Clinical trials: Refractory Constipation
Constipation
Transabdominal Electrical Stimulation for Constipation
Several transabdominal electrical stimulation studies have been reported for constipation in childhood. This study aims to assess the efficacy of this technique in adults with chronic constipation and compare two different…
- Trial name
- NCT02941471
- Testing
- Interferential Stimulation, TENS stimulation
- Volunteers
- 14 people
- Sponsor
- St Mark's Hospital Foundation
Constipation - Functional, Refractory Constipation
Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation
The goal of this observational study is to identify the characteristics of brain functional connectivity in refractory constipation and fluoxetine-sensitive patients.
- Conditions
- Constipation - Functional, Refractory Constipation, Fluoxetine, fMRI
- Trial name
- NCT06221722
- Testing
- BOLD-fMRI, Regular treatment of functional constipation, fluoxetine
- Where
- 3 sites in China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Multiple Myeloma
A Safety and Efficacy Study of Revlimid® 5 mg Capsules in Patients With Relapsed or Refractory Multiple Myeloma Who Have Received Long-term Treatment With it Under the Actual Condition of Use
To understand the safety and efficacy of Revlimid® 5 mg Capsules (hereinafter referred to as Revlimid) in patients with "relapsed or refractory multiple myeloma" (hereinafter referred to as "relapsed or refractory MM") who have…
- Trial name
- NCT02922543
- Where
- Japan
- Volunteers
- 361 people
- Sponsor
- Celgene
Constipation
Contribution of Percutaneous Endoscopic Caecostomie in the Management of Severe Constipation Refractory to Medical Treatment
The investigators' study aims to compare the results of percutaneous endoscopic caecostomie (CPE) to optimal medical therapy in the treatment of patients with constipation refractory to medical treatment.
- Trial name
- ConstiCAPE (NCT02566746)
- Testing
- Chait Trapdoor caecostomie catheter, continuation of optimal medical therapy
- Where
- 3 sites in France
- Volunteers
- 28 people
- Sponsor
- Nantes University Hospital
Constipation, Surgery
Effectiveness and Cost-effectiveness of Sacral Neuromodulation in Patients With Idiopathic Slow-transit Constipation
Rationale: Previous reviews showed that the evidence regarding the effectiveness of sacral neuromodulation (SNM) in patients with therapy-resistant, idiopathic (slow-transit) constipation is of suboptimal quality.
- Trial name
- NCT02961582
- Testing
- Sacral Neuromodulation, Personalized Conservative Treatment
- Where
- 2 sites in Netherlands
- Volunteers
- 67 people
- Sponsor
- Maastricht University Medical Center
Refractory Constipation, Somatic Symptom Disorder (DSM-5)
Evaluation of Fluoxetine for Refractory Constipation With Somatic Symptom Disorder Features
This single-center, randomized, double-blind, placebo-controlled trial evaluates the efficacy and safety of fluoxetine (40 mg/day) versus placebo in 194 adults with refractory chronic constipation exhibiting Somatic Symptom…
- Conditions
- Refractory Constipation, Somatic Symptom Disorder (DSM-5), Functional Constipation (FC)
- Trial name
- REFLECT (NCT06506136)
- Testing
- Fluoxetine
- Volunteers
- 194 people
- Sponsor
- Zhifeng Zhao, PhD
Refractory Constipation, Fecal Incontinence in Children
The Role of Anorectal Manometry in Pediatric Chronic Refractory Constipation
This research protocol outlines a two-year descriptive cross-sectional study to investigate the role of high-resolution anorectal manometry (HRAM) in children aged 4-18 years with chronic refractory constipation.The study plans…
- Trial name
- NCT07291661
- Testing
- High resolution anorectal manometry using a multiuse water perfused catheter
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Assiut University
Constipation, Critical Illness
The Effect of Naloxegol on Refractory Constipation in the Intensive Care Unit
Naloxegol has recently been approved by the US Food and Drug Administration to treat opioid induced constipation in non-cancer chronic pain patients. Its effectiveness in acute care patients, however, is not known.
- Trial name
- NaRC-ICU (NCT02705378)
- Testing
- Polyethylene glycol, naloxegol
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Ulcerative Colitis, Crohn Disease
Efficacy of Fecal Microbiota Transplantation for Inflammatory Bowel Disease
The gut microbiota is determined to constitute a "microbial organ" which has pivotal roles in the intestinal diseases and body's metabolism.
- Conditions
- Ulcerative Colitis, Crohn Disease, Constipation (Excl Faecal Impaction)
- Trial name
- NCT02575040
- Testing
- Fecal microbiota transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Refractory Constipation
Fluoxetine for Refractory Constipation
The goal of this clinical trial is to learn if fluoxetine works to treat refractory constipation . It will also learn about the safety of fluoxetine.
- Trial name
- NCT06750445
- Testing
- Fluoxetine, Polyethylene Glycol 400 0.4%
- Where
- 3 sites in China
- Volunteers
- 316 people
- Sponsor
- Zhifeng Zhao, PhD
Functional Constipation in Children
Preliminary Results of Laparoscopic Assisted Transanal Proximal Rectosigmoidectomy Combined With Malone Antegrade Continence Enema for the Management of Intractable Functional Constipation in Children
Technique for surgical management of intractable functional constipation
- Trial name
- NCT07180680
- Testing
- laparoscopic assisted transanal proximal rectosigmoidectomy
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Al-Azhar University
Obstructive Defecation Syndrome, Chronic Constipation
Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS)
The primary purpose of this study is to determine how effective and how durable STARR (stapled transanal rectal resection) surgery is in relieving symptoms of intractable constipation associated with obstructive defecation…
- Conditions
- Obstructive Defecation Syndrome, Chronic Constipation, Rectocele, Intussusception
- Trial name
- NCT00256984
- Testing
- Stapled Transanal Resection (STARR) with Transtar (PROXIMATE®) 33 mm Circular Stapler
- Where
- 7 sites in United States
- Volunteers
- 75 people
- Sponsor
- Ethicon Endo-Surgery
Functional Constipation (FC), Somatic Symptom Disorder (DSM-5)
Transcranial Alternating Current Stimulation for Refractory Constipation With Somatic Symptom Disorder
The purpose of this randomized, double-blind, placebo-controlled trial is to evaluate the efficacy and safety of transcranial alternating current stimulation (tACS) in adults with refractory functional constipation comorbid with…
- Conditions
- Functional Constipation (FC), Somatic Symptom Disorder (DSM-5), Refractory Constipation
- Trial name
- RELIEF-tACS (NCT07323407)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Constipation, Surgery
Effectiveness and Safety of Sacral Neuromodulation in Patients With Idiopathic Slow-transit Constipation
Rationale: Previous reviews showed that the evidence regarding the effectiveness of sacral neuromodulation (SNM) in patients with therapy-resistant, idiopathic (slow-transit) constipation is of suboptimal quality.
- Trial name
- NCT02961465
- Testing
- Sacral Neuromodulation
- Where
- 2 sites in Netherlands
- Volunteers
- 23 people
- Sponsor
- Maastricht University Medical Center
Pib Specific Phage, Intractable Constipation
Clinical Study of Phage Therapy for Chronic Constipation Efficacy and Safety
The overall aim was to evaluate the efficacy of PiB-specific phages for the treatment of refractory constipation through clinical studies, primarily for the publication of scientific papers and to guide the development of phage…
- Trial name
- NCT05973721
- Testing
- phage
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai 10th People's Hospital
Chronic Constipation
Anorectal Manometery in Pediatric Chronic Refractory Constipation
Anorectal manometry and high-resolution anorectal manometry (HRAM) are becoming the investigation of choice for understanding the pathophysiology of chronic constipation with or without fecal incontenance in children in many…
- Trial name
- NCT06543979
- Testing
- lubiprostone , single arm, biofeed back sessions, botox injection
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Parkinson Disease, Constipation
Fecal Microbiota Transplantation Via Oral Capsule for Treating Refractory Constipation in Parkinson's Disease
The aim of this clinical trial is to assess the impact of fecal microbiota transplantation (FMT) delivered via oral capsules in patients with Parkinson's disease who suffer from refractory constipation.
- Trial name
- FORT-PD (NCT07038226)
- Testing
- Oral capsule-delivered FMT
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Kyung Hee University Hospital
Amorphous, Eosinophilic, and Acellular Deposit, Constipation
S1702 Isatuximab in Treating Patients With Relapsed or Refractory Primary Amyloidosis
This phase II trial studies how well isatuximab works in treating patients with primary amyloidosis that has come back or does not respond to treatment.
- Conditions
- Amorphous, Eosinophilic, and Acellular Deposit, Constipation, Diarrhea, Early Satiety
- Trial name
- NCT03499808
- Testing
- Isatuximab, Laboratory Biomarker Analysis
- Where
- 345 sites in United States
- Volunteers
- 43 people
- Sponsor
- SWOG Cancer Research Network
Constipation, Refractory
Long-term Evaluation of Percutaneous Endoscopic Caecostomy in Refractory Constipation
This observational monocentric study aims to evaluate the long-term effectiveness and tolerance of percutaneous endoscopic caecostomy (PEC) in patients with chronic refractory constipation.
- Trial name
- CONSTICAP 2 (NCT07160192)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital
Refractory Constipation
Optimization of taVNS Intervention Strategies for Refractory Constipation
The goal of this clinical trial is to learn whether transcutaneous auricular vagus nerve stimulation (taVNS) works to treat refractory constipation in adults. It will also learn about the safety and tolerability of taVNS.
- Trial name
- NCT07344402
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital of Digestive Diseases