Clinical trials: Radiation Esophagitis
Oral Cavity Cancer, Head and Neck Cancers - Tonsils
Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis
As mentioned above, several prior studies have shown the positive effects of oral use of aloe vera juice in managing chemotherapy and radiation-induced oral mucositis and esophagitis.
- Conditions
- Oral Cavity Cancer, Head and Neck Cancers - Tonsils, Esophageal Cancer, Laryngeal Cancer
- Trial name
- NCT05369234
- Testing
- 100% Aloe Vera Juice, Magic Mouthwash, Salt and Baking soda rinse
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Covenant Health Cancer Center
Esophageal Carcinoma, Hypopharyngeal Carcinoma
Doxepin Hydrochloride in Treating Esophageal Pain in Patients With Thoracic Cancer Receiving Radiation Therapy to the Thorax With or Without Chemotherapy
This randomized pilot clinical trial studies the effects of taking doxepin hydrochloride as compared to placebo (inactive drug) in treating esophageal pain in patients with cancer located in the chest area receiving radiation…
- Conditions
- Esophageal Carcinoma, Hypopharyngeal Carcinoma, Laryngeal Carcinoma, Lymphoma
- Trial name
- NCT02062632
- Testing
- Doxepin Hydrochloride, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Advanced Cancers
Randomized Trial of Glutamine in Patients With Mucositis or Esophagitis
The goal of this clinical research study is to learn if glutamine can help control and prevent sores, blisters, or inflammation in your mouth or esophagus due to your current treatment.
- Trial name
- NCT01952847
- Testing
- Glutamine, Questionnaires
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- M.D. Anderson Cancer Center
Radiation Esophagitis, Locally Advanced Lung Carcinoma
Esomeprazole and Radiation Induced Esophagitis
Thoracic radiation therapy combined with chemotherapy (with or without immunotherapy) is the cornerstone of management in patients with locally advanced non-small cell lung cancer (NSCLC).
- Trial name
- EERENs (NCT06120803)
- Testing
- Esomeprazole 40 mg
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Rush University Medical Center
Lung Cancer
Folic Acid Interferes With Radiation Esophagitis
This randomized study compared the incidence and severity of radiation esophagitis with folic acid and with conventional symptomatic treatment.
- Trial name
- NCT05296369
- Testing
- Folic acid
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Guizhou Medical University
Radiation-induced Esophagitis
Spirulina Derivative for Radiation Esophagitis
To evaluate the efficacy and safety of a Spirulina-derived product in preventing and treating radiation-induced esophagitis in esophageal cancer patients undergoing intensity-modulated radiotherapy (IMRT).
- Trial name
- NCT07324018
- Testing
- Hydrogel of spirulina-derived exosomes., Radiotherapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- West China Hospital
Non-Small Cell Lung Cancer
Risk-Adapted Segmental Esophagus-Sparing Radiotherapy for Definitive Non-Small Cell Lung Cancer
This is a multicenter, open-label, randomized, phase 3 superiority trial. The purpose is to find out whether a risk-adapted segmental esophagus-sparing radiotherapy plan is better than a standard radiotherapy plan at reducing…
- Trial name
- ES-SPARE (NCT07908732)
- Testing
- Risk-Adapted Segmental Esophagus-Sparing IMRT/VMAT, Standard IMRT/VMAT Without Active Esophageal Avoidance
- Volunteers
- 140 people
- Sponsor
- Ruijin Hospital
Radiation Esophagitis
Reducing Acute Upper Gastrointestinal Side-Effects of Thoracic Irradiation
The purpose of the study is to explore options for preventing and reducing symptoms of radiation esophagitis (RE). The researchers will also look what symptoms participants experience, and whether there are differences in weight…
- Trial name
- NCT05659576
- Testing
- Sucralfate, Usual Care, One consent
- Where
- 7 sites in United States
- Volunteers
- 142 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Radio Dermatitis, Mucositis Oral
Using Red Light Therapy to Ease Skin Side Effects and Mouth Side Effects, in Children and Young People Aged 0 to 16 Years Old, Receiving Radiotherapy
The goal of this interventional study is to see if the daily use of red light therapy called photobiomodulation can help sore skin and sore mouths in children having radiotherapy.
- Conditions
- Radio Dermatitis, Mucositis Oral, Oesophagitis
- Trial name
- RADIANT (NCT07183267)
- Testing
- Photobiomodulation
- Where
- United Kingdom
- Volunteers
- 248 people
- Sponsor
- The Christie NHS Foundation Trust
Radiation Toxicity, Esophagitis
Deep-sea Fish Oil for Prevention of Acute Radiation-induced Esophagitis
Purpose：To observe and evaluate the clinical efficacy and safety of deep-sea fish oil in preventing acute radiation-induced esophagitis (ARIE).
- Conditions
- Radiation Toxicity, Esophagitis, Esophageal Cancer
- Trial name
- NCT06392971
- Testing
- Deep-sea fish oil
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Chengdu Medical College
Small Cell Lung Cancer
Mecapegfilgrastim Prevents Neutropenia and Radiation Esophagitis
Evaluation of the efficacy and safety of Mecapegfilgrastim for the prevention of neutropenia and radiation esophagitis after hyperfractionation in patients with limited-stage small cell lung cancer
- Trial name
- NCT04171986
- Testing
- Mecapegfilgrastim
- Where
- China
- Volunteers
- 93 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Esophagitis
The Effects of Whole Food Intervention on Mucositis in Patients Treated for Thoracic Cancer
This study will evaluate whether a Whole Food Intervention reduces the frequency or severity of esophagitis in patients receiving treatment for non-small cell lung cancer.
- Trial name
- NCT02575391
- Testing
- Whole Food Intervention
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Providence Health & Services
Lung Neoplasms, Esophagitis
Study of Epigallocatechin-3-gallate (EGCG) for Esophagus Protection in Patients With Lung Cancer Receiving Radial Radiotherapy
The investigators conducted this phase II study of EGCG therapy protection of the esophagus from damage induced by radiotherapy.
- Conditions
- Lung Neoplasms, Esophagitis, Prevention & Control, Epigallocatechin Gallate
- Trial name
- NCT02577393
- Testing
- EGCG, mLDG
- Volunteers
- 83 people
- Sponsor
- Shandong Cancer Hospital and Institute
Non Small Cell Lung Cancer, Small Cell Lung Cancer
Immunonutrition Reduces Acute Esophagitis After Thoracic Radiotherapy in Lung Cancer
This study aims to evaluate the efficacy of immunonutrition in reducing acute esophagitis after thoracic radiotherapy in lung cancer.
- Trial name
- Relief (NCT06840704)
- Testing
- Oral immunonutrition
- Where
- 6 sites in China
- Volunteers
- 121 people
- Sponsor
- Hunan Cancer Hospital
Eosinophilic Esophagitis
Radiation Dose in Humans From Orally Administered Tc99m-Heparin
This is a research study of a new agent used for evaluation of inflammation in the GI tract. This agent is investigational and thus is being studied to determine appropriate dosing and administration in both normal controls (i.e.
- Trial name
- NCT04069429
- Testing
- Computerized Tomography scan, Single Photon Emission Computed Tomography scans, Technetium Tc 99M
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Utah
Radiation-induced Oesophagitis
Tepilta® Versus Oxetacaine, Antacids and Placebo
This is a randomised, double-blind, placebo-controlled, therapeutic confirmatory multicentre trial with 4 parallel treatment groups.
- Trial name
- NCT01336530
- Testing
- oxetacaine, aluminium and magnesium hydroxide, oxetacaine, magnesium and aluminium hydroxide
- Where
- 32 sites in Austria, Germany
- Volunteers
- 40 people
- Sponsor
- MEDA Pharma GmbH & Co. KG
Non-small Cell Lung Carcinoma, Small Cell Lung Carcinoma
Phase I Trial Of IMRT Using A Contralateral Esophagus Sparing Technique (CEST) In Locally Advanced Lung Cancer
This research study is examining the benefit of a novel radiation planning approach on the likelihood of developing severe esophagitis (irritation and inflammation of the esophagus) during the course of radiation therapy with…
- Trial name
- NCT02394548
- Testing
- Contralateral Esophageal Sparing Technique (CEST)
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital
Dysphagia, Lung Cancer
Manuka Honey in Preventing Esophagitis-Related Pain in Patients Receiving Chemotherapy and Radiation Therapy For Lung Cancer
RATIONALE: Manuka honey may prevent or reduce esophagitis-related pain caused by chemotherapy and radiation therapy. It is not yet known whether Manuka honey is more effective than standard care in preventing pain.
- Conditions
- Dysphagia, Lung Cancer, Pain, Esophagitis
- Trial name
- NCT01262560
- Testing
- Manuka honey in liquid form, Manuka honey in lozenge form, Standard supportive care
- Where
- 59 sites in United States
- Volunteers
- 163 people
- Sponsor
- Radiation Therapy Oncology Group
Breast Carcinoma
Prevention of Oral Mucositis and Improvement of Quality of Life for Patients With Breast Cancer Undergoing Adjuvant Radiotherapy
Breast cancer patients receiving adjuvant radiotherapy after surgery, particularly when the supraclavicular lymph nodes are included in the treatment area, frequently experience side effects of esophagitis such as sore throat…
- Trial name
- SAFE (NCT06958445)
- Testing
- Alginos Oral Suspension
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Taipei City Hospital
Small Cell Lung Cancer, Non Small Cell Lung Cancer
The Effect of Caphosol® on the Development of Esophagitis in (N)SCLC Patients Treated With Concurrent Chemo/Radiotherapy
Rationale: In the Netherlands 1770 people are being diagnosed with SCLC (Small Cell Lung Cancer) and 8764 patients are being diagnosed with NSCLC (Non Small Cell Lung Cancer) in 2011.
- Trial name
- CARACTER (NCT01809756)
- Testing
- Caphosol
- Where
- 2 sites in Netherlands
- Volunteers
- 55 people
- Sponsor
- Amphia Hospital