Clinical trials: Retinal Edema
DIABETIC MACULAR EDEMA
Triamcinolone vs. Laser for Diabetic Macular Edema
The purpose of this study is to determine if intravitreal triamcinolone acetonide (IVTA) injection at the time of cataract surgery will improve visual acuity and decrease post-operative swelling in diabetic patients requiring…
- Trial name
- IVTA (NCT00229931)
- Testing
- Triamcinolone acetonide, laser
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Oklahoma
Macular Edema, Cystoid
Intraretinal Cystoid Changes After Vitrectomy With Membrane Peeling
Aim of the study is to assess the rate of postoperative intraretinal cystoid changes after pars plana vitrectomy with membrane peeling and peribulbar application of triamcinolone acetonide and to examine possible risk factors for…
- Trial name
- NCT04472039
- Testing
- optical coherence tomography (OCT)
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Diabetic Macular Edema, Vogt Koyanagi Harada Disease
Custom Needle Preparation for Suprachoroidal Steroid Injection (One Year Results)
Suprachoroidal drug delivery is a recent route for managing various ocular conditions. Safety and long term results are still under investigations.
- Conditions
- Diabetic Macular Edema, Vogt Koyanagi Harada Disease, Retinal Vein Occlusion
- Trial name
- NCT05496530
- Testing
- Suprachoroidal triamcinolone acetonide injection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Diabetic Retinopathy
Aflibercept for Retinopathy in the Real World
Diabetic retinopathy remains the leading cause of blindness in patients of working age in the Western World, and there is a global epidemic of diabetes.
- Trial name
- ARRoW (NCT02812030)
- Testing
- National Eye Institute Visual Functioning Questionnaire
- Sponsor
- Timothy Jones
Diabetic Macular Edema, Age-Related Macular Degeneration
Effect of Corona Virus on Intravitreal Injections
During pandemic of corona virus, patients compliance may be affected. We aim to study the factors lead to unregulated visits and its implications on the final visual outcome.
- Conditions
- Diabetic Macular Edema, Age-Related Macular Degeneration, Choroidal Neovascularization, Myopic Choroidal Neovascularisation
- Trial name
- NCT05494775
- Testing
- Anti-vascular endothelial growth factors (Anti-VEGFs)
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Benha University
Retinitis Pigmentosa, Maculopathy, Age Related
High Resolution Retina Imaging
To increase the clinical experience of using the rtx1 camera in various retinal disorders and to follow the evolution of structural alterations during retinal diseases using adaptive optics imaging with the rtx1 camera
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- IHR (NCT04128150)
- Where
- 3 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Uveitis, Macular Edema
Macular Edema Nepafenac vs. Difluprednate Uveitis Trial
Macular edema is a condition in which there is swelling in the macula, the part of the retina that gives you your best vision. This swelling can cause your vision to decline.
- Trial name
- MEND (NCT01939691)
- Testing
- Difluprednate, Nepafenac, Prednisolone acetate
- Where
- 3 sites in India
- Volunteers
- 9 people
- Sponsor
- University of California, San Francisco
Diabetic Macular Edema
Intravitreal Injection Versus Sub-Tenon's Infusion of Triamcinolone Acetonide for Refractory Diabetic Macular Edema During Cataract Surgery
Triamcinolone has already been used by different routes of administration to treat diabetic macular edema. In the present study, intravitreal injection (IVI) and posterior sub-Tenon's infusion (STI) of triamcinolone acetonide…
- Trial name
- NCT00801450
- Testing
- Triamcinolone acetonide
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
AMD Population - Intermediate or Advanced AMD, DR Population- With or Without Diabetic Macular Edema
Usability and Ergonomic Evaluation of Self-Positioning System for Retinal Imaging
The purpose of the study "Usability and Ergonomic Evaluation of Self-Positioning System for Retinal Imaging" is to enable self-operation of a monitoring device in home-simulated environment
- Trial name
- NCT03270865
- Testing
- PAF (Positioning And Fixation device)
- Where
- Israel
- Volunteers
- 16 people
- Sponsor
- Notal Vision Ltd.
CYSTOID MACULAR EDEMA
Acute Pseudophakic Cystoid Macular Edema Treatment Trial: Intravitreal Ranibizumab Versus Triamcinolone Acetonide
This is an open-label, Phase I/II study evaluating intravitreal ranibizumab (R) vs. intravitreal Triesence (triamcinolone acetonide) (T) in subjects with acute pseudophakic cystoid macular edema (CME).
- Trial name
- NCT02294656
- Testing
- Ranibizumab,, Triamcinolone acetonide
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Soll Eye
Diabetes Mellitus, Diabetic Retinopathy
A Phase 2 Study Exploring The Safety And Efficacy Of Novel Drug Treatment In Subjects With Diabetic Macular Edema (DME)
This study will evaluate the safety and efficacy of AG-014699 in diabetic patients
- Trial name
- NCT00457470
- Testing
- AG-014699
- Sponsor
- Pfizer
Diabetic Retinopathy, Macular Edema
A Study to Evaluate the Safety and Efficacy of THR-317 for the Treatment of Diabetic Macular Oedema (DME)
This study is conducted to evaluate the safety of THR-317 when administered intravitreally and to assess the compound's efficacy in improving best-corrected visual acuity (BCVA) and reducing central subfield thickness (CST) in…
- Trial name
- NCT03071068
- Testing
- Anti-PlGF recombinant monoclonal antibody, 4mg dose, Anti-PlGF recombinant monoclonal antibody, 8mg dose
- Where
- 13 sites in Czechia, Hungary and 1 more
- Volunteers
- 49 people
- Sponsor
- ThromboGenics
Age-Related Macular Degeneration
Intravitreal Faricimab in Patients With Refractory Macular Edema
This prospective study will include about 40 patients with resistant wet age-related macular degeneration (AMD), diabetic macular edema (DME), or retinal vein occlusion edema (RVO) edema.The inclusion criteria are that all…
- Trial name
- NCT07093385
- Testing
- Faricimab Injection
- Where
- Iraq
- Volunteers
- 43 people
- Sponsor
- University of Baghdad
Macular Edema, Diabetic Macular Edema
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Activity of Intravitreal LKA651 in Patients With Macular Edema
To evaluate the safety and tolerability of LKA651 in patients with macular edema from diabetic macular edema (DME), neovascular age-related macular degeneration (AMD), or retinal vein occlusions (RVO)
- Conditions
- Macular Edema, Diabetic Macular Edema, Neovascular Age-related Macular Degeneration, Retinal Vein Occlusions
- Trial name
- NCT02867735
- Testing
- LKA651
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Post-surgical Cystoid Macular Edema (PSCME)
Treatment of Post-surgical Cystoid Macular Edema With Topical Steroids Trial (TEMPEST-1)
The purpose of this study is to compare the change in visual acuity of patients with post surgical cystoid macular edema who will be treated with two different regimens.
- Trial name
- TEMPEST (NCT01769352)
- Testing
- PredA + Kelac
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Johns Hopkins University
Diabetic Macular Edema, Visual Acuity
Treatment of Refractory Diabetic Macular Edema With Infliximab
The purpose of this study is to determine if treatment with infliximab improves macular edema which is refractory to laser photocoagulation in patients with diabetes.
- Conditions
- Diabetic Macular Edema, Visual Acuity, Diabetic Retinopathy
- Trial name
- NCT00505947
- Testing
- infliximab
- Where
- 2 sites in Greece
- Volunteers
- 12 people
- Sponsor
- University of Athens
Wet AMD, Macular Oedema
Intravitreal Bevacizumab for Retinal Disorders
Bevacizumab is an anti-VEGF agent used in approved for use in metastatic colorectal carcinoma (FDA Approved). This study analyzes the safety and efficacy of off-label Intravitreal Injection of bevacizumab (Avastin) for CNVM…
- Conditions
- Wet AMD, Macular Oedema, Proliferative Diabetic Retinopathy
- Trial name
- NCT00403026
- Testing
- Bevacizumab ( Avastin)
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Narayana Nethralaya
Branch Retinal Vein Occlusion, Ranibizumab
Combination of Intravitreal Ranibizumab With or Without Macular Laser Photocoagulation for ME Secondary to BRVO
To investigate the efficacy of laser photocoagulation combined with ranibizumab intravitreal injection in macular edema (ME) secondary to branch retinal vein occlusion (BRVO) in long term.
- Conditions
- Branch Retinal Vein Occlusion, Ranibizumab, Laser Photocoagulation
- Trial name
- NCT03054766
- Testing
- Ranibizumab combined macular laser, Ranibizumab
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Hospital
Proliferative Diabetic Retinopathy, Diabetic Macular Edema
Laser-Ranibizumab-Triamcinolone for Proliferative Diabetic Retinopathy
The purpose of the study is to find out if treatment with an intravitreal injection of triamcinolone or an intravitreal injection of ranibizumab can prevent loss of vision caused by panretinal photocoagulation treatment.
- Trial name
- LRTforDME+PRP (NCT00445003)
- Testing
- Ranibizumab, Triamcinolone Acetonide, Focal/grid laser
- Where
- 56 sites in United States
- Volunteers
- 333 people
- Sponsor
- Jaeb Center for Health Research
Intravitreal Injection, Ocular Rinse
The Effect of Ocular Rinse Volume on Surface Irritation After Intravitreal Injections
This is the first randomized controlled trial looking into post-injection rinse volume of standard ophthalmic eyewash and its affect on patient comfort up to 72 hours after injections.
- Conditions
- Intravitreal Injection, Ocular Rinse, Age-Related Macular Degeneration, Diabetic Macular Edema
- Trial name
- NCT05615805
- Testing
- OSDI questionnaire, SPEEDII questionnaire
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma