Clinical trials: Recurrent Pancreatitis
Chronic Pancreatitis
The PASTEC Study: Endoscopic Stenting Versus Surgery for the Treatment of Bile Duct Stricture in Chronic Pancreatitis
Biliary obstruction complicates the course of chronic pancreatitis in 3%-23% of patients and in these cases, endoscopy and surgery are the treatment modalities of choice.
- Trial name
- PASTEC (NCT02366988)
- Testing
- Endoscopic Biliary Stenting, Surgical treatment Bilio-enteric anastomosis
- Where
- 7 sites in France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Lille
Pancreatitis, Chronic, Pancreatitis
Celiac Plexus Block for Chronic Pancreatitis RCT
Rationale: Chronic pancreatitis is a chronic inflammatory disease of the pancreas which results in debilitating abdominal pain, decreased productivity and increased health care costs.
- Trial name
- NCT02399800
- Testing
- Celiac Block with triamcinolone and bupivicaine, No Celiac Block, Intra Plexus Triamcinolone and Bupivicaine Injection
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Southern California
Chronic Pancreatitis
Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis
The objective is to evaluate the dietary nitrogen assimilation and metabolic utilisation capability of patients with chronic pancreatitis.
- Trial name
- NCT00957151
- Testing
- Creon
- Volunteers
- 12 people
- Sponsor
- Hospital Avicenne
Chronic Pancreatitis, Pancreatogenic Type 3C Diabetes Mellitus
Evaluation of OGTT in Patients With Post-pancreatitis Diabetes Mellitus for Diagnosis and Characterization
To evaluate the islet function and insulin secretion pattern of post-pancreatitis diabetes mellitus by oral glucose tolerance testing, and to explore the pathophysiological characteristics of PPDM-C which provide evidence for the…
- Conditions
- Chronic Pancreatitis, Pancreatogenic Type 3C Diabetes Mellitus, Diabetes Mellitus, Oral Glucose Tolerance Test
- Trial name
- NCT05989867
- Testing
- blood test, Continuous Glucose Monitor
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Changhai Hospital
Exocrine Pancreatic Insufficiency
An Open-Label Study to Evaluate the Intraduodenal Delivery of Enzymes From Administration of VIOKASE16 in Exocrine Pancreatic Insufficiency (EPI)
EPI leading to maldigestion is a frequent finding in many diseases of the pancreas, such as chronic pancreatitis (CP). Steatorrhea is the most important digestive manifestation in EPI.
- Trial name
- NCT00559052
- Testing
- VIOKASE 16
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Axcan Pharma
Pancreatitis
Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis
Pancreatic exocrine insufficiency is known to impair nutrient absorption, especially fat, but few data exist about protein absorption.
- Trial name
- NCT01154608
- Testing
- Creon, No enzyme therapy
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Islets of Langerhans Transplantation, Diabetes Mellitus
Arginine-stimulated Indication of Early Outcome After Islet Transplantation
Through islet transplantation, functional β-cell mass can be restored. Allogeneic islet transplantation is a treatment modality for a select group of patients with complicated type 1 diabetes mellitus.
- Conditions
- Islets of Langerhans Transplantation, Diabetes Mellitus, Chronic Pancreatitis
- Trial name
- ALADDIN (NCT05540197)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Acute Recurrent Pancreatitis, Chronic Pancreatitis
Secretin Enhanced MRCP for Evaluation of Pancreatic Duct in Pediatric Population
1. To assess the effect of RG1068 at a dose of 0.2 mcg/kg intravenously (IV) on the diameter of the pancreatic duct when used during Magnetic Resonance Pancreatography. 2.
- Trial name
- NCT00621283
- Testing
- RG1068 (Synthetic Human Secretin)
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Pancreatitis, Chronic, Pancreatectomy; Hyperglycemia
A Prospective Observational Study of TPIAT
Multi-center, prospective, observational cohort study of patients undergoing total pancreatectomy with islet autotransplantation (TPIAT)
- Conditions
- Pancreatitis, Chronic, Pancreatectomy; Hyperglycemia, Pancreatitis
- Trial name
- POST (NCT03260387)
- Testing
- TPIAT
- Where
- 12 sites in United States
- Volunteers
- 433 people
- Sponsor
- University of Minnesota
Chronic Pancreatitis, Pancreatectomy
A Study to Investigate the Effect of Delayed Release Pancrelipase on Maldigestion in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis and Pancreatectomy
This study assessed the effect of pancrelipase delayed release capsules on fat and nitrogen absorption in subjects with PEI due to Chronic Pancreatitis and Pancreatectomy.
- Conditions
- Chronic Pancreatitis, Pancreatectomy, Pancreatic Exocrine Insufficiency
- Trial name
- NCT00414908
- Testing
- Pancrelipase delayed release capsule
- Where
- 30 sites in United States, Bulgaria and 6 more
- Volunteers
- 52 people
- Sponsor
- Solvay Pharmaceuticals
Chronic Pancreatitis, Acute Recurrent Pancreatitis
Internet Based Cognitive Behavioral Therapy in Pediatric Chronic Pancreatitis
Abdominal pain is common in children with chronic and acute recurring pancreatitis (CP, ARP), and as they continue into adulthood, the disease progresses with increased pain and greater exposure to opioids.
- Trial name
- NCT03707431
- Testing
- Web-based CBT, Pain Education
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Seattle Children's Hospital
Chronic Pancreatitis, Respiratory Insufficiency
Is There an Association Between Chronic Pancreatitis and Pulmonary Function
To evaluate pulmonary function in chronic pancreatitis compared with healthy volunteers and patients with cirrhosis.
- Conditions
- Chronic Pancreatitis, Respiratory Insufficiency, Cirrhosis, Liver, Lung Function Decreased
- Trial name
- RespPanc (NCT03850977)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Painful Chronic Pancreatitis, Visceral Pain
Neuromodulation in Patients With Painful Chronic Pancreatitis
The purpose of this trial is to explore if a novel vagal neuromodulation approach provides analgesic benefit through central mechanisms in patients with chronic pancreatitis
- Conditions
- Painful Chronic Pancreatitis, Visceral Pain, Neuropathic Pain
- Trial name
- NCT03357029
- Testing
- GammaCore Device
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Jens Brøndum Frøkjær
Pancreatitis, Chronic
Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis
The purpose of this study is to determine the efficacy of 2 different doses of intramuscular (IM) vitamin D3 as compared to an oral replacement dose in normalizing vitamin D levels in the blood of patients with tropical calcific…
- Trial name
- NCT00956839
- Testing
- Vitamin D3 (Cholecalciferol)
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Chronic Pancreatitis, Exocrine Pancreas Carcinoma
Biospecimen Collection to Identify Gene Mutations for High Risk Pancreatic Cancer in Pediatric Patients, INSPPIRE 2 Study
This clinical trial collects blood, saliva, urine, or stool samples to help identify possible genetic mutations that may increase a person's chance at developing pancreatic cancer.
- Conditions
- Chronic Pancreatitis, Exocrine Pancreas Carcinoma, Recurrent Acute Pancreatitis
- Trial name
- NCT06651580
- Testing
- Biospecimen Collection, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 26 sites in United States, Australia and 2 more
- Volunteers
- 1,600 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Pancreatitis, Mesenchymal Stem Cells
Autologous Mesenchymal Stromal Cells and Islet Co-transplantation in TP-IAT
This is a clinical trial for chronic pancreatitis (CP) patients undergoing total pancreatectomy with islet autotransplantation (TP-IAT).
- Trial name
- NCT05095532
- Testing
- Bone marrow-derived mesenchymal stem cells
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Medical University of South Carolina
Chronic Pancreatitis
Translation and Validation of Chinese COMPAT-SF
The goal of this observational study is to translate, adapt, and test the reliability of a Chinese version of the Comprehensive Pain Assessment Tool Short Form (COMPAT-SF) for people with chronic pancreatitis.
- Trial name
- COMPAT-SF-CV (NCT06917716)
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Chronic Pain
Novel Cellular Therapy for the Treatment of Pain Associated With Chronic Pancreatitis
The goal of this clinical trial is to test whether adult stem cells, called mesenchymal stem cells (MSCs) collected from the patient's bone marrow can help reduce pain caused by chronic pancreatitis and improve pancreatic…
- Trial name
- MSCPainRelief (NCT05925036)
- Testing
- Mesenchymal stem cells
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Chronic Pancreatitis
Endoscopic Stenting for Chronic Abdominal Pain
The prospective sham randomized study will evaluate the role of endoscopic stenting inpatients with chronic pancreatitis and chronic abdominal pain.
- Trial name
- NCT00754676
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Leigh Powell
Chronic Pancreatitis
Safety And Efficacy Of Tanezumab In Patients With Chronic Pancreatitis
Tanezumab is effective in reducing the pain associated with chronic pancreatitis.
- Trial name
- NCT01146561
- Testing
- Tanezumab
- Where
- 9 sites in United States
- Volunteers
- 2 people
- Sponsor
- Pfizer