Clinical trials: Respiratory Failure With Hypoxia
Chronic Respiratory Failure, Acute Respiratory Failure
Validation Study of the EMILY AI Device in Acute and Chronic Respiratory Failure
Currently, there is no holistic solution for patients with respiratory diseases that includes oxygenation and management of a patient with respiratory disease, combining dynamic and automatic O2 administration and the detection…
- Trial name
- NCT06952816
- Testing
- Emily.AI
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Aether Tech S.L.
Respiratory Failure With Hypoxia
Physiological Study of High PEEP in Noninvasive Ventilation
To investigate the physiological effects of high positive end-expiratory pressure (PEEP) during noninvasive ventilation in patients with hypoxemic respiratory failure, and to elucidate the mechanisms underlying high PEEP-induced…
- Trial name
- NCT07503509
- Testing
- high PEEP
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chongqing Medical University
Hypoxemic Respiratory Failure
Correlation of Peak Tidal Inspiratory Flow Measured Before and After Extubation in Adult Patients With Hypoxemia
In this study, patients who are ready for extubation and indicated for high-flow nasal cannula therapy after extubation will be enrolled, the investigators would measure the patient peak tidal inspiratory flow (PTIF) pre and post…
- Trial name
- NCT04971148
- Testing
- HFNC flow set at patient peak tidal inspiratory flow, HFNC flow set at 1.33 times of patient peak tidal inspiratory flow, HFNC flow set at 1.67 times of patient peak tidal inspiratory flow
- Where
- 2 sites in United States, Spain
- Volunteers
- 5 people
- Sponsor
- Rush University Medical Center
COVID-19, Respiratory Failure With Hypoxia
Elmo Respiratory Support Project - COVID-19
The number of COVID-19 cases has been growing exponentially, so that the industrialized economies are facing a significant shortage in the number of ventilators available to meet the demands imposed by the disease.
- Trial name
- NCT04470258
- Testing
- ELMO PROJECT AT COVID-19: STUDY IN HUMANS, ELMO PROJECT AT COVID-19: PROOF OF CONCEPT AND USABILITY
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Escola de Saúde Pública do Ceará
Respiratory Failure With Hypoxia
Helmet Noninvasive Ventilation vs. High-flow Nasal Cannula in Moderate-to-severe Acute Hypoxemic Respiratory Failure
Helmet noninvasive ventilation and high-flow nasal cannula are novel tools for the first-line treatment of acute hypoxemic respiratory failure.
- Trial name
- HENIVOTpilot (NCT04502576)
- Testing
- Noninvasive respiratory support
- Where
- 5 sites in Italy
- Volunteers
- 110 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Respiratory Failure With Hypoxia, Respiratory Failure Without Hypercapnia
PRone positioN in Patients With spontanEous ventiLation and Acute Hypoxemic respIratory FailurE
The proposed randomized controlled trial aims at comparing the application of the prone position in spontaneously breathing patients with acute hypoxemic respiratory failure from any cause versus standard treatment on the rate of…
- Trial name
- PRONELIFE (NCT04142736)
- Testing
- Prone Position
- Where
- Spain
- Volunteers
- 650 people
- Sponsor
- Corporacion Parc Tauli
Respiratory Failure With Hypoxia
Clinical Comparison of Flow Regulated Nasal Oxygen Delivery System (FRNDS) Cannula and Plethysmography Belts
SUMMARY: This is a quantitative, non-inferiority study using healthy participants to compare tidal volumes at rest measured by both a standard RIP belt and a flow-regulated nasal oxygen delivery system FRNDS cannula.
- Trial name
- FRNDS (NCT06713213)
- Testing
- Flow-regulated nasal oxygen delivery system (FRNDS)
- Where
- 2 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Hypoxemic Respiratory Failure, Hypoxia
Automated Oxygen Control by O2matic to Patients Admitted With Acute Hypoxemia
The aim of this study is to examine if automated oxygen delivery with O2matic allows for faster weaning from oxygen supply and better oxygen control than manually controlled oxygen therapy for patients admitted to the emergency…
- Conditions
- Hypoxemic Respiratory Failure, Hypoxia, Hypoxemia, Respiratory Failure
- Trial name
- O2MATIC-ACUT (NCT04079465)
- Testing
- O2matic
- Where
- 2 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- Hvidovre University Hospital
Early Acute Respiratory Failure
Early Non-invasive Ventilation Outside the Intensive Care Unit
A large multicentre, randomized, controlled trial to demonstrate that non invasive ventilation given at an early stage of acute respiratory failure (ARF) outside the intensive care unit (ICU) can prevent the deterioration of ARF…
- Trial name
- NAVIGATE (NCT01572337)
- Testing
- Non-invasive ventilation, Standard care
- Where
- 14 sites in Greece, Italy and 1 more
- Volunteers
- 520 people
- Sponsor
- Università Vita-Salute San Raffaele
Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice
Feasibility and Safety of Supraglottic Oxygen Delivery Via an Endotracheal Tube for Non-intubated ERCP Anesthesia: A Two-Stage Phase II Clinical Study
Endoscopic retrograde cholangiopancreatography (ERCP) is a technique for evaluating the bile duct, pancreatic duct, and ampulla.
- Conditions
- Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice, Pancreatitis, Cholelithiasis
- Trial name
- NCT07051980
- Testing
- Supraglottic Oxygen Delivery via an Endotracheal Tube
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhejiang University
Acute Respiratory Failure With Hypoxia, Malnutrition
Supplemental Parenteral Nutrition in Pediatric Respiratory Failure
Optimal delivery of nutritional support during critical illness is central to appropriate intensive care unit management, and yet fundamental gaps in knowledge exist regarding timing, route, dose, and type of nutritional support…
- Trial name
- SuPPeR (NCT01937884)
- Testing
- Parenteral Nutrition
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Arizona
Acute Respiratory Failure With Hypoxia
PEEP in Patients With Acute Respiratory Failure
Positive end-expiratory pressure (PEEP) has become an essential component of the care of critically ill patients who require ventilatory support.
- Trial name
- NCT04912960
- Testing
- Mechanical ventilation
- Where
- 3 sites in Spain
- Volunteers
- 15 people
- Sponsor
- Jesus Villar
Nocturnal Hypoventilation, Neuromuscular Disease
Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Newly Diagnosed Patients
The aim of the study is to compare the efficacy and tolerance of autotitrating non-invasive ventilation (NIV) versus standard NIV in patients with newly diagnosed nocturnal hypoventilation who have never experienced nocturnal…
- Conditions
- Nocturnal Hypoventilation, Neuromuscular Disease, Chest Wall Disorder
- Trial name
- NCT00901485
- Testing
- AutoVPAP, VPAPIIIST-A
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- ResMed
Corona Virus Infection, Hypoxic Respiratory Failure
Timed Awake Prone and Repositioning for Patients With Covid-19-induced Hypoxic Respiratory Failure.
Awake prone positioning has been reported to improve oxygenation for patients with COVID-19. Awake timed and repositioning is a novel method to improve patients' compliance and prolong the prone time.
- Trial name
- NCT05689216
- Testing
- Awake timed prone and repositioning
- Where
- 3 sites in China
- Volunteers
- 286 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Critical Illness, Respiratory Failure
High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
Intubation in the intensive care unit is a standard procedure with a high risk of adverse events such as hypoxaemia and cardiovascular instability.
- Conditions
- Critical Illness, Respiratory Failure, Multi Organ Failure, Hypoxia
- Trial name
- HiPOXIC (NCT05883137)
- Testing
- Optiflow Switch
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Respiratory Insufficiency, Acute Respiratory Insufficiency
NIV-NAVA vs NIV-PS/PC in Respiratory Insufficiency
This study evaluates the difference between Non Invasive Ventilation with Neurally Adjusted Ventilatory Assist (NIV-NAVA) and Conventional Non Invasive Ventilation with Pressure Support (PS) or Pressure Control (PC).
- Trial name
- NCT02592512
- Testing
- NIV-NAVA, NIV-PS/PC
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Vejle Hospital
Acute Respiratory Failure With Hypoxia
pRotective vEntilation With Veno-venouS Lung assisT in Respiratory Failure
This is a trial of a new way of treating patients with respiratory failure. The investigators propose to deliver a multi-centre clinical trial to determine whether veno-venous extracorporeal carbon dioxide removal (VV-ECCO2R) and…
- Trial name
- REST (NCT02654327)
- Testing
- VV-ECCO2R to enable lower tidal volume mechanical ventilation
- Where
- United Kingdom
- Volunteers
- 1,120 people
- Sponsor
- Belfast Health and Social Care Trust
Altitude Intolerance, High-Altitude Illness
Relationship Between Succinate Dehydrogenase Mutations and High-Altitude Illness
This study is is the first step of a full study named CHEMOGENE because it explores the genetic determinant of an alteration of the chemoreflex.
- Trial name
- NCT00202683
- Where
- France
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Société Française de Cardiologie
Hypoventilation, Hypoxia
Using Capnography to Reduce Hypoxia During Pediatric Sedation
The investigators hypothesize that the addition of capnography during moderate sedation will improve recognition of hypoventilation and apnea.
- Trial name
- NCT01463527
- Testing
- Nellcor NPB-70 Capnograph
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- Yale University
Acute Respiratory Failure With Hypoxia, Hypoxemia
Conduct of Nasal High Flow Oxygen in Acute Respiratory Failure
Although many studies have investigated the clinical benefits of nasal high flow during acute hypoxemic respiratory failure, there is no data (and even less so recommendations) on how to best conduct this technique, including its…
- Trial name
- DECIPHEROBS (NCT03311087)
- Where
- 10 sites in France
- Volunteers
- 100 people
- Sponsor
- Hôpital Louis Mourier