Clinical trials: Randomised Controlled Trial
Influenza, Human
Tropical Influenza Control Strategies for the Elderly
TROPICS1 is a randomized, observer-blind, active comparator-controlled, single-center, Phase IV trial in 200 participants aged ≥65 years.
- Trial name
- TROPICS1 (NCT02655874)
- Testing
- Influenza vaccine, Tetanus-diphtheria-pertussis vaccine
- Where
- Singapore
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Coronary Arterial Disease (CAD), Angina (Stable)
The Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow
The goal of this clinical trial is to investigate the effect of sublingual nitroglycerin on absolute coronary blood flow in adult patients undergoing coronary angiography.
- Trial name
- FLOW-NITRO (NCT06823843)
- Testing
- Glycerin trinitrate (GTN)
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Respiratory Tract Infections, Influenza
Trial of Vitamin D Supplementation for the Prevention of Influenza and Other Respiratory Infections (ViDiFlu)
Purpose: The study null hypothesis is that vitamin D supplementation will not influence time to acute respiratory tract infection in sheltered accommodation residents.
- Trial name
- ViDiFlu (NCT01069874)
- Testing
- Cholecalciferol (Vitamin D/Vigantol oil), Miglyol oil
- Where
- 2 sites in United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Major Depressive Disorder (MDD), Neuroimaging
Efficacy of Bright Light Therapy on Cognitive Impairment in Major Depressive Disorder and Its Neuroimaging Mechanisms: Protocol for a Randomised Controlled Trial
This study aims to validate the therapeutic efficacy and safety of bright light therapy (BLT) in ameliorating cognitive impairment (CI) in major depressive disorder (MDD), characterize the functional and structural features of…
- Conditions
- Major Depressive Disorder (MDD), Neuroimaging, Bright Light Treatment, Cognitive Impairment
- Trial name
- NCT07508215
- Testing
- BLT, DRL
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University Sixth Hospital
Compliance, Patient
Treatment of Latent Tuberculosis in Socially Marginalised Citizens
An open-label, randomised controlled trial comparing compliance to treatment for latent tuberculosis infection in socially marginalised citizens.
- Trial name
- DOT-LTBI (NCT03266991)
- Testing
- Rifapentine, Isoniazid
- Where
- 2 sites in Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Dental Plaque
Effect of the SIMS Programme on Preschool Children's Oral Hygiene Level
This is a cluster randomised control trial targeting 5-6-year-old children and their parents in Kampar district, Perak, Malaysia for a period of 6 months.
- Trial name
- SIMSP (NCT04339647)
- Testing
- The SIMS programme
- Where
- Malaysia
- Volunteers
- 653 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Dental Caries in Children
The Effectiveness of Dental Health Home Visits on Caries Prevention in Young Children
Tooth decay affects 75% of Malaysian preschool children, most of which remain untreated. Untreated decay can cause pain, and impair nutritional status and physical growth.
- Trial name
- NCT04885348
- Testing
- Intervention Group (Dental Home Visits + Dental Home Education Leaflets), Control Group (Dental Home Education Leaflets)
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- Ministry of Education, Malaysia
Drug Interactions
S(+)-Ibuprofen Effects on Asprin Treated Volunteers
The purpose of this clinical trial is to determine whether S(+)-ibuprofen affect the platelet inhibition under steady state acetylsalicylic acid conditions.
- Trial name
- NCT00442585
- Testing
- S(+)-ibuprofen
- Where
- Austria
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gebro Pharma GmbH
Active Root Caries, Over Sixty-five Years of Age
Treatment of Root Caries in an Older Irish Population.
This study will involve filling teeth which have decay on their roots with three different filling materials. Patients will attend Cork University Dental School and hospital for a clinical examination and to complete a…
- Conditions
- Active Root Caries, Over Sixty-five Years of Age, >=Two Carious Root Surfaces Per Patient
- Trial name
- NCT01866059
- Testing
- Calcium silicate cement, Glass Ionomer Cement, Resin Modified Glass Ionomer Cement
- Where
- Ireland
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University College Cork
Overconsumption, Obesity
Nutri-score Labels on the Nutritional Quality of Out-of-home Food Selection
Participants will be asked to make hypothetical food choices in an online simulation study of an OOH delivery app. This study will be a three-arm randomised controlled design, with intervention type as the 3-level grouping…
- Trial name
- NCT07423845
- Testing
- Labelling condition - Calorie labelling, Labelling condition - Nutri-score labelling, Labelling condition: Nutri-score labelling + educational intervention
- Where
- United Kingdom
- Volunteers
- 870 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
SARS-CoV-2 Infection, COVID-19
A Study Looking at the Effectiveness, Immune Response, and Safety of a COVID-19 Vaccine in Adults in the United Kingdom
This is a study to evaluate the efficacy, immune response, and safety of a coronavirus disease 2019 (COVID-19) vaccine called SARS-CoV-2 rS with Matrix-M1 adjuvant in adults aged 18-84 years in the United Kingdom.
- Trial name
- NCT04583995
- Testing
- SARS-CoV-2 rS/Matrix M1-Adjuvant, Licensed seasonal influenza vaccine
- Where
- 33 sites in United Kingdom
- Volunteers
- 15,185 people, healthy volunteers welcome
- Sponsor
- Novavax
Advance Care Planning, Nursing Homes
Effect of Advance Care Planning to Improve Patient-centered Care of Nursing Home Residents
Advance Care Planning (ACP) is an approach to support individuals in understanding and sharing their values, treatment goals, and preferences regarding future medical care.
- Trial name
- BEVOR (NCT04333303)
- Testing
- Implementation of a complex regional Advance Care Planning program
- Where
- 4 sites in Germany
- Volunteers
- 5,927 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Attitudes Towards Tobacco Industry
A Brief Intervention Programme for TID
The brief RCT will be conducted in the form of a questionnaire survey, with two kinds of leaflets embedded in the same questionnaire.
- Trial name
- NCT03800966
- Testing
- Leaflet
- Where
- Hong Kong
- Volunteers
- 1,069 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dietary Deficiency
Fish Consumption and Dietary Diversity in Timor-Leste
A one-year, cluster-randomized, partially masked, controlled trial to test and compare the effects of fish aggregating devices and social and behaviour change communication on the frequency and volume of household fish…
- Trial name
- NCT04729829
- Testing
- Social and behaviour change communication, Fish aggregating device
- Where
- Timor-Leste
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- WorldFish
Varicose Vein of Lower Limbs
Catheter-directed Foam Sclerotherapy With Tumescence
Foam sclerotherapy has been established as another option of treatment for varicose veins of the lower limbs. Its advantages are the application to patients with high surgical risk and immediate return to usual activities.
- Trial name
- NCT02753270
- Testing
- Short catheter, Long catheter preceded by tumescence
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Gingivitis, Gingivitis; Chronic
A Multicentre Randomised Controlled Trial Evaluating the Efficacy of the SMILE™ Module for Improving Short-term Periodontal Outcomes, Compliance, and Acceptability Among Clinical Dental Students
This multicentre randomised controlled trial aims to evaluate the efficacy and safety of the SMILETM (Siwak Method for Integrated Lifestyle Enhancement) module in improving short-term periodontal outcomes, oral hygiene behaviour…
- Trial name
- SMILE (NCT07702383)
- Testing
- SMILE Module, Conventional Toothbrushing Module
- Where
- 4 sites in Malaysia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Total Knee Replacements
Analgesic Effect of Adding an Adductor Canal Block to a Femoral Triangle Block for Total Knee Replacement
The aim of the study is to investigate whether the addition of an adductor canal block to a femoral triangle block will provide better analgesia for patients after total knee replacements.
- Trial name
- NCT03461679
- Testing
- Adductor canal block, Femoral triangle block
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Oral Health, Knowledge
Effectiveness MyBRUSH Module in Improving Knowledge, Attitude, and Behaviour on Toothpaste Use and Toothbrushing Among 12-Year-Old Children
The goal of this intervention study is to study the effectiveness of the oral health education module (MyBRUSH) in improving the knowledge, attitude, and behaviour on toothpaste use and toothbrushing among 12-year-old children.
- Conditions
- Oral Health, Knowledge, Attitude, Behavior
- Trial name
- MyBRUSH module (NCT07125560)
- Testing
- MyBRUSH module, BEGIN program
- Where
- 8 sites in Malaysia
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Dental Caries
Effectiveness of Fluoride Varnish in Prevention of Dental Caries in School Children
Despite the availability of free health dental service in Sri Lanka, the prevalence and severity of dental caries among 6year old school children stand at a very high level according to the results of national oral health survey…
- Trial name
- NCT02877888
- Testing
- fluoride varnish 22600ppm
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Peradeniya
Nocturnal Enuresis
A New Check-list Method for Nocturnal Enuresis
The study is aimed to demonstrate the benefits of newly formed written check-list of behavioral instructions and investigate its effects on parent's awareness, consciousness and motivation toward MNE.
- Trial name
- NCT03510975
- Testing
- desmopressin melt form 120 μg, Verbal behavioral therapy, Behavioral therapy with written check-list
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ankara Training and Research Hospital
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