Clinical trials: Renin-Angiotensin-Aldosterone System
Microalbuminuria, Macroalbuminuric Diabetic Nephropathy
Triple Blockade of the Renin Angiotensin Aldosterone System in Diabetic (Type 1&2) Proteinuric Patients
Study Hypothesis: Reduction in albuminuria has been shown to decrease progression of diabetic nephropathy. In diabetic nephropathy patients treated with maximal antihypertensive doses with dual RAAS blockade (total daily dose…
- Conditions
- Microalbuminuria, Macroalbuminuric Diabetic Nephropathy, Diabetes, Proteinuria
- Trial name
- NCT00961207
- Testing
- Aliskiren
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Cook County Health
Hyperkalemia
IMpact of hyPeRkalaemia on thErapy With Renin angiotenSin aldoSterone System Inhibitors
There are limited data regarding the burden of hyperkalaemia in patients attending emergency departments (ED) or who are hospitalised (excluding those already receiving dialysis).
- Trial name
- IMPRESS (NCT04510792)
- Testing
- No intervention
- Where
- United Kingdom
- Sponsor
- Portsmouth Hospitals NHS Trust
Septic Shock
Alterations of the Renin-angiotensin-aldosterone System in sEptic Shock
Septic shock is a common and life-threatening condition associated with an in-hospital mortality rate exceeding 40%. The symptomatic management of septic shock relies primarily on vasopressor therapy, particularly norepinephrine.
- Trial name
- ARES (NCT07721974)
- Testing
- Collection of fluid samples
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Failure, Chronic
Inhibition of Aldosterone in Patients With Chronic Renal Disease
The purpose of this study is to examine whether the inhibition of aldosterone will result in lower excretion of protein via urine.
- Trial name
- NCT00430924
- Testing
- Eplerenone
- Where
- 2 sites in Denmark
- Volunteers
- 42 people
- Sponsor
- Lene Boesby
Arrhythmogenic Right Ventricular Dysplasia
Blockade of the Renin-angiotensin-aldosterone System in Patients With ARVD
Arrhythmogenic right ventricular dysplasia (ARVD) is a rare cardiomyopathy characterized by the progressive replacement of cardiomyocytes by fatty and fibrous tissue in the right ventricle (RV).
- Trial name
- BRAVE (NCT03593317)
- Testing
- Spironolactone
- Where
- 13 sites in France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Hypertension Resistant to Conventional Therapy
Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension
A randomized clinical trial comparing sequential nephron blockage (SNB) with dual blockade of the renin-angiotensin system (RAAS) plus bisoprolol (DBB) in the treatment of resistant arterial hypertension (RH) was designed to…
- Trial name
- ResHypOT (NCT02832973)
- Testing
- Spironolactone, Furosemide,, Amiloride
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- Sao Jose do Rio Preto Medical School
Kidney, Polycystic
HALT Progression of Polycystic Kidney Disease Study A
The efficacy of interruption of the renin-angiotensin-aldosterone system (RAAS) on the progression of cystic disease and on the decline in renal function in autosomal dominant kidney disease (ADPKD) will be assessed in two…
- Trial name
- HALT PKD A (NCT00283686)
- Testing
- Lisinopril, Telmisartan, Standard Blood Pressure Control
- Where
- 7 sites in United States
- Volunteers
- 558 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Heart Failure, Rehabilitation
Prognosis Predictors for Heart Failure
This study is looking for the predictors of the survival or rehospitalization of patients with heart failure with reduced ejection fraction. Participants who are discharged from an acute heart failure hospitalization are enrolled.
- Conditions
- Heart Failure, Rehabilitation, Morality, Hospitalization
- Trial name
- NCT04838470
- Testing
- cardiac rehabilitation
- Volunteers
- 792 people
- Sponsor
- Chang Gung Memorial Hospital
Kidney, Polycystic
HALT Progression of Polycystic Kidney Disease Study B
The efficacy of interruption of the renin-angiotensin-aldosterone system (RAAS) on the progression of cystic disease and on the decline in renal function in autosomal dominant kidney disease (ADPKD) will be assessed in two…
- Trial name
- HALT PKD B (NCT01885559)
- Testing
- Lisinopril, Telmisartan
- Where
- 7 sites in United States
- Volunteers
- 486 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Blood Pressure, Hypertension
Blood Pressure Regulation - Role of Potassium
Project titel: Oral potassium supplementation in healthy men - interactions with the renin-angiotensin-aldosterone system and the sympathetic nervous system Protocol number: KARAASS-1 EudraCT number: 2013-004460-66 Introduction…
- Trial name
- NCT02380157
- Testing
- Kaleorid, 750mg (trade name), Potassium chloride (active substance)
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Renin-Angiotensin Aldosterone System (RAS)
Human Intestinal Amino Acid Absorption and the Role of a Local RAS
This study is to find out what role a local intestinal RAS (renin angiotensin system) plays in the context of amino acid absorption in the human intestinal tract and how this RAS and thus the amino acid absorption is influenced…
- Trial name
- NCT04524494
- Testing
- biopsy of intestinal tissue, blood draw, urine collection
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital Basel
Acute Decompensated Heart Failure, Congestive Heart Failure
Six Months Efficacy and Safety of Aliskiren Therapy on Top of Standard Therapy, on Morbidity and Mortality in Patients With Acute Decompensated Heart Failure
This study evaluated the effect of early initiation of aliskiren therapy, compared to standard therapy, in the reduction of cardiovascular death and heart failure re-hospitalization events within 6 months, in congestive heart…
- Trial name
- ASTRONAUT (NCT00894387)
- Testing
- Aliskiren
- Where
- 308 sites in United States, Argentina and 22 more
- Volunteers
- 1,639 people
- Sponsor
- Novartis Pharmaceuticals
PreDiabetes, Impaired Glucose Tolerance
The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans
The primary objective is to examine the impact of the Renin-Angiotensin-Aldosterone System (RAAS) blockade with medications (valsartan) or RAAS and neprilysin inhibition (valsartan/sacubitril) vs.
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Obesity, Blood Pressure
- Trial name
- NCT03938389
- Testing
- Sacubitril-Valsartan Tab 97-103 MG, Valsartan 160mg
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University
Obstructive Sleep Apnea
Vasoactive Hormones and Oxygen Saturation During Apneic Events in Patients With Obstructive Sleep Apnea
The mechanisms involved in development and maintenance of hypertension in obstructive sleep apnea are not clarified. We hypothesize that patients with obstructive sleep apnea have an abnormal level of some vasoactive hormones…
- Trial name
- NCT00438412
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Chronic Kidney Disease, Proteinuria
Optimalization of Nephroprotection Using Atorvastatin (Sortis)
The main purpose of the study is find whether the addition of statin (Atorvastatin) to dual renin-angiotensin-aldosterone system blockade involving angiotensin converting enzyme inhibitor and AT-1 angiotensin II receptor blocker…
- Trial name
- NCT00572312
- Testing
- atorvastatin (Sortis) 40 mg
- Sponsor
- Medical University of Gdansk
Diabetes Mellitus, Type 2, Kidney Disease, Chronic
Semaglutide's Effect on Renal Hemodynamics and Function in Patients With Type 2 Diabetes Mellitus and Nephropathy
The goal of this double-blinded, placebo-controlled, randomized, crossover study is to examine the effect of semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), on renal hemodynamics and function in patients with…
- Trial name
- Sema-RMA (NCT06555146)
- Testing
- Semaglutide, 0.5 mg/mL
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Bispebjerg Hospital
Chronic Kidney Disease, Proteinuria
Optimalization of Nephroprotection Using Agents Inhibiting Renin-Angiotensin-Aldosterone System
The main purpose of the study is find whether the addition of aldosterone antagonist, spironolactone to dual renin-angiotensin-aldosterone system blockade involving angiotensin converting enzyme inhibitor and AT-1 angiotensin II…
- Trial name
- NCT00528385
- Testing
- Spironolactone (Spironol) 25 mg
- Sponsor
- Medical University of Gdansk
Hypertension
Compare the Effect of Aliskiren Plus Valsartan Versus Angiotensin-Converting Enzyme Inhibitor (ACEi) Plus Angiotensin Receptor Blocker (ARB) [Ramipril Plus Telmisartan] on the Renin-Angiotensin-Aldosterone System (RAAS) in Hypertensive Patients
This study is designed as a mechanistic study to compare the effect of two different combinations of anti-hypertensive treatments (aliskiren and valsartan vs.
- Trial name
- NCT00939588
- Testing
- Aliskiren/ Valsartan, Telmisartan/ Ramipril
- Where
- Russia
- Volunteers
- 88 people
- Sponsor
- Novartis Pharmaceuticals