Clinical trials: Refractive Surgery, active
Myopic Traction Maculopathy
Predictors of Vitrectomy Outcomes in Myopic Foveoschisis
This prospective pilot study evaluates factors that predict outcomes after vitrectomy for myopic foveoschisis (MFS), a sight-threatening complication of high myopia that can lead to progressive visual loss, foveal detachment…
- Trial name
- NCT07774637
- Testing
- pars plana vitrectomy
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore National Eye Centre
Dry Eye Disease (DED)
Evaluating Crosslinked Hyaluronate Canalicular Gel for the Treatment of DED in Patients Undergoing Cataract Surgery
To review how patients report using a hyaluronate crosslinked canalicular gel placed before cataract surgery
- Trial name
- LaReCa (NCT07155057)
- Testing
- Cross-Linked Hyaluronate Gel Prefilled Syringe 30 MG/3ML
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Myopia, Astigmatism
SMILE Surgery in One Eye Compared to Ray Tracing-guided LASIK Surgery in the Fellow Eye
Participants will undergo LASIK surgery in one eye using ray tracing guided technology in one eye and LASIK surgery in the other eye using wavefront guided technology.
- Trial name
- NCT07721714
- Testing
- Ray tracing guided LASIK surgery
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Stanford University
Strabismus Surgery
Refractive and Topographic Changes After Strabismus Surgery
Strabismus, characterized by a misalignment of the eyes, is a common condition that can result in functional and cosmetic issues, often affecting vision and binocular coordination.
- Trial name
- NCT06929130
- Volunteers
- 60 people
- Sponsor
- Assiut University
Myopia, High Myopia
Clinical Results of Small Incision Lenticule Extraction (SMILE) for the Correction of High Myopia
Small Incision Lenticule Extraction (SMILE) was introduced in 2011 using the VISUMAX femtosecond laser (Carl Zeiss Meditec, Jena, Germany). It is designed for correction of myopia and myopic astigmatism.
- Trial name
- NCT04110067
- Testing
- Small Incision Lenticule Extraction (SMILE) with Visumax (Carl Zeiss Meditec, Jena)
- Where
- Germany
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Suphi Taneri
Myopia, Astigmatism
A Three-Phase Contralateral Comparison of Ray-Tracing Guided LASIK Versus Three Other Refractive Surgery Platforms to Correct Myopia or Myopia With Astigmatism
This purpose of this study is to compare a new form of LASIK called Ray Tracing Guided LASIK to 3 other forms of corneal refractive surgery: 1. KLEx (KeratoLenticule Extraction) using the Zeiss Visumax 800 Laser, 2.
- Trial name
- NCT07201298
- Testing
- Ray-Tracing Guided LASIK, Keratorefractive Lenticule Extraction (KLEx), WaveFront Optimized LASIK
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hoopes Vision
Cataract, Cataract Senile
Impact of a Novel Extended Depth of Focus Intraocular Lens on Visual and Lifestyle Enhancement
The introduction of presbyopia-correcting intraocular lenses (PC-IOLs) has provided cataract and refractive surgeons the ability to provide patients with a wider range of visual success and spectacle independence post-cataract…
- Conditions
- Cataract, Cataract Senile, Presbyopia
- Trial name
- NCT04570579
- Testing
- Vivity Extended Depth of Focus Intraocular Lens
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Alanna Nattis, DO
Refractive Surgery, Myopia; Refractive Error
Clinical Study of SMILE 4.0-VISULYZE in Correcting Refractive Errors
The aim of this study is to further optimize the surgical input parameters for patients undergoing Small Incision Lenticule Extraction (SMILE) using the regression model established by the SMILE 4.0-VISULYZE system, thereby…
- Trial name
- NCT06982807
- Testing
- Group 4.0-VISULYZE, traditional group
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Affiliated Hospital of Nantong University
Optical Coherence Tomography, Refractive Errors
To Study the Effects of Refractive Surgery on OCT Measurements in the Eye
Corrective eye surgeries, such as Lasik, are widely used to correct focusing problems such as myopia, or nearsightedness. Often these patients develop other conditions like myopic maculopathy or glaucoma which require monitoring…
- Conditions
- Optical Coherence Tomography, Refractive Errors, Myopia
- Trial name
- NCT05856786
- Testing
- Optical coherence tomography
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Nebraska
Rhegmatogenous Retinal Detachment, Hypotony Ocular
Ocular Hypotony and Refractive Predictability in RRD Surgery
This study evaluates how preoperative ocular hypotony (Goldmann IOP ≤ 7 mmHg) affects refractive predictability, axial length measurements, and visual outcomes in patients undergoing combined phacovitrectomy with silicone oil for…
- Trial name
- HYP-RRD (NCT07283614)
- Testing
- Combined Phacovitrectomy with Intraocular Lens Implantation and Silicone Oil Tamponade, Silicone Oil Removal
- Where
- Kazakhstan
- Volunteers
- 45 people
- Sponsor
- Kazakh Eye Research Institute
Myopia, Astigmatism
KLEx Versus FS-LASIK for the Treatment of Myopia and Compound Myopic Astigmatism
FemtoLASIK is a type of laser eye surgery used to correct vision problems such as nearsightedness, farsightedness, and astigmatism. It involves two main steps: creating a flap and reshaping the cornea.
- Conditions
- Myopia, Astigmatism, Myopic Astigmatism
- Trial name
- NCT06477081
- Testing
- FS-LASIK procedure, KLEx
- Where
- Mexico
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Irregular Astigmatism, Astigmatism
Improving Visual Quality in Patients With Irregular Corneas Using Asymmetrical Toric Intraocular Lenses
Cataract surgery in patients with irregular corneas presents unique challenges, primarily due to the high variability in keratometry and corneal tomography measurements, which complicates accurate intraocular lens (IOL)…
- Conditions
- Irregular Astigmatism, Astigmatism, Cataract and IOL Surgery
- Trial name
- VITAL (NCT07294716)
- Testing
- AMILens Individual
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- Johannes Kepler University of Linz
Myopic Astigmatism
A Study to Investigate the Safety and Effectiveness of the Technolas® TENEO 317 Model 2 Excimer Laser for Laser In Situ Keratomileusis (LASIK) Surgery to Treat Myopia or Myopic Astigmatism
This will be a multicenter, prospective, open label, non-randomized, single arm study evaluating the safety and effectiveness of the Technolas® TENEO 317 Model 2 (version 1.28 US software) Excimer Laser when used in LASIK surgery…
- Trial name
- NCT07377474
- Testing
- TENEO 317 Model 2 (1.28 US) Excimer Laser
- Volunteers
- 32 people
- Sponsor
- Bausch & Lomb Incorporated
Myopia, Myopia; Astigmatism
Assessment of IOP After Corneal Refractive Surgery Based on AI
Significance, Background, and Current Status Studies show the global average prevalence of myopia is 22%, with hyperopia incidence being similar.
- Conditions
- Myopia, Myopia; Astigmatism, Refractive Surgery, Intraocular Pressure Changes
- Trial name
- AIOP-CRS-AI (NCT07544615)
- Where
- China
- Volunteers
- 10,030 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Cataract, Fuchs Endothelial Corneal Dystrophy
Partial Range Of Field IOLs in DMEK-Enabled Procedures
Study Overview This study aims to evaluate the visual outcomes, quality of vision, and patient satisfaction after receiving an extended range PRoF intraocular lens (IOL) during triple Descemet Membrane Endothelial Keratoplasty…
- Trial name
- PROFIDE (NCT07441616)
- Testing
- combined cataract and lamellar endothelial keratoplasty
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Tomography
UNITY DX Cornea Study
The purpose of this study is to validate the clinical measurement performance of an investigational biometer. Subjects will undergo multiple measurements of the eye, and the agreement, repeatability, and reproducibility of…
- Trial name
- NCT07768735
- Testing
- UNITY DX, ANTERION
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Corneal Astigmatism, Cataract
Effectiveness, Stability and Influence Factors of Femtosecond Laser Assisted Cataract Surgery
What is this study about? This study looks at whether a laser procedure called femtosecond laser-assisted arcuate keratotomy (FSAK) helps people with both cataracts and mild astigmatism see more clearly after cataract surgery.
- Trial name
- NCT07081919
- Testing
- femtosecond laser-assisted arcuate keratotomy (FSAK) combined with standard cataract surgery
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Refractive Errors
Treatment of Residual Hypermetropic Refraction on Young Patients After LASIK Using Human Fresh Corneal Lenticule Implantation With ReLEX Smile Surgery
LASIK (laser-assisted in situ keratomileusis) is a type of refractive surgery for correction of myopia, hyperopia and astigmatism.
- Trial name
- Relex-Smile (NCT04793893)
- Testing
- ReLex Smile
- Where
- Kosovo
- Volunteers
- 42 people
- Sponsor
- Eye Hospital Pristina Kosovo
Refractive Surgery
Clinical Application Research of 5-Degree (0.05 D) Precision Optometry in Corneal Refractive Surgery
In recent years, the incidence of myopia has been high globally and is exhibiting a rapid upward trend, with projections estimating it will reach 49.8% by 2050.
- Trial name
- NCT07146828
- Testing
- Binocular Wavefront Optometry Machine (BWFOM, Ai-Zhitong Medical Technology Co., Ltd., Zhejiang, China)
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Affiliated Hospital of Nantong University
Traumatic Cataract
Long-term Visual and Refractive Outcomes After Traumatic Cataract Surgery in Children
This prospective multicenter observational study aims to evaluate long-term visual and ocular biometric outcomes in pediatric patients aged 0-16 years who were diagnosed with traumatic cataract and underwent cataract extraction…
- Trial name
- NCT07087275
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Jin Yang