Clinical trials: Renal Denervation
Uncontrolled Hypertension, Atrial Fibrillation
Adjunctive Renal Denervation in the Treatment of Atrial Fibrillation
The objective of the H-FIB trial is to determine the role of renal sympathetic denervation in the prevention of Atrial Fibrillation (AF) recurrence in patients with hypertension for whom a catheter-based AF ablation procedure is…
- Trial name
- H-FIB (NCT01635998)
- Testing
- Boston Scientific Vessix Renal Denervation System
- Where
- 8 sites in United States, Czechia and 1 more
- Volunteers
- 50 people
- Sponsor
- Vivek Reddy
Ventricular Tachycardia, Cardiomyopathy
Renal Denervation In Patient Undergoing VT Ablation:Combined Renal Denervation and VT Ablation vs. Simply VT Ablation
Study hypothesis: With optimal medical therapy and repeated ablations, an additional renal denervation may have protective effects in terms of vegetative intrinsic activity and lead to a significant reduction in VT Burdens.
- Trial name
- ARDEVAT (NCT02071511)
- Testing
- Ablation of ventricular arrhythmias, Ablation of ventricular arrhythmias + renal denervation
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypertension, Chronic Kidney Disease
Impact of Sympathetic Renal Denervation- a Study in Patients After Renal Transplantation
The study is aiming to document the safety and effectiveness of renal denervation in patients after renal transplantation with hypertension.
- Conditions
- Hypertension, Chronic Kidney Disease, Renal Transplantation, Sympathetic Activity
- Trial name
- ISAR-denerve (NCT01899456)
- Testing
- Catheter-based renal denervation
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Technical University of Munich
Hypertension
The Effect of Renal Denervation on Biological Variables
Hypertension is a major and growing public health concern. Chronic elevation of sympathetic nervous system (SNS) activity has been identified as a major contributor to the complex pathophysiology of (essential) hypertension.
- Trial name
- NCT01427049
- Testing
- renal denervation
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- UMC Utrecht
Kidney Failure, Chronic, Renal Dialysis
Renal Denervation in End Stage Renal Disease Patients With Refractory Hypertension
The purpose of this this study is to investigate the clinical utility of renal denervation in the treatment of ESRD patients with refractory hypertension.
- Trial name
- NCT00753116
- Testing
- Renal Denervation with a catheter-based procedure
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medtronic Vascular
Loin Pain-Hematuria Syndrome
Prairie Loin Pain Hematuria Syndrome Renal Denervation Study: A Feasibility Study
Loin Pain Hematuria Syndrome (LPHS) is a poorly understood, painful and incapacitating condition that typically afflicts young women and was first described in 1967.
- Trial name
- NCT04332731
- Testing
- Symplicity Spyral™ multi electrode renal denervation system, Renal angiogram
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Saskatchewan Health Authority - Regina Area
Hypertension
Randomized Controlled Trial of Renal Denervation for Resistant Hypertension
Hypertension represents a significant global public health problem, contributing to vascular and renal morbidity, cardiovascular mortality, and economic burden.
- Trial name
- NCT02900729
- Testing
- Radiofrequency ablation catheter, Amlodipine, losartan potassium and hydrochlorothiazide
- Where
- 13 sites in China
- Volunteers
- 254 people
- Sponsor
- Shanghai WiseGain Medical Devices Co., Ltd.
Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation
A Feasibility Study to Evaluate the Effect of Concomitant Renal Denervation and Cardiac Ablation on AF Recurrence
The purpose of this post market clinical investigation is to complete preliminary evaluation on whether or not concomitant renal denervation with the EnligHTN™ Renal Denervation System and cardiac ablation will result in improved…
- Conditions
- Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Hypertension
- Trial name
- RDN+AF (NCT01907828)
- Testing
- Renal Artery Ablation, Cardiac Ablation
- Where
- 2 sites in Germany
- Volunteers
- 61 people
- Sponsor
- Abbott Medical Devices
Hypertension, Vascular Diseases
Spyral InSight Study
The purpose of the Spyral InSight Early Clinical Feasibility Study is to characterize the physiological response to renal nerve stimulation (RNS) in humans prior to and post renal denervation.
- Conditions
- Hypertension, Vascular Diseases, Cardiovascular Diseases
- Trial name
- Spyral InSight (NCT07013929)
- Testing
- Renal nerve stimulation
- Where
- 2 sites in Greece, Ireland
- Volunteers
- 19 people
- Sponsor
- Medtronic Vascular
Uncontrolled Hypertension, Autosomal Dominant Polycystic Kidney Disease
Renal Denervation in ADPKD- RDN-ADPKD Study
RDN-ADPKD is a prospective, randomized (1:1, central randomization), single-center, hypothesis-generating, feasibility study. The purpose of the RDN-ADPKD study is to demonstrate efficacy and document safety of renal denervation…
- Conditions
- Uncontrolled Hypertension, Autosomal Dominant Polycystic Kidney Disease, Renal Denervation
- Trial name
- RDN-ADPKD (NCT05460169)
- Testing
- Renal denervation
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hypertension, Renal Denervation Therapy
Efficacy and Safety of Renal Denervation on Isolated Diastolic Hypertension
This study aims to evaluate the efficacy and safety of renal denervation (RDN) in patients with isolated diastolic hypertension (IDH).
- Trial name
- NCT06783296
- Testing
- Renal Denervation, Renal Angiography
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Shanghai 10th People's Hospital
Hypertension Resistant to Conventional Therapy, Kidney Failure, Chronic
Chemical Renal Ethanol Sympatholysis Under CT Guidance Use for the Control of Therapy-Resistant Hypertension
In this study the investigators are going to assess the feasibility of this innovate technique of renal sympathetic denervation by translumbar access under ct-guidance.
- Trial name
- SCRATCH (NCT02653222)
- Testing
- Renal sympathicolysis, Ambulatory Blood Pressure Monitoring, Magnetic Resonance Angiography
- Where
- 2 sites in France
- Volunteers
- 2 people
- Sponsor
- University Hospital, Grenoble
Uncontrolled Hypertension, Renal Denervation
Renal Denervation in Chronic Kidney Disease - RDN-CKD Study
RDN-CKD GR Study is a prospective, randomized (1:1), double-blind (unblinded interventionalist and blinded study team), sham controlled study.
- Conditions
- Uncontrolled Hypertension, Renal Denervation, Chronic Kidney Disease (Stage 3)
- Trial name
- RDN-CKD GR (NCT07742787)
- Testing
- Renal denervation
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- Hippocration General Hospital
Hypertension, Vascular Diseases
SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study
The purpose of this study is to test the hypothesis that renal denervation decreases blood pressure and is safe when studied in the absence of antihypertensive medications.
- Conditions
- Hypertension, Vascular Diseases, Cardiovascular Diseases
- Trial name
- NCT02439749
- Testing
- Symplicity Spyral™ multi-electrode renal denervation system
- Where
- 47 sites in United States, Australia and 7 more
- Volunteers
- 366 people
- Sponsor
- Medtronic Vascular
Chronic Kidney Disease
Renal Denervation in Patients With Chronic Kidney Disease
People with hypertension are at a higher risk for cardiovascular disease and death so it is important to lower blood pressure to normal levels as quickly as possible.
- Trial name
- NCT01832233
- Testing
- Renal Denervation
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Saskatchewan Health Authority - Regina Area
Adult Polycystic Kidney Disease
Renal Sympathetic Denervation for Reduction of Pain and Improvement of Insulin Sensitivity in Adult Polycystic Kidney Disease
In patients with polycystic kidney disease, pain may be resistant to drug therapy and may reduce quality of life. This study investigate the effect of renal denervation on this pain.
- Trial name
- NCT02062671
- Testing
- renal denervation
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Odense University Hospital
Heart Failure
Renal Denervation in Chronic Heart Failure
Renal denervation can be carried out for heart failure
- Trial name
- REACH (NCT02146794)
- Testing
- Renal denervation
- Volunteers
- 7 people
- Sponsor
- Imperial College London
Chronic Heart Failure
Effect at 6 Months of Renal Denervation in Chronic Heart Failure d'Insuffisance Cardiaque
Management of chronic heart failure (CHF) is a major public health problem. It is associated with high mortality, frequent hospitalization and represents a large cost to the health care system.
- Trial name
- DENRENIC (NCT02471729)
- Testing
- EnligHTN™ Renal Denervation System
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Institute Arnault Tzanck, France
Hypertension, Resistant to Conventional Therapy
Renal Denervation in Refractory Hypertension
Open, multicenter, randomized study is enrolling patients in 3 sites in Czech Republic. Patients with refractory hypertension will be randomized in 1:1 manner either to renal denervation plus optimal medical antihypertensive…
- Trial name
- PRAGUE-15 (NCT01560312)
- Testing
- Renal denervation (Symplicity® Catheter System™)
- Where
- 3 sites in Czechia
- Volunteers
- 106 people
- Sponsor
- Charles University, Czech Republic
Hypertension Secondary to Renal Disease
Treatment of Resistant Hypertension by Renal Sympathetic Denervation in Patients Undergoing Dialysis Therapy
The study is designed to investigate the efficacy of renal nerve denervation in treating drug-resistant hypertension in patients with end stage renal disease.
- Trial name
- TreatDialRDN (NCT01881035)
- Testing
- Renal nerve denervation
- Where
- Finland
- Volunteers
- 6 people
- Sponsor
- Turku University Hospital