Clinical trials: Reward Learning
Low Weight Eating Disorders, Anorexia Nervosa
Reward Systems and Food Avoidance in Eating Disorders
The researchers plan to explore brain networks involved in emotion processing and learning using a brain scan and test meals. One core feature of Anorexia Nervosa (AN) is eating a small number of high-calorie or high-fat foods.
- Trial name
- NCT02795455
- Testing
- Interoceptive Exposure (IE), Family Based Therapy-Weight Gain Control (FBT-WG), meal replacement shake
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Reward Responses, Gastrointestinal Hormones
Assessment of Reward Responses to Erythritol Using Flavor Preference Learning
The aim of this project is to investigate the reward responses to oral erythritol compared to sucrose and sucralose using flavor preference learning in healthy participants.
- Conditions
- Reward Responses, Gastrointestinal Hormones, Glycemic Control, Appetite
- Trial name
- NCT05279183
- Testing
- Erythritol, Sucrose, Sucralose
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Sulpiride's Effect on Striatal BOLD Signal During Working Memory Gating, Interaction of Sulpiride, Average Reward Rate and Evidence Accumulation
Dopamine and Cognition
Rationale: To unravel the role of dopamine in gating of working memory, motivation and learning. Objective: The primary objective of this study is to isolate effects of blocking D2 receptor stimulation on gating of working…
- Conditions
- Sulpiride's Effect on Striatal BOLD Signal During Working Memory Gating, Interaction of Sulpiride, Average Reward Rate and Evidence Accumulation, Interaction of Sulpiride, Average Reward Rate and Cognitive Effort
- Trial name
- NCT05884671
- Testing
- Sulpiride 400 MG
- Where
- Netherlands
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Donders Centre for Cognitive Neuroimaging
Marijuana, THC
THC Memory & Reward Learning Pilot
Tetrahydrocannabidiol (THC) is the psychoactive chemical in cannabis that makes people high. This study aims to dissect acute impairment of various forms of memory and learning by THC in cannabis compared to placebo.
- Conditions
- Marijuana, THC, Cannabis
- Trial name
- NCT05116527
- Testing
- Marijuana, Hash, THC, or Grass
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Learning Disabilities
Effects of Oxytocin on Reinforcement Learning
The main aim of the study is to investigate whether intranasal oxytocin (24IU) influences reward sensitivity and performance monitoring during reinforcement learning.
- Trial name
- NCT03846271
- Testing
- intranasal oxytocin
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Obesity, Childhood, Eating Behavior
Study of Brain, Reward, and Kids' Eating
Children from rural communities are at greater risk for obesity than children from more urban communities. However, some children are resilient to obesity despite greater exposure to obesogenic influences in rural communities…
- Trial name
- BRAKE (NCT05456516)
- Testing
- Food Rating
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Penn State University
Schizophrenia Spectrum Disorders, Negative Symptoms in Schizophrenia
ENGAGE: Virtual Reality-based Psychotherapy for Negative Symptoms in Schizophrenia
The primary goal of this pilot study is to examine the feasibility and acceptability of a new Virtual Reality-based intervention against negative symptoms in schizophrenia spectrum disorders (SSD).
- Trial name
- ENGAGE (NCT06993831)
- Testing
- Virtual Reality-based psychotherapy
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Behavior
Modulating Reward Learning Using Transcranial Magnetic Stimulation
Our specific aim is to examine the effects of single TMS pulse on reward processing during goal-directed behavior. In these experiments the investigators will utilize a scalp-recorded brain oscillation called frontal midline…
- Trial name
- NCT06323057
- Testing
- Single pulse TMS to the frontal cortex
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Major Depressive Disorder, Anhedonia
Depression and Dopamine Transporter Function Study Using C-11 Altropane
Major depressive disorder (MDD) is often characterized by anhedonia and impaired ability to modulate behavior as a function of rewards.
- Trial name
- NCT01701141
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Breastfeeding, Breastfeeding Education
Improved Child Nutrition and Development Through Social Transfers
The goal of this clinical trial is to learn if a conditional social transfer works to improve rates of complementary breastfeeding.
- Conditions
- Breastfeeding, Breastfeeding Education, Breastfeeding Duration, Breastfeeding Continuation
- Trial name
- TENDER (NCT07569172)
- Testing
- Social Transfer
- Where
- Côte d’Ivoire
- Volunteers
- 1,040 people
- Sponsor
- Swiss Tropical & Public Health Institute
Ultra-processed Foods (UP)
Effects of Processed Foods on Brain Reward Circuitry and Food Cue Learning
Examine if ultra-processed (UP) foods are more effective in activating reward, attention, and memory brain regions and in promoting food cue learning than minimally-processed foods.
- Trial name
- NCT06165952
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Stanford University
Depression / Major Depressive Disorder
Longitudinal Effects of Brain Stimulation on Decision-Making and Reward Learning
This study investigates the longitudinal effects of brain stimulation treatments on decision-making and reward learning. Here, daily assessments of reinforcement learning behavior are used in patients with depression who receive…
- Trial name
- NCT07823218
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Bonn
Anorexia Nervosa
Appetitive Conditioning in Anorexia Nervosa
Anorexia nervosa (AN) is characterized by a reduced drive to pursue rewarding experiences and stimuli. Food consumption - which is almost universally experienced as pleasurable - is not described as rewarding by those with AN.
- Trial name
- ACAN (NCT05531604)
- Testing
- appetitive conditioning
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
tVNS Effects on Motivation in Depression
Attaining goals or rewards commonly entails response costs. In light of cost and benefits, how do participants decide what effort should be put in to give it a shot? Figuratively, you may "go with your gut", but the literal…
- Trial name
- NCT05120336
- Testing
- transcutaneous vagus nerve stimulation
- Where
- Germany
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Adiposity, Insulin Sensitivity/Resistance
The Influence of Obesity and Insulin Sensitivity on Reward Processing and Decision Making
Reward learning and decision-making processes, which operate largely outside of conscious control, shape food choices and eating behaviors.
- Conditions
- Adiposity, Insulin Sensitivity/Resistance, Decision-Making, Reward Learning
- Trial name
- No acronym (NCT07638059)
- Testing
- Beverage: Conditioned Stimulus -, Beverage: Conditioned Stimulus +
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Vagus Nerve Stimulation in Reward Learning
Pulsed tVNS Protocol and Reinforcement Learning
The aim of this study is to investigate the potential of a phasic taVNS stimulation protocol for reinforcement learning. The investigators will disentangle its effects on learning actions and outcomes through the administration…
- Trial name
- NCT06205108
- Testing
- taVNS stimulation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Anorexia Nervosa
Influence of Reward and Punishment on Goal-directed and Habit Learning in Adolescent Anorexia Nervosa
The proposed study of adolescents with anorexia nervosa (AN) will examine the association of behavioral differences in constructs of decision making, brain structure and connectivity, and eating disorder (ED) symptoms.
- Trial name
- NCT04051879
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Children's Nutrition Intake
The Nutritional Effect of Parental Use of Food as a Reward
Control rules are common parental practices that use food as reward to encourage children to conduct parents' preferred behaviors.
- Trial name
- NCT02354157
- Testing
- no intervention
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- McGill University
High-risk Alcohol Consumption Pattern, Low-risk Alcohol Consumption Pattern
Learning in Young Adults as Predictor for the Development of Alcohol Use Disorders
Overall goal of this study is to scrutinize the relation of learning behavior and related brain activity to the development of alcohol use disorder (AUD).
- Trial name
- LeAD (NCT01744834)
- Where
- 3 sites in Germany
- Volunteers
- 201 people
- Sponsor
- Technische Universität Dresden
Psychosis
Determining the Role of Social Reward Learning in Social Anhedonia
This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels.
- Trial name
- SAMI (NCT05617898)
- Testing
- Motivational Interviewing, Nutrition Didactic Training
- Where
- 2 sites in United States
- Volunteers
- 152 people
- Sponsor
- University of Alabama at Birmingham