Clinical trials: Radical Prostatectomy
Prostate Cancer
Biomarkers for Neoadjuvant Pembrolizumab in Non-Metastatic Prostate Cancer Positive by 18FDG-PET Scanning
Various approaches are currently being developed for prostate cancer immunotherapy. However, a major challenge facing the development of cancer immunotherapy is the identification of tumors that would best respond to this type of…
- Trial name
- PICT-01 (NCT04009967)
- Testing
- Pembrolizumab
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- CHU de Quebec-Universite Laval
Lymphoceles Following Pelvic Lymph Node Dissection
Cold Plasma for the Reduction of Lymphoceles Following PLND
This study protocol will evaluate the efficacy of Bovie Medical's J-Plasma® helium based plasma technology in the reduction of lymphoceles following pelvic lymph node dissection (PLND) during robotic assisted radical…
- Trial name
- NCT02658851
- Testing
- J-Plasma
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Apyx Medical
Prostate Cancer
Early Salvage Therapy for Patients With Advanced Features for Biochemical Relapse After Radical Prostatectomy for Localized Prostate Carcinoma In Correlation With Supposed Molecular-genetic Parameters of Higher Aggressiveness
The primary objective of the trial is to compare the impact and safety of delayed salvage therapy (dSRT, i.e., SRT initiated at PSA values of 0.4-0.5 ng/ml) to those of early salvage therapy (eSRT, i.e., at PSA levels of 0.2…
- Trial name
- ESTABLISH (NCT05232578)
- Testing
- Early salvage radiotherapy (eSRT), Delayed Salvage radiotherapy (dSRT)
- Volunteers
- 380 people
- Sponsor
- General University Hospital, Prague
Prostate Cancer
Feasibility and Safety Study Using Preoperative High-Dose Single-Fraction Image-Guided Radiotherapy for Men Undergoing Radical Prostatectomy at High-Risk for Extraprostatic Cancer
This study is being done to test the safety of a single high-dose of radiation therapy before radical prostatectomy (removal of the prostate).
- Trial name
- NCT01163448
- Testing
- High-Dose Single-Fraction Image-Guided Radiotherapy for Men Undergoing Radical Prostatectomy
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Prostate Cancer
Study of STM-416p Administered to Patients Undergoing Radical Prostatectomy
A Study of STM-416p Administered Intraoperatively to Patients Undergoing Radical Prostatectomy
- Trial name
- NCT06450106
- Testing
- STM-416p
- Where
- 4 sites in United States, Australia
- Volunteers
- 18 people
- Sponsor
- SURGE Therapeutics
Urinary Incontinence Following Surgical Procedure
A PSM Analysis to Evaluate Electrical Pudendal Nerve Stimulation for PPI
The goal of this propensity score matching study is to compare the posttreatment outcomes of post-radical prostatectomy Incontinence patients undergoing either electrical pudendal nerve stimulation or pelvic floor muscle training…
- Trial name
- NCT06130306
- Testing
- electrical pudendal nerve stimulation, pelvic floor muscle training combined with transanal electrical stimulation
- Where
- China
- Volunteers
- 389 people
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Erectile Dysfunction
The Effect of Low Intensity Shockwave Therapy for ED in Post Radical Prostatectomy Patients Who Didn't Respond to PDE5i
Low Intensity Shock Wave Therapy (LI-ESWT) was shown to have a beneficial effect on ED patients responding to PDE5i's. This study aimed to determine the capability of LI-ESWT to affect patients who underwent radical prostatectomy…
- Trial name
- LI-ESWT (NCT01274949)
- Testing
- LI-ESWT
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Locally Advanced and Metastatic Prostate Cancer
Safety and Early Efficacy of Radical Prostatectomy for Newly Diagnosed Very High Risk Locally Advanced and Oligometastatic Prostate Cancer
Prostate cancer is the most common non-skin cancer diagnosed among men and the second leading cause of male cancer deaths in the United States. In 2013, it is estimated that 29,270 men have died from prostate cancer.
- Trial name
- NCT02971358
- Testing
- Radical prostatectomy
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University of Vienna
Prostate Cancer, Erectile Dysfunction
Pentafecta Outcomes After Robot-assisted Laparoscopic Radical Prostatectomy
Robot-assisted laparoscopic radical prostatectomy (RALRP) is a surgical technique for the treatment of prostate cancer. The aim of this study was to report our initial experience with RALRP, by applying the concept of pentafecta.
- Conditions
- Prostate Cancer, Erectile Dysfunction, Complication of Surgical Procedure, Urinary Incontinence
- Trial name
- NCT03706508
- Testing
- Robot-assisted laparoscopic radical prostatectomy
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Mechanical Ventilation, Postoperative Pulmonary Complications (PPCs)
Intraoperative Driving Pressure and Postoperative Lung Ultrasound Score in Robot-Assisted Radical Prostatectomy
The primary objective of this study is to evaluate the relationship between intraoperative driving pressure and postoperative lung ultrasound scores in patients undergoing robot-assisted laparoscopic radical prostatectomy.
- Conditions
- Mechanical Ventilation, Postoperative Pulmonary Complications (PPCs), Prostatic Neoplams, Driving Pressure
- Trial name
- NCT07610824
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Ankara Etlik City Hospital
Prostate Cancer, Urinary Incontinence
Augmented BLAdder NecK rEconstruction Trial for Improved Urinary Function After Radical Prostatectomy
The investigators are conducting a prospective, randomized trial to investigate whether patients randomized to receive an augmented bladder neck reconstruction (aBNR) at the time of robotic-assisted laparoscopic prostatectomy…
- Conditions
- Prostate Cancer, Urinary Incontinence, Surgery
- Trial name
- BLANKET (NCT04305379)
- Testing
- Augmented Bladder Neck Reconstruction, Standard Bladder Neck Reconstruction
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Johns Hopkins University
Urinary Incontinence, Stress
Perineal Ultrasound in Men Before and After Radical Prostatectomy
Prospective study to evaluate a new technique. Comparison of perineal sonography in men before and after radical prostatectomy and in incontinent men after radical prostatectomy before and after operative treatment with male…
- Trial name
- NCT03037008
- Testing
- Perineal Sonography
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Kantonsspital Winterthur KSW
Prostate Adenocarcinoma, Stage IIIB Prostate Cancer American Joint Committee on Cancer (AJCC) v8
Extremely Hypofractionated Intensity Modulated Stereotactic Body Radiotherapy for the Treatment of Prostate Cancer With Rising PSA After Radical Prostatectomy
This phase II trial investigates the effect of extremely hypofractionated intensity modulated stereotactic body radiotherapy in treating patients with prostate cancer that has rising prostate specific antigen (PSA) after radical…
- Conditions
- Prostate Adenocarcinoma, Stage IIIB Prostate Cancer American Joint Committee on Cancer (AJCC) v8, Stage IIIC Prostate Cancer AJCC v8, Stage IV Prostate Cancer AJCC v8
- Trial name
- EXCALIBUR (NCT04915508)
- Testing
- Hormone Therapy, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Stage I Prostate Adenocarcinoma, Stage II Prostate Adenocarcinoma
Bicalutamide and Raloxifene Hydrochloride in Treating Patients With Prostate Cancer Undergoing Surgery
This phase II pilot trial studies how well bicalutamide and raloxifene hydrochloride work in treating patients with prostate cancer undergoing surgery.
- Trial name
- NCT03147196
- Testing
- Bicalutamide, Laboratory Biomarker Analysis, Questionnaire Administration
- Sponsor
- Mayo Clinic
Erectile Dysfunction
The Relationship Between Bone Pelvis Measurements and Erectile Function in Patients Who Had Nerve-Sparing Robot-Assisted Radical Prostatectomy Operation
In order to evaluate the relationship between bone pelvis measurements and erectile function in patients who underwent nerve-sparing robot-assisted radical prostatectomy, bone pelvis measurements will be measured from MRI images…
- Trial name
- NCT06179316
- Testing
- Robot Assisted Radical Prostatectomy
- Volunteers
- 120 people
- Sponsor
- Ankara Training and Research Hospital
Prostatic Neoplasms, Prostatectomy
Evaluating the Effect of the VCD on Erectile Function and Penile Length Post RRP
The purpose of this study is to perform a randomized prospective study to evaluate whether the vacuum erection device facilitates an earlier return of erectile function post radical prostatectomy.
- Trial name
- NCT00177125
- Testing
- ErectAid
- Where
- 2 sites in United States
- Volunteers
- 220 people
- Sponsor
- University of Minnesota
Prostate Cancer
Prostatic Artery Embolization Before Radical Prostatectomy in Prostate Cancer: A Proof-of-concept Study
MRI findings after successful PAE in patients suffering from BPH suggest a complete necrosis of the prostate after this intervention. Thus, PAE might also play a role in the treatment of prostate cancer.
- Trial name
- NCT02917161
- Testing
- Prostatic Artery Embolization (PAE)
- Where
- 2 sites in Switzerland
- Volunteers
- 12 people
- Sponsor
- Dominik Abt
Prostate Cancer, Prostatectomy
High Dose Rate (HDR) Brachytherapy Salvage After Prostatectomy
The goal of this observational study is to learn about the long-term effects of HDR Brachytherapy in men with isolated local relapses after radical prostatectomy.
- Conditions
- Prostate Cancer, Prostatectomy, Local Recurrence of Malignant Tumor of Prostate, Radiotherapy; Complications
- Trial name
- NCT06982469
- Testing
- Brachytherapy
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Prostate Cancer
Men Undergoing Radical Prostatectomy
The purpose of this study is to see if the protein pattern in your blood can predict whether or not your prostate tumor is aggressive.
- Trial name
- NCT00582530
- Testing
- Whole Blood Draw
- Where
- United States
- Volunteers
- 513 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Urologic Cancer, Prostate
Comparison of the Integrated Posterior-Anterior-Lateral Approach and the Posterior Approach in Robotic Radical Prostatectomy
This study aims to compare perioperative, pathological, and early functional outcomes of PAL （Posterior, Anterior and Lateral）combined approach RARP and posterior approach (with Retzius space preserved) RARP in the treatment of…
- Conditions
- Urologic Cancer, Prostate, Robot Assisted Laparoscopic Radical Prostatectomy
- Trial name
- NCT07305142
- Testing
- PAL combined approach group, posterior approach group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University