Clinical trials: Radiotherapy Side Effect
Cardiotoxicity, Breast Cancer
NT-proBNP to Assess Trastuzumab-induced Cardiotoxicity
Trastuzumab-induced cardiotoxicity (TIC) will be monitored in patients with HER2+ breast cancer undergoing trastuzumab treatment before and after breast cancer surgery.
- Conditions
- Cardiotoxicity, Breast Cancer, Treatment Side Effects
- Trial name
- NCT06340516
- Testing
- Plasma NT-proBNP
- Where
- Sweden
- Volunteers
- 700 people
- Sponsor
- Vastra Gotaland Region
Radiotherapy Side Effect, Chemotherapy Effect
Neoadjuvant Chemotherapy or Chemoradiotherapy in Resectable Oesophageal Carcinoma（NewEC Study）
To provide comprehensive efficacy and safety profiles of neoadjuvant chemoradiotherapy (NCRT) versus neoadjuvant chemotherapy (NCT) versus surgery alone in resectable oesophageal carcinoma.
- Conditions
- Radiotherapy Side Effect, Chemotherapy Effect, Oesophageal Carcinoma, Effect of Drugs
- Trial name
- NCT04027543
- Testing
- Neoadjuvant chemoradiotherapy, Oesophagectomy, Neoadjuvant chemotherapy
- Where
- 3 sites in United States, China
- Volunteers
- 423 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Hypothermia; Anesthesia, Hyperthermia, Anesthesia Related
Inadvertent Hypothermia or Hyperthermia in Pediatric Radiotherapy Practices Under Anesthesia
In prospective, observational cohort study, changes in body temperature will be investigated before the procedure and during recovery in Radiotherapy patients aged 0-18 years who need sedation due to childhood malignancies.
- Conditions
- Hypothermia; Anesthesia, Hyperthermia, Anesthesia Related, Radiotherapy Side Effect, Childhood Cancer
- Trial name
- NCT05478850
- Testing
- radiotherapy under anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 152 people
- Sponsor
- Ankara City Hospital Bilkent
Cardiotoxicity, Heart Failure
Novel On-body Evaluation of Cardiac Health for Oncology
The goal of this study is to develop a wearable sensor system that can estimate left ventricular ejection fraction (LVEF), which is a measurement of the heart's function.
- Trial name
- NOECHO (NCT07158450)
- Where
- 11 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Skribe Medical
HER2-positive Breast Cancer, Targeted Therapy
Cardiotoxicity of Targeted Therapy for HER-2 Positive Breast Cancer Patients at High Altitude
This is a prospective, multicenter, cohort study aiming to explore the cardiotoxicity of targeted therapy for HER-2 positive breast cancer patients who lives in high altitude area.
- Conditions
- HER2-positive Breast Cancer, Targeted Therapy, Cardiac Toxicity, High Altitude
- Trial name
- NCT05063643
- Testing
- High altitude
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Affiliated Hospital of Qinghai University
Breast Cancer, Adverse Effect of Radiation Therapy
Study to See Whether Breath-Hold Techniques During RT Are Effective in Helping to Improve Sparing of the Heart
The study hopes to determine whether patients with left-sided breast cancer are at an increased risk of cardiac changes due to radiation to the breast +/- Anthracycline-based chemotherapy +/- Herceptin and whether a deep…
- Trial name
- NCT02052102
- Testing
- Radiation therapy
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- AHS Cancer Control Alberta
Childhood Cancer, Hearing Loss
Screening for Hearing Loss After Childhood Cancer
The HEAR-study pilots and evaluates a national, low-threshold screening program to detect hearing problems in Swiss adult childhood cancer survivors.
- Trial name
- HEAR (NCT06036407)
- Testing
- Hearing test
- Where
- Switzerland
- Volunteers
- 476 people
- Sponsor
- University of Bern
Breast Radiotherapy Toxicity
Quantification of Breast RadioTherapy Associated Late Toxicity Using Novel UltraSound Techniques
Around 20% of women who receive breast radiotherapy (RT) experience moderate to severe breast hardening and shrinkage. These side-effects have been shown to be important factors influencing quality of life after breast…
- Trial name
- QuaRTUS (NCT02388230)
- Testing
- Ultrasound imaging
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Cardiac Toxicity, Lymphoma
Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Disease
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells.
- Trial name
- NCT00002827
- Testing
- bleomycin sulfate, filgrastim, dexrazoxane hydrochloride
- Where
- 39 sites in United States, Australia and 1 more
- Volunteers
- 294 people
- Sponsor
- Children's Oncology Group
Cervical Cancer, Radiotherapy Side Effect
Study on Adaptive Radiotherapy and Multimodal Information of Cervical Cancer Assisted by Artificial Intelligence
The standard treatment for non-operative cervical cancer is concurrent external radiation therapy and chemotherapy followed by brachytherapy.
- Conditions
- Cervical Cancer, Radiotherapy Side Effect, Biomarker, Artificial Intelligence
- Trial name
- SOARAMIOCC (NCT04022018)
- Testing
- Adaptive radiotherapy, no adaptive radiotherapy
- Where
- China
- Volunteers
- 122 people
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
Glioblastoma Multiforme
UNITE Study: Understanding New Interventions With GBM ThErapy
The objective of this study was to evaluate the effect of several ophthalmologic prophylactic treatment strategies for the management of ocular side effects (OSEs) in participants with epidermal growth factor receptor…
- Trial name
- NCT03419403
- Testing
- Steroid eye drops, Vasoconstrictor eye drops, Cold compress
- Where
- 22 sites in United States, Australia and 3 more
- Volunteers
- 40 people
- Sponsor
- AbbVie
Prostate Cancer, Radiotherapy Side Effect
Less to Hold - A Comparison of Bladder Toxicities (Side Effects) in Patients Undergoing Prostate Radiotherapy Between Patients Treated With Empty Bladder and Those on a Drinking Protocol.
Radical radiotherapy to the prostate is conventionally treated with a full bladder with the aim of minimising dose to the bladder and small bowel to prevent significant side effects.
- Trial name
- NCT03832803
- Testing
- Empty bladder, Full bladder
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Lancashire Teaching Hospitals NHS Foundation Trust
Colorectal Cancer
Effect of Probiotics Supplementation on the Side Effects of Radiation Therapy Among Colorectal Cancer Patients
Colorectal cancer (CRC) is one of the most common types of cancer worldwide in general and in Jordan in specific. The studies that investigate the role of Probiotics supplementation in improving the inflammatory response…
- Trial name
- NCT03742596
- Testing
- Probiotic Formula Capsule, Control
- Where
- Jordan
- Sponsor
- King Hussein Cancer Center
Cardiotoxicity, Cardiomyopathies
The Cardio-Oncology Breast Cancer Study
The main objective of this randomized controlled trial is to test the association between standard cardiac risk factors, biomarkers and parameters of echocardiography, electrocardiography, and cardiac magnetic resonance imaging…
- Conditions
- Cardiotoxicity, Cardiomyopathies, Breast Cancer
- Trial name
- COBC (NCT02571894)
- Testing
- Subclinical cardiotoxicity surveillance and treatment
- Where
- Sweden
- Volunteers
- 320 people
- Sponsor
- Karolinska University Hospital
Brain Metastases, Radiotherapy Side Effect
GM1 Prophylaxis for WBRT Related Cognitive Dysfunction
To evaluate the efficacy and safety of GM1 for preventing cognitive impairment related to whole brain radiotherapy in breast cancer patients with brain metastases.
- Conditions
- Brain Metastases, Radiotherapy Side Effect, Cognitive Impairment, Gangliosidosis, GM1
- Trial name
- GLORY (NCT04395339)
- Testing
- Monosialotetrahexosyl ganglioside (GM1), Control
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Sun Yat-sen University
Ototoxic Hearing Loss, Ototoxicity, Drug-Induced
Cisplatin-induced Cochlear and Vestibular Damage in Head and Neck Cancer
The goal of this observational study is to learn about the occurrence of and to identify suitable strategies for screening and monitoring of inner ear damage in patients receiving cisplatin chemoradiotherapy for head and neck…
- Conditions
- Ototoxic Hearing Loss, Ototoxicity, Drug-Induced, Cisplatin-induced Hearing Loss, Cisplatin Ototoxicity
- Trial name
- NCT06929468
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Simon Jäger
Breast Cancer
Assessment of Cardiotoxicity After Chemotherapy for Breast Cancer by Cardio-vascular Magnetic Resonance (MR)
Consecutive patients with a first diagnosis of breast cancer will be identified at the Tom Baker Cancer Centre (TBCC) and included into the study, if they are going to receive chemotherapy with anthracyclines and / or Trastuzumab…
- Trial name
- Cardiotox (NCT00679874)
- Testing
- Cardio-vascular MRI
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University of Calgary
Prostate Cancer, Radiotherapy Side Effect
Prostate Reirradiation Toxicity Outcomes Feasibility Study
The RO-PIP trial aims to determine the feasibility of recruitment to a trial randomising patients to salvage ultra-hypofractionated external beam radiotherapy or high dose rate brachytherapy and provide prospective data on…
- Trial name
- RO-PIP (NCT05614700)
- Testing
- Brachytherapy, Sterotactic Body Radiotherapy
- Volunteers
- 60 people
- Sponsor
- University of Leeds
Radiodermatitis, Breast Neoplasms
Effects of Herbal Products on Reduction of Radiation-induced Dermatitis in Breast Cancer Patients
The herbal products on reduction of radiation-induced dermatitis in patients with breast cancer
- Conditions
- Radiodermatitis, Breast Neoplasms, Adverse Effect of Radiation Therapy
- Trial name
- NCT02922244
- Testing
- Control, Cucumber cream, Centella cream
- Where
- Thailand
- Volunteers
- 150 people
- Sponsor
- Chulabhorn Cancer Center
HER2-positive Breast Cancer, HER2+ Breast Cancer
HER2HEART-US: Prevention of Cardiotoxicity in Breast Cancer Patients Receiving HER2-directed Therapy
Ten to 15% of patients with breast cancer are HER2 positive, with treatment focused on targeting the HER2 receptor. Although these treatments are generally well tolerated, they are associated with an increased risk of…
- Trial name
- NCT06844669
- Testing
- Carvedilol, Empagliflozin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Washington University School of Medicine