Clinical trials: Respiratory Viral Infections
Viral Infection, Acute Respiratory Infection
Urgent Care Management of Respiratory Illness Enabled With Novel Testing Pathway
Rapid diagnosis and precise treatment have become possible with multiplex polymerase chain reaction (PCR) panels that can identify a variety of causative agents of acute respiratory illnesses such as bacterial and viral…
- Conditions
- Viral Infection, Acute Respiratory Infection, Upper Resp Tract Infection
- Trial name
- URGENT (NCT05467007)
- Testing
- BioFire® Respiratory Panel 2.1-EZ
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- Andrew Meltzer
Infections, Respiratory, Virus Diseases
A Trial Investigating the Safety and Effects of Four BNT162 Vaccines Against COVID-19 in Healthy and Immunocompromised Adults
Originally, the study was planned to include two parts, i.e., Part A and Part B, however Part B was cancelled due to changes in the overall clinical development plan.
- Conditions
- Infections, Respiratory, Virus Diseases, Infection Viral, Vaccine Adverse Reaction
- Trial name
- NCT04380701
- Testing
- BNT162a1, BNT162b1, BNT162b2
- Where
- 5 sites in Germany
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Respiratory Tract Infections, Transmission
Transmission Of Respiratory Tract microOrganisms In a School Environment
Through contact with peers in daycare and (primary)school young children play a large role in spreading respiratory pathogens. In this study the investigators will investigate this transmission, the subsequent colonization and…
- Conditions
- Respiratory Tract Infections, Transmission, Microbial Colonization, Viral Respiratory Tract Infection
- Trial name
- TORTOISE (NCT06248983)
- Where
- 2 sites in Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
COVID-19 Respiratory Infection, Respiratory Syncytial Virus Infections
Infection Watch Study
This study will reach out to patients who have undergone diagnostic testing for the following respiratory illnesses from January 1st, 2018 to July 9th, 2023: COVID-19, Influenza, Rhinovirus, and Respiratory Syncytial Virus.
- Conditions
- COVID-19 Respiratory Infection, Respiratory Syncytial Virus Infections, Rhinoviral Infections, Influenza Viral Infections
- Trial name
- NCT04623047
- Where
- United States
- Volunteers
- 10,034 people, healthy volunteers welcome
- Sponsor
- Duke University
Respiratory Tract Viral Infections, Human Metapneumovirus (hMPV) Infection
Study of ALVR106 in Patients With Respiratory Viral Infections After Hematopoietic Cell and Solid Organ Transplant
A study to evaluate ALVR106; an allogeneic, off-the-shelf multi-virus specific T cell therapy that targets four community acquired respiratory viruses: respiratory syncytial virus (RSV), influenza, human metapneumovirus (hMPV)…
- Conditions
- Respiratory Tract Viral Infections, Human Metapneumovirus (hMPV) Infection, Parainfluenza (PIV) Infection, Respiratory Syncytial Viral (RSV) Infection
- Trial name
- NCT04933968
- Testing
- ALVR106
- Where
- 21 sites in United States
- Volunteers
- 17 people
- Sponsor
- AlloVir
Influenza, SARS (Severe Acute Respiratory Syndrome)
Predicting Severity and Disease Progression in Influenza-like Illness (Including COVID-19)
Respiratory infections such as colds, flu and pneumonia affect millions of people around the world every year. Most cases are mild, but some people become very unwell.
- Conditions
- Influenza, SARS (Severe Acute Respiratory Syndrome), Respiratory Viral Infection, Respiratory Tract Infections
- Trial name
- PREDICT-ILI (NCT04664075)
- Testing
- Respiratory infections
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Imperial College London
Respiratory Tract Viral Infection
Assessement of Viral Shedding Duration After a Respiratory Tract Infection in Oncology and Hematology Patients
The purpose of this study is to assess the duration of the viral shedding in hematology and oncology patients after a respiratory tract viral infection.
- Trial name
- ONCOVIR (NCT03389997)
- Testing
- nasal swabs
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Poitiers University Hospital
COVID-19, Respiratory Tract Infections
Tobacco Use and the Risk of COVID-19 and Adverse Outcomes
This is an observational study of pooled population-based samples in three Nordic countries. Country-specific data has already been analysed in previous studies in Sweden, Finland, and Norway.
- Conditions
- COVID-19, Respiratory Tract Infections, Infections, Pneumonia, Viral
- Trial name
- NCT05321433
- Where
- Sweden
- Volunteers
- 757,585 people
- Sponsor
- Karolinska Institutet
Viral Infection, Bacterial Infections
Distinguishing Bacterial and Viral Infections by MeMed BV® Test to Limit Gut Colonization by MDRO
The fast increase of Multidrug-resistant microorganisms (MDRO) due to the high amount of antimicrobials being poorly used may be limited by better regulating antimicrobial usage globally.
- Conditions
- Viral Infection, Bacterial Infections, Multi-antibiotic Resistance, Respiratory Tract Infections
- Trial name
- CRONUS (NCT05897801)
- Testing
- MeMed BV®
- Where
- 3 sites in Greece
- Volunteers
- 230 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Respiratory Viral Infection, Respiratory Tract Diseases
PREvent Viral Exposure and Transmission Study: a COVID-19 (SARS-CoV-2) PEP Study (PREVENT)
This is an open label controlled household-randomised trial designed to evaluate the efficacy of RESP301 alongside standard of care ("SOC") versus SOC alone.
- Conditions
- Respiratory Viral Infection, Respiratory Tract Diseases, COVID-19 Respiratory Infection
- Trial name
- PREVENT (NCT04842331)
- Testing
- RESP301 (a nitric oxide generating solution), Standard of Care (SOC)
- Where
- United Kingdom
- Sponsor
- Thirty Respiratory Limited
Viral Respiratory Tract Infection
Safety and Tolerability of Single and Multiple Doses of Neumifil
This is a Phase 1, single-centre, randomised, placebo-controlled first in human study in healthy subjects. The study will assess the safety and tolerability of single-ascending (Part A) and multiple-ascending (Part B) doses of…
- Trial name
- NCT05093530
- Testing
- Neumifil
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pneumagen Ltd.
Upper Respiratory Tract Infections, Acute Respiratory Tract Infection
Implementation of Academic Detailing Interventions on Prescribing of Antimicrobial Drugs in Primary Health Care
World increase in mortality from consequences of antimicrobial resistance (AMR) represents a significant public health problem. Irrational prescribing of antimicrobial drugs (AMD) in general population is one of the main causes…
- Conditions
- Upper Respiratory Tract Infections, Acute Respiratory Tract Infection, Viral Infection
- Trial name
- NCT05090475
- Testing
- Academic detailing intervention
- Where
- Croatia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- General Hospital Koprivnica
COVID-19 Infection
A Trial Looking at the Use of Camostat in People Who Have Tested Positive for Coronavirus (COVID-19) (SPIKE-1)
This is a phase II randomised, multicentre, prospective, open label clinical trial. The trial aims to recruit patients who test positive for COVID-19 who have mild symptoms and therefore can treat their symptoms in the community.
- Trial name
- SPIKE-1 (NCT04455815)
- Testing
- Camostat
- Where
- 9 sites in United Kingdom
- Volunteers
- 34 people
- Sponsor
- Cancer Research UK
Respiratory Viral Infection
The Technical and Operational Performance of the QuidelOrtho Savanna RVP4 Analyzer
The purpose of this study is for the research team to become familiar with and evaluate the technical and operational performance of the QuidelOrtho Savanna RVP4 analyzer by testing 120 archived specimens that were previously…
- Trial name
- NCT05846360
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Wisconsin, Madison
SARS-CoV Infection, Respiratory Viral Infection
COVID-19 Testing Sample Acquisition Throughput and Efficiency
This QI project seeks to evaluate the relative test sample acquisition throughput, personal protective equipment utilization, and relative operational costs of provider-administered COVID-19 (SARS-CoV-2) nasal samples with and…
- Conditions
- SARS-CoV Infection, Respiratory Viral Infection, Personal Protective Equipment, Covid19
- Trial name
- HexapodBooth (NCT04532411)
- Testing
- Personal Protective Testing Booth
- Where
- United States
- Volunteers
- 28,948 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Influenza, Respiratory Viral Infection
A Study to Evaluate the Safety and Efficacy of XC221 in Patients With Uncomplicated Influenza or Other Acute Viral Upper Respiratory Infections
The main purpose of the study was to evaluate the effectiveness of XC221, tablets, at a dose of 200 mg/day compared to placebo in patients with uncomplicated influenza or other acute respiratory viral infections (ARIs).
- Trial name
- NCT05544916
- Testing
- XC221
- Where
- 13 sites in Russia
- Volunteers
- 260 people
- Sponsor
- Valenta Pharm JSC
Influenza, Respiratory Viral Infection
Pharmacokinetics and Bioequivalence of XC8 10 mg and 40 mg Tablets in Fasted Volunteers
Comparative study of the pharmacokinetics of XC8, film-coated tablets, 10 mg and XC8, film-coated tablets, 40 mg, when administered once in equal doses (40 mg) on an empty stomach in healthy volunteers.
- Trial name
- NCT05558462
- Testing
- XC8
- Where
- Russia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Valenta Pharm JSC
Influenza Viral Infections, Respiratory Viral Infection
Severe Acute Respiratory Infections (SARI) in Belgium (2011-2020)
The Belgian Severe Acute Respiratory Infections network (BELSARI-net) was implemented during the influenza season 2011-2012 following the recommendations of the World Health Organization (WHO) to monitor severity of influenza…
- Conditions
- Influenza Viral Infections, Respiratory Viral Infection, Severe Acute Respiratory Infection
- Trial name
- SARIpreSC2 (NCT05620953)
- Testing
- respiratory specimen
- Volunteers
- 12,145 people
- Sponsor
- Sciensano
Respiratory Viral Infection
Respiferon Project
Respiratory viral infections (RVIs) represent a major public health problem and a great burden in terms of morbidity and mortality in children and adults worldwide.
- Trial name
- Respiferon (NCT06017310)
- Testing
- Evaluate the performance of IFN I/III
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Cancer, Covid19
COVID-19 Prevention and Treatment in Cancer; a Sequential Multiple Assignment Randomised Trial;
A multi-centre Australian trial with four arms aims to evaluate several different immune modulating drugs for prevention and treatment of COVID-19 specifically in the cancer population.
- Conditions
- Cancer, Covid19, Respiratory Viral Infection
- Trial name
- C-SMART (NCT04534725)
- Testing
- Interferon alfa, Selinexor, Lenzilumab
- Where
- 5 sites in Australia
- Volunteers
- 441 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia