Clinical trials: Respiratory Failure (Pediatric Patients)
Airway Obstruction, Pain
Dental Isolation Systems Among Pediatric Patients With Different Airway Patency
This randomized clinical trial will aim to evaluate the effect of DryShield isolation (DSI) and Rubber Dam isolation (RDI) systems on arterial oxygen saturation (SpO2), heart rate (HR), blood pressure (BP), behavior, subjective…
- Conditions
- Airway Obstruction, Pain, Behavior
- Trial name
- NCT06128811
- Testing
- Rubber Dam Isolation, DryShieled isolation, fissure sealant
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Patient-Ventilator Asynchrony, Mechanical Ventilation Complication
Nurse Education to Reduce Patient-Ventilator Asynchrony in the PICU
A prospective cluster-randomized quality improvement trial was conducted to evaluate whether a structured nurse education program on ventilator waveform interpretation and alarm management reduces patient-ventilator asynchrony in…
- Conditions
- Patient-Ventilator Asynchrony, Mechanical Ventilation Complication, Nurse Education
- Trial name
- NCT07273487
- Testing
- Nurse Education on Ventilator Waveform and Alarm Management
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
ECMO Outcomes, Respiratory Failure (Pediatric Patients)
ECMO Use in Pediatric Oncology and HSCT Patients: A Descriptive and Comparative Analysis
This was an observational study, with a descriptive and comparative portion. The descriptive analysis, a large single center experience, examined bleeding complications, infectious rates, and survival outcomes in patients under…
- Conditions
- ECMO Outcomes, Respiratory Failure (Pediatric Patients), Malignancies, Hematologic, Solid Tumor Malignancies
- Trial name
- NCT07712835
- Testing
- Extracorporeal membrane oxygenation (ECMO)
- Volunteers
- 22 people
- Sponsor
- Children's Mercy Hospital Kansas City
Respiratory Insufficiency in Children, Noninvasive Ventilation
Validation of Indirect Calorimetry in Children Undergoing Non-invasive Ventilation
Nutritional status in critically ill pediatric patients is considered a fundamental prognostic factor in terms of mortality, morbidity, complications and outcome.
- Conditions
- Respiratory Insufficiency in Children, Noninvasive Ventilation, Nutrition Assessment
- Trial name
- CALO-NIV (NCT03824249)
- Testing
- Indirect Calorimetry
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Respiratory Insufficiency
Thoracoabdominal Asynchrony and Respiratory Distress
The investigators hypothesize that a simple 3-point tracking device that uses motion sensors attached to the abdomen and chest of a child will provide information regarding thoracoabdominal asynchrony (TAA), a major component of…
- Trial name
- NCT04626154
- Testing
- Objectively monitoring thoracoabdominal asynchrony
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Chronic Lung Disease, Quality of Life
Pulmonary Rehabilitation and Quality of Life in Children With Chronic Lung Diseases: A Multidisciplinary Approach
Chronic lung diseases (CLDs) such as asthma, cystic fibrosis, and bronchopulmonary dysplasia significantly impact pediatric patients' respiratory function and overall well-being.
- Conditions
- Chronic Lung Disease, Quality of Life, Respiratory Function Impaired
- Trial name
- NCT06870032
- Testing
- standard medical care, structured pulmonary rehabilitation
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Horus University
Acute Respiratory Failure
NIV NAVA Versus NIV-PS in Pediatric Patients - Pilot Study
This pilot study will be an observational no randomize study in which the NiNAVAped protocol will be applied solely to the NIV NAVA arm.
- Trial name
- NINAVAPed (NCT01873261)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario La Paz
Acute Respiratory Failure, Acute Respiratory Infection
Airway Inflammatory Response During Illness in Children With Respiratory Failure
The purpose of this study has two major goals: 1) to measure the amount of two specific hormones interleukin (IL)-10 and interleukin (IL)-12p70 in mucous and blood; and 2) compare the hormone levels in two specific areas of the…
- Conditions
- Acute Respiratory Failure, Acute Respiratory Infection, Acute Respiratory Distress Syndrome
- Trial name
- NCT02047877
- Where
- United States
- Sponsor
- University of North Carolina, Chapel Hill
Nasal Congestion and Inflammations
Safety and Effectiveness of Sonu for Pediatric Nasal Congestion
To demonstrate the safety and effectiveness of Sonu for the treatment of pediatric patients with moderate to severe nasal congestion.
- Trial name
- NCT06773013
- Testing
- Acoustic Resonance (Sound) Therapy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Third Wave Therapeutics
Respiratory Failure
Closed-loop FiO2 Controller During High Flow Oxygen Treatment In Pediatric Patients (COFICOHFOT)
Recently, high flow oxygen therapy (HFOT) is becoming more popular in the treatment of any kind of respiratory failure. Pediatric mechanical ventilation consensus conference (PEMVECC) guidelines suggest measuring oxygen…
- Trial name
- COFICOHFOT (NCT05032365)
- Testing
- Close-loop FiO2 controller, Conventional
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Acute Respiratory Distress Syndrome, Pneumonia in Children
AI-Guided Mechanical Ventilation in Children: A Randomized Controlled Trial
This prospective, randomized controlled trial aims to evaluate whether an AI-driven decision support system can improve clinical outcomes for mechanically ventilated pediatric patients (aged 1 month to 18 years) in the PICU…
- Conditions
- Acute Respiratory Distress Syndrome, Pneumonia in Children, Respiratory Failure (Pediatric Patients), Congenital Heart Disease in Children
- Trial name
- NCT07728136
- Testing
- AI-generated recommendations for ventilator parameters.
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wu Rongzhou
Respiratory Failure, Respiratory Distress Syndrome
Ventilator Induced Diaphragm Dysfunction in Pediatric Critically Ill Patients (VIDD)
evaluation of diaphragmatic disfunction eventually occurred in pediatric patient undergoing mechanical ventilation therapy
- Conditions
- Respiratory Failure, Respiratory Distress Syndrome, Mechanical Ventilation Complication
- Trial name
- VIDD (NCT03768232)
- Testing
- ultrasound asessment
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Persistent Allergic Rhinitis
Oxymetazoline Bridge Therapy With Intranasal Corticosteroids in Pediatric Allergic Rhinitis
Persistent allergic rhinitis in children is commonly treated with intranasal corticosteroids (INS), which are considered first-line therapy.
- Trial name
- NCT07593898
- Testing
- Mometasone Furoate (MF) Metered Dose Inhaler (MDI), 100 mcg, Oxymetazoline 0.05% nasal solution
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Bronchiolitis, Respiratory Failure (Pediatric Patients)
Nurse-led High-flow Nasal Cannula Weaning Protocol in Pediatric Intensive Care Unit
Bronchiolitis is a leading cause of pediatric hospital admissions. Despite its limited clinical benefits, the use of HFNC in children with bronchiolitis is increasing.
- Conditions
- Bronchiolitis, Respiratory Failure (Pediatric Patients), High Flow Nasal Cannula
- Trial name
- NCT06621641
- Testing
- The new HFNC weaning protocol
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Pneumococcal Pneumonia, Rotavirus Enteritis With Hypovolemic Shock
Artificial Intelligence-driven Virtual Standardized Pediatric Patients Trial
Background: China's healthcare system for children faces significant challenges, particularly due to the limited pediatric service capacity of primary healthcare institutions.
- Conditions
- Pneumococcal Pneumonia, Rotavirus Enteritis With Hypovolemic Shock, Hand-foot-and-mouth Disease, Acute Appendicitis
- Trial name
- NCT06699433
- Testing
- Virtual standardized patients (VSPs), Case teaching manuals, Case teaching videos
- Where
- 3 sites in China
- Volunteers
- 459 people, healthy volunteers welcome
- Sponsor
- Southern Medical University, China
Critical Illness, Respiratory Failure
PRactice of VENTilation in Critically Ill PEDiatric Patients
The goal of this worldwide observational study is to investigate ventilation practice in critically ill pediatric patients. The main questions it aims to answer are: 1.
- Trial name
- PRoVent-PED (NCT06220825)
- Where
- Netherlands
- Volunteers
- 2,500 people
- Sponsor
- University Medical Center Groningen
Respiratory Insufficiency, Respiratory Failure
Cross-over Comparison of the V60 System to Other Bi-Level Noninvasive Ventilators
The purpose of this study is to compare a new noninvasive ventilator to existing ventilators already used for patient care.
- Trial name
- NCT00817804
- Testing
- Use of the V60 Mask Ventilator
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Respironics, California, Inc.
Sleep Apnea Syndromes in Children, Obesity in Children
Overview: Use of Respiratory Support At Home in Children
the primary outcome is to describe the perceived success of the use of the respiratory support from the parent's point of view
- Conditions
- Sleep Apnea Syndromes in Children, Obesity in Children, Bronchopulmonary Dysplasia (BPD), Neuromuscular Disease
- Trial name
- ELIPSE (NCT06692660)
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Pediatric Respiratory Diseases
Outcome of Patients Admitted to Pediatric Intensive Care for Acute Respiratory Failure
This study aims to assess the quality of life of patients six months after admission to a pediatric intensive care unit for acute respiratory failure.
- Trial name
- NCT06470932
- Testing
- Follow-up consult
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Chronic Kidney Diseases, Chronic Renal Disease
Evaluation of Respiratory Function and Functional Capacity in Pediatric Patients With Chronic Kidney Disease (CKD)
Chronic kidney disease (CKD) is defined as a permanent abnormality in kidney structure or function that persists for more than 3 months (for example, glomerular filtration rate [GFR] <60 mL/min/1.73 m2 or albuminuria ≥30 mg/24…
- Conditions
- Chronic Kidney Diseases, Chronic Renal Disease, Chronic Renal Failure
- Trial name
- NCT05339997
- Testing
- 6 minute walk test,
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Acibadem University