Clinical trials: Rheumatic Fever
Rheumatic Heart Disease, Rheumatic Heart Disease in Children
Clinical Trial Phase I/IIa to Evaluate the Safety and Immunogenicity of StreptInCor
This is a Phase I/IIa, randomized, double-blind, placebo-controlled, dose-escalation clinical trial to test the candidate vaccine StreptInCor.
- Conditions
- Rheumatic Heart Disease, Rheumatic Heart Disease in Children, Vaccine Adverse Reaction, Rheumatic Diseases
- Trial name
- StreptInCorVac (NCT07078357)
- Testing
- StrepIncor
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Ankylosing Spondylitis, Rheumatic Arthritis
Biomarkers in Inflammatory Rheumatic Diseases Diagnosis
Ankylosing spondylitis (AS), Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) are three diseases where early diagnosis remains a major challenge.
- Conditions
- Ankylosing Spondylitis, Rheumatic Arthritis, Systemic Lupus Erythematosus
- Trial name
- BIRDD (NCT06778343)
- Where
- Portugal
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Osteoarthritis, Knee
The Effect of Cryotherapy in Pain Control, Function and Quality of Life in Individuals With Knee Osteoarthritis
The purpose of this study is to verify the effect of cryotherapy in pain control, function and quality of life in individuals with knee osteoarthritis.
- Trial name
- NCT02725047
- Testing
- Cryotherapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade Federal de Sao Carlos
Still's Disease Adult Onset
An Efficacy and Safety Study of GNR-086 (Canakinumab Biosimilar) and Ilaris® in Patients With Adult-onset Still's Disease
This is a randomized single-blind comparative parallel group study of the efficacy and safety of canakinumab biosimilar GNR-086 (JSC \"GENERIUM\", Russia) and Ilaris® (Novartis Pharma Stein AG, Switzerland) in the…
- Trial name
- NCT06497491
- Testing
- GNR-086, Ilaris®
- Where
- 17 sites in Russia
- Volunteers
- 118 people
- Sponsor
- AO GENERIUM
Juvenile Rheumatoid Arthritis
Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid Arthritis
The primary objective of this study was to determine the efficacy of etanercept in pediatric patients with systemically active system onset juvenile rheumatoid arthritis (SOJRA).
- Trial name
- NCT00078806
- Testing
- Etanercept
- Volunteers
- 19 people
- Sponsor
- Amgen
Chronic Inflammatory Rheumatism
Catastrophism in Chronic Inflammatory Rheumatism
Catastrophic is defined as a negative cognitive and emotional response based on inadequate pain expression. It has three components: rumination, amplification and vulnerability.
- Trial name
- CRIC (NCT04174092)
- Testing
- completing self-questionnaires
- Where
- 2 sites in France
- Volunteers
- 533 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Rheumatic Heart Disease, Heart Diseases
Mobile Health in Structural Heart Disease
The primary objective of this investigation was to assess the impact of new mobile health devices on health outcomes among patients with rheumatic and structural heart disease in a resource limited area.
- Trial name
- ASEF-VALUES (NCT02881398)
- Testing
- mHealth, Standard-Care
- Volunteers
- 253 people
- Sponsor
- Sri Sathya Sai Institute of Higher Medical Sciences
Rheumatic Heart Disease in Children
School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions
The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD.
- Trial name
- PREVENT (NCT06720272)
- Testing
- School nurse program
- Where
- 2 sites in Nepal, Zambia
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Thomas Pilgrim
Juvenile Idiopathic Arthritis (JIA), Familial Mediterranean Fever (FMF )
Gait Profile and Variables in Pediatric Rheumatic Disease Using a Smart Insole System
In pediatric rheumatic diseases, joint swelling, effusion, tenderness, and painful restriction of joint movement, particularly in weight-bearing joints, frequently alter walking function.
- Conditions
- Juvenile Idiopathic Arthritis (JIA), Familial Mediterranean Fever (FMF ), Healthy Controls
- Trial name
- NCT06705673
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Rheumatic Heart Disease, Valvular Disease
Role of Statins In Slowing Rheumatic Heart Disease (RHD) Progression
The goal of this study is to address specific implementation questions necessary and sufficient to ensure the feasibility of the larger randomized trial examining the efficacy of statin medications in slowing rheumatic heart…
- Trial name
- NCT04575857
- Testing
- Atorvastatin
- Where
- Nepal
- Volunteers
- 100 people
- Sponsor
- University of Washington
Rheumatic Heart Disease
A Long-term Follow up Study for Patients Who Participated in the GOAL Trial (GOAL-Post)
GOAL-Post is comprised of two studies that will help refine recommendations for the duration of secondary prophylaxis for children diagnosed with latent RHD, which is currently not known
- Trial name
- NCT05211024
- Testing
- Penicillin G Benzathine
- Where
- Uganda
- Volunteers
- 1,423 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Rheumatic Heart Disease
Rheumatic Heart Disease Community Streptococcal Treatment Program "RESET"
The primary objective of this study is to determine the impact of a pragmatic RHD primary prevention program in Uganda. The secondary Objective are as follow: 1.
- Trial name
- NCT05276999
- Testing
- Healthcare provider education, Community Awareness campaign
- Where
- Uganda
- Volunteers
- 66,123 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Rheumatic Disease, Rheumatic Disorder
Survey About Diet in Chronic Inflammatory Rheumatic Diseases
A French Survey on patients' practices, knowledge and beliefs about diet in chronic inflammatory rheumatic diseases (rheumatoid arthritis, psoriatic arthritis, spondylarthritis) Use of a questionnaire about what patients have…
- Conditions
- Rheumatic Disease, Rheumatic Disorder, Inflammatory Rheumatism, Rheumatoid Arthritis
- Trial name
- NCT05283096
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 203 people
- Sponsor
- Poitiers University Hospital
Rheumatic Heart Disease, Heart Failure
Dapagliflozin Effect on Rheumatic Mitral Stenosis
Rheumatic mitral stenosis remains a health problem in developing countries. Progressive fibrosis of the valves and myocardium is the main pathophysiology that plays an important role.
- Conditions
- Rheumatic Heart Disease, Heart Failure, Mitral Stenosis
- Trial name
- Dapa-Rhemis (NCT05618223)
- Testing
- Dapagliflozin
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Universitas Sebelas Maret
Fatigue, Inflammatory Rheumatism
Guided Self-Management Intervention Targeting Fatigue in Rheumatic Inflammatory Diseases
Fatigue is common and debilitating in rheumatic inflammatory diseases as for other chronical medical conditions. The purpose of this study is to develope and evaluate a cognitive behavioural intervention targeting fatigue.
- Trial name
- NCT03216616
- Testing
- Cognitive Behavioural Therapy
- Volunteers
- 40 people
- Sponsor
- Diakonhjemmet Hospital
Inflammatory Rheumatism, Polymyalgia Rheumatica
PRediction Of DIverse Glucocorticoids toxIcity OUtcomeS
To date, there is no available tool that allows, at individual level, determination of the probability to develop clinically relevant complications of prolonged glucocorticoid therapy.
- Conditions
- Inflammatory Rheumatism, Polymyalgia Rheumatica, Giant Cell Arteritis, Idiopathic Inflammatory Myopathies
- Trial name
- PRODIGIOUS (NCT04664465)
- Where
- 12 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Juvenile Idiopathic Arthritis, Familial Mediterranean Fever
Assessment of Cardiorespiratory Fitness Using the PACER in Patients With Juvenile Idiopathic Arthritis and Familial Mediterranean Fever
Juvenile Idiopathic Arthritis (JIA) and Familial Mediterranean Fever (FMF) are the most common autoimmune and autoinflammatory rheumatic diseases in childhood.
- Conditions
- Juvenile Idiopathic Arthritis, Familial Mediterranean Fever, Healty Controls
- Trial name
- NCT06697028
- Testing
- Usability and Comparison
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Scabies, Impetigo
Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory
The purpose of this study is to determine whether a coordinated regional approach to healthy skin programs in six remote Aboriginal communities can demonstrate, not only a reduction in the burden of scabies and streptococcal skin…
- Conditions
- Scabies, Impetigo, Pyoderma, Streptococcal Infections
- Trial name
- EAHSP (NCT00884728)
- Where
- Australia
- Volunteers
- 2,329 people
- Sponsor
- Menzies School of Health Research
Rheumatic Arthritis
Effects of Task-Oriented Training and Mulligan Mobilization on Hand Function, Pain and Quality of Life in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic and progressive inflammatory disease that frequently affects the hand joints. Over time, this disease leads to joint deformities, pain, decreased muscle strength and severe impairment in…
- Trial name
- NCT07029113
- Testing
- Task-oriented trainig, Mulligan mobilization, Conventional treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Sars-CoV2, Rheumatoid Arthritis
Morbimortality of Covid-19 in Patients With Chronic Inflammatory Rheumatism Treated With Immunosuppressants
A retrospective monocentric study with large active files of patients monitored for rheumatoid arthritis, spondyloarthritis and systemic lupus erythematosus with as main endpoint the morbimortality of Covid-19 in these patients…
- Conditions
- Sars-CoV2, Rheumatoid Arthritis, Rheumatic Diseases
- Trial name
- CORhum (NCT04426279)
- Testing
- questionnaire assesment
- Where
- France
- Volunteers
- 539 people
- Sponsor
- University Hospital, Lille