Clinical trials: Renin-Angiotensin-Aldosterone System
Diabetes Mellitus, Type 2, Arterial Hypertension
Antidiuretic Function Before and During Treatment With SGLT2 Inhibitors
Subjects treated with Canagliflozin, Dapagliflozin and Empagliflozin obtained improvement on blood pressure values, body weight and cardiovascular mortality but pathophysiological explanations of these effects are not yet known.
- Conditions
- Diabetes Mellitus, Type 2, Arterial Hypertension, Body Weight Changes
- Trial name
- GliRACo1 (NCT03917758)
- Testing
- SGLT2 inhibitor
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
End Stage Renal Disease, Peritoneal Dialysis
Effect of Add-on Spironolactone to Losartan Versus Losartan Alone on Peritoneal Membrane Among Peritoneal Dialysis Patients
The ESCAPE-PD (Effects of add-on SpironolaCtone to losartan versus Alone on Peritoneal mEmbrane among continuous ambulatory Peritoneal Dialysis patients) study is a randomized, open-label, single center, active-controlled…
- Trial name
- ESCAPE-PD (NCT03953950)
- Testing
- Spironolactone, Losartan
- Where
- Thailand
- Volunteers
- 84 people
- Sponsor
- Chiang Mai University
Glomerulonephritis, IGA, Hypertension
A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA Nephropathy
The purpose of this study is to evaluate the effect of aliskiren, a novel direct rennin inhibitor, on renal function and progress of renal disease in hypertensive patients with IgA nephropathy.
- Trial name
- NCT01184599
- Testing
- aliskiren
- Where
- 4 sites in Japan
- Volunteers
- 30 people
- Sponsor
- Kagawa University
Heart Failure
A Pharmacogenomic Study of Candesartan in Heart Failure
The purpose of this study is to evaluate the impact of genetic variations on the response to candesartan in patients with heart failure who are already treated with an ACE inhibitor.
- Trial name
- NCT00400582
- Testing
- Candesartan up to 32 mg daily
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Montreal Heart Institute
Obstructive Sleep Apnea
Vitamin D Levels and Heart Rate Variability on Endothelial Function Via RAAS Augmentation in OSA
The role of obstructive sleep apnea (OSA) in contributing to hyperaldosteronism, which can lead to increased morbidity and mortality, is less well-established.
- Trial name
- RAAS_OSA (NCT05232201)
- Where
- Malaysia
- Volunteers
- 150 people
- Sponsor
- University Malaysia Sarawak
Chronic Kidney Disease, Proteinuria
Optimalization of Nephroprotection Using Atorvastatin (Sortis)
The main purpose of the study is find whether the addition of statin (Atorvastatin) to dual renin-angiotensin-aldosterone system blockade involving angiotensin converting enzyme inhibitor and AT-1 angiotensin II receptor blocker…
- Trial name
- NCT00572312
- Testing
- atorvastatin (Sortis) 40 mg
- Sponsor
- Medical University of Gdansk
COVID-19, SARS-CoV 2
COVID-19 Survival - The COVIVA Study
The COVID-19 pandemic poses a major and imminent challenge for health care systems regarding patient triage and allocation of limited resources worldwide.
- Trial name
- COVIVA (NCT04366765)
- Where
- Switzerland
- Volunteers
- 1,325 people
- Sponsor
- University Hospital, Basel, Switzerland
Septic Shock
Alterations of the Renin-angiotensin-aldosterone System in sEptic Shock
Septic shock is a common and life-threatening condition associated with an in-hospital mortality rate exceeding 40%. The symptomatic management of septic shock relies primarily on vasopressor therapy, particularly norepinephrine.
- Trial name
- ARES (NCT07721974)
- Testing
- Collection of fluid samples
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Congestive Heart Failure, Low Cardiac Output
Losartan in Decompensated Heart Failure
The dual blockade of the renin-angiotensin-aldosterone system with an angiotensin-converting enzyme inhibitor and an angiotensin-receptor blocker used together in heart failure patients has been demonstrated to be beneficial.
- Trial name
- NCT01857999
- Testing
- Losartan
- Where
- Brazil
- Volunteers
- 21 people
- Sponsor
- InCor Heart Institute
Radiographic Contrast Agent Nephropathy
Renin-angiotensin-aldosterone System (RAAS) Blockade and Contrast Induced Nephropathy
The aim of the current study is to evaluate prospectively whether concomitant administration of renin-angiotensin-aldosterone system (RAAS) blockers (namely ACE-I and ARBs') influence the change in estimated glomerular filtration…
- Trial name
- NCT01525888
- Testing
- stop angiotensin converting enzyme inhibitor or angiotensin receptor blocker (ACE-I/ARB)
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Hypertension
Increasing Potassium Intake in Hypertensive Individuals
This study evaluates the safety of increasing dietary potassium intake in a hypertensive population that may be at risk for hyperkalemia.
- Trial name
- NCT02759367
- Testing
- High potassium diet
- Volunteers
- 20 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Chronic Kidney Disease, Proteinuria
Optimalization of Nephroprotection Using Agents Inhibiting Renin-Angiotensin-Aldosterone System
The main purpose of the study is find whether the addition of aldosterone antagonist, spironolactone to dual renin-angiotensin-aldosterone system blockade involving angiotensin converting enzyme inhibitor and AT-1 angiotensin II…
- Trial name
- NCT00528385
- Testing
- Spironolactone (Spironol) 25 mg
- Sponsor
- Medical University of Gdansk
Kidney Failure, Chronic
Inhibition of Aldosterone in Patients With Chronic Renal Disease
The purpose of this study is to examine whether the inhibition of aldosterone will result in lower excretion of protein via urine.
- Trial name
- NCT00430924
- Testing
- Eplerenone
- Where
- 2 sites in Denmark
- Volunteers
- 42 people
- Sponsor
- Lene Boesby
Blood Pressure, Hypertension
Blood Pressure Regulation - Role of Potassium
Project titel: Oral potassium supplementation in healthy men - interactions with the renin-angiotensin-aldosterone system and the sympathetic nervous system Protocol number: KARAASS-1 EudraCT number: 2013-004460-66 Introduction…
- Trial name
- NCT02380157
- Testing
- Kaleorid, 750mg (trade name), Potassium chloride (active substance)
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Hyperaldosteronism
Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism
The tissue kallikrein-kinin (KKS) and renin-angiotension-aldosterone system (RAAS) had been implicated in regulating blood pressure and electrolyte homeostasis.
- Trial name
- NCT00155064
- Testing
- captopril, Losartan (drug)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Covid 19
Diagnosis of Endocrine Dysfunctions in Covid-19
As observed with SARS-CoV responsible for SARS 2003, the new coronarovirus SARS-CoV-2 uses the angiotensin converting enzyme type 2 (ACE2) as cellular receptor to infect cells.
- Trial name
- Dyhor-19 (NCT04587375)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
COVID-19
Renin-Angiotensin-Aldosterone System Inhibitors, Hypertension, and COVID-19
Background. Angiotensing converting enzyme type 2 (ACE2), a key enzyme of the renin-angiotensin-aldosterone system (RAAS), is the receptor of SARS-CoV-2 for cell entry into lungs.
- Trial name
- COVHYP (NCT04374695)
- Volunteers
- 700 people
- Sponsor
- Versailles Hospital
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Ipsilateral and Contralateral Index for the Interpretation of Adrenal Vein Sampling (AVS) in Primary Aldosteronism
Adrenal vein sampling (AVS) is currently considered the gold standard for subtype diagnosis of primary aldosteronism (PA). However, the percentage of unsuitable procedures due to the unsuccessful cannulation of one of the two…
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
- Trial name
- NCT04378387
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Turin, Italy
Preeclampsia, Type 1 Diabetes
Urine-plasminogen as a Predictor for Development Of Preeclampsia in Pregnant Women With Type 1 Diabetes Mellitus
A tonic active epithelial Na+ channel (ENaC) in pre-eclampsia (PE) escaped normal hormonal control may offer an attractive explanatory model for the pathophysiology of established PE. The channel is activated by plasmin.
- Trial name
- NCT01821053
- Where
- Denmark
- Volunteers
- 85 people
- Sponsor
- Odense University Hospital
Obesity, Abdominal
Role of the Renin Angiotensin Aldosterone System in the Mechanisms of Transition to Heart Failure in Abdominal Obesity
R2C2 study has shown that abdominal obesity is associated with a cardiac and vascular remodelling in healthy volunteers. This remodelling is correlated with renin-angiotensin aldosterone system (RAAS) activation and/or systemic…
- Trial name
- R2C2-II (NCT01716819)
- Testing
- Urine sample, Blood sample, Assessment of sleep apnea syndrome
- Where
- France
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France