Clinical trials: Rectal Fistulas
Rectal Fistula
Photodynamic Therapy in Anal Fistula
Objective: Validate and analyze the results of intralesional photodynamic therapy in the treatment of complex anal fistula. Methods: Prospective observational study including patients treated for complex anal fistula who…
- Trial name
- NCT03864718
- Testing
- photodynamic therapy
- Volunteers
- 49 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Anal Fistula
RCT on LIFT Versus Modified Parks Technique Versus Two-Stage Seton
LIFT is a sphincter-saving procedure that is based on the concept of secure closure of the internal opening and concomitant removal of infected cryptoglandular tissue in the intersphincteric plane.
- Trial name
- NCT04377542
- Testing
- LIFT, Parks, Seton
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Mansoura University
Anal Fistula Surgery, Anal Fistula
Impact of Surgical Timing on Anal Fistula Outcomes
This study aims to evaluate if the amount of time a person experiences symptoms of an anal fistula before having surgery affects their surgical outcomes and recovery.
- Conditions
- Anal Fistula Surgery, Anal Fistula, Surgery Timing
- Trial name
- NCT07482241
- Volunteers
- 90 people
- Sponsor
- Assiut University
Crohn's Disease, Anal Fistula
Study to Assess the Safety and Efficacy of Expanded Allogenic Adipose-derived Stem Cells (eASCs) (Cx601), for Treatment of Complex Perianal Fistulas in Perianal Crohn's Disease.
The purpose of this study is to asses the safety and efficacy of adipose-derived adult stem cells from healthy donnors for treatment of complex perianal fistulas in Crohn's disease.
- Trial name
- NCT01372969
- Testing
- Cx601
- Where
- 6 sites in Spain
- Volunteers
- 24 people
- Sponsor
- Tigenix S.A.U.
Crohn Disease, Rectal Fistula
A Study Using Artificial Intelligence to Identify Adults With Complex Perianal Fistulas Associated With Crohn's Disease
Natural Language Processing and machine learning are examples of artificial intelligence tools. This study will check if these tools correctly identify people with Crohn's disease with complex perianal fistulas from their medical…
- Trial name
- INTUITION-CPF (NCT04844593)
- Where
- 3 sites in Spain
- Volunteers
- 32 people
- Sponsor
- Takeda
Anal Fistula, Rectal Fistula
Mechanical Bowel Preparation Prior To Sphincter-Sparing Surgery For Complex Anal Fistulae
The goal of this clinical trial is to learn whether bowel preparation with Plenvu before surgery improves healing of complex anal fistula in adults aged 18 to 64 years with a fistula of cryptoglandular origin or associated with…
- Conditions
- Anal Fistula, Rectal Fistula, Crohn Disease
- Trial name
- PLEN-SPARE (NCT07897539)
- Testing
- Mechanical bowel preparation
- Where
- Sweden
- Volunteers
- 116 people
- Sponsor
- Region Skane
Anal Fistula Surgery, Transsphincteric Anal Fistula
Modified LIFT Versus Standard LIFT for Transsphincteric Anal Fistula
This study evaluated two sphincter-preserving surgical techniques for transsphincteric anal fistula: standard ligation of the intersphincteric fistula tract (LIFT) and modified LIFT via a lateral approach.
- Trial name
- NCT07603635
- Testing
- Standard LIFT, Modified LIFT via a Lateral Approach
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Tugberk Tok
Fistula in Ano
Long Term Outcomes After Surgery for Anal Fistula
Anal fistula is a common condition with a wide variety of clinical presentations, which can make evaluation and treatment challenging and surgical outcomes uncertain.
- Trial name
- NCT04588701
- Testing
- surgical procedures commonly done for anal fistula
- Volunteers
- 483 people
- Sponsor
- University of Michigan
Anal Fistula
Fistulectomy and Primary Sphincter rEconstruction vs. endorectaL Advancement Flap in the Treatment of High Anal Fistulas
The optimal method of surgical treatment of complex anorectal fistulas has not been found yet. The aim of this study is to compare two techniques in treatment of high anorectal fistulas.
- Trial name
- SELF (NCT04119700)
- Testing
- Muco-muscular endorectal advancement flap after fistulectomy, Primary sphincter reconstruction after fistulectomy
- Where
- Russia
- Volunteers
- 142 people
- Sponsor
- Russian Society of Colorectal Surgeons
Anal Fistula, Crohn's Disease
Long-term Follow-up of Anal Fistulae in Crohn's Disease Treated With Anti-TNFalpha and Interest of New MRI Sequences
Main purposes of this study are : Analysis of relapse risk of anal fistulae with prospective follow-up of patients undergoing pelvic MRI every 6 months for one year.
- Trial name
- FISTULE (NCT02883296)
- Testing
- Pelvis Magnetic resonance imaging
- Volunteers
- 15 people
- Sponsor
- Central Hospital, Nancy, France
Anal Fistula
Multicenter Prospective Evaluation of Radiofrequency for Anal Fistulas
Anal fistula treatment is associated with increasing risk of anal incontinence until 40% of cases. New and alternative treatments (glue, advancement flap, plug…) decrease this risk, but with fistula efficacy treatment in 40 to…
- Trial name
- RADIOFIST (NCT03131297)
- Testing
- treatment by radiofrequency
- Where
- 4 sites in France
- Volunteers
- 50 people
- Sponsor
- F Care Systems NV
Simple Anal Fistula
Effect of Platelet-Rich Plasma Injection on Wound Healing After Fistulotomy for Simple Anal Fistula Randomized Controlled Trial (RCT)
Anal fistula is a common benign anorectal condition characterized by an abnormal tract between the anal canal and perianal skin, often resulting from cryptoglandular infection.
- Trial name
- PRPIWHAFSAFRCT (NCT07248007)
- Testing
- PRP injection
- Volunteers
- 70 people
- Sponsor
- Assiut University
Perianal Abscess, Anal Fistulas
Multicenter Study for Diagnosis and Treatment of Perianal Abscesses
Drainage of perianal abscesses is a well established treatment. Traditionally its been done in general anesthesia after the swelling has been localised its been drained with a knife.
- Conditions
- Perianal Abscess, Anal Fistulas, Incontinence
- Trial name
- NCT02306382
- Testing
- Perianal abscess drainage, 3D ultrasonography
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- University Hospital, Umeå
Fistula in Ano, Crohn Disease
Autologous Stem Cells in the Management of Fistulating Perianal Crohn's Disease
Crohn's disease is a chronic inflammatory condition that can affect any part of the bowel which can be controlled by a combination of medical and surgical treatments but cannot be cured.
- Trial name
- NCT06822686
- Testing
- Harvest and injection of stem cells
- Sponsor
- Oxford University Hospitals NHS Trust
Fistula in Ano
Fistula-in-ano in Infants and Children
In this prospective, randomized trail, duration of non-cutting seton placement in patients with fistula-in-ano is evaluated.
- Trial name
- NCT05666609
- Testing
- placement of non-cutting seton (silicone)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Anal Fistula
Tissue Therapy of Transsphincteric Anal Fistula
This clinical study aims to evaluate the outcome of the treatment of complex perianal fistulas (PAF) by the combination of minimal surgical debridement with regenerative cellular therapeutics.
- Trial name
- REP-PAF (NCT06303752)
- Testing
- ADRC injection, ADRC001 injection
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- University of Southern Denmark
Crohn Disease, Rectal Fistula
A Study of the Quality of Life in Adults With Crohn's Disease With Complex Perianal Fistulas
The main aim of the study is to assess the quality of life of people with Crohn's disease after treatment for complex perianal fistulas (CPF) in a standard clinic setting.
- Trial name
- CONFLICT (NCT04876690)
- Where
- 5 sites in Portugal
- Volunteers
- 15 people
- Sponsor
- Takeda
Anal Fistula, Crohn Disease
Stem Cells Treatment of Complex Crohn's Anal Fistula
A pilot study to investigate the safety and feasibility of stem cells treatment of complex anal fistula in patients with Crohn's disease.
- Trial name
- fistula (NCT03466515)
- Testing
- stem cells injection
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- University of Southern Denmark
Transsphincteric Anal Fistula
Ligation of Intersphincteric Track (LIFT) Versus Fistulectomy in Trans-sphincteric Anal Ffistula.
78 patients with transsphincteric fistula allocated into two groups group A underwent LIFT group B u nderwent fistulectomy , comparison between the outcome og both procedures
- Trial name
- professor (NCT04351074)
- Testing
- LIFT, fistulectomy
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Zagazig University
Anal Fistula, Complex Perianal Fistula
Evaluating an rhPDGF-BB-enhanced Collagen Plug for Perianal Fistula Healing
The average success rate for healing and remission of complex perianal fistulas, idiopathic or Crohn's-related, is approximately 50%.
- Trial name
- NCT06632418
- Testing
- RhPDGF-BB
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Alexander Hawkins