Clinical trials: Randomized Clinical Trial
Adhesive Capsulitis
Adhesive Capsulitis and Dynamic Splinting
The purpose of this study is to examine the efficacy of dynamic splinting in reducing contracture following diagnosis of adhesive capsulitis.
- Trial name
- NCT01874821
- Testing
- Dynasplint, Standard of Care
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Dynasplint Systems, Inc.
Post Operative Pain, Acute
Postoperative Pain After Dexamethasone Injection by Two Techniques in Irreversible Pulpitis
The aim of this randomized clinical trial to evaluate the effect of dexamethasone in two different techniques on postoperative pain by dividing patients randomly into three groups: Group I: buccinator injection of dexamethasone.
- Trial name
- Dex/postop (NCT07755306)
- Testing
- dexamethasone 8mg
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Knee Arthropathy, Postoperative Pain
Evaluation of a Fast-track Knee Arthroplasty Concept
Mobilisation following knee arthroplasty is an important aspect to achieve early and enhanced recovery after surgery and sufficient joint function. Analgesia is a crucial therapeutic element in this context.
- Conditions
- Knee Arthropathy, Postoperative Pain, Postoperative Complications
- Trial name
- KneeOptOut (NCT03114306)
- Testing
- local infiltration analgesia, regional-anaesthesiological catheter analgesia
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Recurrent or Metastatic Gastric Cancer
Trial of 4-regimen (SP, FL/Tax, FL/Doc, FOLFOX) in Patients With Recurrent or Metastatic Gastric Cancer
This study is to evaluate the antitumor activity (i.e. progression free survival, overall survival, response rate, etc), safety and quality of life in patient with recurrent or metastatic gastric cancer during 4-regimen (i.e.
- Trial name
- NCT01283204
- Testing
- SP, FL/Tax, FL/Doc
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Yonsei University
Malocclusion, Anxiety
Patient Education Before Orthognathic Surgery
To evaluate the effectiveness in the use of an educational material through: Assessment of knowledge about post-operative orthognathic surgery; assessing levels of anxiety with the survey of Anxiety Inventory-STATE-TRAIT…
- Conditions
- Malocclusion, Anxiety, Micrognathism, Prognathism
- Trial name
- NCT01803204
- Testing
- Booklet - Preoperative Educational
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- University of Sao Paulo
Postoperative Complications
GDFT on the Postoperative Outcome in Head and Neck Cancer Surgery
The goal of this clinical trial is to evaluate whether goal-directed fluid therapy (GDFT) can improve the postoperative recovery in patients undergoing head and neck cancer surgery.
- Trial name
- NCT06468852
- Testing
- Goal-Directed Fluid Therapy
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Beijing Tongren Hospital
Endocarditis
Early Valve Surgery Versus Conventional Treatment in Infective Endocarditis Patients With High Risk of Embolism
Infective endocarditis (IE) is associated with an overall in-hospital mortality rate of 15-25% and a high incidence of embolic events (20-50%).
- Trial name
- CHIRURGENDO (NCT03718052)
- Testing
- Early valve surgery (EVS), Conventional Care
- Where
- France
- Volunteers
- 73 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease, Myocardial Ischemia
Role of Plavix in Hemorrhagic and Ischemic Complications of Catheterization.
Patients who have stents placed in their coronary arteries require treatment with at least two medications to prevent platelets from sticking to the stainless steel stent and forming a blood clot that can result in a heart…
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Bleeding
- Trial name
- NCT00421252
- Testing
- clopidogrel 600 mg, arterial access sheath
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Beth Israel Deaconess Medical Center
Rheumatoid Arthritis (RA)
Safety and Efficacy of MK-8457 and Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Despite MTX Therapy (P08683, MK-8457-008)
The purpose of this study is to assess the safety and efficacy of MK-8457 + Methotrexate (MTX) in participants with active rheumatoid arthritis (RA) despite MTX therapy.
- Trial name
- NCT01569152
- Testing
- MK-8457 100 mg, Methotrexate
- Volunteers
- 82 people
- Sponsor
- Merck Sharp & Dohme LLC
Post-concussion Syndrome, Post-concussive Symptoms
PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin
PURPOSE: The long-term goal of this line of research is to develop rational, biologically based evidence for the treatment of post-concussion syndrome (PCS) in children.
- Conditions
- Post-concussion Syndrome, Post-concussive Symptoms, Traumatic Brain Injury, Concussion
- Trial name
- PLAYGAME (NCT01874847)
- Testing
- Melatonin, Sugar pill
- Where
- Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Inactivity, Physical, Lifestyle Risk Reduction
Effects of a Lifestyle and Sleep Intervention in Non-exercising Adults
Background. Cardiovascular diseases (CVDs) are the leading cause of premature mortality and disability accounting for one third of all deaths worldwide with considerable impacts on economics and on quality of life.
- Trial name
- SPIRAL+ (NCT06424847)
- Testing
- Lifestyle intervention (physical activity and diet), Lifestyle (physical activity and diet) and Sleep intervention, Health education intervention
- Where
- France
- Volunteers
- 201 people
- Sponsor
- University Hospital, Grenoble
Hemorrhoids, Postoperative Pain
Pudendal Nerve Block Techniques for Pain Control After Hemorrhoidectomy
Hemorrhoidectomy is frequently associated with severe postoperative pain despite multimodal analgesia. Ultrasound-guided pudendal nerve block has become an effective regional analgesic technique, but it remains unknown whether…
- Trial name
- PINPOINT (NCT07813338)
- Testing
- Transgluteal Pudendal Nerve Block, Transperineal pudendal nerve block
- Volunteers
- 140 people
- Sponsor
- Vinmec Healthcare System
Temporomandibular Disorders (TMD)
Effects of Occlusal Splint vs Occlusal Splint Added to Manual Therapy in Patients With Temporomandibular Disorders
A randomized clinical trial evaluates physiotherapy plus splint treatment versus conventional splint treatment in patients with myofascial-origin temporomandibular disorder (TMD).
- Trial name
- MTvsOS (NCT06859138)
- Testing
- Manual Therapy, Splint therapy
- Where
- Spain
- Volunteers
- 38 people
- Sponsor
- University of Jaén
Healthy
Effects of InFat™ Product on Stool Biochemistry and Stool Characteristics in Formula-fed Term Chinese Infants
The purpose of this study is to demonstrate the efficacy of infant formula having proportion of palmitate in the sn-2 position comparable to human milk in Chinese term infants.
- Trial name
- NCT00480948
- Testing
- Infant formula feeding (InFat™), Control
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Enzymotec
Shivering
Prophylactic Mirtazapine or Dexamethasone for Post-spinal Anesthesia Shivering
This study was conducted to evaluate the effect of a prophylactic dose of oral mirtazapine on shivering compared with prophylactic intravenous infusion (IVI) dexamethasone in patients undergoing gynecological surgeries under…
- Trial name
- NCT03675555
- Testing
- Mirtazapine, Dexamethasone phosphate
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ain Shams University
Urogenital Prolapse
LAparoscopic Preventive PRErectal Mesh
Urogenital prolapse is a frequent and invalidating pathology in women, involving the anterior vaginal wall and the uterus in most cases. Posterior vaginal wall prolapse is present in only 50% of cases.
- Trial name
- LAPREM (NCT03766048)
- Testing
- Single-Anterior-Mesh, SAM, Double-Mesh, DM
- Where
- 9 sites in France
- Volunteers
- 834 people
- Sponsor
- University Hospital, Lille
Autism
Evaluating Pathways Mutual Gaze Protocol on Social Skills in Young Children Suspected of Autism
Purpose of the Study: The goal of this clinical trial is to find out if a technique called the "mutual gaze procedure," used in Pathways Early Intervention (Pathways), is the key to helping improve social communication, language…
- Trial name
- NCT06596226
- Testing
- Pathways Parent Mediated Intervention, Pathways Parent Mediated Intervention without Mutual Gaze
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas at Dallas
Covid19
Hyperbaric Versus Normobaric Oxygen Therapy for COVID-19 Patients
At least 1 in 6 COVID-19 patients admitted to hospital to receive extra oxygen will die of complications. In patients with COVID-19, invasive treatment such as mechanical ventilation (e.g.
- Trial name
- NCT04500626
- Testing
- Oxygen
- Where
- 2 sites in Canada
- Volunteers
- 234 people
- Sponsor
- Ottawa Hospital Research Institute
Otorhinolaryngologic Diseases
Evaluation of Office-Based Sheathed Flexible Nasopharyngoscopy
The processing of standard flexible nasopharyngoscopes is a time-consuming and costly process. The goal of this study is to determine the efficiency and cost-effectiveness of sheathed flexible endoscope in an office setting.
- Trial name
- NCT01669278
- Testing
- Endosheath
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Bronchiolitis, Viral
Single Injection of Dexamethasone for Acute Bronchiolitis in Young Children
The purpose of this study was to determine whether a single intramuscular injection of dexamethasone decreased the duration of symptoms of acute bronchiolitis in young children.
- Trial name
- NCT00122785
- Testing
- dexamethasone
- Where
- Thailand
- Volunteers
- 170 people
- Sponsor
- Khon Kaen University