Clinical trials: Respiratory Rate
Hyperoxia
Proteomics for Identification of Hyperoxia-induced Changes in Protein Expression
Aim of the present study is to investigate the influence of hyperoxia on the protein expression using the differential analysis of protein expression in tissues (proteomics).
- Trial name
- NCT02553668
- Testing
- Oxygen (FiO2 1,0), Facemask
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital of Cologne
Chronic Obstructive Pulmonary Disease
Community-based Management of Chronic Obstructive Pulmonary Disease in Nepal
Chronic Obstructive Pulmonary Disease (COPD) is the fourth most important cause of death worldwide and is one of the commonest non-communicable diseases (NCDs) in Nepal.
- Trial name
- COBIN-P (NCT03797768)
- Testing
- Behavioural-FCHV Visit
- Where
- Denmark
- Volunteers
- 1,438 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Influenza A H1N1
Dose, Safety, and Pathogenicity of a New Influenza H1N1 Challenge Strain
A total of up to 90 participants may be given H1N1 influenza challenge virus. In Part A, 40 participants will be randomly allocated to one of two groups to be given one of two virus doses (Virus Dose 1 or Virus Dose 2).
- Trial name
- NCT05572450
- Testing
- Infectious Titre 1, Infectious Titre 2, Infectious Titre 3
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hvivo
Adult Subject
Effect of Super-Oxygenated Water on Blood Oxygen Saturation
Therapeutic delivery of additional Oxygen to blood stream via hyperbaric and extracorporeal oxygenation that raises blood Oxygen saturation level, apart from oxygenation in the lungs, is known to induce tissue repair, restore…
- Trial name
- NCT07016191
- Testing
- Ingestion of Water
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Inhale, Inc
Asthma
Non Invasive Ventilation in Acute Asthma
The aim of this study is to compare the efficacy of noninvasive positive pressure ventilation versus best medical therapy in patients with acute severe asthma
- Trial name
- NCT00510991
- Testing
- nippv
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
COVID-19
Fibroblast Growth Factor 23 and Sclerostin in Relation to Calcium in COVID-19 Patients
Hypocalcemia is associated with COVID-19 patients and is linked to poor prognosis, Fibroblast growth factor 23 (FGF23) and Sclerostin inhibit vitamin D activation and are linked to hypocalcemia.
- Trial name
- NCT05275491
- Testing
- Calcium, Fibroblast growth factor 23, Sclerostin
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Advanced Solid Tumor, Melanoma
VSV-02 Compassionate Use in Advanced Solid Tumors
This is a clinical study for patients with advanced solid tumors who have limited or no effective treatment options available. The study aims to evaluate a new investigational drug called VSV-02 Injection, which is developed by…
- Conditions
- Advanced Solid Tumor, Melanoma, Breast Cancer, Lung Cancer
- Trial name
- NCT07260591
- Testing
- VSV-02 Injection
- Where
- China
- Volunteers
- 6 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Long COVID
Mental Intervention and Nicotinamide Riboside Supplementation in Long Covid
Long COVID, also referred to as post-acute sequela of COVID-19 (PASC), is present in a substantial number of individuals, and treatment for this is warranted.
- Trial name
- MINIRICO (NCT05703074)
- Testing
- Nicotinamide Riboside (NR), Mind-body reprocessing therapy (MBRT), Care as usual
- Where
- Norway
- Volunteers
- 310 people
- Sponsor
- University Hospital, Akershus
Syncope, Chest Pain
Autonomic Monitoring in Neurocardiogenic Syncope
This is a prospective observational pilot study of suitability of autonomic monitoring via the VU-AMS device for prediction of neurocardiogenic syncope (NCS) in children referred to cardiopulmonary exercise testing (CPET) for a…
- Conditions
- Syncope, Chest Pain, Dyspnea
- Trial name
- ANSS (NCT05907018)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Influenza, Common Cold
Pomegranate Products for Prevention of Common Cold
Pomegranate has a long history of use in folk medicine. There is vast data on the health benefits of pomegranate fruit and juice.
- Conditions
- Influenza, Common Cold, Cough, Headache
- Trial name
- NCT00617318
- Testing
- Pomegranate
- Where
- United States
- Volunteers
- 461 people, healthy volunteers welcome
- Sponsor
- Texas Heart Institute
Influenza
Immunogenicity and Safety Study of Different Formulations of GlaxoSmithKline (GSK) Biologicals H7N1 Influenza Vaccine Administered to Adults 65 Years of Age and Older
The purpose of this placebo controlled study is to evaluate the safety and immunogenicity of different formulations of GSK Biologicals H7N1 influenza vaccine in subjects 65 years of age and older.
- Trial name
- NCT01949090
- Testing
- Investigational H7N1 vaccine GSK2789869A
- Where
- 8 sites in United States, Canada
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COVID-19, Neuro-Degenerative Disease
Randomised Clinical Trial to Evaluate the Efficacy of an Online Cognitive Rehabilitation Programme (COPERIA-COG) for Patients With Persistent COVID-19
The pandemic caused by SARS-CoV-2 infection has led to the emergence of diffuse and heterogeneous persistent symptoms in addition to the well-known acute symptoms, which have come to be referred to as persistent COVID.
- Conditions
- COVID-19, Neuro-Degenerative Disease, Psychological, SARS CoV 2 Infection
- Trial name
- COPERIA-COG (NCT05629897)
- Testing
- Sessions of cognitive stimulation
- Where
- 2 sites in Spain
- Volunteers
- 88 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Covid19
DYNamic Assessment of Multi Organ Level Dysfunction in Patients Recovering From Covid-19
In this study the investigators are hoping to the find out what changes occur within the body of people recovering from Covid-19 at 5-7 months and 11-13 months following discharge from hospital, compared to healthy controls, and…
- Trial name
- DYNAMOCovid-19 (NCT05060497)
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Myotonic Dystrophy 1
Venous Thromboembolism in Myotonic Dystrophy Type 1
Investigators identified a high risk of deep vein thrombosis and pulmonary embolism in patients presenting myotonic dystrophy type 1 treated in our hospital, 10 times higher than general population matched on age and sex.
- Trial name
- DM1-VTE (NCT03424460)
- Testing
- Haemostasis tests, Monocytes and megacaryocytes culture and RNA extraction, RNA extraction
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome, Prone Position
Early Verticalization of the Patient With Acute Respiratory Distress Syndrome: Assessment of Feasibility and Safety.
Acute Respiratory Distress Syndrome (ARDS) is defined according to the Berlin definition (1) as diffuse lung damage occurring in patients with a predisposing risk factor.
- Trial name
- STAND_ARDS1 (NCT04472260)
- Testing
- Verticalization and Prone position
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Sleep Apnea, Obstructive
Predictive Factors for Prescribing a Mandibular Advancement Device for the Treatment of Obstructive Sleep Apnea
This project evaluates the morphological predictive factors for prescribing a mandibular advancement device in the therapeutic approach of Obstructive sleep apnea (OSA).
- Trial name
- NCT05677620
- Testing
- Pharyngeal Computed Tomography, Drug-Induced Sleep Endoscopy (Propofol), Mandibular Advancement Device
- Where
- Portugal
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Metastatic Non-Small Lung Cell Cancer, Recurrent Non-Small Lung Cell Cancer
Phase 2 DoceRamPem for Patients With Metastatic or Recurrent NSCLC Who Progressed on Platinum-Doublet and PD-1/PD-L1 Blockade
This phase 2 trial will evaluate the safety and efficacy of combining immunotherapy with a PD-1 checkpoint inhibitor (Pembrolizumab), an anti-VEGF receptor (Ramucirumab), and a taxane chemotherapy (Docetaxel) in treating patients…
- Conditions
- Metastatic Non-Small Lung Cell Cancer, Recurrent Non-Small Lung Cell Cancer, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8
- Trial name
- DoceRamPem (NCT04340882)
- Testing
- Docetaxel, Pembrolizumab, Ramucirumab
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Severe Acute Respiratory Syndrome Coronavirus 2
A Clinical Trial of COVAC-1, a COVID-19 Vaccine, in Generally Healthy Adults
VIDO has developed a vaccine called COVAC-1. The study vaccine contains a portion of the SARS-CoV-2 spike protein, called S1. The spike protein is the part of the virus that is responsible for attaching to the surface of host…
- Trial name
- NCT05155982
- Testing
- COVAC-1
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Systemic Sclerosis, Pulmonary; Hypertension
Dimethyl Fumarate (DMF) in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
A double-blinded, placebo-controlled study of Dimethyl fumarate (DMF) in 34 Systemic Sclerosis-Pulmonary Hypertension (SSc-PAH) patients.
- Trial name
- NCT02981082
- Testing
- Dimethyl Fumarate (DMF)
- Where
- 4 sites in United States
- Volunteers
- 6 people
- Sponsor
- Robert Lafyatis
Lung Diseases, Obstructive
Aridol Challenge as a Tool to Predict Treatment Response to Inhaled Corticosteroids in COPD
The purpose of this study is to determine whether the Aridol (mannitol) challenge test can predict response to treatment with inhaled corticosteroids in COPD subjects.
- Trial name
- NCT00117182
- Testing
- Dry powder mannitol, Budesonide 400mcg administered via turbuhaler, Ipratropium bromide 80mcg
- Where
- 13 sites in Australia
- Volunteers
- 140 people
- Sponsor
- Syntara