Clinical trials: Respiratory Muscle Paralysis, active
Cerebral Palsy (CP)
Expiratory Muscle Training in Children With Cerebral Palsy
This study aims to examine the effects of expiratory muscle training on posture, trunk control, balance, selective motor control, and respiratory function in children with spastic-type cerebral palsy (CP).
- Trial name
- CP-EMT (NCT07048223)
- Testing
- Expiratory Muscle Training
- Volunteers
- 20 people
- Sponsor
- Istinye University
Pulmonary Edema, Pneumonia
Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU
Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second.
- Conditions
- Pulmonary Edema, Pneumonia, Atelectasis, Pleural Effusion
- Trial name
- NCT06538376
- Testing
- Portable Dynamic Digital Radiography (DDR)
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Brigham and Women's Hospital
Residual Neuromuscular Blockade, Diaphragm Dysfunction
Diaphragm Ultrasound and Neuromuscular Monitoring for Predicting Early Respiratory Events After Extubation
The goal of this prospective observational study is to learn whether diaphragm ultrasound and quantitative neuromuscular monitoring can predict early respiratory events after extubation in adults having elective surgery under…
- Conditions
- Residual Neuromuscular Blockade, Diaphragm Dysfunction, Postoperative Pulmonary Complications, Airway Extubation
- Trial name
- DIAPHEX (NCT07912437)
- Testing
- Diaphragm ultrasonography4
- Volunteers
- 100 people
- Sponsor
- Mustafa Duran
Diaphragmatic Plication, Diaphragmatic Paralysis
Short- and Long-term Effects of Robot-assisted Plication in Diaphragmatic Paralysis
Diaphragmatic paralysis may lead to severe symptoms such as breathlessness and reduced physical capacity. Diaphragmatic plication using Robotic-Assisted Thoracic Surgery (RATS) is a minimally invasive surgical technique developed…
- Conditions
- Diaphragmatic Plication, Diaphragmatic Paralysis, Diaphragmatic Eventration
- Trial name
- RAPIDLY (NCT06919185)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala County Council, Sweden
Atrial Fibrillation
Diaphragmatic Evaluation by Fluoroscopy to Identify Phrenic Nerve Dysfunction Related to Electroporation
Pulsed Field Ablation (PFA) represents a recent advance in the treatment of atrial fibrillation (AF), with a safety profile potentially superior to traditional thermal techniques, such as radiofrequency or cryoablation.
- Trial name
- DEFINE-PFA (NCT07462910)
- Testing
- Dynamic fluoroscopy
- Where
- 9 sites in Canada, France and 1 more
- Volunteers
- 250 people
- Sponsor
- French Cardiology Society
ARDS (Acute Respiratory Distress Syndrome)
Continuous vs Bolus Neuromuscular Blockade Regimens in Moderate to Severe Hypoxemic Respiratory Failure and ARDS (COBRA)
Current clinical guidelines, such as those from the Surviving Sepsis Campaign and ARDSNet, recommend short-term NMBA use for patients with moderate to severe ARDS who exhibit persistent ventilator dyssynchrony or high plateau…
- Trial name
- COBRA (NCT07567768)
- Testing
- Neuromuscular Blocking Agent - Bolus Dosing, Neuromuscular Blocking Agent - Continuous Infusion
- Volunteers
- 100 people
- Sponsor
- University of Calgary
ARDS, TTM
TwichView-guided Atricurium Dose Adjustment Trial
The goal of this clinical trial is to learn if using a monitor that measures muscle response can lower the amount of muscle relaxant medicine needed in adults who are treated in an intensive care unit (ICU) and need a continuous…
- Conditions
- ARDS, TTM, ECMO, Neuromuscular Blockade Monitoring
- Trial name
- NCT07807046
- Testing
- EMG-based quantitative TOF-guided atracurium titration
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Fu Jen Catholic University Hospital
Neuromuscular Diseases, Congenital Diaphragmatic Hernia
Respiratory Muscles and Work of Breathing in Children
Respiratory muscle testing allows a quantitative assessment of inspiratory and expiratory muscles in children of any age with primary or secondary respiratory muscle impairment, in order to better understand the pathophysiology…
- Conditions
- Neuromuscular Diseases, Congenital Diaphragmatic Hernia, Lung Diseases, Cardiac Diseases
- Trial name
- WOB&MR_Ped (NCT05051254)
- Testing
- Esogastric pressure measurement
- Where
- France
- Volunteers
- 550 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diaphragm Paralysis
Diaphragm Paralysis: Surgery or Mechanical Ventialion
Summary Rationale: The diaphragm is a dome-shaped muscle which separates the thoracic cavity from the abdomen. In patients with diaphragm paralysis the treatment (surgery versus non-invasive ventilation) is based on physician…
- Trial name
- PARASOL (NCT05027035)
- Testing
- surgical plication" or "nocturnal non-invasive ventilation
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Spastic Cerebral Palsy (sCP)
Bilateral Asymmetry of Respiratory Muscle Activity During Breathing in Children With Spastic Cerebral Palsy
This observational cross-sectional study investigates the bilateral asymmetry of respiratory muscle activity during breathing in children with spastic cerebral palsy (CP).
- Trial name
- NCT07777809
- Testing
- Surface Electromyography (sEMG) assessment
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Sahmyook University
Mitochondrial Disorders, Mitochondrial Genetic Disorders
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
The North American Mitochondrial Disease Consortium (NAMDC) maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.
- Conditions
- Mitochondrial Disorders, Mitochondrial Genetic Disorders, Mitochondrial Diseases, Disorder of Mitochondrial Respiratory Chain Complexes
- Trial name
- NAMDC (NCT01694940)
- Where
- 17 sites in United States, Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Hypotonia, Muscle, Obstructive Sleep Apnea
Long-term Evaluation of Nasopharyngeal Airway in Hypotonia
This research is studying the long term use of a nasal airway device (self-supporting nasopharyngeal airway; "ssNPA") in children with hypotonic upper airway obstruction to learn about its effectiveness and tolerability as a…
- Conditions
- Hypotonia, Muscle, Obstructive Sleep Apnea, Nasal Airway Obstruction
- Trial name
- NCT06614582
- Testing
- Self-Supporting Nasopharyngeal Airway (ssNPA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Respiratory Insufficiency, Neuromuscular Blockade
Partial Neuromuscular Blockade in Acute Hypoxemic Respiratory Failure
PNEUMA is a preliminary safety and feasibility trial of a novel approach to the titration of neuromuscular blockade (NMB) to safe spontaneous breathing in patients with moderate to severe acute hypoxemic respiratory failure…
- Conditions
- Respiratory Insufficiency, Neuromuscular Blockade, Mechanical Ventilation
- Trial name
- PNEUMA (NCT04524585)
- Testing
- Cisatracurium
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- University Health Network, Toronto
Cerebral Palsy, Respiratory Function Tests
Respiratory Function, Respiratory Muscle Strength, and Hand Function in Hemiparetic Cerebral Palsy
The goal of this observational study is to learn how respiratory function and respiratory muscle strength are related to hand use in children and teenagers with hemiparetic cerebral palsy (CP) aged 6 to 18 years.
- Conditions
- Cerebral Palsy, Respiratory Function Tests, Fine Motor Skills
- Trial name
- NCT07394439
- Volunteers
- 37 people
- Sponsor
- Halic University
Acute Respiratory Failure
INtubation With Sedation Only to Preserve Independent Respiratory Effort Trial
The INtubation with Sedation Only to Preserve Independent Respiratory Effort (INSPIRE) trial is a pragmatic, non-blinded, parallel-group, randomized clinical trial comparing the effect of intubation with sedation only…
- Trial name
- INSPIRE (NCT07845305)
- Testing
- Intubation with a sedative medication only, Intubation with a sedative medication and neuromuscular blockade agent
- Where
- United States
- Volunteers
- 228 people
- Sponsor
- Vanderbilt University Medical Center
Lung Transplantation
Impact of Inspiratory Muscle Training (IMT) With Intermittent Variable Resistance (IVR) Versus Constant Resistance (CR) on Functional Capacity in Lung Transplantation (LTx) Patients (I-TRAIN-LTx Study)
Objectives: Primary Objective: To compare Maximum Inspiratory Pressure (MIP) in lung transplant (LT) patients between the use of inspiratory muscle training (IMT) with intermittent variable resistance (IVR) or constant resistance…
- Trial name
- I-TRAIN-LTx (NCT06963190)
- Testing
- Constant Resistance (CR), Intermittent Variable Resistance (IVR)
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Hospital Universitario Marqués de Valdecilla
Spinal Cord Injuries (SCI), Respiratory Insufficiency
Abdominal Stimulation to Improve Cough After Spinal Cord Injury
The goal of this clinical trial is to learn if abdominal functional electrical stimulation (FES) using the VentFree Respiratory Muscle Stimulator improves cough strength in adults with a new spinal cord injury (SCI).
- Trial name
- COUFES (NCT07626931)
- Testing
- Respiratory Muscle Stimulator, Supervised Cough Training
- Volunteers
- 150 people
- Sponsor
- Liberate Medical
Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB)
Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries
Sleep-disordered breathing (SDB) is common in individuals with cervical spinal cord injuries, with studies suggesting prevalence rates ranging from 27% to 62%.
- Conditions
- Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB), Sleep Apnea, Cervical Spinal Cord Injruy
- Trial name
- NCT06818604
- Testing
- CPAP, BiPAP
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Cerebral Palsy
Transcutaneous Diaphragmatic Electrical Stimulation and Pulmonary Function in Non-Ambulatory Cerebral Palsy
Does transcutaneous diaphragmatic electrical stimulation (TDES), added to a 6-week structured multimodal rehabilitation program, improve diaphragm function, head-neck control, and sitting balance in children with cerebral palsy…
- Trial name
- NCT07622875
- Testing
- Multimodal Rehabilitation, Transcutaneous diaphragmatic electrical stimulation (TDES)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara Etlik City Hospital
Driving Pressure, Neuromuscular Blockade Monitoring
Effect of Neuromuscular Block Depth on Driving Pressure and Postoperative Respiratory Events in Abdominal Surgeries
This randomized controlled study aims to evaluate the effects of deep versus moderate neuromuscular blockade on intraoperative driving pressure and the development of postoperative critical respiratory events in patients…
- Conditions
- Driving Pressure, Neuromuscular Blockade Monitoring, Postoperative Respiratory Complications
- Trial name
- NCT07464288
- Testing
- Rocuronium
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent