Clinical trials: Revascularization
Coronary Revascularization, Coronary Artery Disease
The CORE Platform Trial
Background: The leading cause of death worldwide is cardiovascular disease, with an estimated 19.8 million deaths per year. Coronary artery disease is a type of cardiovascular disease that can be treated with revascularisation…
- Trial name
- CORE (NCT07892976)
- Testing
- MIDCAB procedure, CABG procedure
- Where
- 3 sites in Belgium, Denmark and 1 more
- Volunteers
- 15,000 people
- Sponsor
- Copenhagen Trial Unit, Center for Clinical Intervention Research
Extracranial Carotid Artery Disease, TCAR
Real-World Treatment of Extracranial Carotid Artery Disease With the ENROUTE™ Transcarotid Neuroprotection System
The ENTRUST registry's objective is to collect real-world data (RWD) and health economic data on the ENROUTE™ Transcarotid Neuroprotection System (ENROUTE™ Transcarotid NPS), including populations in which outcomes of…
- Conditions
- Extracranial Carotid Artery Disease, TCAR, Transcarotid Artery Revascularization
- Trial name
- ENTRUST (NCT07455747)
- Testing
- Use of ENROUTE™ Transcarotid Neuroprotection System in conjunction with any commercially available Boston Scientific stent marketed for treatment of carotid artery disease
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Boston Scientific Corporation
Peripheral Artery Disease, Intermittent Claudication
Improving Mobility After Revascularization in Peripheral Artery Disease
Lower extremity revascularization combined with supervised exercise significantly improves walking performance compared to revascularization alone in people who have PAD without limb threatening ischemia.
- Conditions
- Peripheral Artery Disease, Intermittent Claudication, Peripheral Vascular Disease, Mobility Limitation
- Trial name
- IMPACT PAD (NCT06686121)
- Testing
- Home Based Exercise, Nitrate Rich Beetroot Juice, Attention Control
- Where
- 8 sites in United States
- Volunteers
- 386 people
- Sponsor
- Northwestern University
BEHAVIOR CHANGE-BASED PHYSICAL ACTIVITY INTERVENTION IN PAD PATIENTS AFTER ENDOVASCULAR REVASCULARIZATION
BEHAVIOR CHANGE INTERVENTION AFTER ENDOVASCULAR REVASCULARIZATION IN PAD
The study titled "Investigation of the Effect of a Behavior Change-Based Physical Activity Program in Patients with Peripheral Artery Disease Who Have Undergone Endovascular Revascularization" will be conducted by Specialist…
- Trial name
- NCT07328646
- Testing
- Behavior Change-Based Physical Activity Program, Supervised Exercise Program, Combined Behavior Change and Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Muğla Sıtkı Koçman University
Peripheral Artery Disease (PAD), CT Perfusion
Clinical Value of CT Perfusion in Peripheral Artery Disease
Peripheral artery disease (PAD) affects millions worldwide and can lead to serious complications such as leg ulcers, gangrene, and amputation.
- Conditions
- Peripheral Artery Disease (PAD), CT Perfusion, Revascularization, Microcirculation
- Trial name
- iPAD (NCT07816757)
- Volunteers
- 200 people
- Sponsor
- Fudan University
Coronary Artery Disease, Coronary Artery Bypass Grafting
Extensive BITA Grafting in the Canary Islands: an IPTW Analysis
Coronary artery bypass grafting (CABG) remains the preferred revascularization strategy for patients with complex multivessel coronary artery disease.
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Myocardial Revascularization
- Trial name
- BITA-SURV (NCT07796750)
- Where
- Spain
- Volunteers
- 666 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Coronary Artery Disease (CAD), Bypass, Cardiopulmonary
Multivessel Minimally Invasive Coronary Bypass Grafting as HYBRID Revascularization Versus Conventional Off-pump Coronary Artery Bypass Grafting
The MICRA-HYBRID trial is a prospective, multicenter, randomized controlled study comparing multivessel hybrid coronary revascularization (HCR) as minimally invasive arterial bypass grafting to left-sided coronary targets (LAD…
- Conditions
- Coronary Artery Disease (CAD), Bypass, Cardiopulmonary, Minimally Invasive Coronary Revascularization Surgery, Off-pump Coronary Artery Bypass
- Trial name
- MICRA-HYBRID (NCT07314138)
- Testing
- Multivessel Hybrid Coronary Revascularization, Off-pump coronary arterial bypass grafting (OPCAB)
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Myocardial Infarction, Stroke
Women's Health Initiative Strong and Healthy Study
The WHISH trial applies state-of-the science behavioral principles and currently available technologies to deliver a physical activity intervention without face-to-face contact to ~25,000 older U.S. women expected to consent.
- Conditions
- Myocardial Infarction, Stroke, Cardiovascular Mortality, Hip Fractures
- Trial name
- WHISH (NCT02425345)
- Testing
- Physical Activity
- Volunteers
- 49,331 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Ischemic Stroke, Carotid Stenosis
Radial Versus Femoral Access For Carotid Artery Stenting
Background: For moderate to severe carotid artery atherosclerotic stenosis, in the past decades, carotid artery stenting (CAS) has been an alternative to carotid endarterectomy (CEA) for the treatment of carotid artery stenosis.
- Conditions
- Ischemic Stroke, Carotid Stenosis, Cerebral Revascularization, Carotid Artery Diseases
- Trial name
- RACE-CAS (NCT05416853)
- Testing
- Carotid Artery Stenting (CAS)
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Percutaneous Coronary Intervention, Myocardial Revascularization
Clinical Study of Chinese Herbal Compound Qidan Xiaoke Granules in Patients After Coronary Revascularization
1. Evaluate the efficacy and safety of Qidan Xiaohe granules in patients after coronary revascularization surgery; 2. Develop a traditional Chinese medicine rehabilitation treatment plan and evaluation system for the use of Qidan…
- Conditions
- Percutaneous Coronary Intervention, Myocardial Revascularization, Coronary Artery Disease
- Trial name
- NCT07616544
- Testing
- Qidan Xiaoke Granules + Standard Medical Therapy
- Volunteers
- 164 people
- Sponsor
- Liu Qiang
Coronary Artery Disease, Postoperative Period
Establishment of Disease Characteristics and a Chinese Medicine Prognosis Risk Model Based on a Large-Scale Database After Coronary Revascularization
This study aims to develop a risk prediction model for patients who have undergone coronary revascularization (such as stent placement or bypass surgery).
- Conditions
- Coronary Artery Disease, Postoperative Period, Myocardial Revascularization
- Trial name
- NCT07613060
- Volunteers
- 600 people
- Sponsor
- Liu Qiang
Percutaneous Coronary Intervention, Myocardial Revascularization
Baduanjin Intervention in Clinical Studies After Coronary Revascularization Surgery
1. To evaluate the efficacy and safety of the Baduanjin exercise programme in patients following coronary revascularisation surgery; 2.
- Conditions
- Percutaneous Coronary Intervention, Myocardial Revascularization, Coronary Artery Disease
- Trial name
- NCT07607951
- Testing
- Standardized Western medical treatment + Standardized Baduanjin rehabilitation training, Standardized Western medical treatment + Aerobic exercise training
- Volunteers
- 310 people
- Sponsor
- Liu Qiang
Coronary Artery Disease, Coronary Artery Disease (CAD)
Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)
This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (CAD), Multivessel Coronary Artery Disease, CABG
- Trial name
- STICH 3*0-NL (NCT07269366)
- Testing
- CABG, PCI
- Where
- Netherlands
- Volunteers
- 358 people
- Sponsor
- University Medical Center Groningen
Coronary Artery Disease, Myocardial Revascularization
Nursing Intervention for Adaptation After Myocardial Revascularization
Introduction: Myocardial revascularization is an essential procedure for patients with cardiovascular disease. Its recovery in the outpatient setting involves significant challenges for both the patient and the caregiver.
- Conditions
- Coronary Artery Disease, Myocardial Revascularization, Postoperative Recovery After Cardiac Surgery, Nursing Care
- Trial name
- ADAPT-CABG (NCT07576569)
- Testing
- Nursing Intervention Program, Usual Care
- Where
- Colombia
- Volunteers
- 40 people
- Sponsor
- Universidad de la Sabana
MACE, Cardiac Death
Real-World Cohort Study of Cardiopulmonary Function in Chinese Patients With Cardiovascular Disease: CPET Evaluation and Five-Year Prognostic Follow-Up Based on a Multicenter Structured Data Platform
The goal of this observational study is to observe the characteristics of cardiopulmonary exercise testing (CPET) parameters in patients across different cardiovascular diseases and to evaluate the predictive value of…
- Conditions
- MACE, Cardiac Death, Unplanned Repeat Revascularization, Cardiac Rehospitalization
- Trial name
- China-CPET (NCT07130968)
- Where
- China
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Acute Cerebrovascular Accident, Thrombectomy
Investigation of Brain Blood Flow Changes in Acute Ischemic Stroke Patients After Successful Endovascular Thrombectomy
Introduction: Endovascular thrombectomy (EVT) is an effective treatment strategy to mitigate the ischemic tissue damage caused by the acute cerebral large-vessel occlusion.
- Conditions
- Acute Cerebrovascular Accident, Thrombectomy, Cerebral Revascularization, No Reflow Phenomenon
- Trial name
- RESTORE-AIS (NCT07534319)
- Testing
- No planned intervention
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Percutaneous Coronary Revascularization, Coronary Stenosis
Evaluation of Effectiveness and Safety of Hybrid Coronary Revascularization
This study evaluated the effectiveness and safety of Hybrid Coronary Revascularization in real-world practice.
- Conditions
- Percutaneous Coronary Revascularization, Coronary Stenosis, Coronary Artery Disease Progression, Coronary Artery Bypass Grafting
- Trial name
- HCR registry (NCT03788369)
- Testing
- Hybrid Coronary Revascularization
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Seung-Jung Park
Coronary Artery Disease, Antiplatelet Therapy
Minimally Invasive Coronary Artery Bypass Supported by Cangrelor
The purpose of this study is to find out whether it is safe and practical to perform MIDCAB surgery (a minimally invasive heart bypass procedure) while patients receive a continuous cangrelor infusion during the operation.
- Conditions
- Coronary Artery Disease, Antiplatelet Therapy, Minimally Invasive Coronary Revascularization Surgery
- Trial name
- MINOTAUR (NCT07514962)
- Testing
- Cangrelor-guided MIDCAB surgery (for the prospective cases), Aspirin MIDCAB surgery (for the historical controls)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Cardiocentro Ticino
Heart Attack, Revascularization
A Prospective Randomized Trial of External Vein Graft Support in Surgical Myocardial Revascularization
The aim of the thesis is to compare a group of patients using vein grafts with and without external support, specifically their patency.
- Trial name
- Vest II (NCT06629701)
- Testing
- External support for vein grafts
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- University Hospital Pilsen
Revascularization of Immature Young Permenant Teeth
Compare Between the Effect of CGF and PRF on Revascularization of Immature Roots of the Mandibular Permanent First Molar
in this study investigators do revascularization technique to promote root growth of immature mandibular first permanent molar by using CGF and PRF from blood sample of patients
- Trial name
- NCT07460869
- Testing
- Revascularization/Conservative management
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University