Clinical trials: Revision
Reproductive Performance Following Ovarian Transplantation
Transplantation of Frozen Thawed Ovarian Tissue High Reproductive Performance
Design: prospective cohort study. Setting: Tertiary university-affiliated ART and oncology centers. Patients: 20 cancer survivors who underwent ovarian transplantation of frozen-thawed ovarian tissue, with the aim to conceive.
- Trial name
- NCT02659592
- Testing
- transplantation of ovarian tissue
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Osteoarthritis
The Press Fit Condylar (P.F.C.) Sigma Rotating Platform (RP) TC3 Revision Knee in Revision Knee Arthroplasty
The purpose of this study is to evaluate the long-term clinical and functional performance of the P.F.C. Sigma Rotating Platform TC3 knee system in revision knee surgery and to determine whether the implant design results in a…
- Trial name
- TC3 (NCT00733681)
- Testing
- PFC Sigma RP TC3 Revision knee system
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 181 people
- Sponsor
- DePuy International
Infection of Total Knee Joint Prosthesis, Aseptic Loosening of Prosthetic Joint
Surgical / Economic Effect of the Aquamantys System in Blood Management for Aseptic and Septic Revision TKA
To assess the surgical and economic effectiveness of the Aquamantys System in managing intra- and post-operative blood loss, and reducing transfusion needs in patients undergoing both aseptic and septic revision total knee…
- Trial name
- NCT02266407
- Testing
- Aquamantys System
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medtronic Surgical Technologies
Aseptic Loosening, Arthroplasty Complications
Total Hip Arthoplastry Revision by Dual-mobility Acetabular Cup Cemented in a Metal Reinforcement
Total hip arthroplasty (THA) requires bone reconstruction in case of severe acetabular injury, with risk of dislocation, especially postoperatively.
- Trial name
- PTH (NCT03680443)
- Testing
- assembly in THA revision
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Revision Total Hip Arthroplasty, Periprosthetic Fracture of Hip
Prospective Follow-up of the Prevision Hip Stem With Comparison of Different Implant Variants
The study design is confirmative for non-inferiority of the functional outcome of the implants and is intended to examine the safety and performance of the Prevision hip stem.
- Trial name
- PREMO (NCT06626490)
- Testing
- Prevision Revision hip endoprosthesis stem implantation
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 120 people
- Sponsor
- Aesculap AG
Goiter
Subtotal Versus Total Thyroidectomy for Benign Goiter
The extent of thyroid resection in benign goiter is controversial. Potential advantages of TT over BST may include: one-stage removal of incidental thyroid cancer reported in up to 10% of operatively treated benign thyroid…
- Trial name
- NCT01273714
- Testing
- thyroid resection
- Where
- Poland
- Volunteers
- 8,006 people
- Sponsor
- Jagiellonian University
Type 2 Diabetes Treated With Insulin
C-peptide Concentrations in Type 2 Diabetes Treated With Insulin; is it Time to Revise the Treatment of Type 2 Diabetes
C-peptide is used to evaluate beta cell reserves. Patients with type 2 diabetes are treated with insulin for different indications.
- Trial name
- NCT04005261
- Testing
- C-peptide concentrations
- Where
- Turkey (Türkiye)
- Volunteers
- 249 people
- Sponsor
- Goztepe Training and Research Hospital
Disorders of Consciousness, Vegetative State
Effectiveness of tTIs for Improving Consciousness in Patients With DoC
The goal of this clinical trial is to learn if a new type of brain stimulation called theta-burst patterned temporal interference stimulation (tTIs) works to improve awareness in people with disorders of consciousness (DoC).
- Conditions
- Disorders of Consciousness, Vegetative State, Minimally Conscious State
- Trial name
- NCT07539740
- Testing
- Theta-burst Patterned Temporal Interference Stimulation (tTIs)
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Zhujiang Hospital
Surgical Wound Infection
Antibiotic Prophylaxis for Revision, Clean Head and Neck Surgery
We hypothesized that revision clean head \& neck surgery may have a higher rate of wound infection that may be lowered with prophylactic antibiotic treatment.
- Trial name
- NCT01980082
- Testing
- Cefazolin
- Where
- Israel
- Volunteers
- 53 people
- Sponsor
- Rabin Medical Center
Opioid-use Disorder, Addiction
Competitive Revision for CLARO: Collaboration Leading to Addiction Treatment and Recovery From Other Stresses
The purpose of this study is to develop and then test an enhanced version of the parent study's collaborative care intervention for co-occurring disorders (CC-COD) to reduce the risk of suicide and overdose among individuals with…
- Conditions
- Opioid-use Disorder, Addiction, Depression, Post Traumatic Stress Disorder
- Trial name
- NCT04634279
- Testing
- Collaborative care Plus
- Where
- 12 sites in United States
- Volunteers
- 68 people
- Sponsor
- RAND
Survival of the Implants With Revision as Endpoint, Clinical Performance With HHS
Primary Uncemented Partly Ti-coated Total Hip Prosthesis With and Without HA, and Alumina-on-alumina Articulation
Both HA coated and certain uncoated femoral stems have good results in general. On the cup side the results are more variable, either with or without HA.
- Conditions
- Survival of the Implants With Revision as Endpoint, Clinical Performance With HHS, Patients Satisfaction With the Hip Implant
- Trial name
- NCT01118247
- Testing
- Uncemented primary total hip arthroplasty
- Where
- Norway
- Volunteers
- 400 people
- Sponsor
- University Hospital of North Norway
Consciousness Disorders
Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU
Disorders of consciousness (DoC) caused by severe brain injury affect millions of people worldwide each year. A patient's level of consciousness in the intensive care unit (ICU) significantly impacts the recovery from disability…
- Trial name
- COMPASS (NCT06568536)
- Testing
- Repeated behavioral assessments, functional electroencephalography and brain imagery, TMS-EEG
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Amputation
AMI Construction in Lower Extremity Residual Limbs
This study will involve the development of a novel approach to lower extremity residual limb surgical revision that offers the promise of augmenting volitional motor control, restore proprioception and reverse atrophy
- Trial name
- NCT04063592
- Testing
- Residual limb revision
- Where
- 3 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Diagnosis Prosthetic Joint Infection
Synovial Aspiration and Serological Testing in Two-stage Revision Arthroplasty of Prosthetic Joint Infection
The two-stage protocol is gold standard in terms of infection control treating prosthetic joint infections of total hip and total knee arthroplasty.
- Trial name
- SyPJI (NCT03038464)
- Testing
- Synovial biopsy
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Breast Cancer, Chemotherapy Effect
The Maintenance Regimen and Revised Regimen for Advanced Breast Cancer Survivors After First-line Salvage Therapy
Worldwide, breast cancer is the most incident and prevalent cancer among women. Despite advances in the treatment of advanced breast cancer (ABC) during the past decade, adjuvant systemic therapy has yield little progression for…
- Conditions
- Breast Cancer, Chemotherapy Effect, Disease-free Survival
- Trial name
- NCT03423849
- Testing
- Vinorelbine, Gemcitabine, Cisplatin
- Volunteers
- 200 people
- Sponsor
- Zhiyong Yu
Aortic Valve Stenosis
REdo Transcatheter Aortic VALVE Implantation for the Management of Transcatheter Aortic Valve Failure
Transcatheter aortic valve implantation (TAVI) is a key-hole technique to replace an aortic heart valve that is narrowed and/or leaking.
- Trial name
- REVALVE (NCT06557798)
- Testing
- Any commercially available Edwards or Medtronic transcatheter aortic valve with the TAV-in-TAV (Redo TAVI) indication, Surgical explantation and aortic valve replacement, Conservative management
- Where
- 63 sites in Denmark, Finland and 9 more
- Volunteers
- 550 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Pain
Development and Validation of a New Pain Scale for Children
In clinical practice with young children, gold standard rating scales used to evaluate the pain are VAS (Visual Analogue Scale) and FPS-R (Faces Pain Scale - Revised), which are self-assessment tools.
- Trial name
- NOUNOURS (NCT02252003)
- Testing
- Pain scales testing
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Joint Disease
Post Market Clinical Follow-Up Study Protocol for PROFEMUR® Gladiator Cemented Femoral Stems
MicroPort Orthopedics (MPO) is conducting this post market clinical follow-up (PMCF) study to evaluate the safety and efficacy of its total hip arthroplasty (THA) European Union (EU) .
- Trial name
- NCT02397746
- Testing
- total hip arthroplasty implant
- Volunteers
- 75 people
- Sponsor
- MicroPort Orthopedics Inc.
Pain
Effects of Sustained-release Oral Sodium Nitrite on Postoperative Pain and Recovery Following Total Knee Arthroplasty
This study will determine whether a drug called sodium nitrite helps improve pain and post-operative recovery associated with knee replacement surgery.
- Trial name
- NCT05893160
- Testing
- JAN101 SR
- Sponsor
- University of Alabama at Birmingham
Arthroplasty, Replacement, Hip
MARS MRI in Revision THA With a Ceramic Femoral Head and Titanium Sleeve
Revision total hip replacement using a ceramic head utilizes a titanium sleeve which introduced another articulation into the system that may lead to a local soft tissue reaction.
- Trial name
- NCT05686915
- Testing
- MARS MRI, Titanium Labs, Cobalt Labs
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Colorado Joint Replacement