Clinical trials: Replacement
Frailty, Thoracic Surgery
A Frailty-specific Prehabilitation Program for Mild to Moderately Frail Patients Undergoing Cardiac Surgeries/Procedures
The purpose of this study is to investigate the effects of the frailty-specific prehabilitation program on functional capacity, frailty, cardiac-specific functional status, serum albumin level, high-sensitivity C-reactive protein…
- Trial name
- NCT07824700
- Testing
- Frailty-specific prehabilitation program
- Where
- Hong Kong
- Volunteers
- 144 people
- Sponsor
- The University of Hong Kong
Diabetes
Glycemic Response to Six Meal Replacements in Persons With Type 2 Diabetes Mellitus
This will be a randomized, cross-over design. Subjects will be randomized to one of six interventions on six separate study days, 1 week apart.
- Trial name
- NCT03155867
- Testing
- Meal replacement
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Société des Produits Nestlé (SPN)
Pain, Total Knee Replacement
Analysis of Postoperative Analgesic of Different Nerve Blocks for Total Knee Replacement Surgery
This study is a retrospective analysis using the accumulated clinical database from 2017/09-2023/12 to analyze patients who underwent total knee arthroplasty and received nerve blocks.
- Conditions
- Pain, Total Knee Replacement, Motor Function
- Trial name
- NCT06521619
- Testing
- Femoral and sciatic nerve blocks
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Fu Jen Catholic University Hospital
Diquat Poisoning, Blood Purification
Leveraging Plasma Concentration Levels to Optimize Extracorporeal Treatment in Acute Diquat Poisoning
This study aimed to evaluate the clinical value of plasma diquat concentration in guiding personalized extracorporeal treatment regimens for patients with acute diquat poisoning.
- Trial name
- NCT06807151
- Testing
- Extracorporeal Treatment
- Where
- China
- Volunteers
- 163 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Arthroplasty
Preoperative Pain, Function, and Activity for Total Hip and Knee Arthroplasty Patients
This study wish to show if the preoperative level of pain, function or activity for hip and knee arthroplasty patients has any predictive value of the time it takes to fulfill the well-defined discharge criteria.
- Trial name
- NCT01248039
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Hvidovre University Hospital
Acute Kidney Injury
Renal Replacement Therapy Plus Extracorporeal Carbon Dioxide Removal
This study aims to assess whether in patients with acute kidney injury (AKI) requiring mechanical ventilation, a strategy that combines renal replacement therapy (RRT) and extracorporeal carbon dioxide removal (ECCO2R) allows…
- Trial name
- NCT02595619
- Testing
- RRT plus ECCO2R
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- University of Turin, Italy
Anemia
Iron Replacement to Reduce Anemia During Neoadjuvant Chemotherapy
This is an open-label, single institution study evaluating the efficacy of intravenous iron sucrose monotherapy in patients with thoracic, breast, GU and GI malignancies undergoing neoadjuvant chemotherapy with the goal of…
- Trial name
- Iron-RANC (NCT05800600)
- Testing
- Venofer
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Fox Chase Cancer Center
Pain, Postoperative
Efficacy of Fascia Iliaca Block Versus Intraoperative Nerve Infiltration During Anterior Hip Replacement Surgery
Surgical trauma causes nerve sensitization leading to amplification and prolongation of postoperative pain. In experimental studies, pre-injury neural blockade using local anesthetics has been shown to reduce post-injury…
- Trial name
- NCT01693900
- Testing
- Pre-operative Ultrasound FICB Group, Intra-operative FICB Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Randy Fayne, DO
Cardiovascular Surgical Procedures, Arthroplasty, Replacement
Trial to Reduce Antimicrobial Prophylaxis Errors (TRAPE)
The specific aims are to determine the incidence of medication errors related to antimicrobial prophylaxis for cardiovascular surgery, joint replacement surgery, and hysterectomies across a heterogeneous sample of hospitals…
- Conditions
- Cardiovascular Surgical Procedures, Arthroplasty, Replacement, Hysterectomy
- Trial name
- NCT00114036
- Testing
- Quality improvement strategies
- Where
- 3 sites in United States
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Venous Thromboembolism
Evaluation of AVE5026 as Compared to Enoxaparin for the Prevention of Thromboembolism in Patients Undergoing Total Hip Replacement Surgery
The primary objective was to compare the efficacy of once daily [q.d.] subcutaneous [s.c.] injections of Semuloparin sodium (AVE5026) with q.d. s.c.
- Trial name
- SAVE-HIP1 (NCT00697099)
- Testing
- Semuloparin sodium, Enoxaparin sodium
- Where
- 30 sites in United States, Argentina and 28 more
- Volunteers
- 2,326 people
- Sponsor
- Sanofi
Osteoarthritis, Inflammatory Arthritis
Rotator Cuff Sparing Total Arthroplasty
Design: Prospective, randomized clinical trial, of 120 patients requiring a total shoulder replacement (TSR). Purpose: To collect and evaluate long-term clinical data on patients whose total shoulder replacement (TSR) is…
- Trial name
- NCT01961986
- Testing
- TSR - traditional subscapularis release, TSR - rotator cuff sparing
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- NYU Langone Health
Acute Kidney Injury
Trial to Assess the Efficacy and Safety of Nafamostat Mesilate During Continuous Renal Replacement Therapy
Randomized study to evaluate the efficacy and safety of nafamostat mesilate use during continuous renal replacement therapy in acute kidney injury patients at a high risk of bleeding.
- Trial name
- NCT02478242
- Testing
- Nafamostat mesilate, Normal saline
- Volunteers
- 60 people
- Sponsor
- Kyungpook National University Hospital
Antibiotic Prophylaxis Surgery
Efficacy and Safety of Intraosseous Antibiotic Prophylaxis in Total Hip Replacement
The goal of this clinical trial is to learn if intraosseous antibiotic (cefazolin) administration can improve antibiotic levels in adults undergoing primary total hip replacement.
- Trial name
- NCT07549542
- Testing
- CeFAZolin 1000 MG, Saline (0.9%, sterile, for infusion)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Rutgers, The State University of New Jersey
Covid-19, SARS
Tocilizumab vs CRRT in Management of Cytokine Release Syndrome (CRS) in COVID-19
Some patients infected with the COVID-19 can develop uncontrolled immune response, leading to potentially life-threatening damage to lung tissue. Tocilizumab was first approved by the U.S.
- Conditions
- Covid-19, SARS, Cytokine Storm, Cytokine Release Syndrome
- Trial name
- TACOS (NCT04306705)
- Testing
- Tocilizumab, Standard of care, Continuous renal replacement therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tongji Hospital
Osteoarthritis
The Press Fit Condylar (P.F.C.) Sigma Rotating Platform (RP) TC3 Revision Knee in Revision Knee Arthroplasty
The purpose of this study is to evaluate the long-term clinical and functional performance of the P.F.C. Sigma Rotating Platform TC3 knee system in revision knee surgery and to determine whether the implant design results in a…
- Trial name
- TC3 (NCT00733681)
- Testing
- PFC Sigma RP TC3 Revision knee system
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 181 people
- Sponsor
- DePuy International
Non-inflammatory Degenerative Joint Disease, Osteoarthritis
Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement
This study is intended to gather medium (5- to 7-years) and long-term (minimum 8- to 10-years) information regarding the performance and safety of the commercially available 36mm CERAMAX® Ceramic on Ceramic (COC) Total Hip System…
- Conditions
- Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Post-Traumatic Osteoarthritis of Hip
- Trial name
- COC36mmPAS (NCT02096198)
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- DePuy Orthopaedics
Aortic Stenosis
Impact of Beta-blocker on Outcome Among Patients Undergoing Transcatheter Aortic Valve Replacement (B-TAVR)
This is a multi-centric, open-label, randomized trial to evaluate the safety and efficacy of temporary discontinuation of beta-blocker treatment in patients undergoing transcatheter aortic valve replacement.
- Trial name
- NCT06472934
- Testing
- Transcatheter aortic valve replacement in the absence of B-blocker treatment, Transcatheter aortic valve replacement
- Where
- 11 sites in Austria, Germany and 1 more
- Volunteers
- 498 people
- Sponsor
- University Hospital, Basel, Switzerland
Osteoarthritis
"Score Infectivity" During Reoperation on Total Hip or Knee Prosthesis
The hip or knee is a validated treatment of end-stage osteoarthritis, and these interventions commonly make a significant improvement in the quality of life of patients. Infection can occur in 1-5% of cases.
- Trial name
- NCT02467764
- Testing
- Retrospective study
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis
The goal of this study is to create a prospective registry (<100 patients) to show the effectiveness of the genicular artery embolization procedure overtime in reducing bilateral or unilateral osteoarthritic knee pain as measured…
- Conditions
- Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
- Trial name
- GAE (NCT06781463)
- Testing
- Registry (N/A)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Osteoarthritis, Total Knee Arthroplasty
Use of Cold and Compression Therapy With Total Knee Replacement Patients
The purpose of the study is to evaluate the effectiveness of a device that delivers cold and intermittent compression as compared to ice and compressive wraps on patients who have undergone knee replacement.
- Trial name
- NCT00712816
- Testing
- Game Ready Injury Treatment System (CoolSystems Inc.), Ice with compressive bandages
- Where
- 11 sites in United States, Australia
- Volunteers
- 224 people
- Sponsor
- CoolSystems, Inc.
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