Clinical trials: Refractory Migraine
Refractory Migraine, Headache
Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment
The goal of this clinical trial is to test whether injecting lidocaine into two blood vessels of the brain can help treat chronic headaches (migraines)
- Trial name
- LIGHT 2 (NCT07361549)
- Testing
- Lidocaine (drug), Saline
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Daniel A Tonetti, MD
Migraine, Aura
MIST II PFO-Migraine Trial With BioSTAR® Bioabsorbable Septal Repair Implant
The objective of the study is to investigate the safety and effectiveness of PFO closure with the BioSTAR Septal Repair Implant System in a population of patients that have refractory migraine (with aura) and who have failed…
- Conditions
- Migraine, Aura, Patent Foramen Ovale
- Trial name
- NCT00283738
- Testing
- BioSTAR Septal Repair Implant System
- Where
- 2 sites in United States
- Volunteers
- 610 people
- Sponsor
- NMT Medical
Refractory Chronic Migraine
A Feasibility Clinical Trial to Evaluate High Frequency Spinal Cord Stimulation for the Treatment of Patients With Chronic Migraine
The purpose of this study is to assess short- and long-term safety, tolerability and efficacy of cervical High Frequency Spinal Cord Stimulation (HF-SCS) in patients suffering from chronic migraine refractory to conventional…
- Trial name
- rCM HF-SCS (NCT01653340)
- Testing
- Senza™, High Frequency Spinal Cord Stimulator for Refractory Chronic Migraine
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- University of Roma La Sapienza
Migraine, Headache Disorders, Primary
Efficacy of Greater Occipital Nerve Radiofrequency for Refractory Migraine Treatment
Objective: Ultrasound-guided pulsed radiofrequency therapy can be used on the greateroccipital nerve (GON) in patients with chronic migraine (CM) who are unresponsive to conservative treatments.
- Trial name
- NCT05199064
- Testing
- Ultrasound guided greater occipital nerve (GON) radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Tepecik Training and Research Hospital
Migraine
Botox Vs Spinal Cord Stimulation in the Treatment of Refractory Migraine Clinical Trial
The clinical trial is focused on the treatment of selected patients with a migraine after implantation of spinal cord stimulator (SCS) based on previous neurological examination.
- Trial name
- BTX/SCS/TMig (NCT05382832)
- Testing
- SCS
- Volunteers
- 50 people
- Sponsor
- EPC Education s.r.o.
Refractory Migraine
Investigation of Efficacy and Safety of Botulinum Toxin A (Botox-Allergan Inc) in Migraine Headaches
The hypothesis of this study is that injection of botulinum toxin A into the muscles around the head (frontal, temporal, posterior neck, occipital) can reduce the intensity and frequency of migraine headaches by 50%.
- Trial name
- NCT00660192
- Testing
- Botox
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Chronic Migraine Headache
Occipital Nerve Stimulation for the Treatment of Chronic Migraine Headache.
Background: Medically intractable chronic migraine (CM) is a disabling illness characterized by headache greater than 15 days per month.
- Trial name
- ONSTIM (NCT00200109)
- Testing
- Occipital Nerve Stimulation
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 110 people
- Sponsor
- MedtronicNeuro
Chronic Migraine
A Two-Arm Study Evaluation H.P. Acthar Injection Gel in Treatment of Chronic Migraines
This small study is to investigate the efficacy of Acthar in the treatment of chronic migraine in patients who have failed multiple treatments, including Botox (which is defined as having <30% reduction from baseline in the…
- Trial name
- NCT01813591
- Testing
- H.P. Acthar Gel
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Dent Neuroscience Research Center
Headache, Migraine, Chronic Migraine Headache
Stellate Ganglion Blockade for Refractory Chronic Migraine
Stellate Ganglion Block (SGB) is an interventional anesthetic technique used to treat pain conditions affecting the head, face, neck, and upper extremities by temporarily blocking sympathetic nerve output.
- Trial name
- SGB-RCM (NCT06891118)
- Testing
- Procedure/Surgery: Ultrasound-Guided Stellate Ganglion Block
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara City Hospital Bilkent
Migraine
Clinical Experience With Transcutaneous Supraorbital Nerve Stimulation in Refractory Migraine
Migraine is included in the top-ten disabling diseases and conditions among the Western populations. Non-invasive neurostimulation (t-SMS), including the Cefaly® device, for the treatment of various types of pain is a relatively…
- Trial name
- NCT03125525
- Testing
- Cefaly device
- Volunteers
- 37 people
- Sponsor
- Corfu Headache Clinic
Migraine Disorders
Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Migraine
This is a clinical trial to assess the efficacy of botox treatment of the sphenopalatine ganglion as an add-on treatment in drug resistant migraine.
- Trial name
- MiBlock (NCT04069897)
- Testing
- Botulinum toxin type A
- Where
- 4 sites in Norway
- Volunteers
- 170 people
- Sponsor
- St. Olavs Hospital
Chronic Pain
Home-based Transcranial Stimulation in the Treatment of Patients With Refractory Chronic Pain
Refractory chronic pain represents a serious and limiting health condition which does not respond to standard pharmacological therapy.
- Trial name
- NCT05099406
- Testing
- Transcranial electrical stimulation
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- University of Santiago de Compostela
Refractory Migraine
Pulsed Electromagnetic Field Therapy in the Refractory Migraine
Pulsed electromagnetic field (PEMF) as prophylactic treatment may prevent the attacks of migraine or decrease them even in the patients with refractory migraine.
- Trial name
- NCT01670214
- Testing
- pulsed electromagnetic field
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Niyayesh Clinic
Chronic Migraine, Cluster Headache
Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache
The purpose of this study is to evaluate the safety and efficacy of intra-arterial (IA) delivery of Dexamethasone and Ketorolac into the arteries supplying the sphenopalatine ganglion (SPG) - a collection of neurons that plays an…
- Conditions
- Chronic Migraine, Cluster Headache, Trigeminal Neuralgia
- Trial name
- NCT04353505
- Testing
- Ketorolac, Dexamethasone
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Migraine
Treatment for Migraines With an Implantable Device
The purpose of this study is to evaluate the safety and effectiveness of an implantable device for difficult to treat migraine. There are a significant number of patients who have drug refractory migraine and alternative…
- Trial name
- NCT00286078
- Testing
- Precision
- Where
- 15 sites in United States
- Volunteers
- 179 people
- Sponsor
- Boston Scientific Corporation
Migraine Headache
Low-dose Propofol for the Treatment of Severe Refractory Migraine Headache in the Emergency Department
Migraine headache is a frequent Emergency Department complaint. While first-line Emergency Department treatment for this condition is well-established, optimal second-line treatment options are not well-defined.
- Trial name
- NCT02492295
- Testing
- Propofol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Albert Einstein Healthcare Network
Migraine Disorders, Refractory Migraine
EMBRACE Study: Enduring Migraine Benefit From Responsive Artery Coil Embolization
This single-site, open-label pilot study evaluates the safety, feasibility, and potential durability of the TEMMA procedure (Targeted Embolization for Migraine Management), an endovascular treatment strategy targeting meningeal…
- Conditions
- Migraine Disorders, Refractory Migraine, Chronic Migraine
- Trial name
- EMBRACE (NCT07313800)
- Testing
- TEMMA Endovascular Treatment
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Cortex Neurovascular
Migraine, Headache
Ticagrelor Therapy for RefrACTORy Migraine Study
This is a prospective, open-label, single-arm pilot study treating 40 subjects to assess the hypothesis that P2Y, G protein-coupled 12 (P2Y12) inhibition with Brilinta/ticagrelor (90 mg by mouth (PO) twice a day) reduces episodic…
- Conditions
- Migraine, Headache, Migraine Headache
- Trial name
- TRACTOR (NCT02518464)
- Testing
- Ticagrelor 90 mg twice per day
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Columbia University
High Frequency Episodic Migraine and Chronic Migraine
TI-001 (Intranasal Oxytocin) for Treatment of High Frequency Episodic Migraine and Chronic Migraine
This study evaluates the use of oxytocin, given as a nasal spray, for treatment of high frequency episodic migraine and chronic migraine.
- Trial name
- NCT01839149
- Testing
- TI-001
- Where
- 6 sites in Australia, Chile and 1 more
- Volunteers
- 240 people
- Sponsor
- Trigemina, Inc
Migraine, Chronic Migraine Headache
Bilateral Embolization of the Middle Meningeal Arteries for Refractory Chronic Migraine
This study is to test the safety and feasibility of a procedure called embolization of the middle meningeal arteries (MMA), using a product called Onyx. Embolization creates a plug in the arteries.
- Conditions
- Migraine, Chronic Migraine Headache, Refractory Migraine
- Trial name
- MMAE-Migraine (NCT07223008)
- Testing
- embolization of middle meningeal arteries
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Johns Hopkins University