Clinical trials: Rheumatic Fever
Rheumatic Heart Disease, Rheumatic Heart Disease in Children
Clinical Trial Phase I/IIa to Evaluate the Safety and Immunogenicity of StreptInCor
This is a Phase I/IIa, randomized, double-blind, placebo-controlled, dose-escalation clinical trial to test the candidate vaccine StreptInCor.
- Conditions
- Rheumatic Heart Disease, Rheumatic Heart Disease in Children, Vaccine Adverse Reaction, Rheumatic Diseases
- Trial name
- StreptInCorVac (NCT07078357)
- Testing
- StrepIncor
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Ankylosing Spondylitis, Rheumatic Arthritis
Biomarkers in Inflammatory Rheumatic Diseases Diagnosis
Ankylosing spondylitis (AS), Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) are three diseases where early diagnosis remains a major challenge.
- Conditions
- Ankylosing Spondylitis, Rheumatic Arthritis, Systemic Lupus Erythematosus
- Trial name
- BIRDD (NCT06778343)
- Where
- Portugal
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Rheumatic Heart Disease in Children
School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions
The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD.
- Trial name
- PREVENT (NCT06720272)
- Testing
- School nurse program
- Where
- 2 sites in Nepal, Zambia
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Thomas Pilgrim
Juvenile Idiopathic Arthritis (JIA), Familial Mediterranean Fever (FMF )
Gait Profile and Variables in Pediatric Rheumatic Disease Using a Smart Insole System
In pediatric rheumatic diseases, joint swelling, effusion, tenderness, and painful restriction of joint movement, particularly in weight-bearing joints, frequently alter walking function.
- Conditions
- Juvenile Idiopathic Arthritis (JIA), Familial Mediterranean Fever (FMF ), Healthy Controls
- Trial name
- NCT06705673
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Rheumatic Heart Disease
A Long-term Follow up Study for Patients Who Participated in the GOAL Trial (GOAL-Post)
GOAL-Post is comprised of two studies that will help refine recommendations for the duration of secondary prophylaxis for children diagnosed with latent RHD, which is currently not known
- Trial name
- NCT05211024
- Testing
- Penicillin G Benzathine
- Where
- Uganda
- Volunteers
- 1,423 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Rheumatic Heart Disease
Rheumatic Heart Disease Community Streptococcal Treatment Program "RESET"
The primary objective of this study is to determine the impact of a pragmatic RHD primary prevention program in Uganda. The secondary Objective are as follow: 1.
- Trial name
- NCT05276999
- Testing
- Healthcare provider education, Community Awareness campaign
- Where
- Uganda
- Volunteers
- 66,123 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Juvenile Idiopathic Arthritis, Familial Mediterranean Fever
Assessment of Cardiorespiratory Fitness Using the PACER in Patients With Juvenile Idiopathic Arthritis and Familial Mediterranean Fever
Juvenile Idiopathic Arthritis (JIA) and Familial Mediterranean Fever (FMF) are the most common autoimmune and autoinflammatory rheumatic diseases in childhood.
- Conditions
- Juvenile Idiopathic Arthritis, Familial Mediterranean Fever, Healty Controls
- Trial name
- NCT06697028
- Testing
- Usability and Comparison
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Rheumatic Arthritis
Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of YHB1411-2 in Healthy Male Volunteers
A block-randomized, double-blind, placebo-controlled, single-dose escalating, phase I clinical trial to evaluate the safety, tolerability and pharmacokinetics of YHB1411-2 in healthy male volunteers
- Trial name
- NCT01525147
- Testing
- YHB1411-2: Level 2, YHB1411-2: Level 3, YHB1411-2: Level 4
- Where
- South Korea
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
Rheumatic Fever
Clinical Trial to Assess Safety and Immunogenicity of a Synthetic Vaccine Against Streptococcus Pyogenes
This is a double-blind, randomized, placebo-controlled phase I clinical trial with dose-escalation of a synthetic vaccine against Streptococcus pyogenes.
- Trial name
- NCT03998592
- Testing
- Streptococcus pyogenes vaccine (50 µg), Streptococcus pyogenes vaccine (100 µg), Streptococcus pyogenes vaccine (200 µg)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Butantan Institute
Rheumatoid Arthritis, Osteoarthritis
Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments
B cells are known to play an important role in auto-immune diseases by activating T cells, secreting inflammatory cytokines and autoreactive antibodies.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Systemic Lupus Erythematosus, Sjogren's Syndrome
- Trial name
- NCT01642706
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Antiphospholipid (aPL)-Positive, Rheumatic Arthritis
MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)
The primary objective of this multicenter observational registry is to characterize the clinical, epidemiological, and biological profiles of individuals of Middle Eastern, North African, and Levantine ancestry, including…
- Conditions
- Antiphospholipid (aPL)-Positive, Rheumatic Arthritis, Celiac Disease, Focal Segmental Glomerulosclerosis (FSGS)
- Trial name
- MERIT (NCT07892651)
- Where
- Jordan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Axiom Bioregistry
Rheumatic Heart Disease
The Prevalence of Rheumatic Heart Disease in School Children in Fiji
This study is an epidemiological observational cross-sectional study designed to estimate the prevalence of echocardiographically confirmed RHD in school children from 5-14 years of age in Fiji.
- Trial name
- NCT00779662
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Queensland Institute of Medical Research
Rheumatic Heart Disease
Testing a Registry-Based Strategy (ACT+) to Reduce Loss to Follow-Up in Rheumatic Heart Disease Screening in Uganda
This study aims to improve follow-up care after positive rheumatic heart disease (RHD) screening in Northern Uganda. It will identify barriers and co-develop an enhanced ACT+ strategy, then evaluate its effectiveness in…
- Trial name
- SHIELD 2 (NCT07606131)
- Testing
- The ACT+ Strategy
- Where
- Uganda
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Rheumatic Heart Disease, Mitral Stenosis
Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region
The purpose of this study is to investigate whether there are genetic differences between patients with rheumatic heart disease and members of the general population.
- Trial name
- NCT02188862
- Where
- 3 sites in Fiji, New Caledonia and 1 more
- Volunteers
- 2,372 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Rheumatic Heart Disease
Rheumatic Heart Disease School Project
Acute rheumatic Fever (ARF) results from an autoimmune response due to molecular mimicry between the M-protein on the group A β-hemolytic streptococci (GABHS) cell membrane and cardiac myosin, and may lead through recurrent or…
- Trial name
- NCT01550068
- Testing
- Echocardiography
- Where
- Nepal
- Volunteers
- 8,519 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Rheumatic Heart Disease in Children
Penicillin to Prevent Early Rheumatic Heart Disease in School-Aged Children
This study will look at whether children ages 5-8 who take Penicillin V by mouth twice a day are less likely to develop rheumatic heart disease (RHD) over a 3-year period compared to children who do not take the medicine.
- Trial name
- MEERCATS 2 (NCT07798232)
- Testing
- Oral Penicillin V
- Where
- Uganda
- Volunteers
- 9,622 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Rheumatic Heart Disease
RhEumatiC Heart diseAse Genetics
Rheumatic fever (RF) is an autoimmune disease that is mediated by the cellular and humoral immune response that follows an untreated pharyngeal Streptococcus pyogenes infection.
- Trial name
- RECHARGE (NCT02118818)
- Testing
- Next generation sequencing
- Where
- Rwanda
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Rheumatic Heart Disease
Artificial Intelligence to Scale Early Rheumatic Heart Disease Detection
The main goal of this project is to see if RADAR (Rapid AI-assisted Detection and Analysis of Rheumatic heart disease), which is a machine and deep-learning AI model, can help make rheumatic heart disease (RHD) screening easier…
- Trial name
- SHIELD 1 (NCT07599956)
- Testing
- AI assisted echocardiography
- Where
- Uganda
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acute Rheumatic Fever
Plasma Adiponectin Levels and Relations With Cytokines in Children With Acute Rheumatic Fever
We aimed to investigate if adiponectin facilitates diagnosis of ARF by analyzing adiponectin levels in acute and convalescent periods of the acute rheumatic fever and by comparing results with that of healthy control group; also…
- Trial name
- NCT01886846
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University