing at the…
- Conditions
- Heart Failure, Cardiac Resynchronization Therapy, Left Ventricular Septal Pacing, Right Ventricular Septal Pacing
- Trial name
- NCT05985408
- Testing
- left ventricular septal pacing, right ventricular apical pacing
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Right Ventricular Dysfunction, Right Heart Failure
Paceport Swan-Ganz Data Collection Study
RV dysfunction has been associated with increased mortality in the ICU and cardiac surgical patients. Thus, early identification of RV dysfunction at less severe stages will allow for earlier intervention and potentially better…
- Conditions
- Right Ventricular Dysfunction, Right Heart Failure, Congestive Heart Failure
- Trial name
- NCT04782154
- Where
- Canada
- Volunteers
- 136 people
- Sponsor
- Montreal Heart Institute
Pulmonary Embolism, Right Ventricular Dysfunction
Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE
SONIC-PE is a multicenter, prospective, single-arm study of 10 patients with bilateral PE treated with ultrasound-facilitated, catheter-directed lower-dose fibrinolysis (total dose 8 mg tPA given as 2 mg/hour/catheter over 2…
- Conditions
- Pulmonary Embolism, Right Ventricular Dysfunction, Right Ventricular Failure
- Trial name
- SONIC-PE (NCT06310018)
- Testing
- Ultrasound-facilitated, catheter-directed lower-dose fibrinolysis, Tissue Plasminogen Activator
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Right Heart Failure, Pulmonary Hypertension
Clinical Characteristics and Outcomes of Patients With Pulmonary Hypertension Associated Right Heart Failure
The study aims to describe the clinical characteristics and clarify the predictors of the short- and long-term outcomes of RHF patients, further assist the diagnosis, risk stratification and treatment of RHF.
- Trial name
- NCT06023134
- Testing
- Echocardiography, Right heart catheterization
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Jingyi Ren
Atrial Fibrillation (AF), Pacemaker Therapy
Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF
This prospective, randomized controlled trial aims to evaluate the effect of left bundle branch pacing (LBBP) compared with conventional right ventricular (RV) pacing on the cumulative duration (total time) of atrial high-rate…
- Conditions
- Atrial Fibrillation (AF), Pacemaker Therapy, Atrioventricular Block, Preserved Ejection Fraction
- Trial name
- LBBP-AHRE (NCT07250529)
- Testing
- Right Ventricular Pacing, Left Bundle Branch Pacing
- Where
- Greece
- Volunteers
- 244 people
- Sponsor
- University Hospital of Patras
Heart Failure
3D Assessment of RV Function in Patients Undergoing LVAD Implantation
This goal of this study is to analyze images of the right ventricle taken via 3D transesophageal echocardiography (TEE) during left ventricular assist device (LVAD) implantation.
- Trial name
- NCT05376254
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Pulmonary Embolism With Right Ventricle Enlargement
Diuretic Versus Placebo in Pulmonary Embolism
Pulmonary Embolism (PE) is a frequent and severe disease with an annual incidence of about 75000 cases in France and a short-term mortality rate of about 10%.
- Trial name
- DiPER (NCT02268903)
- Testing
- Diuretics : Furosemide
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Arterial Hypertension, Right-Sided Heart Failure
Cardiac Metabolic Remodeling After Pulmonary Vasodilator Therapy in Pulmonary Arterial Hypertension: A Pilot Study
Pulmonary arterial hypertension(PAH) is associated with the development of right heart failure. In the setting of heart failure, the heart shifts to increasing dependence on glucose metabolism.
- Trial name
- NCT04090866
- Testing
- PET/MRI
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Wisconsin, Madison
End Stage Heart Failure
Sildenafil for the Prevention of Right Heart Failure Following LVAD Implantation
Continuous-flow left ventricular assist devices (LVAD) move blood from the left ventricle (the largest chamber of the heart) to the aorta (the body's main artery) to help the heart better meet the needs of the body and to improve…
- Trial name
- NCT03356353
- Testing
- Sildenafil Citrate
- Where
- 4 sites in Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Right Ventricular Failure, Pulmonary Embolism
Quantitative Assessment of RV Strain Using cMRI Following Catheter Intervention on PE
Acute pulmonary embolism (PE) is a condition in which the vessels carrying blood to the lungs become suddenly blocked, usually by a blood clot.
- Trial name
- RVEF (NCT03341208)
- Testing
- Cardiac Magnetic Resonance Imaging
- Volunteers
- 10 people
- Sponsor
- University of Arizona
Pulmonary Hypertension, Arrhythmias, Cardiac
Arrhythmias in Pulmonary Hypertension Assessed by Continuous Long-term Cardiac Monitoring
Arrhythmias are considered a prominent phenomenon in pulmonary hypertension (PH) as the disease progresses. According primarily to retrospective studies with up to 24 hours of monitoring, supraventricular tachycardias (SVT) can…
- Conditions
- Pulmonary Hypertension, Arrhythmias, Cardiac, Heart Rate Variability, Risk Assessment
- Trial name
- ASPIRE (NCT04554160)
- Testing
- Loop recorder implantation, A smartwatch
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet