Clinical trials: Rds
Preterm, Premature
Effects of Kinesiotaping on Respiratory Muscles in Very Preterm Infants
This study aimed to evaluate the effects of kinesio taping on blood gas parameters, respiratory rate, heart rate, oxygen saturation, and pressure limits in preterm infants with RDS who are on NIV.
- Conditions
- Preterm, Premature, Infant, Newborn, Diseases, Respiratory Distress Syndrome
- Trial name
- NCT06285669
- Testing
- kinesiotaping application
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Ondokuz Mayıs University
Acute Respiratory Distress Syndrome
Safety and Tolerance of Umbilical Cord Mesenchymal Stem Cells in Patients With Acute Respiratory Distress Syndrome
The goal of this clinical trial is to evaluate the safety and tolerability of multiple doses of human umbilical cord mesenchymal stem cell injection in patients with Mild to Moderate Acute Respiratory Distress Syndrome (ARDS)…
- Trial name
- NCT05983627
- Testing
- Human Umbilical Cord Mesenchymal Stem Cells
- Volunteers
- 9 people
- Sponsor
- Asia Cell Therapeutics (Shanghai) Co., Ltd.
Respiratory Distress Syndrome, Adult
Role of Vascular Endothelial Growth Factor (VEGF) in Acute Lung Injury/Adult Respiratory Distress Syndrome (ARDS)
Understanding the role VEGF plays in ARDS consequently provides an ideal opportunity to discover new therapies for ARDS.
- Trial name
- NCT00319631
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Cardiac Disease
Efficacy and Safety of Sivelestat in Preventing Postoperative Acute Lung Injury or Acute Respiratory Distress Syndrome After Cardiac Surgery
The aim of this study is to assess the effectiveness and safety of sivelestat sodium in preventing acute lung injury and/or acute respiratory distress syndrome (ALI/ARDS) following cardiac surgery, with the objective of providing…
- Trial name
- NCT06276569
- Testing
- Sivelestat
- Where
- China
- Volunteers
- 382 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Respiratory Distress Syndrome, Adult, Multi-antibiotic Resistance
Multi-drug Resistant Gram-negative Bacteria and Veno-venous Extracorporeal Membrane Oxygenation (ECMO)
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-support technique used in patients with most severe acute respiratory distress syndrome (ARDS).
- Trial name
- MDR-ECMO (NCT06199141)
- Where
- Italy
- Volunteers
- 279 people
- Sponsor
- University of Padova
Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury
Esophageal Pressure-Guided Optimal PEEP/mPaw in CMV and HFOV: The EPOCH Study
The use of positive end-expiratory pressure (PEEP) has been shown to prevent the cycling end-expiratory collapse during mechanical ventilation and to maintain alveolar recruitment, keeping lung portions open, increasing the…
- Trial name
- EPOCH (NCT02342756)
- Testing
- Targeting transpulmonary pressure to avoid VILI
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Toronto
Acute Lung Injury, Acute Respiratory Distress Syndrome
Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients
sRAGE, the soluble form of the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury, but is also involved in acute systemic inflammation.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Severe Sepsis, Septic Shock
- Trial name
- NCT00811629
- Testing
- sRAGE
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Respiratory Distress Syndrome, Conventional Mechanical Ventilation
Invasive Ventilation for Neonates With Acute Respiratory Distress Syndrome(ARDS)
Acute respiratory distress syndrome (ARDS) in neonates has been defined in 2017.The death rate is over 50%. HFOV and CMV are two main invasive ventilation strategies. However, which one is better needing to be further elucidated.
- Conditions
- Acute Respiratory Distress Syndrome, Conventional Mechanical Ventilation, High Frequency Oscillation Ventilation
- Trial name
- NCT03591796
- Testing
- HFOV, CMV
- Where
- China
- Volunteers
- 386 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Severe Influenza, Intensive Care (ICU)
Early Corticosteroids in Severe Influenza Pneumonia
This is a Phase III, multicentre, randomized, controlled, double-blind, superiority trial aiming to evaluate the efficacy of dexamethasone versus placebo in patients admitted to intensive care or intermediate care with influenza…
- Conditions
- Severe Influenza, Intensive Care (ICU), Reanimation, Infectious Diseases
- Trial name
- ECSIP (NCT07786662)
- Testing
- Dexametasone
- Where
- 48 sites in France
- Volunteers
- 544 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Chemical Injury, Chemicals; Intoxication
The Medical Management in Patients Exposed to Weapons of Mass Destruction
Observation study measuring medical response in contaminated environment.
- Conditions
- Chemical Injury, Chemicals; Intoxication, Acute Respiratory Distress Syndrome, Distress Respiratory Syndrome
- Trial name
- CBRNEObs (NCT05026645)
- Testing
- Clinical interventions performed in acute settings (contaminated environment), Protection (clinician and patient), Decontamination (clinician and patient)
- Where
- 15 sites in United States, Canada and 4 more
- Volunteers
- 1,000 people
- Sponsor
- St. Justine's Hospital
Acute Respiratory Distress Syndrome
Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study)
Numerous trials support the efficacy and safety of volatile anesthetic agents, namely inhalation of sevoflurane through dedicated devices, for the sedation of ICU patients.
- Trial name
- SEGA (NCT02166853)
- Testing
- sevoflurane, midazolam
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pneumonia, Diaphragm; Movement
Evaluation of the Relevance of Diaphragmatic Stroke Ultrasound for the Etiological Diagnosis of Acute Respiratory Distress in an Emergency Department.
The goal of this Prospective interventional multicenter diagnostic study is to investigate the use of diaphragmatic ultrasound (DE) as a diagnostic tool in an adult emergency department for patients in acute respiratory distress.
- Conditions
- Pneumonia, Diaphragm; Movement, Diaphragmatic Ultrasound, Emergency Medical Services
- Trial name
- EchoDiaph (NCT06650137)
- Testing
- diaphragmatic ultrasound
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Respiratory Distress Syndrome (RDS) of Neonate
Non-invasive Ventilation With Neurally Adjusted Ventilatory Assist Versus Nasal Continuous Airway Pressure in Premature Infants
The purpose of this study is to compare if a new noninvasive ventilation mode (NIV NAVA) is better in noninvasive ventilation of premature infants than currently used Nasal Continuous Airway Pressure (ncpap), and if NIV NAVA…
- Trial name
- NIV NAVA (NCT01624012)
- Testing
- NIV NAVA, Nasal continuous positive airway pressure
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- University of Oulu
ARDS
PRONing to Facilitate Weaning From ECMO in Patients With Refractory Acute Respiratory Distress Syndrome
ECMO has emerged as a promising intervention that may provide more efficacious supportive care to patients with refractory severe acute respiratory distress syndrome (ARDS).
- Trial name
- PRONECMO (NCT04607551)
- Testing
- Prone positionning, Supine position
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-invasive Ventilatory Support, Infant Respiratory Distress Syndrome
Observational Study in Preterm Neonates Who Are Sufficiently Stable on Non-Invasive Ventilatory Support
The purpose of this observational study is to collect data on vital signs, oxygen requirements and other data related to ventilator care in preterm neonates under standard of care treatment.
- Trial name
- NCT01861795
- Testing
- Preterm Neonates
- Where
- 3 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Takeda
Covid-19
Coronavirus Response - Active Support for Hospitalised Covid-19 Patients
The CRASH-19 trial is a multinational, open-label, factorial, randomised trial in adults hospitalised with suspected or confirmed acute COVID-19 infection.
- Trial name
- CRASH-19 (NCT04343001)
- Testing
- Aspirin, Losartan, Simvastatin
- Where
- 2 sites in Nigeria, Pakistan
- Sponsor
- London School of Hygiene and Tropical Medicine
COVID-19 Acute Respiratory Distress Syndrome, Cytokine Release Syndrome
Tazemetostat for the Treatment of Moderate to Severe COVID-19 Infection
The purpose of this study is to assess the safety and efficacy of repurposing tazemetostat for the treatment of Acute Respiratory Distress Syndrome (ARDS) or Systemic Cytokine Release Syndrome (SCRS) in COVID-19 patients.
- Trial name
- IST (NCT05018975)
- Testing
- Tazemetostat
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Diaphragm Injury, Pathology
Effects of Mechanical Ventilation on the Diaphragm in COVID-19 Intensive Care Patients. A Post-mortem Pathology Study
The diaphragm is the fundamental muscle of the respiratory system. The diaphragmatic dysfunction is present in 60% of critical patients at hospital admission and up to 80% after prolonged mechanical ventilation and difficult…
- Conditions
- Diaphragm Injury, Pathology, COVID-19 Acute Respiratory Distress Syndrome, Ventilation Therapy; Complications
- Trial name
- NCT05191433
- Where
- 2 sites in Italy
- Volunteers
- 41 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Covid19, Lung Injury
Melatonin Agonist on Hospitalized Patients With Confirmed or Suspected COVID-19
COVID-19 is impacting on health systems in Brazil and worldwide. Reducing the risk of clinical deterioration and prolonged disease duration in hospitalized patients with COVID-19 may alleviate the burden caused by the pandemic.
- Trial name
- NCT04470297
- Testing
- Ramelteon 8mg
- Volunteers
- 100 people
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Acute Respiratory Distress Syndrome, Acute Lung Injury
Effects of PEEP and FIO2 in ALI and ARDS
Current American-European Consensus Conference (AECC) definitions for ALI and ARDS are inadequate for inclusion into clinical trials due to the lack of standardization for measuring the oxygenation defect.
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Acute Respiratory Failure
- Trial name
- HELP (NCT00435110)
- Testing
- standard ventilatory settings, PEEP and FiO2
- Where
- Spain
- Volunteers
- 178 people
- Sponsor
- Instituto Canario de Investigacion Biomedica