Clinical trials: Respiratory Mechanics
Mechanical Ventilation Complication, Acute Respiratory Failure
Non-invasive Respiratory Monitoring During SBT
Spontaneous breathing trials (SBTs) assess readiness for extubation, yet the use of conventional parameters used to establish weaning success may be elusive, especially in high-risk patients.
- Conditions
- Mechanical Ventilation Complication, Acute Respiratory Failure, Re-intubation Rate
- Trial name
- NCT05295186
- Where
- 2 sites in Italy
- Volunteers
- 238 people
- Sponsor
- University of Bari
Respiratory Insufficiency, Respiration, Artificial
Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients
Sedation is widely used in mechanically ventilated patients. Propofol, benzodiazepines and opioids are the most used drugs. The study hypothesis is that sedation with remifentanil (an opioid drug) could improved respiratory…
- Conditions
- Respiratory Insufficiency, Respiration, Artificial, Conscious Sedation
- Trial name
- NCT00665119
- Testing
- remifentanil
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Acute Lung Injury, ARDS
The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients
The investigators aim to study the specific elastance in ALI/ARDS patients during invasive mechanical ventilation.
- Trial name
- NCT00143468
- Testing
- mechanical ventilation
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Respiratory Insufficiency
Non-invasive Measurements of Elastance and Resistance
The study aims to assess the agreement between respiratory mechanics parameters measured noninvasively by means of brief airways occlusions at the beginning of inspiration and the reference parameters obtained with standard…
- Trial name
- ERNI (NCT01530282)
- Testing
- Invasive method, Non invasive method
- Volunteers
- 15 people
- Sponsor
- University of Turin, Italy
Neuromuscular Blockade
The Effect of Deep Neuromuscular Blockade on Respiratory Mechanics
This study is a randomized, controlled, double-blinded, and parallel design study. A total 58 patients were randomized to receive a deep block or a moderate block scheduled for elective robot assisted laparoscopic radical…
- Trial name
- NCT04174222
- Testing
- Moderate NMB, Deep NMB
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Copd
Impact of Long-acting Bronchodilator- -Corticoid Inhaled Therapy on Ventilation, Lung Function and Breathlessness
Multicentre, prospective, non-randomised, single-arm, open label, mechanistic study to investigate the mechanism of action of BGF 160 on ventilation pattern complexity and variability
- Trial name
- VARI-OSCIL (NCT06110403)
- Testing
- TRIXEO AEROSPHERE
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Lille
Pulmonary Disease, Respiratory Failure
Ventilator Mode and Respiratory Physiology
Modern intensive care units (ICUs) are increasingly adopting newer modes of mechanical ventilation such as adaptive pressure control (APC) modes but there are limited data available regarding risks and benefits of newer modes…
- Conditions
- Pulmonary Disease, Respiratory Failure, Respiratory Effort, Breathing Mechanics
- Trial name
- NCT06624254
- Testing
- lung mechanics, respiratory drive and effort
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Acute Lung Injury, Acute Respiratory Distress Syndrome
The Specific Lung Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients in Supine and Prone Position
The investigators aim is to study the specific lung elastance in ALI/ARDS patients during invasive mechanical ventilation, in supine and prone position.
- Trial name
- NCT00568659
- Testing
- specific elastance
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Policlinico Hospital
Shoulder Arthroscopic Surgery
The Effect of the Shoulder Arthroscopic Surgery on Respiratory Mechanics
During shoulder arthroscopic surgery, extravasation of irrigation fluid can occur around the shoulder and trachea, compressing the upper airway.
- Trial name
- NCT01407328
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Respiratory Distress, Lung Injury
Infant Pulmonary Mechanics: High Flow Nasal Cannula Versus Nasal CPAP
This study is designed to evaluate the effect of heated humidified high flow nasal cannula (HHHFNC) as compared to noninvasive nasal continuous positive airway pressure (NCPAP) on lung function as a measure of lung injury in…
- Trial name
- NCT01939067
- Testing
- Heated Humidified High Flow Nasal Cannula, Nasal Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Lumbar Disc Herniation, Respiratory Mechanics
Pulmonary Mechanics and Cerebral Oxygenation During Prone Lumbar Disc Surgery
This prospective observational study aims to evaluate the relationship between changes in respiratory mechanics and cerebral oxygenation in adult patients undergoing elective lumbar disc surgery in the prone position under…
- Conditions
- Lumbar Disc Herniation, Respiratory Mechanics, Cerebral Oxygenation
- Trial name
- NCT07862257
- Testing
- Prone Positioning
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Mechanical Ventilation
Effect of Two Modes of Mechanical Ventilation on Metabolic Demands and Respiratory Mechanics
Adequate supply of energy is an essential part of the overall treatment of critically ill patients and adjustment of energy requirements of patients is important clinical evolution .The adequate assessment of energy expenditure…
- Trial name
- NCT04205422
- Testing
- BIPAP, APRV
- Volunteers
- 120 people
- Sponsor
- Assiut University
Sever Chest Trauma, Mechanical Ventilation
Driving Pressure in Trauma
Traumatic chest injuries are responsible for significant morbidity and the cause of trauma-related death in 20%-25% of cases. Thoracic trauma can include multiple injuries, mainly osseous (ribs, sternal fractures, flail chest)…
- Trial name
- NCT03367442
- Testing
- no intervention
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Acute Respiratory Distress Syndrome (ARDS)
Validation of Digital Chest-X-ray (CXR) to Assess Lung Recruitment in ARDS
Lung recruitability is essential for optimal Positive end-expiratory pressure (PEEP) selection in ARDS patients. It is defined as the potential for the non aerated or poorly aerated lung mass to become aerated due to the increase…
- Trial name
- RECRUTEX (NCT02081105)
- Testing
- PEEP of 5 or 15 cm H2O
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Hospices Civils de Lyon
Laparoscopic Cholecystectomy
Respiratory Mechanics and Metabolic Changes During Low Pressure Laparoscopic Cholecystectomy
The investigators aim to investigate the differences between deep continuous muscle relaxation and moderate blockade during low-pressure (8 mmHg) laparoscopic cholecystectomy in respect to metabolic changes and respiratory…
- Trial name
- NCT02469831
- Testing
- Rocuronium
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Spinal Stenosis, Lumbosacral Region
Stability Comparison of TIVA and Sevoflurane in Prone Spinal Surgery(TIVA:Total Intravenous Anesthesia)
Key Points: 1. Objective: o To compare the effects of Total Intravenous Anesthesia (TIVA) and sevoflurane anesthesia on respiratory mechanics, hemodynamic parameters, and neuromonitoring during prone position spinal surgeries. 2.
- Trial name
- TIVA (NCT06558695)
- Testing
- Sevoflurane, TIVA
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Exercise
Effects of Pilates on Respiratory Mechanics
The aim of this study was to evaluate the influence of a fitness program from the application of Pilates on lung function, thoracoabdominal mobility and respiratory muscle strength in women.
- Trial name
- NCT01841385
- Testing
- Pilates method
- Where
- Brazil
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Pneumoperitoneum
Moderate vs Deep Neuromuscular Block on Biotrauma During Laparoscopy
The purposes of this study is to investigate the effects of moderate vs. deep neuromuscular block on respiratory mechanics and biotrauma in patients with intraoperative protective lung ventilation for laparoscopy.
- Trial name
- NCT03576118
- Testing
- Deep neuromuscular block, Moderate neuromuscular block
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Ajou University School of Medicine
Mechanical Ventilation, Lung Infection
Breath and Air Stacking on Respiratory Mechanics in Tracheostomized Patients
The researchers hypothesized that the aid of the resuscitator by the technique Air Stacking increase lung volume, promoting increased lung compliance and improvement of the ventilatory pattern.
- Trial name
- NCT04012489
- Testing
- Breath Stacking, Air Stacking
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Brazilian Institute of Higher Education of Censa
Prematurity, Respiratory Distress Neonatal
Effect of Automated Oxygen Control on Early-childhood Lung Mechanics
Preterm infants are at higher risk of long-term respiratory problems and abnormal lung function in childhood. Respiratory support including mechanical ventilation, that is the use of a machine to move air into and out of the…
- Conditions
- Prematurity, Respiratory Distress Neonatal, Oxygen Delivery
- Trial name
- NCT07866820
- Testing
- Forced oscillometry technique
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College Hospital NHS Trust