Clinical trials: Refractory Epilepsy, open to volunteers
Medication Refractory Epilepsy Patients With Electrodes Already Implanted Based on Clinical Criteria for Standard Monitoring
Model-based Electrical Brain Stimulation
Neuropsychiatric disorders are a leading cause of disability worldwide with depressive disorders being one of the most disabling among them.
- Trial name
- NCT05327387
- Testing
- model-based electrical brain stimulation
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Southern California
Refractory Epilepsy
Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy
Vagus nerve stimulation (VNS) is an adjunctive treatment for refractory epilepsy. Although widely used, there is still a substantial number of patients with insufficient response.
- Trial name
- BLUELIGHTVNS (NCT06304389)
- Testing
- electroencephalography, electrocardiogram, pupillometry, evoked potentials, light administration, transcutaneous vagus nerve stimulation, electroencephalography, pupillometry, electrocardiogram, light administration
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Refractory Epilepsy in Children
Non-Helium Magnetoencephalography in Pediatric Refractory Epilepsy
The goal of this observational study is to evaluate the effectiveness of Magnetoencephalography (MEG) in the preoperative assessment of children with refractory epilepsy, particularly in identifying the seizure focus, and to…
- Trial name
- NCT07064421
- Testing
- Magnetoencephalography plus Stereo-electroencephalography/Electrocorticography, Stereo-electroencephalography/Electrocorticography
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Refractory Epilepsy, Sleep
Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG
This study aims to collect electrophysiological and clinical data from patients aged 14-65 with drug-resistant epilepsy who underwent SEEG.
- Trial name
- NCT06524479
- Testing
- SEEG recordings and SPES
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy (Treatment Refractory)
Epilepsy Cycles Longitudinal Monitoring to Inform Personalized Seizure-risk Estimation (ECLIPSE)
The occurrence of seizures in epilepsy is not entirely random. Temporal patterns that organize the occurrence of seizures over weeks and months were previously unraveled using intracranial EEG System (IEEG) that monitors…
- Trial name
- ECLIPSE (NCT06952764)
- Testing
- Seizure risk forecast, Control seizure risk forecast
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Epilepsy (treatment Refractory)
Percutaneous Repair for Drug - Resistant Epilepsy by Intervention of Closing the Patent Foramen Ovale（PREDICT-PFO Trial）
Patent foramen ovale (PFO) is the most common cause of right-to-left shunt (RLS) in the adult heart, with a prevalence of approximately 25% in the general population.
- Trial name
- PREDICT-PFO (NCT06863350)
- Testing
- patent foramen ovale closure
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Sichuan University
Epilepsy, Refractory
Using Micro-filaments to Detect "fast Ripples" and Improve the Identification of the Epileptogenic Zone
record fast ripples with novel intracranial electrodes with micro-tetrodes to improve the identification of epileptogenic zone (EZ) and investigate the neuronal circuits underlying brain dynamics associated with epilepsy
- Trial name
- NeuroSeizure (NCT05254730)
- Testing
- macro-micro tetrodes for intracranial recording
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Adrien Peyrache
Quality of Life, Epilepsy (treatment Refractory)
Evaluation of the Epilepsy-related Quality of Life, Seizure-related Accidents and Validation of the Mjn-SERAS Solution in the Normalised Patient Environment with Real-World Data
The study will be prospective, multicentre, postmarketing clinical study, with a controlled and randomized design, to perform the analysis of 130 subjects with a clinical diagnosis of epilepsy, patients whose clinical semiology…
- Trial name
- SERAS_Home_RWD (NCT05845255)
- Testing
- mjn-SERAS
- Where
- 6 sites in Germany, Spain and 1 more
- Volunteers
- 130 people
- Sponsor
- MJN Neuroserveis, S.L
Refractory Epilepsy, Focal Epilepsy
Atlas of Human Cognition by SEEG (MAPCOG-SEEG)
The main objective of MAPCOG_SEEG is to create a database including brain recordings of cognition performed in clinical routine in patients during the pre-surgical SEEG assessment.
- Trial name
- MAPCOG-SEEG (NCT03644732)
- Testing
- SEEG Group
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Grenoble