Clinical trials: Radical Cystectomy
Radical Cystectomy, Perioperative Complications
Advanced Hemodynamic Monitoring for Goal-directed Hemodynamic Management During Radical Cystectomy
The purpose of this study is to determine whether increasing cardiac output by a combination of intravenous fluids and inotropic drugs can reduce mortality and morbidity in radical cystectomy operations.
- Conditions
- Radical Cystectomy, Perioperative Complications, Hemodynamic Monitoring
- Trial name
- NCT00966147
- Testing
- Increasing oxygen delivery .
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Recurrent Bladder Cancer, Stage 0 Bladder Cancer
Urinary Diversion During Robotic Assisted Radical Cystectomy in Patients With Bladder Cancer
This randomized clinical trial studies intracorporeal or extracorporeal urinary diversion during robotic assisted radical cystectomy in reducing complications in patients with bladder cancer.
- Conditions
- Recurrent Bladder Cancer, Stage 0 Bladder Cancer, Stage I Bladder Cancer, Stage II Bladder Cancer
- Trial name
- NCT02252393
- Testing
- robot-assisted laparoscopic surgery, intraoperative complication management/prevention, quality-of-life assessment
- Sponsor
- Case Comprehensive Cancer Center
Bladder Cancer
Prediction of Impaired Survival in Elderly Bladder Cancer Patients Opting for Radical Cystectomy
The investigators proposes a prospective cohort study in patients with high risk bladder cancer who have opted for radical cystectomy.
- Trial name
- NCT02039310
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Michigan
Radical Cystectomy
Hemodynamic Effects of Pressure-regulated Volume Control Mode in Patients With Diastolic Dysfunction Undergoing Radical Cystectomy
Diastolic function is a combination of ventricular chamber compliance, active myofilament relaxation, and elastic recoil of systolic potential energy.
- Trial name
- NCT05048199
- Testing
- pressure regulated volume-controlled mode of ventilation, volume-controlled mode of ventilation
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Mansoura University
Bladder Cancer
Study of Outcomes After Surgery/Treatment to Treat Bladder Cancer
The purpose of this study is to create a registry of older patients undergoing surgical and/or medical treatment for bladder cancer.
- Trial name
- PORCH (NCT01776138)
- Testing
- Collect Blood and Survey Instruments
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Urinary Bladder Cancer
Comparing Operative, Postoperative and Quality of Life of Patients After Salvage and Radical Cystectomy
To compare operative difficulties, type of urinary diversion, intraoperative \& postoperative complications and quality of life in patients underwent radical cystectomy and those after salvage cystectomy.
- Trial name
- NCT06115434
- Testing
- cystectomy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Cystostomy Infection
Infection Among Patients Undergoing Radical Cystectomy.
Investigators plan to perform a review of medical records a single urology department to identify patients with febrile perioperative infection who underwent radical cystectomy and urinary diversion for bladder cancer from…
- Trial name
- NCT03290742
- Where
- Poland
- Volunteers
- 133 people
- Sponsor
- Pomeranian Medical University Szczecin
Cystectomy, Robotic Surgical Procedures
Time Efficiency of Intracorporeal Orthotopic Diversion With Robotic Staplers After Robot Assisted Radical Cystectomy
Objectives and Specific Aims Time efficiency of robot assisted radical cystectomy (RARC) with totally intracorporeal stapled orthotopic neobladder remains a main drawback of this procedure.
- Conditions
- Cystectomy, Robotic Surgical Procedures, Surgical Staplers
- Trial name
- NCT02665156
- Testing
- Intracorporeal stapled neobladder using robotic staplers
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Regina Elena Cancer Institute
Muscle-Invasive Bladder Carcinoma
An Open Label, Single-arm, Phase 2 Study of Neoadjuvant Nivolumab and Nab-paclitaxel Before Radical Cystectomy for Patients With Muscle-invasive Bladder Cancer (NURE-Combo)
To assess whether nivolumab+nab-paclitaxel combination results in patients with muscle-invasive bladder cancer
- Trial name
- NURE-Combo (NCT04876313)
- Testing
- Nivolumab + Nab-paclitaxel, Nivolumab
- Where
- Italy
- Volunteers
- 29 people
- Sponsor
- IRCCS San Raffaele
Bladder Cancer
Radiation and Durvalumab Immunotherapy As Neoadjuvant Treatment for MIBC
This study assesses the effect of sequential radiation and durvalumab immunotherapy given as treatment prior to surgery with radical cystectomy for bladder cancer.
- Trial name
- RADIANT (NCT04543110)
- Testing
- Durvalumab, Immune Modulating Radiation
- Where
- 4 sites in Canada
- Volunteers
- 16 people
- Sponsor
- Ottawa Hospital Research Institute
Bladder Cancer, Urothelial Carcinoma
18Fluorine-Fluciclovine PET/CT for Staging Muscle Invasive Bladder Cancer Preceding Radical Cystectomy
This research study is studying a positron emission tomography (PET) agent called 18F-fluciclovine to evaluate how well 18F-fluciclovine-PET scans determine the extent of muscle invasive bladder cancer (as compared to regular CT…
- Trial name
- NCT04018053
- Testing
- 18F-fluciclovine, PET/CT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Brigham and Women's Hospital
Bladder Cancer
Neoadjuvant Dose Dense Gemcitabine and Cisplatin (DD GC) In Patients With Muscle-Invasive Bladder Cancer
The purpose of this study is to find out if standard chemotherapy (gemcitabine and cisplatin) given on a dose-dense treatment schedule (with less time between treatments) can help shrink the tumor better than standard…
- Trial name
- NCT01589094
- Testing
- Gemcitabine and Cisplatin (DD GC)
- Where
- 8 sites in United States
- Volunteers
- 51 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Urologic Cancer
Preoperative Guided Imagery in Patients Undergoing Urologic Surgery
This is a prospective randomized controlled trial of patients undergoing major urologic-oncologic surgery at the University of California, San Francisco (UCSF) Medical Center and the Helen Diller Family Comprehensive Cancer…
- Trial name
- NCT05072639
- Testing
- Guided Meditation
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- University of California, San Francisco
Bladder Cancer
Resiliency in Patients Undergoing Radical Cystectomy for Bladder Cancer
This is a prospective cross-sectional survey-based study composed of both a retrospective chart review and 3-series patient survey.
- Trial name
- NCT06337305
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Kansas Medical Center
Bladder Cancer, Radical Cystectomy
The Effect of Goal-directed Hemodynamic Therapy in Radical Cystectomy
Goal-directed therapy (GDT) has been applied to various clinical settings and has been widely researched recently as a method for perioperative management of patients.
- Trial name
- NCT03505112
- Testing
- Goal-directed therapy
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Seoul National University Hospital
Bladder Cancer Requiring Cystectomy, Ileal Conduit
A Feasibility Randomized Trial Evaluating Early vs Late Stent Removal Following Radical Cystectomy and Ileal Conduit Formation for Bladder Cancer
Bladder cancer is the 4th most common cancer in men and 5th most common type of cancer in Canada. Urothelial cancer accounts for approximately 90% of malignancies.
- Conditions
- Bladder Cancer Requiring Cystectomy, Ileal Conduit, Urinary Diversion
- Trial name
- STENT-OPT (NCT06595446)
- Testing
- Early Stent removal, Late Stent removal
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Western University, Canada
Bladder Cancer
Celecoxib and Rosiglitazone in Treating Patients Who Are Undergoing Cystoscopic Surveillance for Early-Stage Noninvasive Carcinoma of the Bladder or Radical Cystectomy for Muscle-Invasive Carcinoma of the Bladder
RATIONALE: Celecoxib may stop the growth of tumor cells by blocking the enzymes necessary for their growth and by stopping blood flow to the tumor. Rosiglitazone may help tumor cells develop into normal bladder cells.
- Trial name
- NCT00084578
- Testing
- celecoxib, rosiglitazone maleate, conventional surgery
- Sponsor
- Fox Chase Cancer Center
Bladder Cancer
Nerve Sparing Versus Non Nerve Sparing Robot-assisted Radical Cystectomy-orthotopic Ileal Neobladder for Bladder Cancer in the Male
To compare the perioperative, functional, and oncologic outcomes between non nerve sparing and nerve sparing robot-assisted radical cystectomy with orthotopic ileal neobladder in male patients with bladder cancer.
- Trial name
- NCT05018429
- Testing
- nerve sparing
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Mechanical Ventilation Pressure High
Effect of Airseal System Valve-less Trocar on the Ventilatory Parameters During Robotic-assisted Radical Cystectomy
The aim of the investigators' study is to investigate if the use of the AirSeal insufflation system impairs ventilatory parameters of patients less than a conventional system in patients undergoing robot-assisted laparoscopic…
- Trial name
- NCT02506270
- Testing
- Airseal Trocar, conventional trocar
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- Regina Elena Cancer Institute
Bladder Cancer, Renal Cell Carcinoma
Prospective Versus Retrospective Complications in Radical Cystectomy and Nephrectomy
The study will examine which differences there are in comorbidity and complications collected retrospectively from medical records compared with data collected prospectively in two groups of patients undergoing either radical…
- Trial name
- NCT03052504
- Testing
- Registration of complications
- Where
- Denmark
- Volunteers
- 156 people
- Sponsor
- Jørgen Bjerggaard Jensen