Clinical trials: Rhegmatogenous Retinal Detachment
Retinal Detachment Rhegmatogenous
Use of Preoperative Gas in Eyes With Macula-off Rhegmatogenous Retinal Detachment (RRD)
The purpose of this study is to evaluate whether a preoperative intraocular gas injection improves visual outcomes in patients with a macula-off rhegmatogenous retinal detachment (RRD).
- Trial name
- NCT07855770
- Testing
- Intravitreal 100% C3F8 Injection, Pars plana vitrectomy or pars plana vitrectomy with scleral buckle
- Where
- 2 sites in United States
- Volunteers
- 190 people
- Sponsor
- Wills Eye
Rhegmatogenous Retinal Detachment
Corneal Endothelial Cell Loss After Pneumatic Retinopexy for the Repair of Primary Rhegmatogenous Retinal Detachment
There are multiple ways to treat retinal detachment, the aim of this study is to compare the amount of corneal endothelial cell loss after pneumatic retinopexy in comparison to vitrectomy.
- Trial name
- NCT02185469
- Testing
- Pneumatic retinopexy, vitrectomy, sulfur hexafluoride (SF6)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Retinal Detachment
Study of Denufosol (INS37217) in Subjects With Rhegmatogenous Retinal Detachment
The purpose of this study is to test if denufosol will remove the fluid build-up in the eye so that the retina can be re-attached without invasive surgery.
- Trial name
- NCT00083967
- Testing
- denufosol tetrasodium (INS37217) Intravitreal Injection
- Where
- 33 sites in United States
- Volunteers
- 23 people
- Sponsor
- Merck Sharp & Dohme LLC
Rhegmatogenous Retinal Detachment
Combined Laser-surgical Technology of RRD Treatment
Purpose: to assess the efficacy and safety of combined laser-surgical technology of RRD treatment
- Trial name
- NCT04403750
- Testing
- Combined laser-surgical technology of RRD treatment
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Retinal Detachment, Rhegmatogenous Retinal Detachment
Lamivudine and Plasma Markers of Inflammation in Retinal Detachment
The goal of this clinical trial is to test whether an oral medication (lamivudine) enters the eye and reduces blood markers of inflammation in people who undergo retinal detachment surgery (pars plana vitrectomy).
- Trial name
- NCT06056596
- Testing
- Lamivudine 300 MG
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Wisconsin, Madison
Rhegmatogenous Retinal Detachment
Clinical Trial of Cryotherapy Versus Postoperative Laser Photocoagulation
The purpose of this randomized clinical trial was to compare reattachment rates among patients with rhegmatogenous retinal detachment who underwent scleral buckle surgery with retinopexy by cryotherapy versus postoperative (one…
- Trial name
- NCT01068379
- Testing
- criopexy, laser
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Retinal Detachment Rhegmatogenous
Air Tamponade Versus Fluorinated Gas Tamponade for Rhegmatogenous Retinal Detachment
TITLE: RCT of air tamponade versus fluorinated gas tamponade for rhegmatogenous retinal detachment DESIGN: Non-inferiority RCT of 150 patients from 10 UK centres AIMS: To assess whether air tamponade is non inferior to gas…
- Trial name
- GREEN (NCT07034469)
- Testing
- air, Gas SF6 (Sulfur Hexafluoride) and others
- Volunteers
- 150 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Rhegmatogenous Retinal Detachment, Proliferative Vitreoretinopathy
A Multi-Center Study on the Use of Rho-Kinase Inhibitor to Reduce or Prevent PVR in RRD Eyes at High Risk for PVR
The purpose of this study is to determine if a drug called netarsudil is safe and able to prevent the development of scar tissue after retinal detachment repair.
- Trial name
- NCT05660447
- Testing
- Netarsudil 0.02% Ophthalmic Solution [RHOPRESSA], Glycerin 0.2%/Hypromellose 0.2%/Peg 1%/Soln,Oph,Ud
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wills Eye
Retinal Detachment
Impact of ILM Peeling in RRD/ I-Peel
Retinal detachment is associated with a substantial risk of re-detachment in 10-20% and to the formation of secondary epiretinal membranes in up to 15%.
- Trial name
- I-Peel (NCT04767555)
- Testing
- ILM (inner limiting membrane) peeling
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- Berner Augenklinik
Rhegmatogenous Retinal Detachment
Early Prevention Strategies of Severe Proliferative Vitreoretinopathy Base on Precision Diagnosis of Single Cell Sequencingvitreoretinopathy
Study of initiating proliferative vitreoretinopathy (PVR)cell subtype (PVR initiating cells (PVR-IC) in RPE cells of rhegmatogenous retinal detachment (RRD) patients; to prove the percentage of PVR-IC decides the risk of serious…
- Trial name
- NCT04520789
- Testing
- RPE cell collection and single cell heterogeneity study, Postoperative intervention, Conventional Surgery for Retinal Detachment
- Volunteers
- 60 people
- Sponsor
- Shanghai 10th People's Hospital
Rhegmatogenous Retinal Detachment of Both Eyes (Diagnosis)
Characters of Epiretinal Membranes in Patients With Previous Vitrectomy for Retinal Detachment
31 patients were included in the study,15 cases with ERM in silicone filled eyes and 16 eyes with idiopathic ERM
- Trial name
- RD (NCT04288440)
- Testing
- Surgery, Vitrectomy machine
- Where
- Egypt
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Tanta University
Rhegmatogenous Retinal Detachment, Proliferative Vitreoretinopathy
Intravitreal Infliximab for Proliferative Vitreoretinopathy
Proliferative vitreoretinopathy (PVR) is the most common cause for failure of rhegmatogenous retinal detachment repair and is characterized by the growth and contraction of cellular membranes within the vitreous cavity on both…
- Conditions
- Rhegmatogenous Retinal Detachment, Proliferative Vitreoretinopathy, Retinal Detachment
- Trial name
- FIXER (NCT04891991)
- Testing
- Intravitreal infliximab, Pars plana vitrectomy
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Retinal Detachment
23 Gauge and 20 Gauge Vitrectomy for Rhegmatogenous Retinal Detachments
This study is a comparison (23 gauge vs 20 gauge instrumentation) of surgical instrumentation for retinal detachment repair.
- Trial name
- NCT01716507
- Testing
- Retinal Detachment repair
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Wills Eye
Rhegmatogenous Retinal Detachments
Study of Vitreoretinal Molecular Changes During Rhegmatogenous Retinal Detachment
Retinal detachment is a condition with an estimated incidence of between 9.5 and 18.2 cases per 100,000 individuals. It is an ophthalmological emergency that threatens visual acuity and requires surgery.
- Trial name
- LIPIDRET (NCT06347302)
- Testing
- Blood sampling, vitreous sampling, Sub-retinal fluid sampling
- Where
- France
- Volunteers
- 137 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Retina; Detachment, Rhegmatogenous
Head Positioning After Retina Detachment Repair
This study aims to determine if one day post-operative prone head positioning can be as good as seven days post-operative prone head positioning in patients with retinal detachments with inferior retinal breaks after pars that…
- Trial name
- NCT03714503
- Testing
- Retina re-attachment repair using C3F8 gas tamponade
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Kansas Medical Center
Retinal Detachment With Break
Suprachoroidal Visco-buckling for the Treatment of Rhegmatogenous Retinal Detachment
The study compares standard surgery for retinal detachment (RD) (vitrectomy, cryotherapy and gas) with a surgical variation that replaces the intraocular gas tamponade with suprachoroidal injection of viscoelastic underneath the…
- Trial name
- VIKING (NCT04557527)
- Testing
- Pars plana vitrectomy, laser or cryo retinopexy and intraocular gas tamponade, Suprachoroidal viscobuckle with 2.3% Sodium hyaluronate (Healon 5 Ophthalmic viscoelastic device)
- Where
- 6 sites in United Kingdom
- Volunteers
- 36 people
- Sponsor
- King's College Hospital NHS Trust
Rhegmatogenous Retinal Detachment, High-risk for Proliferative Vitreoretinopathy (PVR)
Prophylactic Intravitreal 5-Fluorouracil and Heparin to Prevent PVR in High-risk Patients With Retinal Detachment.
This study investigates the effectiveness of a simple treatment to prevent proliferative vitreoretinopathy (PVR). Intraoperative intravitreal 5-fluorouracil (5-FU) and low molecular weight heparin (LMWH) is used as a prophylactic…
- Trial name
- PRIVENT (NCT02834559)
- Testing
- 5-fluorouracil and low molecular weight heparin
- Where
- 13 sites in Germany
- Volunteers
- 326 people
- Sponsor
- Universitätsklinikum Köln
Retinal Detachment
Prognostic Value of Hemodynamic Disturbances in Rhegmatogenous Retinal Detachment (CRADO-RED)
Retinal detachments correspond to a separation of the neuroepithelium from the pigment epithelium. They can be exudative (sometimes in conjunction with a tumor), tractional, traumatic (postoperative) or rhegmatogenous (in…
- Trial name
- CRADO-RED (NCT02618083)
- Testing
- color Doppler ultrasound
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Rhegmatogenous Retinal Detachment
Pneumatic Retinopexy Versus Vitrectomy for Retinal Detachment in Patients With Extended Criteria
Objective: To compare outcomes of retinal detachment repair following pneumatic retinopexy (PnR) versus pars plana vitrectomy in terms of anatomical success, functional success and patient quality of life in patients with…
- Trial name
- NCT02871531
- Testing
- Pneumatic retinopexy, Vitrectomy
- Where
- 2 sites in Canada
- Volunteers
- 178 people
- Sponsor
- Unity Health Toronto
Retinal Detachment Rhegmatogenous
Emulsification of Different Viscosity Silicone Oil After Complicated Retinal Detachment Surgery
Silicone oil has been used as a surgical tool in complicated retinal detachment surgery. There are some complications occurring in pars plana vitrectomy with silicone oil tamponade.
- Trial name
- NCT02988583
- Testing
- Surgery using low viscosity silicone oil, Surgery using high viscosity silicone oil
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Khon Kaen University