Clinical trials: Renal Hemodynamics
ADPKD, Glomerulonephritis
Effects of Systemic NO-Inhibition on Renal Hemodynamics in Patiens With Polycystic Kidney Disease and Chronic Glomerulonephritis
The study tests the hypothesis that systemic and renal nitric oxide availability is changed in polycystic kidney disease and chronic glomerulonephritis.
- Trial name
- NCT00345137
- Testing
- Ng-monomethyl-L-arginine (drug)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Cirrhosis, Liver Cirrhosis
Role of Nitric Oxide in Cirrhosis: Relationship With Systemic Hemodynamics, Renal Function, Vasoactive Systems and Endotoxemia
This study is to determine whether a compound, nitric oxide, made within the body, is the factor responsible for the changes in blood pressure and renal (kidney) functions that may occur during the course of cirrhosis.
- Trial name
- NCT00005107
- Testing
- N-monomethyl-L-arginine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Renal Circulation, Renal Plasma Flow
Effect of Elevated Plasma-Free-Fatty-Acids on Renal Hemodynamic Parameters
Type 2 diabetes is frequently associated with elevation of plasma-free fatty acids (FFA). Studies indicate that elevation of plasma-FFA induces insulin resistance and also causes endothelial dysfunction as well as hemodynamic…
- Conditions
- Renal Circulation, Renal Plasma Flow, Glomerular Filtration Rate, Fatty Acids, Nonesterified
- Trial name
- NCT00431665
- Testing
- NG-monomethyl-L-Arginine (L-NMMA), triglycerides (Intralipid 20%), heparin
- Where
- Austria
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Living Kidney Donation, Preoperative Anxiety
Preoperative Psychotherapy and Its Effects on Anxiety, Hemodynamics, and Pain in Living Kidney Donors
Chronic kidney failure is a condition in which the kidneys progressively lose their ability to filter waste, maintain fluid and electrolyte balance, and support essential physiological functions.
- Conditions
- Living Kidney Donation, Preoperative Anxiety, Postoperative Pain
- Trial name
- PREPSY-KD (NCT07261917)
- Testing
- Preoperative Psychiatric Consultation, No Intervention: Standard Preoperative Care
- Where
- Turkey (Türkiye)
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Type 2 Diabetes Mellitus, Diabetic Kidney Disease
Renal Oxygenation, Oxygen Consumption and Hemodynamic Kinetics in Type 2 DIabetes: an Ertugliflozin Study.
Current study will render insight in to the role of renal hypoxia in the diabetic kidney and is able to associate its finding with measurements of renal perfusion and glomerular filtration rate.
- Conditions
- Type 2 Diabetes Mellitus, Diabetic Kidney Disease, Diabetic Nephropathy, Renal Hypoxia
- Trial name
- ROCKIES (NCT04027530)
- Testing
- Ertugliflozin 15 mg
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Hypertension, Obesity
Renal Response to Lower Body Negative Pressure in Pre-hypertensive States
The purpose of this study is to determine whether in pre-hypertensive and hypertensive states such as white coat hypertension, obesity related hypertension or resistant hypertension, renal function is more sensitive to…
- Conditions
- Hypertension, Obesity, White Coat Hypertension, Resistant Hypertension
- Trial name
- NCT01734096
- Testing
- Lower body negative pressure (LBNP), Candesartan cilexetil
- Where
- 2 sites in Switzerland
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- PD Dr. Grégoire Wuerzner
Healthy
Acute Effect of HMG-CoA Reductase Inhibition (Atorvastatin)on Renal Hemodynamics, Tubular Function and Vasoactive Hormones on Healthy Subjects
We wanted to test the acute effect of HMG-CoA reductase inhibition (atorvastatin) on renal hemodynamics, renal tubular function and vasoactive hormones on healthy subjects.
- Trial name
- NCT00344955
- Testing
- HMG-CoA reductase inhibition (atorvastatin)
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Liver Cirrhosis
Phase 1 Study of L-NMMA in Patients With Liver Cirrhosis
Phase 1 study of the effects of nitric oxide inhibition with L-NMMA in patients with liver cirrhosis and healthy controls. It is hypothesized that nitric oxide availability is increased in liver cirrhosis.
- Trial name
- NCT00344916
- Testing
- Ng-monomethyl-L-arginine (drug)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Healthy
Short Term Effects of HMG-CoA Reductase Inhibition (Atorvastatin)on Renal Hemodynamics, Tubular Function and Vasoactive Hormones on Healthy Subjects
We wanted to test the shortterm effects of HMG-CoA reductase inhibition (atorvastatin) on renal hemodynamics, renal tubular function and vasoactive hormones on healthy subjects.
- Trial name
- NCT00345202
- Testing
- HMG-CoA reductase inhibition (atorvastatin)
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Healthy
Effect of Azimilide Dihydrochloride on Renal Function
This study will assess the effect of multiple dosing of 125 mg azimilide on glomerular filtration rate (GFR) and total creatinine clearance (GFR + active secretion) in healthy subjects.
- Trial name
- NCT00318838
- Testing
- Azimilide dihydrochloride
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Forest Laboratories
Chronic Kidney Failure
Hemodynamics in Chronic Kidney Disease
The goal of this observational study is to learn about the role of thoracic and whole body bioimpedance in the hemodynamic profile of patients with chronic kidney disease.
- Trial name
- HORUZ (NCT06987032)
- Where
- Belgium
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Ziekenhuis Oost-Limburg
Diabetes, Diabetic Kidney Disease
Effect of Acute Hypoxia on Renal Hemodynamic in Healthy Volunteers, Patients With Diabetes and Patients With Diabetes and Kidney Disease
Diabetes mellitus is a non-transmissible disease whose incidence is growing worldwide . This pathology is defined by a chronic hyperglycaemia linked to a deficiency of either insulin secretion or its action or both.
- Conditions
- Diabetes, Diabetic Kidney Disease, Hypoxia, Healthy Volunteer
- Trial name
- DIAKIPOX (NCT06846034)
- Testing
- Hypoxia administration study group, Renal clairance study
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Liver Failure
Study to Evaluate if the Drug Vasopressin Protects the Kidneys for Patients Undergoing Liver Transplant
The purpose of this study is evaluate the medication vasopressin for its ability to preserve kidney function in patients undergoing liver transplantation.
- Trial name
- NCT00886262
- Testing
- Vasopressin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Heart Failure With Preserved Ejection Fraction, Obesity
PErirenal Adipose Tissue and RenaL Hemodynamics in Patients With Heart Failure With Preserved Ejection Fraction
Rationale: Perirenal adipose tissue (PRAT) thickness has been associated to worsening renal function and hypertension. The role of PRAT in heart failure with a preserved ejection fraction (HFpEF) has never been established.
- Conditions
- Heart Failure With Preserved Ejection Fraction, Obesity, Renal Insufficiency
- Trial name
- PEARL-HFPEF (NCT05219188)
- Testing
- 3.7 mS, CT radiation
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Hypertension
Hemodynamic Effects of Aliskiren Compared to Captopril on the Kidney in Healthy Volunteers on a Low- and High- Sodium Diet
This study will measure the effects of different doses of aliskiren on kidney blood flow and function in healthy adults and determine how salt intake affects the response to aliskiren.
- Trial name
- NCT00518765
- Testing
- Aliskiren
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novartis
Hemodynamic Monitoring
Comparison of Transthoracic Electrical Bioimpedance and Pulse Contour Analysis in Renal Transplantation Patients
Hemodynamics monitoring using non-invasive transthoracic electrical bioimpedance ICON are compatible with standard invasive monitoring using pulse contour analysis EV1000
- Trial name
- NCT03893513
- Testing
- Transthoracic Electrical Bioimpedance, Pulse Contour Analysis
- Where
- Indonesia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Dita Aditianingsih
Obstructive Sleep Apnea, Healthy
Renal Hemodynamics and Tubular Function in Patients With Obstructive Sleep Apnea and Healthy Controls
Nitrogen-oxide (NO) plays an important role for blood pressure regulation, renal hemodynamics, and the renal excretion of sodium.
- Trial name
- NCT00410085
- Testing
- L-NMMA (N-mono.methyl-L-arginine)
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Hemodialysis, Ischemia Preconditioning
Assessment of the Impact of Repeated Ischemic Preconditioning Episodes on Hemodynamic and Metabolic Parameters in Patients at Various Stages of Chronic Kidney Disease
The aim of our study is to evaluate the impact of repeated episodes of ischemic quenching on changes in blood pressure, heart rate and laboratory parameters of inflammation in patients with kidney diseases.
- Conditions
- Hemodialysis, Ischemia Preconditioning, Chronic Kidney Disease, Blood Pressure Disorders
- Trial name
- NCT07746102
- Testing
- Preconditioning with control ischemic episodes
- Where
- 2 sites in Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Renal Failure, Hemodynamics
Hemodynamic Assessment APCO Monitor vs Crit Line for Renal Replacement Rx
Fluid and volume management are a challenging part of critical care and the difficulties increase in the face of renal failure. Utilizing the Crit-Line to monitor blood volume changes in conjunction with arterial pressure cardiac…
- Trial name
- APCOvC-Line (NCT00666003)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Baystate Medical Center
Healthy Individuals, Arterial Hypertension
The Influence of Aircraft Noise Exposure on Renal Hemodynamic in Healthy Individuals
Epidemiological studies have found a link between aircraft noise exposure and increased incidence of arterial hypertension and thus cardiovascular disease.
- Trial name
- LÄRM (NCT02783456)
- Testing
- Noise, Silence
- Where
- Germany
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School