Clinical trials: Resuscitation Patients With Sepsis
Cirrhosis, Liver, Sepsis
Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension
In critically ill patients with liver disease like cirrhosis or ACLF, fluid therapy needs to be instituted after identification of patients who will be fluid responsive and initiate appropriate inotropes early to prevent the…
- Conditions
- Cirrhosis, Liver, Sepsis, Acute on Chronic Liver Failure
- Trial name
- NCT05059795
- Testing
- Albumin + electrolyte solution, POCUS guided fluid resuscitation
- Where
- 2 sites in India
- Volunteers
- 350 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Septic Shock, Severe Sepsis
Restrictive Intravenous Fluids Trial in Sepsis
IV fluid resuscitation has long been recognized to be an important treatment for patients with severe sepsis and septic shock. While under-resuscitation is known to increase morbidity and mortality, contemporary data suggests…
- Trial name
- RIFTS (NCT03137446)
- Testing
- Intravenous Fluid Cap
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Rhode Island Hospital
Septic Shock
Resuscitation With Plasma in Surgical and Trauma Patients With Septic Shock
There is a knowledge gap regarding the optimal initial fluid to achieve effective resuscitation and improved outcomes in septic shock.
- Trial name
- NCT03366220
- Testing
- Plasma, Balanced crystalloids
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center, Houston
Resuscitation Patients With Sepsis
Population Pharmacokinetic Modeling to Optimize the Dosage of the Piperacillin / Tazobactam Combination in Patients With Sepsis in Intensive Care
Population pharmacokinetic modeling mathematically describes the pharmacokinetics of a drug and the variables likely to influence it in a "typical" patient population.
- Trial name
- OPT-TAZ (NCT03748095)
- Testing
- Intensive Pharmacokinetic Sampling Cohort, Sparse Pharmacokinetic Sampling Cohort
- Where
- France
- Volunteers
- 91 people
- Sponsor
- University Hospital, Rouen
Septic Shock
Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock
To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock. Hypothesis: Hepatic perfusion did not improved after EGDT in patients with septic shock.
- Trial name
- NCT02060773
- Where
- China
- Sponsor
- Zhongda Hospital
Sepsis
Normal Saline Versus Ringer's Lactate for Initial Fluid Resuscitation in Sepsis
This clinical trial aims to determine if the type of intravenous fluid used for initial resuscitation affects the short-term outcomes of adult patients with sepsis who are treated in the emergency department.
- Trial name
- NCT07240701
- Testing
- Ringer's Lactate, Normal Saline (0.9% Sodium Chloride)
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Egemen Yildiz
Severe Sepsis, Septic Shock
Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial)
The purpose of this trial is to determine the influence of colloid versus crystalloid volume resuscitation and of intensive vs conventional insulin therapy on morbidity and mortality of patients with severe sepsis and septic…
- Trial name
- NCT00135473
- Testing
- 10% Hemohes® (10% Hydroxyethyl starch), Sterofundin® (Ringer lactate solution), Actrapid® (Insulin)
- Where
- 16 sites in Germany
- Volunteers
- 600 people
- Sponsor
- SepNet - Critical Care Trials Group
Septic Shock, Sepsis
Core-to-Big-Toe Temperature Gradient as a Marker of Peripheral Perfusion in Adult Patients With Septic Shock
Septic shock is a life-threatening condition caused by severe infection that leads to dangerously low blood pressure and impaired blood flow to body tissues and organs.
- Trial name
- NCT07871305
- Volunteers
- 54 people
- Sponsor
- Assiut University
Cardiac Output, LIDCO Rapid, Septic Shock
Validation of Uncalibrated Cardiac Output Measurement With LiDCOrapid in the Resuscitation of Critically Ill Patients With Septic Shock: A Prospective Cross-sectional Study.
Transthoracic echocardiography (TTE) has been used as a reference technique for CO measurement and its accuracy has been adequate for many clinical uses. TTE is painless, safe and non-invasive.
- Trial name
- NCT04705493
- Testing
- fluid resuscitation with crystalloid
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Critical Illness, Septic Shock
Human Albumin for Resuscitation in Surgical Septic Shock: A Randomized Controlled Trial (ALBUS Study)
This study will test whether giving human albumin to keep the blood albumin level above 3.5 g/dL, in addition to standard care, improves survival in patients with surgical septic shock.
- Trial name
- ALBUS (NCT07212582)
- Testing
- Human Albumin 20% Solution, Standard Care (in control arm)
- Where
- Thailand
- Volunteers
- 304 people
- Sponsor
- Mahidol University
Acute Respiratory Distress Syndrome, Sepsis
Effect of Albumin Therapy in Mechanically Ventilated Patients With Sepsis-Associated ARDS
Sepsis-associated acute respiratory distress syndrome (ARDS) is a severe condition where severe infection causes fluid accumulation in the lungs, often requiring invasive mechanical ventilation.
- Conditions
- Acute Respiratory Distress Syndrome, Sepsis, Hypoalbuminemia
- Trial name
- ALB-SARDS (NCT07857928)
- Where
- China
- Volunteers
- 260 people
- Sponsor
- The Second Affiliated Hospital of Hainan Medical University
Critically Ill Patients, Septic Shock
Vexus-guided Fluid Management in Patients With Septic Shock After the Resuscitation Phase
It is well recognized the association between fluid volume administered and positive fluid balance with adverse outcomes . Active fluid removal is widely practiced in an attempt to mitigate this potential damage.
- Trial name
- VEXUS (NCT06227702)
- Testing
- Fluid management according to Venous Excess Ultrasound (VExUS) Score
- Volunteers
- 200 people
- Sponsor
- Federal University of São Paulo
Sepsis, Septic Shock
Strong Albumin Solutions in Patients With Septic Shock
Sepsis is an increasingly recognised burden to healthcare systems worldwide. Intravenous fluid therapy is a common first-line intervention recommended by international guidelines.
- Conditions
- Sepsis, Septic Shock, Shock, Toxic
- Trial name
- SWIPE2 (NCT05208242)
- Testing
- hyperoncotic human albumin solution, Buffered crystalloid solutions
- Where
- 2 sites in United Kingdom
- Volunteers
- 47 people
- Sponsor
- Manchester University NHS Foundation Trust
Septic Shock
Proadrenomedullin and Copeptin in Patients With Septic Shock
This study evaluates the usefulness of pro-adrenomedullin (precursor of a vasodilatory peptide involved in septic shock pathogenesis) and copeptin (a stable peptide of the arginine vasopressin precursor) to predict, at the moment…
- Trial name
- proADM (NCT03104933)
- Where
- Spain
- Volunteers
- 103 people
- Sponsor
- Spanish Network for Research in Infectious Diseases
Cirrhosis, Liver, Acute-On-Chronic Liver Failure
20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension
Patients with cirrhosis patients have a high incidence of sepsis which can trigger decompensation and may result in prolonged hospital stay and increased mortality.
- Conditions
- Cirrhosis, Liver, Acute-On-Chronic Liver Failure, Shock, Septic, Shock Hypovolemic
- Trial name
- NCT05441878
- Testing
- 20% albumin, Balanced salt solution
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Septic Shock, Critically Ill
Resuscitation Strategies in Septic Shock
The purpose of this study, in mechanically ventilated septic shock patients, is to determine whether a fluid loading strategy based on parameters derived from the transpulmonary thermodilution technique may lead to more…
- Trial name
- ReSSeS (NCT02150512)
- Testing
- Transpulmonary Thermodilution, Surviving Sepsis Guidelines (SSG)
- Where
- Netherlands
- Volunteers
- 170 people
- Sponsor
- Medisch Spectrum Twente
Tissue Hypoperfusion, Critical Illness
Fecal Lactate and Resuscitation Outcomes in Critical Illness
This study evaluates the prognostic value of fecal lactate and the fecal-to-serum lactate gradient as early biomarkers of tissue hypoperfusion in critically ill patients.
- Conditions
- Tissue Hypoperfusion, Critical Illness, Shock, Sepsis
- Trial name
- DELTA-LAC (NCT07658001)
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital H+ Queretaro
Sepsis, Septic Shock
Sodium Bicarbonate Ringer's Solution Versus Normal Saline for Early Fluid Resuscitation in Patients With Sepsis
At present, people still have different opinions on choosing which kind of crystalloid solution for patients with sepsis, and there is no unified standard yet.
- Trial name
- NCT04621981
- Testing
- Sodium Bicarbonate Ringer's Solution, Normal Saline
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Xiangya Hospital of Central South University
Sepsis, Septic Shock
De-resuscitation Informed by Ultrasound for Patients With Sepsis
Randomized, unblinded clinical trial of 152 critically ill patients with sepsis admitted to the intensive care unit. The primary determine if using the Venous Excess Ultrasound Score (VExUS) to guide fluid deresuscitation in…
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe, Volume Overload
- Trial name
- DRI-US (NCT04921319)
- Testing
- VExUS score
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- The Miriam Hospital
Septic Shock, Fluid Resuscitation
Bicarbonated Ringer's Solution Versus Lactated Ringer's Solution in Patients With Septic Shock
In this prospective randomized controlled trial, investigators aim to study the effects and safety of bicarbonated Ringer's solution in patients with septic shock compared with lactated ringer's solution, and provide evidence for…
- Conditions
- Septic Shock, Fluid Resuscitation, Crystalloid Solution, Intensive Care Unit
- Trial name
- NCT04449757
- Testing
- Bicarbonated Ringer's solution, Lactated Ringer's solution
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Zhongnan Hospital