Clinical trials: RNA Profile
COVID-19, Rehabilitation
Evaluation of Effectiveness of Proprietary Rehabilitation Program in Patients After COVID-19 Infection
The aim of the study is to evaluate the influence of 6 week physical training and respiratory rehabilitation performed in outpatients rehabilitation clinic on quality of life, symptoms, physical endurance, mental state, force of…
- Trial name
- NCT05449379
- Testing
- Respiratory training with the use of resistance set on respiratory muscle trainer, Respiratory training without resistance set on respiratory muscle trainer
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Bialystok
Covid19, Cancer
Evaluation of the Effect and Side Effect Profile of Covid-19 Vaccine in Cancer Patients
The aim of the study is to evaluate the effects and side effects of inactive COVID-19 vaccine in patients with cancer and compare them with the healthy control group.
- Trial name
- NCT04771559
- Testing
- COVID-19 antibody test
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
COVID-19 Pandemic
A Study of FB2001 for Inhalation in Healthy Chinese Adults
FB2001 is a novel inhalable preparation being developed for COVID-19 treatment. A Double-Blinded, Randomized, and Placebo-Controlled Phase 1 Study to Assess the Safety, Tolerability and Pharmacokinetics Profile of Single and…
- Trial name
- NCT05583812
- Testing
- FB2001 for inhalation
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Frontier Biotechnologies Inc.
Influenza Immunization, Healthy Volunteers
Study to Assess the Immune Response and the Safety Profile of a High-Dose Quadrivalent Influenza Vaccine (QIV-HD) Compared to a Standard-Dose Quadrivalent Influenza Vaccine (QIV-SD) in Japanese Adults 60 Years of Age and Older
Primary Objective: To demonstrate that QIV-HD induced an immune response (as assessed by hemagglutination inhibition [HAI] geometric mean titers [GMTs] and seroconversion rates) that was superior to responses induced by QIV-SD…
- Trial name
- NCT04498832
- Testing
- High-Dose Quadrivalent Influenza Vaccine, (Zonal Purified, Split Virus) 2020-2021 Strains (QIV-HD), Local Standard-Dose Inactivated Quadrivalent Influenza Vaccine, 2020-2021 Strains (QIV-SD)
- Where
- 10 sites in Japan
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
HIV Infections
Kaletra Sex/Gender Pharmacokinetics (PK) Study
The levels of lopinavir achieved in the blood following oral ingestion of standard doses of Kaletra (lopinavir/ritonavir) in HIV-infected men was compared with those achieved in HIV-infected women receiving the same dose of the…
- Trial name
- LPVGenderPK (NCT00148759)
- Testing
- LPV/r
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Emory University
Infection, Human Immunodeficiency Virus
A Study To Assess GW433908 (Fosamprenavir) Containing Regimens In HIV-1 Infected Subjects
GW433908 (fosamprenavir; FPV)is a pro-drug of amprenavir (APV) which is more water soluble and can be formulated into a tablet with a reduced pill burden (four 700mg tablets of FPV versus sixteen 150mg capsules daily for APV.
- Trial name
- NCT00296504
- Testing
- fosamprenavir (GW433908), ritonavir
- Where
- 24 sites in United States, Brazil and 6 more
- Volunteers
- 753 people
- Sponsor
- ViiV Healthcare
Covid19, Corona Virus Infection
Investigating the Involvement of ACE and Angiotensinogen Genes' Polymorphism Along With Other Thrombophilic Genotypes in Severe Forms of COVID-19 With/Without Thrombotic Events
An estimated 22% of the global population is at an increased risk of a severe form of COVID-19, while one in four coronavirus patients admitted to intensive care unit will develop a pulmonary embolism.
- Conditions
- Covid19, Corona Virus Infection, Thrombosis, ARDS
- Trial name
- iGenes-COVID19 (NCT04519398)
- Testing
- Complete thrombophilic profile testing by multiplex PCR
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Hepatitis C, Chronic
This Trial Evaluates Safety, Pharmacokinetic Profile and Anti-viral Response of BI 207127 and BI 201335 for Patients With Chronic Hepatitis C
The objective of this trial is to investigate tolerability, safety, pharmacokinetics and antiviral activity of BI 207127 NA in combination with BI 201335 NA and ribavirin for 8 weeks in Japanese treatment-naive patients with…
- Trial name
- NCT01528735
- Testing
- BI 207127 NA, peginterferon, Ribavirin
- Where
- 5 sites in Japan
- Volunteers
- 25 people
- Sponsor
- Boehringer Ingelheim
COVID-19
A Study to Understand is the COVID-19 Vaccine BNT162b2 is Safe in Indonesia People
The purpose of this study is to characterize descriptively the BNT162b2 vaccination safety experience among the Indonesian people.
- Trial name
- NCT05621239
- Testing
- BNT162b2
- Where
- Indonesia
- Volunteers
- 260 people
- Sponsor
- Pfizer
Covid19, Neurological Manifestations
Study of Morphological, Spectral and Metabolic Manifestations of Neurological Complications in Covid-19 Patients
Viral pandemics, such as HIV and SARS-Cov-V1, have shown that they can lead to acute and / or delayed neurological complications.
- Conditions
- Covid19, Neurological Manifestations, Brain Damage
- Trial name
- NSpectroCovid (NCT04546737)
- Testing
- Magnetic Resonance Spectroscopy (MRS).
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
HIV Infection, Inflammation
Impact of Mediterranean Diet in Cardiovascular Risk Among People With HIV
This study (VIHMET) aims to explore how dietary changes, specifically the adoption of a Mediterranean diet, can improve health outcomes in people living with HIV (PLWH) who are on antiretroviral therapy (ART).
- Conditions
- HIV Infection, Inflammation, Cardiovascular Risk, Mediterranean Diet
- Trial name
- VIHMED (NCT06757309)
- Testing
- Mediterranean Diet
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Parc de Salut Mar
Breast Cancer
Assessment of the Impact of RNA Genomic Profile on Treatment Decision-making in HER2 Equivocal Breast Cancer Patients
The American Society of Clinical Oncology (ASCO) and the /College of American Pathologists (CAP) recommend that HER2 status (negative or positive) must be determined in all patients with invasive breast cancer.
- Trial name
- EQUIVOK (NCT03197805)
- Testing
- PAM 50 test
- Where
- 16 sites in France
- Volunteers
- 26 people
- Sponsor
- Centre Jean Perrin
COVID-19
Study of the Vector Vaccine GamCovidVac for the Prevention of COVID-19 With Altered Antigenic Profile With Participation of Adult Volunteers
Safety, reactogenicity and immunogenicity study of the vector vaccine GamCovidVac for the prevention of coronavirus (COVID-19) infection caused by the SARS-CoV-2 virus with altered antigenic profile with participation of adult…
- Trial name
- NCT06068569
- Testing
- GamCovidVac vector vaccine for the prevention of COVID-19 (with altered antigenic profile)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
HIV, HIV Infections
Switching the Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI) or Protease Inhibitor (PI) to Maraviroc in HIV Subjects
Patients with HIV-1 infection on HAART regimen including 2 NRTI/NtRTIs plus one of the following : 1 PI/ritonavir or ATV/unboosted or 1 NNRTI, will be randomized to switch from the NNRTI/PI to maraviroc (300 mg /12 h) or to…
- Trial name
- NCT00966329
- Testing
- maraviroc, control group
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Germans Trias i Pujol Hospital
HCV Infection
Study of ABT-267 in Both Healthy Volunteers and Hepatitis C Virus (HCV) Genotype 1 Infected Subjects
Study of ABT-267 in both healthy volunteers and Hepatitis C virus (HCV) genotype 1 infected subjects.
- Trial name
- NCT01181427
- Testing
- ABT-267, Blood Sample Collection, Cytochrome P450 inhibitor
- Where
- 3 sites in United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Abbott
Obesity, Insulin Resistance
Lifestyle Intervention Targetting Obesity and Insulin Resistance in Chronic Hepatitis C
Chronic hepatitis C (CHC) infection affects approximately 1 in 100 Canadians. Untreated, CHC has significant long-term consequences including cirrhosis, liver cancer and liver failure.
- Conditions
- Obesity, Insulin Resistance, Metabolic Syndrome, Hepatitis C
- Trial name
- NCT00755742
- Testing
- Lifestyle intervention
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Changes in sncRNA in Sperm, Male Fertility
The Effects of Diet on Small Non-coding RNA i Sperm Cells and the Possible Effects on Reproductive Success: Diet Intervention Effects on Sperm
In this study, patients with infertility treated with IVF at the Center of Reproductive Medicine in Linköping, Sweden, will receive recipes and food according to Nordic dietary guidelines.
- Conditions
- Changes in sncRNA in Sperm, Male Fertility, RNA Profile
- Trial name
- DIET-IS (NCT06831292)
- Testing
- Diet intervention NMR
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Ostergotland County Council, Sweden
Dialysis; Complications, COVID-19
Immune Response Following COVID-19 in Hemodialysis Patients
Patients with chronic kidney disease (CKD), particularly those undergoing hemodialysis (HD), are at high risk of a severe form of COVID-19.
- Conditions
- Dialysis; Complications, COVID-19, Cytokine Storm
- Trial name
- IMMUNOVIDIAL (NCT05307601)
- Where
- France
- Volunteers
- 21 people
- Sponsor
- AURA Paris
Acquired Immunodeficiency Syndrome
A Study of Single Dose Nevirapine (NVP) Combined With Combivir® for the Prevention of Mother to Child Transmission (pMTCT) - Treatment Options Preservation Study (TOPS)
To determine whether a regimen of single dose nevirapine combined with either 4 or 7 days of Combivir®, compared to a regimen of single dose nevirapine, for the prevention of mother to child transmission can reduce the rate of…
- Trial name
- NCT00144183
- Testing
- Nevirapine (NVP), Zidovudine (ZCV), 3TC
- Where
- 5 sites in South Africa
- Volunteers
- 407 people
- Sponsor
- Boehringer Ingelheim
Human Immunodeficiency Virus
Omega-3 Supplementation in HIV Patients With Therapeutic Lifestyle Change Diet.
The positive patients to the Human Immunodeficiency Virus (HIV) with Highly Active Antiretroviral Therapy (HAART) present multiple alterations in their corporal composition and dyslipidemia, wich increase the cardiovascular risk.
- Trial name
- NCT02537236
- Testing
- Omega-3 fatty acids, TLC nutritional intervention, Omega-3 fatty acid supplementation with fish oil and TLC nutritional intervention.
- Volunteers
- 200 people
- Sponsor
- Instituto Mexicano del Seguro Social