Clinical trials: Reduced Physical Activity
Healthy
Increasing Physical Activity Levels in Low-Income Women
Regular physical activity is important for good health. Women, particularly women with low incomes, have many personal barriers to regular physical activity.
- Trial name
- NCT00065026
- Testing
- Physical activity opportunities for low-income women
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Aggression, Physical Restraint
The Effectiveness of De-escalation in Management of Aggression
A multicenter, intervention study will be conducted in all psychiatric hospitals in Slovenia. The purpose of the study is to evaluate the effect of verbal and non-verbal de-escalation techniques on the incidence and severity of…
- Conditions
- Aggression, Physical Restraint, Education
- Trial name
- EDtAC_AC (NCT05166278)
- Testing
- De-escalation training
- Where
- 6 sites in Slovenia
- Volunteers
- 6 people
- Sponsor
- University Medical Centre Maribor
Cardiorespiratory Fitness
Sprint Snacks: The Effects of Prolonged Rest on Reduced Exertion Interval Training.
An adapted sprint interval training protocol involving 2-3 repeated 20-second sprints separated by 2-3 minutes rest (termed reduced exertion high- intensity interval training (REHIIT)) has been developed and has been shown to…
- Trial name
- NCT03159949
- Testing
- REHIIT, PR-REHIIT
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Menopause, Hot Flashes
Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women
The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.
- Conditions
- Menopause, Hot Flashes, Blood Pressure Regulation
- Trial name
- NCT06743269
- Testing
- High-Resistance Inspiratory Muscle Strength Training, Low-Resistance Inspiratory Muscle Strength Training, POWERbreathe K3 device
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Heart Failure With Reduced Ejection Fraction, Chronic Heart Failure
Vericiguat and Exercise Hemodynamics in Patients With HFrEF
Heart failure with reduced ejection fraction (HFrEF) is associated with impaired exercise capacity and abnormal exercise hemodynamics despite contemporary guideline-directed medical therapy (GDMT).
- Trial name
- EVERHETT-HF (NCT07697365)
- Testing
- Vericiguat, Guideline-directed medical therapy (GDMT) for heart failure
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Argyrios Ntalianis
Heart Failure
This Study Tests Empagliflozin in Patients With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF). The Study Looks at How Far Patients Can Walk in 6 Minutes and at Their Heart Failure Symptoms
The primary objective of the study is to evaluate the effect of empagliflozin 10 mg versus placebo on exercise ability using the 6 minute walk test in patients with chronic HF with reduced ejection fraction (LVEF ≤ 40%) Secondary…
- Trial name
- NCT03448419
- Testing
- Empagliflozin
- Where
- 109 sites in United States, Australia and 9 more
- Volunteers
- 312 people
- Sponsor
- Boehringer Ingelheim
Insulin Resistance, Obesity
A Study of the Effect of INCB013739 on Cortisone Reducing Enzyme Activity in Obese People Predisposed to Diabetes
The purpose of this study is to determine whether the investigational drug INCB013739 has an effect on systemic and adipose tissue 11-HSD1 activity in obese, insulin resistant subjects.
- Trial name
- NCT00398619
- Testing
- INCB13739
- Where
- 2 sites in United States
- Sponsor
- Incyte Corporation
Obesity
Food Allergen Eliminations and Combined Protocols for Obesity Reduction: a Preliminary Comparison Study
Screened subjects will be tested for hidden food allergies. Subjects will eliminate all food that showed leukocyte reactions for 90-days. Subjects will then also be invited to use the Willis Exercise protocol.
- Trial name
- NCT03821818
- Testing
- Food Allergy Elimination + Willis Exercise
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Galveston Clinical Research Foundation
Type 1 Diabetes Mellitus
Insulin-based Strategies to Prevent Hypoglycemia During Exercise
It has been reported that insulin basal rate reduction initiated at exercise onset can reduce the hypoglycemic risk during exercise.
- Trial name
- NCT03349489
- Testing
- Exercise 1, Exercise 2, Dexcom G4 Platinum
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Obesity; Impaired Glucose Regulation; Prediabetes; Type 2 Diabetes Mellitus
Time-Restricted Eating and Staple Food Reduction Combined With App-Supported Exercise for Weight and Glycemic Control
This multicenter, three-arm randomized controlled trial will evaluate the effects of early time-restricted eating and staple food reduction, each combined with an app-supported exercise intervention, on body weight and glycemic…
- Trial name
- TRE-SFR-EX (NCT07726615)
- Testing
- App-Supported Exercise Intervention, Staple Food Reduction, Early Time-Restricted Eating
- Volunteers
- 300 people
- Sponsor
- Peking University
Cancer, Cardiovascular Diseases
ActivityChoice: Implementing Clinic-Based Physical Activity Program Choices for Cancer Survivors
Cardiovascular disease, the number one leading cause of death in the United States, is highly prevalent in cancer survivors. Physical activity can reduce risk, and referrals to programs addressing survivors' choices are highly…
- Conditions
- Cancer, Cardiovascular Diseases, Physical Inactivity
- Trial name
- NCT05870176
- Testing
- Enhanced Referral, Standard Referral
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Worksite Health Promotion, Lifestyle Risk Reduction
Intervention to Increase Physical Activity and Wellbeing Among Staff and Residents in Assisted Living Facilities
The purpose of the study is to test a program that aims to help staff increase wellness behaviors and test the impact of this program on staff and work outcomes.
- Conditions
- Worksite Health Promotion, Lifestyle Risk Reduction, Occupational Burnout, Healthcare Workers
- Trial name
- WHHIP+FFC 2026 (NCT07785947)
- Testing
- WHHIP, FFC
- Where
- United States
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Chronic Heart Failure With Reduced Ejection Fraction
Effects of Repletion of Sodium Chloride on Natriuresis, Blood Pressure, and Neurohormonal Activity in Patients With Chronic Heart Failure With Reduced Ejection Fraction
The study is a single-center, prospective, randomized, placebo-controlled, double-blind trial conducted at the Institute of Heart Diseases and the Department of Cardiology of Wroclaw Medical University Hospital.
- Trial name
- RESALT-CHF (NCT07614295)
- Testing
- Sodium chloride supplementation
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Wroclaw Medical University
Obesity, Cardiovascular Diseases
High-intensity Exercise Training or Multidisciplinary Treatment in Extremely Obese Adolescents
The aim of the present study was to determine the effects of a multidisciplinary approach and intensity-controlled interval training on cardiovascular risk factors in overweight adolescents
- Trial name
- NCT00682266
- Testing
- intensity controlled interval training (AIT), Multidisciplinary approach (MTG)
- Where
- Norway
- Volunteers
- 54 people
- Sponsor
- Norwegian University of Science and Technology
Normal and Mild Hypercholesterolemic Subjects
Long-term Effectiveness Study on Cholesterol-reducing Activity
The purpose of this study is to investigate the effect of consumption of a drinkable low fat fermented milk enriched with 0,8g or 1,6g of plant sterols on reducing plasma cholesterol (LDL-cholesterol) concentration during 12…
- Trial name
- NCT01521169
- Testing
- 1 - low-fat dairy fermented product (drinkable) enriched with plant sterols (0,8g /day equivalent as free sterols)., 2 - low-fat dairy fermented product (drinkable) enriched with plant sterols (1,6g /day equivalent as free sterols)., 3 - low-fat dairy fermented product (drinkable) without plant sterols.
- Where
- Japan
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Danone Japan
Disorder Related to Lung Transplantation, Bronchiolitis Obliterans
Aerosol Liposomal Cyclosporine for Chronic Rejection in Lung Transplant Recipients
This is a single-center pilot study to investigate the efficacy and safety of aerosolized liposomal cyclosporine A in the treatment of chronic rejection in lung transplant recipients with bronchiolitis obliterans syndrome (BOS).
- Conditions
- Disorder Related to Lung Transplantation, Bronchiolitis Obliterans, Decreased Immunologic Activity, Chronic Rejection of Lung Transplant
- Trial name
- NCT01650545
- Testing
- Liposomal aerosol cyclosporine, standard immune suppression, oral
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Maryland, Baltimore
Physical Activity, Pacemaker
Physical Activity and Pacemaker Study
The benefits of regular physical activity are well-established. Furthermore, the investigators have previously shown that in a population of patients with implanted pacemakers, those who exercise more than 2 hours daily have…
- Conditions
- Physical Activity, Pacemaker, Cardiovascular Diseases, Arrythmia
- Trial name
- NCT03052829
- Testing
- Physical activity counseling, Usual care
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical College of Wisconsin
Hip Fractures, Mild Cognitive Impairment
Reducing Fall Risk Post Hip Fracture in Mild Cognitive Impairment
Hip fracture is recognized as one of the most serious consequences of osteoporosis, less than half regain pre-fracture independence. 95% of all hip fractures in older adults are due to falls.
- Trial name
- NCT04748354
- Testing
- Otago Exercise Program, Usual Care
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Chronic Kidney Disease
L-arginine to Reduce Sympathetic Nerve Activity in CKD Patients
Chronic kidney disease (CKD) is associated with a higher risk of cardiovascular disease and death. An overactive sympathetic nervous system in CKD patients is one of the major mechanisms increasing the cardiovascular risks in…
- Trial name
- NCT03982160
- Testing
- L-Arginine
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas at Arlington
Single Ventricle Heart Disease
Evaluation of Fontan-associated Hepatic Stiffness and the Efficacy of Udenafil in Reducing Liver Stiffness
A study to evaluate the efficacy of MZ101 therapy in reducing liver stiffness.
- Trial name
- FALD (NCT03430583)
- Testing
- Udenafil
- Where
- 17 sites in United States, Canada
- Volunteers
- 88 people
- Sponsor
- Mezzion Pharma Co. Ltd