Clinical trials: Radical Hysterectomy
Cancer of Cervix, Laparoscopic Surgery
Minimally Invasive Therapy Versus Open Radical Hysterectomy for Management of Early Stage Cervical Cancer
Radical hysterectomy and pelvic lymph node dissection (+/- aortic lymph node dissection) is the standard treatment for early stage cervical cancer.
- Trial name
- MITOR (NCT04999696)
- Testing
- radical hysterectomy
- Where
- Taiwan
- Volunteers
- 820 people
- Sponsor
- Chang Gung Memorial Hospital
Locally Advanced Cervical Cancer
Study of Laparoscopic Radical Hysterectomy Based on Space Anatomy in Patients With IB3 and IIA2 Cervical Cancer
Radical hysterectomy is an effect treatment for FIGO IB3 and IIA2 cervical cancer patients who refuse to receive radical concurrent chemoradiotherapy.
- Trial name
- NCT06759480
- Testing
- Laparoscopic radical hysterectomy based on space anatomy, Abdominal radical hysterectomy
- Volunteers
- 500 people
- Sponsor
- International Peace Maternity and Child Health Hospital
Cervical Cancer, Cervical Cancer Stage IB1
Safety of Minimally Invasive Surgery Using Endoscopic Stapler in Early Stage Cervical Cancer Patients (SOLUTION)
The SOLUTION trial aims to show the efficacy and safety of performing radical hysterectomy by minimally invasive surgery using an endoscopic stapler in patients with cervical cancer stage IB1 (FIGO staging 2009) and thus to prove…
- Conditions
- Cervical Cancer, Cervical Cancer Stage IB1, Minimally Invasive Surgery
- Trial name
- SOLUTION (NCT04370496)
- Testing
- Minimally invasive surgery using endoscopic stapler
- Where
- 3 sites in South Korea
- Volunteers
- 124 people
- Sponsor
- Seoul National University Hospital
Carcinoma of the Endometrium, Hysterectomy
Lymphedema After Primary Surgery for Endometrial Cancer
The purposes of this study are to determine the prevalence, size and impact on quality of life of lymphedema of the lower extremities after primary radical surgery with hysterectomy +/- pelvic - and paraaortic lymphadenectomy in…
- Conditions
- Carcinoma of the Endometrium, Hysterectomy, Lymphadenectomy
- Trial name
- LASEC (NCT02115477)
- Testing
- Lymphadenectomy
- Where
- 16 sites in Sweden
- Volunteers
- 262 people
- Sponsor
- Preben Kjolhede, MD, professor
Gynecologic Neoplasms
Safety of Regular Diet as the First Meal in Patients Who Underwent Surgical Treatment for Gynecologic Cancer
The purpose of this study is to determine whether it is safe to give a regular diet as the first postoperative meal in patients who underwent surgical treatment for clinically early-stage gynecologic cancer.
- Trial name
- NCT00328757
- Testing
- Regular diet as the first postoperative meal
- Where
- Thailand
- Volunteers
- 240 people
- Sponsor
- Chiang Mai University
Cervical Cancer
German-funded Laparoscopic Approach to Cervical Cancer
The G-LACC trial is a prospective, interventional, multicenter, open-label, randomized and controlled non-inferiority operative trial.
- Trial name
- G-LACC (NCT06489795)
- Testing
- Laparoscopic or robot-assisted radical/simple hysterectomy, Abdominal radical/simple hysterectomy
- Where
- 14 sites in Germany
- Volunteers
- 756 people
- Sponsor
- Hannover Medical School
Cervical Cancer
Chemotherapy and Radiation Therapy With or Without Surgery in Treating Patients With Stage I Cancer of the Cervix
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00054067
- Testing
- cisplatin, adjuvant therapy, conventional surgery
- Where
- 50 sites in United States, Japan
- Sponsor
- Gynecologic Oncology Group
Cervical Cancer
Laparoscopic or Abdominal Radical Hysterectomy for Cervical Cancer(Stage IA1 With LVSI, IA2)
The purpose of this study is to confirm whether there is a difference between laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) in patient survival for Cervical Cancer (Stage IA1 with LVSI, IA2)
- Trial name
- LAUNCH 1 (NCT04934982)
- Testing
- Total Laparoscopic or Robotic Radical Hysterectomy, Total Abdominal Radical Hysterectomy
- Where
- China
- Volunteers
- 690 people
- Sponsor
- Hua Jiang
Uterine Cervical Neoplasms
SUCCOR-Surgery in Cervical Cancer Comparing Different Surgical Aproaches in Stage IB1 Cervical Cancer
SUCCOR study tries to understand the outcomes of European patients with stage IB1 cervical cancer (FIGO 2009)1, that underwent a radical hysterectomy for cervical cancer in 2013-2014 within the ESGO area (European Society of…
- Trial name
- SUCCOR (NCT03958305)
- Testing
- RADICAL HYSTERECTOMY
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Surgery--Complications
Radical Hysterectomy: Evolution Of Surgical Approach and Related Outcomes
Prospective controlled study (Canadian Task Force II-2) : Comparison analysis regarding surgical outcomes, complications, overall survival (OS), disease free survival (DFS) and cancer specific survival between patients subjected…
- Trial name
- RESurg (NCT03577613)
- Testing
- Open radical hysterectomy, laparoscopic radical hysterectomy, Robotically assisted radical hysterectomy
- Volunteers
- 188 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pathologic Stage I Gastric Cancer AJCC v8, Colorectal Cancer
Clinical Trial to Evaluate the Efficacy and Safety of a Thoracic and Abdominal Endoscopic Surgical System
Evaluation of the efficacy and safety of thoracic and abdominal endoscopic surgical systems manufactured by Shenzhen Cornerstone Robotics Technology Co., Ltd. for use in general, gynaecological and thoracic surgical procedures.
- Conditions
- Pathologic Stage I Gastric Cancer AJCC v8, Colorectal Cancer, Esophageal Cancer, Hepatectomy
- Trial name
- NCT06587152
- Testing
- Robot-assisted surgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Cornerstone Robotics
Hidden Blood Loss, Open Radical Hysterectomy
A Research on Hidden Blood Loss in Open Radical Hysterectomy and Pelvic Lymphadenectomy
The aim of this cross-sectional study is to evaluate the hidden blood loss in patients who underwent open radical hysterectomy and identity its risk factors.
- Conditions
- Hidden Blood Loss, Open Radical Hysterectomy, Cervical Cancer
- Trial name
- NCT03628118
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Cervical Cancer
Laparoscopic or Abdominal Radical Hysterectomy for Cervical Cancer(Stage IB3,IIA2)
The purpose of this study is to confirm whether there is a difference between laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) in patient survival for Cervical Cancer (Stage IB3, IIA2).
- Trial name
- LAUNCH 3 (NCT04939831)
- Testing
- Total Laparoscopic or Robotic Radical Hysterectomy, Total Abdominal Radical Hysterectomy
- Where
- China
- Volunteers
- 1,104 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Cervical Cancer
Preliminary Study on the Metastatic Rate and Clinical Significance of the Anterior Leaf of Vesicouterine Ligament in Early Stage Cervical Cancer
The purpose of this study is to preliminarily explore the metastatic rate and clinical significance of the anterior leaf of vesicouterine ligament resection for early stage cervical cancer, so as to further improve the…
- Trial name
- NCT05904977
- Testing
- Type B resection or type C resection of the anterior leaf of vesicouterine ligament during the radical hysterectomy (type C)
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cervical Cancer
Laparoscopic Versus Open Radical Hysterectomy in Early-Stage Cervical Cancer
The study aims to compare laparoscopic-assisted radical hysterectomy with open radical hysterectomy in women with early-stage cervical cancer.
- Trial name
- LAP-OPEN (NCT07626996)
- Testing
- Laparoscopic Radical Hysterectomy, Open Radical Hysterectomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Zagazig University
Cervical Cancer
Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical Hysterectomy
RATIONALE: Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00980954
- Testing
- carboplatin, cisplatin, paclitaxel
- Where
- 125 sites in United States, Canada and 2 more
- Volunteers
- 236 people
- Sponsor
- Radiation Therapy Oncology Group
Cervical Cancer
Study of Weekly Paclitaxel and Cisplatin in FIGO IB2 and IIA2 Cervical Cancer Followed by Radical Hysterectomy
The purpose was to establish a quick (7-day) cycle schedule of paclitaxel (60 mg/m2) combining with cisplatin (40 mg/m2) NAC regimen could be tolerated without interfering the following surgical treatment and a favorable overall…
- Trial name
- NCT02432365
- Testing
- paclitaxel, cisplatin, Radical hysterectomy and bilateral pelvic lymphadenectomy
- Where
- 5 sites in Taiwan
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cervical Cancer
Postoperative Chemoradiation v.s Radiotherapy for Lymph Node Negative Cervical Cancer Patients
This phase III study is designed to examine if low-risk (lymph node negative), stage I a2-II b cervical cancer patients treated by paclitaxel/cisplatin chemoradiation have greater toxicities but similar survival rate as those…
- Trial name
- NCT01756170
- Testing
- paclitaxel, cisplatin, Radiotherapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- xie congying
Cervical Cancer, Urinary Retention
Impact of Nerve-sparing Radical Hysterectomy on Patients' Urinary Dynamics
Background: Radical hysterectomy is an important therapy for early cervical cancer. Disfunction of urinary dynamics is the most common postoperative adverse effects, which had negative impact on patients' quality of life.
- Trial name
- NCT03020238
- Testing
- BiClamp group, water jet group
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Cervical Carcinoma
Clinical Study of Indocyanine Green Displaying Pelvic Nerve in Radical Operation of Cervical Cancer
Indocyanine green was injected intravenously into patients with cervical cancer before operation. The nerve development was observed by infrared imaging system during operation, which was used as the basis for nerve preserving…
- Trial name
- NCT05087264
- Testing
- Indocyanine green
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University