Clinical trials: Reward Learning
Emotional Processing
Losartan and Emotional Learning
This study explores the effects of single-dose losartan (50mg) versus placebo on emotional processing in healthy volunteers.
- Trial name
- NCT06628154
- Testing
- Losartan potassium 50mg
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Obsessive-Compulsive Disorder
The Neurocircuitry of Relief During Avoidance Learning in Patients With Obsessive-compulsive Disorder
To investigate the neuro-mechanisms underpinning persistent avoidance in OCD patients
- Trial name
- AvoidOCD (NCT04685018)
- Testing
- fMRI acquisition
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Alcohol Use Disorder
The Role of Dopaminergic and Glutamatergic Neurotransmission for Dysfunctional Learning in Alcohol Use Disorders
The aim of this project is to assess reward- based learning behavior and its association with alterations in dopaminergic and glutamatergic transmission in detoxified alcohol-dependent patients and matched controls.
- Trial name
- LeADP5 (NCT02094196)
- Testing
- Alcohol detoxification
- Where
- 2 sites in Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Bipolar Disorder
Reward and Punishment Sensitivity in Bipolar Disorders
Bipolar disorder (BD) represents a chronic mood disorder and one of the leading causes of disability worldwide. Complexity of its clinical presentations leads to delayed diagnosis and difficult management in routine clinical…
- Trial name
- Recodec-BP (NCT04237610)
- Testing
- behavioral assessment
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Depression, Inflammation
Simvastatin and Emotional Processing (OxSTEP)
Simvastatin is being employed because it is a 'statin'. As a drug class, statins have broad anti-inflammatory properties. Low-level inflammation is thought to be a potentially important mediator of the effects of psychosocial…
- Trial name
- OxSTEP (NCT04973800)
- Testing
- Simvastatin 20mg
- Where
- United Kingdom
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Overweight, Obesity
Cue-Reward Learning and Weight Gain in Youth
The objective of the study is to compare children at low risk for obesity (two healthy weight parents) to children at high risk for obesity (two overweight parents) in their response rate to food taste and in their rate of…
- Trial name
- ChildLearn (NCT03254576)
- Testing
- Functional MRI
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Drug Addiction, Vulnerability to Substance Addiction
Individual Differences in Reward and Impulse Control
Background: The risk for becoming addicted to drugs varies among individual, even those using similar drugs in a similar way. It is not known why some people become addicted and others do not.
- Trial name
- NCT01621607
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Caffeine
Does Caffeine Facilitate Human Reward Learning Behaviors?
"Learning from the rewards" is underlying the formulation of knowledge and habits in daily life. Caffeine is the most commonly used "psychoactive" substance that could change one's mind state by affecting the brain and nervous…
- Trial name
- ADoRe (NCT05325502)
- Testing
- caffeine, mannitol
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Yu-Shiuan Lin
Neurocognitive Model, Decision-Making
Motivation, Learning and Decision Making in Changing Environments
The main objective of this study is to develop a models of sequential decision-making, learning and motivation that includes emotions as driving forces of adaptive behaviour.
- Trial name
- MOTILEARN (NCT07314112)
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Dysphoria
Effects of Transcranial Direct Current Stimulation on Reward Learning in Subclinical Depression.
This project will test whether transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) can alter reward learning behaviour in subclinical depression.
- Trial name
- NCT03393312
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Hormonal Changes, Menstrual Cycle
Dopamine, Reward Learning and Sex Hormones
Hormonal transition periods during the menstrual cycle may predispose women to mental disorders. Hormonal fluctuations provide specific neuroendocrine conditions that modulate brain structure and function and these actions affect…
- Trial name
- NCT06365515
- Testing
- Levodopa administration
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Normal Physiology, fMRI
The Effect of Transcranial Magnetic Stimulation on Learning With Reward in Healthy Humans
Background: Two areas on the surface of the brain, the dorsolateral prefrontal cortex (DLPFC) and motor cortex (MC), play a key role during learning.
- Trial name
- NCT01260740
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Motor Performance, Motor Learning
Rewarding Feedback in Motor Learning and Rehabilitation
The effect of rewarding vs. non-rewarding feedback on acquisition of a motor skill is investigated in a single blinded parallel group design.
- Trial name
- KFSP-REWARD (NCT02189564)
- Testing
- Feedback about good performance, Feedback about good performance + money, Feedback about average performance
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Kai Lutz, PhD
Depression, Major Depressive Disorder
Reward Emotion Learning and Ketamine Study
Ketamine's efficacy as an antidepressant is now well established yet the mechanisms underlying its antidepressant effect are yet to be fully described.
- Conditions
- Depression, Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- RELAKS (NCT04850911)
- Testing
- Ketamine Hydrochloride
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Alcohol Use Disorders
Learning and Relapse Risk in Alcohol Dependence
The aim of this project is to assess which behavioral and neuroimaging alterations associated with reward- based learning predict relapse in alcohol- dependent patients within a follow- up period of 12 months.
- Trial name
- LeAD (NCT01679145)
- Where
- 3 sites in Germany
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Healthy
Testing the Contribution of Orbitofrontal Cortex Networks to Reward Identity Learning
This research study examines the contribution of orbitofrontal cortex (OFC) networks to learning reward identity expectations.
- Trial name
- NCT04926961
- Testing
- Real transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Low Weight Eating Disorders, Anorexia Nervosa
Reward Systems and Food Avoidance in Eating Disorders
The researchers plan to explore brain networks involved in emotion processing and learning using a brain scan and test meals. One core feature of Anorexia Nervosa (AN) is eating a small number of high-calorie or high-fat foods.
- Trial name
- NCT02795455
- Testing
- Interoceptive Exposure (IE), Family Based Therapy-Weight Gain Control (FBT-WG), meal replacement shake
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Reward Responses, Gastrointestinal Hormones
Assessment of Reward Responses to Erythritol Using Flavor Preference Learning
The aim of this project is to investigate the reward responses to oral erythritol compared to sucrose and sucralose using flavor preference learning in healthy participants.
- Conditions
- Reward Responses, Gastrointestinal Hormones, Glycemic Control, Appetite
- Trial name
- NCT05279183
- Testing
- Erythritol, Sucrose, Sucralose
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Sulpiride's Effect on Striatal BOLD Signal During Working Memory Gating, Interaction of Sulpiride, Average Reward Rate and Evidence Accumulation
Dopamine and Cognition
Rationale: To unravel the role of dopamine in gating of working memory, motivation and learning. Objective: The primary objective of this study is to isolate effects of blocking D2 receptor stimulation on gating of working…
- Conditions
- Sulpiride's Effect on Striatal BOLD Signal During Working Memory Gating, Interaction of Sulpiride, Average Reward Rate and Evidence Accumulation, Interaction of Sulpiride, Average Reward Rate and Cognitive Effort
- Trial name
- NCT05884671
- Testing
- Sulpiride 400 MG
- Where
- Netherlands
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Donders Centre for Cognitive Neuroimaging
Marijuana, THC
THC Memory & Reward Learning Pilot
Tetrahydrocannabidiol (THC) is the psychoactive chemical in cannabis that makes people high. This study aims to dissect acute impairment of various forms of memory and learning by THC in cannabis compared to placebo.
- Conditions
- Marijuana, THC, Cannabis
- Trial name
- NCT05116527
- Testing
- Marijuana, Hash, THC, or Grass
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital