Clinical trials: Refractory Epilepsy
Infantile Spasms
Short-term Ketogenic Diet as Compared With Conventional Long-term Trial in Refractory Infantile Spasms: A Randomized, Controlled Study
This is a randomized, controlled study to compare Short-term ketogenic diet with conventional long-term trial in refractory infantile spasms.
- Trial name
- NCT00968136
- Sponsor
- Yonsei University
Epilepsy
Atkins Plus KetoCal for Childhood Epilepsy
The modified Atkins diet (MAD) is a relatively new, alternative dietary therapy for intractable childhood and adult epilepsy. Recent evidence suggests that a strict, highly ketotic, first month may be advantageous to both…
- Trial name
- NCT00681239
- Testing
- Modified Atkins diet and KetoCal
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Drug Resistant Epilepsy, Epilepsy, Drug Resistant
Safety of Using NaviFUS System in Patients With Drug Resistant Epilepsy
This study is to evaluate the safety and the intracranial electroencephalography (iEEG) changes of using NaviFUS System for the treatment of patients with drug resistant epilepsy.
- Conditions
- Drug Resistant Epilepsy, Epilepsy, Drug Resistant, Drug Refractory Epilepsy, Epilepsy, Drug Refractory
- Trial name
- NCT03860298
- Testing
- NaviFUS System
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- NaviFUS Corporation
Drug Resistant Epilepsy, Ketogenic Diet
Feasibility, Tolerability and Efficacy of the Ketogenic Diet in Children With Drug-resistant Epilepsy in South Vietnam
According to the World Health Organization, more than 50 million people have epilepsy. Among them, nearly 80% of epileptic patients live in developing countries and 75% of them do not have access to treatment.
- Conditions
- Drug Resistant Epilepsy, Ketogenic Diet, Feasibility, Tolerability
- Trial name
- NCT05697887
- Testing
- Ketogenic diet
- Where
- Vietnam
- Volunteers
- 45 people
- Sponsor
- Number 2 Children's Hospital, Ho Chi Minh City
Transcranial Magnetic Stimulation, Drug Resistant Epilepsy
The Mechanism of cTBS Targeting Dentate Nucleus for DRE
In our previous cross-over study--the continuous θ burst stimulation (cTBS) targeting cerebellum dentate nucleus of 44 drug-refractory epilepsy (DRE) patients, a significant reduction in seizure frequency was observed.
- Conditions
- Transcranial Magnetic Stimulation, Drug Resistant Epilepsy, Cerebellum
- Trial name
- NCT05809349
- Testing
- transcranial magnetic stimulation
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Epilepsy
Treatment of Drug Resistant Epilepsy
The main goal of this study is to provide treatment with cannabidiol (CBD) to children with drug resistant epilepsy through a Physician Expanded Access Investigation New Drug protocol.
- Trial name
- Cannabidiol (NCT02461706)
- Testing
- cannabidiol, Blood Test
- Where
- 2 sites in United States
- Sponsor
- University of Florida
Focal Epilepsy, Transcranial Magnetis Stimulation
Transcranial Magnetic Stimulation (rTMS) for Refractory Focal Epilepsy
Epilepsy as a brain disease is characterised by enhanced brain excitability. Low frequency repetitive transcranial magnetic stimulation (rTMS) can be an effective treatment for refractory focal epilepsy.
- Trial name
- NCT06681480
- Testing
- figure-of-eight active rTMS coil device
- Where
- Slovakia
- Volunteers
- 20 people
- Sponsor
- Comenius University
Drug Resistant Epilepsy, Brain-Computer Interfaces
StereoEEG Motor Neuronal Potentials Decoding
The goals of this study are (1) to evaluate the rate of stereoEEG brain-computer interface (BCI) classification accuracy and (2) to collect the dataset of neuronal signals recorded from stereoEEG electrodes during motor…
- Trial name
- NCT06432907
- Testing
- motor tasks
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Research Center of Neurology, Russia
Epilepsy
P-glycoprotein Inhibition as Adjunct Treatment for Medically Refractory Epilepsy.
In up to 1 out of 3 patients with epilepsy, seizures continue to occur despite the use of one or more antiepileptic medications.
- Trial name
- NCT00524134
- Testing
- Carvedilol-CR
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Columbia University
CDKL5 Deficiency Disorder
Study of Adjunctive Ganaxolone Treatment in Children and Young Adults With CDKL5 Deficiency Disorder
A clinical study to evaluate the efficacy, safety, and tolerability of adjunctive ganaxolone therapy compared to placebo for the treatment of seizures in children and young adults with genetically confirmed CDKL5 gene mutation.
- Trial name
- Marigold (NCT03572933)
- Testing
- ganaxolone
- Where
- 36 sites in United States, Australia and 6 more
- Volunteers
- 101 people
- Sponsor
- Marinus Pharmaceuticals
Epilepsy, Lennox-Gastaut Syndrome, Intractable
Children's Adaptive Deep Brain Stimulation for Epilepsy Trial (CADET): Pilot
The CADET Pilot will investigate the safety and feasibility of deep brain stimulation (DBS) to treat children with Lennox-Gastaut syndrome using a novel DBS device (Picostim DyNeuMo-1).
- Trial name
- CADET Pilot (NCT05437393)
- Testing
- Deep brain stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 4 people
- Sponsor
- University College, London
Refractory Epilepsy
Trial to Evaluate the Safety and Effectiveness of Vagus Nerve Stimulation for Children With Refractory Epilepsy
Children with refractory epilepsy who are candidates for a treatment with vagus nerve stimulation will be prospectively randomized into 2 arms.
- Trial name
- NCT03062514
- Testing
- PINS Vagus Nerve Stimualtor
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Focal Epilepsy
A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
The purpose of this study is to determine whether BHV-7000 is effective in the treatment of refractory focal epilepsy.
- Trial name
- RISE 2 (NCT06132893)
- Testing
- BHV-7000
- Where
- 104 sites in United States, Argentina and 10 more
- Volunteers
- 390 people
- Sponsor
- Biohaven Therapeutics Ltd.
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Drug-Resistant Focal Epilepsy
Temporal Interference Brain Stimulation for Adults With Drug-Resistant Epilepsy Undergoing Stereo-EEG Monitoring
This study evaluates whether a non-invasive brain stimulation technique called Temporal Interference (TI) can reduce epilepsy-related abnormal brain activity and influence sleep-related brain rhythms in adults with focal…
- Trial name
- NCT07764718
- Testing
- Temporal Interference Stimulation, Direct Electrical Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Epilepsy, Epileptic Encephalopathy
Tele-epic (Telemedicine for Epilepsy Care)
Epilepsy is a chronic condition that requires consistent follow-up aimed at seizure control, surveillance of comorbidities, monitoring of antiepileptic drugs (AED) levels and side effects.
- Conditions
- Epilepsy, Epileptic Encephalopathy, Refractory Epilepsy
- Trial name
- Tele-epic (NCT04496310)
- Testing
- Telemedicine
- Where
- 2 sites in Italy
- Volunteers
- 600 people
- Sponsor
- Azienda Usl di Bologna
Refractory Status Epilepticus
Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus
This project is aiming to better understand the use of perampanel as an appropriate standard-of-care therapy for treatment refractory status epilepticus (RSE), to identify determinants of outcomes, and establish safety.
- Trial name
- NCT05684978
- Testing
- Perampanel
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Wayne State University
Epilepsy, Epilepsy (Treatment Refractory)
Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up
The purpose of this research is to address the challenges of correctly monitoring, managing, and diagnosing epilepsy in participants whose seizures are not well captured by standard electroencephalography (EEG) tests and who…
- Trial name
- DETECT LTFU (NCT07110454)
- Testing
- Previous receipt of the Minder System (implantable continuous electroencephalographic (EEG) monitoring (iCEM) system)
- Where
- 21 sites in United States
- Volunteers
- 210 people
- Sponsor
- Epiminder America, Inc.
Epilepsy
Open-label Extension Study to Evaluate the Safety of USL255 in Patients With Refractory Partial-onset Seizures
The purpose of this study is to examine the safety of USL255 as adjunctive therapy in patients with refractory partial onset-seizures.
- Trial name
- NCT01191086
- Testing
- USL255
- Where
- 68 sites in United States, Argentina and 13 more
- Volunteers
- 210 people
- Sponsor
- Upsher-Smith Laboratories
Catamenial Epilepsy
Verapamil and Catamenial Epilepsy
One in 3 epilepsy patients have refractory seizures. This drug resistance is likely related to the over expression of multidrug resistance proteins (MDR).
- Trial name
- NCT00559169
- Testing
- verapamil hyrochloride
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto