Clinical trials: Rhinosinusitis
Rhinosinusitis
Study of Cefditoren Pivoxil in Treatment of Childhood With Acute Rhinosinusitis
Cefditoren pivoxil has been used in rhinosinusitis treatment. However, little is known about the efficacy of this drug at low and high doses.
- Trial name
- RS (NCT01553006)
- Testing
- cefditoren pivoxil
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Chronic Rhinosinusitis
Point-of-Care Computed Tomography (CT) Chronic Rhinosinusitis Study
The purpose of this research study is to determine whether or not computed tomography (CT) scans performed on patients with symptoms of chronic rhinosinusitis (CRS) but without any physical signs of the disease will (1) prove to…
- Trial name
- NCT00871286
- Testing
- Pre-treatment Sinus CT Scan, Post-treatment Sinus CT Scan
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Rhinosinusitis
The Clinical Significance of the Uncinate Process Histopathology in Chronic Rhinosinusitis
Given that the uncinate process is the gatekeeper of the sinuses, we hypothesize that inflammation of the uncinate process is associated with decreased ventilation and drainage of the paranasal sinuses and consequently with the…
- Trial name
- NCT01296919
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Assuta Hospital Systems
Chronic Rhinosinusitis
Chronic Rhinosinusitis in a Danish Population: Evaluation of Causes of Disease, Progress and Treatment
Introduction: Chronic Rhinosinusitis (CRS) is defined as inflammation of the nose and the paranasal sinuses. It is a very common disorder increasing in both incidence and prevalence with significant impact on quality of life and…
- Trial name
- NCT01402349
- Volunteers
- 5,000 people
- Sponsor
- Odense University Hospital
Rhinosinusitis
Laser Assisted Treatment of Chronic Sinusitis With and Without Light Activated Agents
Chronic rhinosinusitis (CRS) is common disorder which affects up to 13% of the US population. CRS affects numerous Quality of Life (QOL) factors including smell, sleep and communication.
- Trial name
- NCT00948519
- Testing
- Laser + ICG, Laser only
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- New York Head & Neck Institute
Rhinosinusitis
Blown Nasal Secretion Measurements in Rhinosinusitis: Repeatability and Validity Compared to Nasal Lavage
To process blown nasal secretions from subjects with rhinosinusitis and to obtain a specimen by nasal lavage. To investigate the reliability and validity of the measurements we will determine their repeatability and compare them…
- Trial name
- NCT00292851
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Chronic Rhinosinusitis
Chronic Rhinosinusitis: Biochemical Markers and Biofilm
The investigators will conduct a descriptive, prospective, three-armed study concerning the pathophysiology of chronic rhinosinusitis.
- Trial name
- NCT01084811
- Testing
- biopsy
- Where
- Norway
- Volunteers
- 230 people
- Sponsor
- University Hospital, Akershus
Rhinosinusitis
FinESS Registry Study
A prospective, post-approval registry study assessing subject rhinosinusitis symptomatic status over time following treatment with FinESS Sinus Treatment using self-administered quality of life survey data.
- Trial name
- NCT00849953
- Where
- 14 sites in United States
- Volunteers
- 500 people
- Sponsor
- Entellus Medical, Inc.
Chronic Rhinosinusitis, Children
Systemic Methylprednisolone in Chronic Rhinosinusitis
The place of systemic corticosteroids in the treatment of children with chronic rhinosinusitis (CRS) remains unclear. We aimed to assess the effectiveness and tolerability of oral methylprednisolone (MP) as an anti-inflammatory…
- Trial name
- NCT01205984
- Testing
- methylprednisolone
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Ondokuz Mayıs University
Chronic Rhinosinusitis
Determinants of Surgical Outcomes in Chronic Sinusitis
Chronic rhinosinusitis (CRS) is a common health condition in the United States resulting in more than 200,000 surgical procedures annually.
- Trial name
- NCT00799097
- Where
- United States
- Volunteers
- 516 people
- Sponsor
- Oregon Health and Science University
Chronic Rhinosinusitis
Mucociliary Clearance Time in Chronic Rhinosinusitis (CRS) Patients After Sinus Surgery
The investigators are looking at the effects of baby shampoo nasal irrigation on the movement of mucous in the nose in patients who have undergone sinus surgery for chronic sinus problems.
- Trial name
- NCT00947986
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Rhinosinusitis
Effect of Sinufoam-Dexamethasone Mixture on Post Endoscopic Sinus Surgery Outcomes
Dexamethasone added to sinufoam, which is placed in the ethmoid cavity at the completion of endoscopic sinus surgery, will improve sinonasal mucosal healing.
- Trial name
- NCT01024075
- Testing
- Dexamethasone, Saline
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Migraine, Sinusitis
Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers
The primary objective of this study is to evaluate histamine, CGRP and VIP levels in saliva as biological markers for activation of trigeminal and parasympathetic nerve fibers in various clinical presentations of primary…
- Trial name
- NCT00208065
- Testing
- almotriptan or pseudoephedrine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Clinvest
Ethmoid Sinusitis, Rhinosinusitis
Study to Evaluate Safety and Effectiveness of AdvaCoat Sinus Gel
The purpose of this study is to evaluate the safety and effectiveness of AdvaCoat® sinus gel, a nasal/sinus dressing, for adhesion prevention following endoscopic ethmoid sinus surgery.
- Trial name
- NCT00554190
- Testing
- AdvaCoat sinus gel, Merogel Injectable
- Where
- 4 sites in United States
- Volunteers
- 29 people
- Sponsor
- Carbylan Therapeutics, Inc.
Chronic Rhinosinusitis
Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis.
The purpose of this study is to compare the bacteria, fungi, and viruses that are present in the sinuses of patients with chronic rhinosinusitis to patients without sinus disease using a new technology, called a microarray, that…
- Trial name
- NCT00847041
- Sponsor
- University of California, San Francisco
Rhino-Sinusitis
Treatment of Acute Rhino-Sinusitis With Essential Oils of Aromatic Plants
This randomized, double blind, parallel group study, compared the efficacy of spray containing aromatic essential oils of some herbal plants, against placebo in the treatment of patients with acute Rhino-sinusitis.
- Trial name
- NCT00610779
- Testing
- mixture of aromatic essential oils.
- Where
- Israel
- Volunteers
- 14 people
- Sponsor
- HaEmek Medical Center, Israel
Acute Respiratory Infection, Bronchitis
Phase 4 Study - Mucinex D as Adjunct Therapy
The objective of the study is to evaluate the safety and efficacy of Mucinex D tablets in providing symptom relief when administered as an adjunct to antibiotic therapy in patients with acute respiratory infection.
- Conditions
- Acute Respiratory Infection, Bronchitis, Rhinosinusitis
- Trial name
- NCT00441246
- Testing
- Mucinex D (600 mg guaifenesin and 60 mg pseudoephedrine HCl extended-release bi-layer tablets)
- Where
- 28 sites in United States
- Volunteers
- 600 people
- Sponsor
- Adams Respiratory Therapeutics
Acute Respiratory Infection, Sinusitis
Middle Meatal Bacteriology During Acute Respiratory Infection in Children
The purpose of this study is to find out whether the children with respiratory infection and the presence of pathogenic bacteria (S. pneumoniae, H. influenzae or M.
- Trial name
- NCT00545961
- Testing
- amoxicillin clavulanate acid
- Where
- 3 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Oulu University Hospital
Respiratory Tract Infections
Procalcitonin Guided Antibiotic Use in Acute Respiratory Tract Infections (PARTI)-Study
Acute respiratory tract infections (ARTI) are among the most frequent reasons for seeking medical attention in primary care. Although from predominantly viral origin, ARTIs are the most important condition for the prescription of…
- Trial name
- NCT00099840
- Testing
- Procalcitonin guided antibiotic therapy
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Basel, Switzerland