Clinical trials: Refractive Surgery
Ectasia
Corneal Collagen Cross-Linking for Ectasia (CXL)
Prospective, randomized multicenter study to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes with ectasia after refractive surgery.
- Trial name
- CXL (NCT00674661)
- Testing
- riboflavin ophthalmic solution, UVA Irradiation
- Where
- 10 sites in United States
- Volunteers
- 130 people
- Sponsor
- Glaukos Corporation
Surgery, Myopia
Topo-guided LASIK and Photorefractive Keratectomy vs Wavefront LASIK and Photorefractive Keratectomy
This study evaluates the difference in results between eyes that have been treated wavefront optimized laser vision correction (either LASIK or Photorefractive Keratectomy) compared to eyes treated with topography-guided laser…
- Trial name
- NCT03075176
- Testing
- Wavefront optimized LASIK, Wavefront optimized Photorefractive Keratectomy, Topography-guided LASIK
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Utah
Cataract, Corneal Astigmatism
ClarVista HARMONI Toric Trial With Intraoperative Exchange
The purpose of this study was to demonstrate the safety and effectiveness of the HARMONI® Modular Intraocular Lens System with a toric optic in subjects with pre-existing corneal astigmatism in need of cataract surgery.
- Conditions
- Cataract, Corneal Astigmatism, Aphakia
- Trial name
- NCT03054649
- Testing
- HARMONI® Modular Intraocular Lens System, Intraoperative optic exchange
- Where
- 2 sites in Mexico, Philippines
- Volunteers
- 44 people
- Sponsor
- ClarVista Medical
Cataract Extraction, Corneal Astigmatism
Assessment of Visual Performance in Patients With Low Levels of Astigmatism
To assess visual performance in patients with low levels (0.5-0.75 Diopters) of corneal astigmatism.
- Trial name
- NCT00842231
- Testing
- Visual performance measures
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Aphakia, Astigmatism
Evaluation of Long-term Safety and Performance of PanOptix Trifocal Intraocular Lens (IOL)
The purpose of this Post-Market Clinical Follow-up (PMCF) study is to describe the long-term safety and performance of the AcrySof IQ PanOptix IOL toric and non-toric models in subjects bilaterally implanted with these IOLs for 3…
- Conditions
- Aphakia, Astigmatism, Presbyopia
- Trial name
- NCT06166901
- Testing
- AcrySof IQ PanOptix IOL Toric, AcrySof IQ PanOptix IOL Non-Toric
- Where
- 7 sites in Spain
- Volunteers
- 211 people
- Sponsor
- Alcon Research
Astigmatism
Hydrophobic Acrylic Toric IOL Designed to Reduce the Effects of Preoperative Corneal Astigmatism
The investigational enVista IOL, Model MX60Tis equipped with toric optics and axis marks on the posterior surface to minimize the possibility of surgically induced astigmatism.
- Trial name
- NCT01852084
- Testing
- enVista® One-Piece Hydrophobic Acrylic Toric IOL, enVista control lens
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- Bausch & Lomb Incorporated
Operative Incision
70 vs 110 Degree Side-cut Angles in Femtosecond LASIK
The purpose of this study is to compare 70 and 110 degree side-cut angles on the same patient undergoing Femtosecond Laser-assisted in Situ Keratomileusis (FS-LASIK).
- Trial name
- NCT03122535
- Testing
- FS-LASIK 70 degree side-cut angle, FS-LASIK 110 degree side-cut angle
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Utah
Image, Body
Whole Eye Optical Coherence Tomography (OCT) to Improve Refractive Surgery and Eye Care
The overall objective is to develop the hardware systems and software algorithms necessary to make accurate measurements of the whole eye with optical coherence tomography (OCT).
- Trial name
- NCT03219567
- Testing
- Optical Coherence Tomography (OCT), Magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Duke University
Myopia
A Prospective, Contralateral, Eye to Eye Comparison of SMILE Surgery to LASIK Surgery
Subjects will undergo SMILE surgery in one eye and LASIK surgery in their other eye to correct myopia.
- Trial name
- NCT03067077
- Testing
- SMILE, LASIK
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Stanford University
Refractive Errors, Myopia
Safety and Suitability of ICL for Correction of Refractive Errors Without the Use of Dispersive OVDs
The goal of this observational study is to test whether surgeries for lenses designed to be implanted in the eye to correct refractive error can be done without the need for using viscoelastic substances that are used routinely…
- Conditions
- Refractive Errors, Myopia, Myopic Astigmatism, Hypermetropia
- Trial name
- NCT06371079
- Testing
- phakic intraocular lens implantation traditional, phakic intraocular lens implantation reduced OVD
- Where
- Iraq
- Volunteers
- 448 people
- Sponsor
- Loay Abdulmutalib Almusawi
Post-operative Pain Control
Post-operative Pain Control After Photorefractive Keratectomy Comparing Acetaminophen/Codeine vs Acetaminophen/Oxycodone
Photorefractive keratectomy (PRK) is a refractive error correction procedure that helps eliminate or reduce the dependence on corrective lenses. An important aspect of PRK is post-operative pain management.
- Trial name
- NCT04399122
- Testing
- acetaminophen/codeine vs acetaminophen/oxycodone
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Cataract
Postmarket Study of an Intraocular Lens Power Selection System
The purpose of the study was to evaluate the visual acuity outcomes when using the Optiwave Refractive Analysis (ORA) with VerifEye+ and Barrett Toric Calculator for calculating intraocular lens (IOL) power and axis in subjects…
- Trial name
- NCT03579433
- Testing
- ORA with VerifEye+, Alcon Barrett Toric Calculator, Acrysof® IQ Toric IOL
- Where
- 9 sites in United States
- Volunteers
- 124 people
- Sponsor
- Alcon Research
Ocular Discomfort
A 8 Weeks Study to Evaluate Efficacy & Safety of rhNGF vs Vehicle in Patients After Cataract and Refractive Surgery
The primary objective of this exploratory study is to assess preliminary efficacy and safety of rhNGF when administered as eye drops to patients after cataract and refractive surgery.
- Trial name
- NCT03035864
- Testing
- rhNGF, Vehicle
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Dompé Farmaceutici S.p.A
Aphakia, Corneal Astigmatism
Evaluation of the Safety and Performance of the HARMONI® Toric Lens
The purpose of this study was to evaluate the safety and effectiveness of the HARMONI® Modular Intraocular Lens System with a toric optic (HMTIOL) in subjects with pre-existing corneal astigmatism in need of cataract surgery.
- Conditions
- Aphakia, Corneal Astigmatism, Cataract
- Trial name
- NCT03050697
- Testing
- HARMONI® Modular Toric Intraocular Lens, Cataract extraction with intraocular lens (IOL) implantation
- Where
- New Zealand
- Volunteers
- 16 people
- Sponsor
- ClarVista Medical
Myopia, Myopic Astigmatism
A Study With Technolas® TENEO 317 Model 2 Excimer Laser to Treat Participants With Myopia or Myopic Astigmatism
The primary objective of this study is to collect safety and effectiveness data for the Technolas Teneo 317 Model 2 excimer laser for LASIK correction in participants with myopia and myopic astigmatism.
- Trial name
- NCT04111757
- Testing
- Technolas® TENEO 317 Model 2
- Where
- 10 sites in United States
- Volunteers
- 168 people
- Sponsor
- Bausch & Lomb Incorporated
Cataract, Astigmatism
Conventional Surgery vs. Verion/VerifEye
Nowadays cataract patient's expectations are closer to those of refractive surgery patients. Patients want to be spectacle independent.
- Trial name
- NCT02513745
- Testing
- Conventional, Refractive Cataract Suite (Verion + ORA)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Carolina Eyecare Physicians, LLC
Refractive Surgery
The RESTORE Study, A Randomized, Controlled, Masked (Reading Center) Prospective Study
To determine patient preference and treatment outcomes with an intracanalicular dexamethasone (0.4mg) insert compared to standard steroid drop regimen in the contralateral eye following bilateral PRK surgery.
- Trial name
- NCT04396990
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Topical Prednisolone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Cataract, Astigmatism
Toric Intraocular Lens Following Cataract Surgery
The objective of this clinical trial is to evaluate the safety and effectiveness of the Bausch + Lomb Toric Accommodating Posterior Chamber Silicone Intraocular Lens used to provide near, intermediate, and distance vision and a…
- Trial name
- NCT01140477
- Testing
- Toric Accommodating Lens, Accommodating Lens
- Where
- United States
- Volunteers
- 229 people
- Sponsor
- Bausch & Lomb Incorporated
Bilateral LASIK Surgery
A Study to Compare the Safety and Efficacy of a New Eye Drop Formulation With REFRESH PLUS® in Participants Following LASIK Refractive Surgery
This study will compare the safety and efficacy of a new eye drop formulation with REFRESH PLUS® in participants following LASIK surgery.
- Trial name
- NCT01886690
- Testing
- carboxymethylcellulose sodium based new eye drop formulation, carboxymethylcellulose sodium based eye drops
- Where
- 2 sites in Australia, Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Allergan
Refractive Error
WaveLight® Refractive Myopic Study
The purpose of this study is to evaluate outcomes of subjects undergoing myopic surgery using the WaveLight® Refractive Suite (Excimer EX500 and Femtosecond FS200 lasers).
- Trial name
- NCT01941498
- Testing
- Wavelight® Refractive Suite, LASIK surgery
- Volunteers
- 104 people
- Sponsor
- Alcon Research