Clinical trials: Retinal Vascular Diseases
Diabetes, Kidney Disease
MIRACLE-T2D Montelukast Intervention for Renal, Cardiovascular and Eye Health in Type 2 Diabetes
Diabetes mellitus type 2 is associated with significant morbidity and mortality; and identifying new treatments for diabetes complications to be used alone or in combination with other therapies is a high priority.
- Conditions
- Diabetes, Kidney Disease, Vascular Disease, Retinopathy
- Trial name
- MIRACLE-T2D (NCT07685886)
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Colorado, Denver
Retinal Hemangioblastoma, Von Hippel-Lindau Disease
Retrospective Case Series of Trans-scleral Cryotherapy for Retinal Hemangioblastoma
Background: Retinal hemangioblastoma (RH) is a tumor. It grows from the retina in the eye. It can threaten a person s vision. Trans-scleral cryotherapy is used to destroy the tumors and minimize the long-term risks of vision…
- Trial name
- NCT04458935
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Retinopathy, GLP-1
Assessment of Retinal-Angio Findings In Patients With Diabetes Type II Treated With Novel Antidiabetic Therapies
ARIADNE is a prospective observational cohort study of patients with type 2 diabetes mellitus (T2DM) treated with daily metformin and scheduled to initiate treatment with newer antidiabetic agents, such as sodium-glucose…
- Conditions
- Diabetic Retinopathy, GLP-1, SGLT 2 Inhibitors, Endothelial Dysfunction
- Trial name
- ARIADNE (NCT07602348)
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University of Athens
Macular Polypoidal Choroidal Vasculopathy (PCV)
Study Assessing the Efficacy and Safety of a Personalized Monotherapy Regimen of Brolucizumab in Patients With Symptomatic Macular Polypoidal Choroidal Vasculopathy
This study is a 60-week, two-arm, randomized, open-label, active-controlled, multi-center study in patients with Polypoidal choroidal vasculopathy (PCV) who have not previously received anti-Vascular endothelial growth factor…
- Trial name
- PROUD (NCT05666804)
- Testing
- Brolucizumab 6mg
- Where
- 15 sites in South Korea
- Volunteers
- 148 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Retinopathy (DR), Cardiopulmonary Bypass
Choroidal Changes During Cardiopulmonary Bypass
This prospective observational study investigates the impact of pulsatile versus non-pulsatile cardiopulmonary bypass (CPB) flow on choroidal circulation in diabetic and non-diabetic patients undergoing elective coronary artery…
- Conditions
- Diabetic Retinopathy (DR), Cardiopulmonary Bypass, Retinal Vascular Diseases
- Trial name
- NCT07034612
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Samsun University
Other Retinal Disorders, Retinal Disease
Retina BioBank: Retina Biomarkers for a Deeper Understanding of Vitreoretinal and Systemic Diseases
The RBBK study is a non-interventional, prospective study that will characterize disease state biomarker levels from aqueous humor, vitreous humor, intraoperative tissue and saliva of subjects with various retinal and systemic…
- Conditions
- Other Retinal Disorders, Retinal Disease, Retinal Vascular Disorder
- Trial name
- RBBK (NCT06796673)
- Where
- 3 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Greater Houston Retina Research
Cardiovascular Abnormalities, Vascular Diseases
Correlating the Measure of Retinal Vascular Density Through Angio-OCT with Calcium Score
Recent case-control studies have proven that the retinal vascularization mirrors the cardiac vascularization: more the coronary network is altered, more the density of retinal vessels is reduced.
- Conditions
- Cardiovascular Abnormalities, Vascular Diseases, Retinal Vascular
- Trial name
- ANOSCA (NCT05624255)
- Testing
- Ophthalmologic consultation
- Where
- France
- Volunteers
- 101 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Retinopathy of Prematurity Both Eyes, Retinal Disease
Safety and Efficacy of 18 mm Short Vitrectomy Probe for Pediatric Vitreoretinal Surgeries
This study aims to study the safety and efficacy of using an 18 mm short vitrectomy probe for pediatric vitreoretinal surgeries and to investigate the surgeon's comfort and reliability of using the shorter probe.
- Conditions
- Retinopathy of Prematurity Both Eyes, Retinal Disease, Persistent Fetal Vasculature, Coats Disease
- Trial name
- NCT06520410
- Testing
- Pars plana vitrectomy with a 18 mm short vitrector
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Retinal Vein Occlusion, Vascular Occlusive Disease
Intravitreal Aflibercept for Macular Edema Due to Central Retinal Vein Occlusion
Central retinal vein occlusion (CRVO) is a common retinal vascular disorder, occurring when there is a blockage to the main blood vessel that transports blood away from the retina.
- Trial name
- INTRAMED-CRVO (NCT06416241)
- Testing
- EYLEA 2 MG in 0.05 ML Injection
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Athens
Retinopathy, Nephropathy
Time To Complications Occurs in Diabetes
Diabetes causing serious complications is well known. In this study the aim is to follow 950 patients with diabetes for 15 years to study when, in who and how the diabetes complications occurs.
- Conditions
- Retinopathy, Nephropathy, Diabetic Neuropathy, Vascular Disease
- Trial name
- NCT00969956
- Where
- Sweden
- Volunteers
- 17 people
- Sponsor
- Karolinska Institutet
Retinal Vascular, Retinal Disease
Perifoveal Vascular Network Assessed by OCT-Angiography in Type I Diabetes Mellitus
This study is directed to evaluate the role of Optical Coherence Tomography Angiography (OCT-A) in the evaluation of the perifoveal vascular network in type 1 diabetic patients, and to investigate the relationship between…
- Conditions
- Retinal Vascular, Retinal Disease, Retinal Ischemia, Retinal Ischaemia Due to Type 1 Diabetes Mellitus
- Trial name
- NCT03422965
- Testing
- Optical Coherence Tomography Angiography, Blood test, Urine test
- Where
- 2 sites in Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Retinal Vascular Disease
Swept-Source Optical Coherence Tomography for Noninvasive Retinal Vascular Imaging
This is a clinical pilot study to assess the feasibility of using a swept-source optical coherence tomography (SSOCT) system to perform noninvasive imaging of the retinal vasculature in patients with existing microvascular…
- Trial name
- SWEPT (NCT01834196)
- Testing
- Swept-Source Optical Coherence Tomography
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Duke University
Anemia, Neonatal, Intracranial Hemorrhages
Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates
The purpose of this study is to test the safety and effectiveness of a whole own (autologous) umbilical cord blood transfusion in the first 5 days after birth if the baby is born premature <34 weeks and developed anemia of…
- Conditions
- Anemia, Neonatal, Intracranial Hemorrhages, Necrotizing Enterocolitis, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT02050971
- Testing
- Umbilical Cord Blood Infusion, Intravenous Infusion of Peripheral Blood or its Components
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Pomeranian Medical University Szczecin
Diabetic Retinopathy, Retinal Diseases
Intravitreal Ranibizumab Combined With Panretinal Photocoagulation in Patients With Proliferative Diabetic Retinopathy
To evaluate the efficacy of combination therapy with ranibizumab (RBZ) and panretinal photocoagulation (PRP) versus PRP alone in patients with treatment-naive bilateral proliferative diabetic retinopathy (PDR) as measured by mean…
- Conditions
- Diabetic Retinopathy, Retinal Diseases, Eye Diseases, Diabetic Angiopathies
- Trial name
- NCT01746563
- Testing
- Ranibizumab, Laser therapy
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Retinal Vein Occlusion
Radial Optic Neurotomy in Central Retinal Vein Occlusion : a Randomized Trial
Natural evolution of severe central retinal vein occlusion with low visual acuity is very poor. A randomized clinical trial will compare troxerutin and platelet anti-aggregating agents (drug treatment) versus surgery and drug…
- Trial name
- OVCR (NCT00379223)
- Testing
- vitrectomy with radial optic neurotomy
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Bordeaux
Disease Management, Diabetes Complications
Determining Rates of Cardiovascular Complications Among Patients of a Managed Diabetes Care Program
The primary objective of this study is to identify whether cardiovascular complication rates are lower in patients who participate in managed diabetes care, in comparison to provincial and national rates.
- Conditions
- Disease Management, Diabetes Complications, Diabetic Vascular Complications, Diabetic Neuropathy
- Trial name
- DECIDE (NCT00498147)
- Testing
- ADEC Program
- Where
- Canada
- Volunteers
- 1,213 people
- Sponsor
- Group Health Centre
Macular Degeneration, Diabetic Retinopathy
A Phase 1 Safety Study of TG100801 Eye Drops in Healthy Volunteers
The formation of new blood vessels (angiogenesis), blood vessel leakage, and inflammation contribute to the progression of the eye disease, age-related macular degeneration (AMD), which is the leading cause of irreversible…
- Trial name
- NCT00414999
- Testing
- TG100801
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- TargeGen
Diabetes, Retinopathy
Microvascular Reactivity.
This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).
- Conditions
- Diabetes, Retinopathy, Vascular Pathology
- Trial name
- NCT00259701
- Testing
- Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University