Clinical trials: Pupillometry
Pain
Brainwave Activity Response on Common Physical Therapy Intervention
This study is designed to evaluate the if there is a predictable patterns in brainwave activity and to see how this changes with external physical therapy interventions such as manipulation, soft tissue massage, and exercise.
- Trial name
- NCT04542707
- Testing
- joint manipulation, Exercise, Soft tissue massage
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Florida Gulf Coast University
Opioid Use
Pupillometry-guided Remifentanil Infusion Versus Conventional Administration in Children
Our study aims to compare the total intravenous dose of remifentanil per anesthesia hour and body weight in two groups of pediatric surgical patients - an interventional group with remifentanil infusion under pupillometry…
- Trial name
- PURFT (NCT03749811)
- Testing
- Pupillometry
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Acute Pain
Pupillometry for Pain Assessment in Critically Ill Patients
This study was part of a quality improvement project at the Department of Anesthesiology and Intensive Care Medicine, Charité - Universitaetsmedizin Berlin.
- Trial name
- NCT02576132
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Speech, Memory, Delayed
Effects of Clear Speech on Listening Effort and Memory in Sentence Processing
Sensorineural hearing loss (SNHL) is among the most prevalent chronic conditions in aging and has a profoundly negative effect on speech comprehension, leading to increased social isolation, reduced quality of life, and increased…
- Conditions
- Speech, Memory, Delayed, Sensorineural Hearing Loss
- Trial name
- NCT06053190
- Testing
- Sentence stimulus, Speaking style
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Utah
Analgesia, Emergencies
Nebulized Fentanyl in Healthy Volunteers
Pain constitutes the predominant motive prompting individuals to seek emergency medical attention, accounting for 80% of admissions to emergency departments.
- Trial name
- AEROfen (NCT06281951)
- Testing
- Fentanyl - Inhalation by facial nebulization, Fentanyl - Nebulisation
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Anesthesia, Local
Analgesic Territory Assessment of the Spinal Erector Block Using Pupillometry
Few works have studied the area of analgesia covered by the spinal erector block in an objective manner, especially on the cephalo-caudal spread.
- Trial name
- TEASER (NCT05762159)
- Testing
- data collected
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Drug Intolerance, Cytochrome P450 CYP2D6 Enzyme Deficiency
Evaluation of Pupillometry for cyp2d6 Phenotyping in Children Treated With Tramadol
Pupillometry will be performed before administration of tramadol, at T0 and then 1 to twice per hour in children having received tramadol as a pain killer as part of his/her routine care.
- Conditions
- Drug Intolerance, Cytochrome P450 CYP2D6 Enzyme Deficiency, Drug Effect
- Trial name
- PUPICYP (NCT03052218)
- Testing
- Pupillometry
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Geneva
Brain Damage, External Ventricular Drain
Pupillometry : Predictive Indicator in External Ventricular Drain Clamping ?
Pupillar diameter variation to predict success or failure of external ventricular derivation clamping. Pupillometry utilisation as a diagnostic tool in external ventricular clamping test in neurological ICU should improve…
- Conditions
- Brain Damage, External Ventricular Drain, Hydrocephalus
- Trial name
- CLAMP (NCT03823430)
- Testing
- Pupillometry
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Association Pro-arte
Traumatic Brain Injury (TBI) Patients
Pupillometry in Critical Care
Traumatic Brain Injury is a leading cause of death and disability in adults worldwide. The investigators want to find the best way to predict which patients with head injuries are going to deteriorate in order to get medical…
- Trial name
- PUPIL (NCT07838350)
- Volunteers
- 9 people
- Sponsor
- Walton Centre NHS Foundation Trust
Anesthesia, Pain
Pupillometry Guided Remifentanil Administration In Pediatric Anesthesia
The aim of this prospective randomized study is to evaluate the impact of peroperative pupillometry monitoring on per and post-operative opioid consumption in pediatric anesthesia.
- Conditions
- Anesthesia, Pain, Child
- Trial name
- NCT02683837
- Testing
- Remifentanil, Pupillometry, Sevoflurane
- Where
- Switzerland
- Sponsor
- University Hospital, Geneva
Vision
Safety Study Looking at the Effects of Stendra on Vision
The purpose of this study is to see if Stendra causes any changes in vision, eye pressure, pupil dilation, and color vision in healthy males.
- Trial name
- NCT02033200
- Testing
- Stendra 200 mg
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC
Drug Effect (Glaucoma Drugs)
Pupillary Response After Glaucoma Medication
Investigation of the effect on the pupillary constriction by latanoprost, dorzolamide,timolol in healthy subjects. The pupillary constriction is compared to no drug.
- Trial name
- pupil (NCT02522039)
- Testing
- Latanoprost, Timolol, Dorzolamide
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Brain Damage
Transcranial Doppler and Quantitative Pupillometry as Neurological Prognostic Factors in Brain Damaged Patients Admitted to Intensive Care Unit
Transcranial Doppler is performed daily in Intensive Care Unit in brain damaged patients. For a few years now, the measurement of the photomotor reflex by quantitative Pupillometry has been routinely performed in Intensive Care…
- Trial name
- NCT04846738
- Testing
- Transcranial Doppler, Pupillometry.
- Where
- France
- Volunteers
- 73 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cardiac Arrest (CA), Anoxic Brain Injury
Early WAKE-up Predictors After Out-of-Hospital Cardiac Arrest
WAKE-OHCA is a prospective observational substudy of the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) trial, identifier NCT05895838.
- Conditions
- Cardiac Arrest (CA), Anoxic Brain Injury, Comatose Survivors of Cardiac Arrest, EEG
- Trial name
- WAKE-OHCA (NCT06979700)
- Testing
- Automated Pupillometry, Transcranial Doppler Ultrasound, Optic Nerve Sheath Diameter
- Where
- 2 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- University of Aarhus
Neurofibromatosis Type 1
A Study to Evaluate the Feasibility of a Physiologic Biomarker to Assess Pain and Other Sensory Problems Using Pupillometry in Participants With Neurofibromatosis Type 1 (NF1)
Background: Neurofibromatosis type 1 (NF1) is a genetic condition that causes tumors to grow along the nerves in the skin, brain, and other parts of the body.
- Trial name
- NCT06507748
- Testing
- AlgometRx Nociometer(R)
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute (NCI)
Postoperative Pain, Objective Assessment of Sedation
Infrared Pupillometry During General Anesthesia to Predict Pain
The study comprises of a series of pupillary measurements using infrared pupillometry in patients undergoing arthroscopic knee surgery of any type.
- Trial name
- NCT02058511
- Testing
- Anesthesia Premedication, Induction and Maintenance, Pupillometry after administration of anesthetic drugs
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Pain
Pupillometry Guided Remifentanil Administration and Total Opioid Consumption During Propofol - Remifentanil TCI
The aim of this prospective randomized study was to evaluate the impact of peroperative pupillometry monitoring on per and post-operative opioid consumption in major gynecological surgery.
- Trial name
- NCT02576600
- Testing
- Videopupillometer Algiscan, Standard practice, Propofol
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Pr Isabelle CONSTANT
Alzheimer s Disease, Major Depressive Disorder (MDD)
VR Pupillometry in Cognitive Impairment
With disease-modifying therapies emerging for dementia and related conditions, identifying cognitive decline as early as possible is increasingly important.
- Conditions
- Alzheimer s Disease, Major Depressive Disorder (MDD), Mild Cognitive Impairment, Dementia
- Trial name
- NCT07402356
- Where
- Germany
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Max-Planck-Institute of Psychiatry
PSP - Progressive Supranuclear Palsy, PD - Parkinson's Disease
Chromatic Pupillometry to Assess the Melanopsin-Light Pathway in Progressive Supranuclear Palsy
The specific aim of this study is to investigate rod, cone and melanopsin driven pupillary light response in individuals with progressive supranuclear palsy (PSP), age-matched healthy controls and individuals with other…
- Conditions
- PSP - Progressive Supranuclear Palsy, PD - Parkinson's Disease, AD - Alzheimer's Disease, ALS (Amyotrophic Lateral Sclerosis)
- Trial name
- PMPSP (NCT03330353)
- Testing
- Pupillometry
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Massachusetts General Hospital
Postoperative Pain
Monitoring Pupillary Reflex Dilatation for Optimized Postoperative Opioid Delivery Before Extubation.
The study will be designed to investigate the effect of pupillometry guided compared to non-PPI-guided postoperative pain therapy, conducted immediately at the end of surgery before extubation, on total postoperative opioid…
- Trial name
- NCT04594382
- Testing
- Pupillometry-Opioid treatment, Pupillometry -standardized opioid treatment
- Where
- Austria
- Volunteers
- 140 people
- Sponsor
- Medical University of Vienna