Clinical trials: Pulmonary Nodule, Multiple
Lung Tumor, Solitary Pulmonary Nodule
Feasibility of Multi-Energy Digital Radiography Detector for Lung Lesions Detection
A single-centre, industry sponsored, pilot study to assess the feasibility of Single Exposure Dual Energy Subtraction with a Multi-Energy digital radiography detector as an imaging platform for lung lesion detection.
- Trial name
- NCT03528733
- Testing
- Multi-Energy Digital Radiography Detector System
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- KA Imaging Inc.
Pulmonary Disease
Simultaneous CLE Guided Crybiopsy in Patients With Pulmonary Nodules
It is planned to use the CLE probe and cryoprobe simultaneously after detection of the round focus. It is planned to include 5 patients with suspected central airway invading lung carcinoma and 15 patients with suspected…
- Trial name
- NCT06056882
- Testing
- CLE-guided cryobiopsy
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- University of Vienna
Pulmonary Nodules
Clinical Study of ctDNA and Exosome Combined Detection to Identify Benign and Malignant Pulmonary Nodules
This study through the detection of EGFR、ALK、ROS1、KRAS、HER2、BARF、NTRG1 seven ctDNA and exosome RNA in the blood and alveolar lavage of lung nodules patients and heavy smoking healthy population.
- Trial name
- ctDNA (NCT04182893)
- Testing
- ctDNA and Exosome Combined Detection
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
Non-Invasive Biomarkers For Early Detection Of Lung Cancers
Recent studies have shown that low-dose chest CT scans can detect lung cancers in high-risk populations (age >50yo, >30 pack-years of tobacco use), and can lower cancer mortality.
- Trial name
- ISRUSAL01 (NCT01580332)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Douglas W. Johnson MD, FACR
Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple
Nitrous Oxide for Identifying the Intersegmental Plane in Segmentectomy: A Randomized Controlled Trial
Lung cancer is currently one of the most common malignant tumors in the world. In recent years, with the popularity of high-resolution CT, more and more early-stage lung cancers have been found.
- Conditions
- Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple, Lung Cancer
- Trial name
- NCT04302350
- Testing
- nitrous oxide
- Where
- 2 sites in China
- Volunteers
- 81 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pulmonary Nodule Cm
Prognostic Value of miR-21 and miR-486 in Pulmonary Nodule Surgery
This study prospectively evaluated the prognostic value of microRNA-21 (miR-21) and microRNA-486 (miR-486) expression in patients with pulmonary nodules who underwent clock-guided minimally invasive surgery.
- Trial name
- NCT07060287
- Testing
- Clock-Guided Minimally Invasive Surgery
- Where
- China
- Volunteers
- 138 people
- Sponsor
- The First Hospital of Hebei Medical University
Pulmonary Nodules, Nerve Block
Local Anaesthetic Spread and Sensory Block Range of the Retro-superior Costotransverse Ligament Space Block
The aim of this clinical trial is to investigate the effects of local anesthetic diffusion range and sensory block range during retro-SCTLB(retro superior costotransverse ligament space block) and TPVB(thoracic paravertebral…
- Trial name
- NCT07153263
- Testing
- Ultrasound-guided retro-SCTLB, Ultrasound-guided TPVB
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Colon Cancer Liver Metastasis, Multiple Pulmonary Nodules
Combined Liver and Right Lung Resection for Colorectal Metastases by Means of J-shaped Thoracophrenolaparotomy
The purpose of this study is to determine whether J-shaped thoracophrenolaparotomy is effective in the surgical treatment of simultaneous liver and right lung metastases from colorectal cancer
- Trial name
- NCT02090816
- Testing
- Surgery of liver and lung
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- University of Milan
Lung Cancers, Peripheral Pulmonary Nodules
General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound
The endoscopic investigation of lung lesions is experiencing significant growth with the increasing number of lung cancer screening programs.
- Trial name
- RESSOURCE (NCT06950515)
- Testing
- Peripheral EBUS under Concious sedation, Peripheral EBUS under General Anesthesia
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Pulmonary Nodule
A Combined Biomarker Model for Risk Stratification of Indeterminate Pulmonary Nodules
This is a prospective, multicenter observational study aim at estimating the potential clinical utility of the CBM and at establishing the SOPs and protocols for a future randomized control trial.
- Trial name
- NCT06074133
- Testing
- Blood collection, Chest Computed Tomography
- Where
- 4 sites in United States
- Volunteers
- 103 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Bronchoscopy, Lung Cancer
Evaluation of the Archimedes ™ System for Transparenchymatous Access to Pulmonary Nodules.
The aim of this study protocol is to evaluate the feasibility of biopsies using the new system called Archimedes® in 12 patients with solitary pulmonary nodules (SPN) suspicious of malignancy not accessible through current…
- Conditions
- Bronchoscopy, Lung Cancer, Solitary Pulmonary Nodule
- Trial name
- SATAN (NCT04140474)
- Testing
- Archimedes procedure
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Limoges
Pulmonary Nodule, Solitary, Multiple Pulmonary Nodules
GE Healthcare VolumeRAD Lung Nodule Detection Study
To perform a multiple reader, multiple case (MRMC) observer study assessing the detection performance of VolumeRAD tomosynthesis of the chest in detecting lung nodules.
- Trial name
- NCT00963651
- Testing
- Chest tomosynthesis and X-ray
- Where
- 4 sites in United States, Sweden
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- American College of Radiology - Image Metrix
Lung; Node
Airway Navigation Database Asia for Diagnosis of Peripheral Pulmonary Nodules
The study is designed to evaluate the efficacy and safety of Augmented Reality Navigation System through intra-airway navigation system to guide bronchoscopy in the diagnosis of peripheral pulmonary nodules and explore the…
- Trial name
- ANDA (NCT04740606)
- Testing
- Augmented Reality Navigation System
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Lung Cancer, Smoking
Pulmonary Nodule Detection: Comparison of an Ultra Low Dose vs Standard Scan.
Lung cancer screening programs are still discussed in Europe today, and one of the concern is radiation due to iterative CT. The aim of this monocentric, prospective, non randomized study is to compare an ultra low dose chest CT…
- Conditions
- Lung Cancer, Smoking, Radiation Exposure
- Trial name
- npUBD (NCT03305978)
- Testing
- Ultra low dose chest CT, Low dose chest CT
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
Pulmonary Nodules, Solitary, Pulmonary Nodules, Multiple
Early Adjuvant Diagnosis of Pulmonary Nodules Based on CTC.
The goal of this observational clinical trial is to evaluate the value of circulating tumor cell detection in the early diagnosis of malignant pulmonary nodule.
- Trial name
- NCT06187935
- Where
- China
- Volunteers
- 172 people
- Sponsor
- China-Japan Friendship Hospital
Pulmonary Nodule, Lung Cancer
European Real-World Registry for Use of the Ion Endoluminal System
The objective of this study is to collect collect real-world data for the Ion endoluminal system.
- Trial name
- NCT06923774
- Testing
- Ion endoluminal system
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Intuitive Surgical
Pulmonary Nodules, Ground-glass Opacity
Percutaneous Robotic Navigation Microwave Ablation Versus CT-guided Microwave Ablation in the Treatment of Pulmonary Nodules With Ground-glass Opacity
1. To compare the precision of robot-guided microwave ablation and CT-guided microwave ablation in the treatment of ground-glass nodules. 2.
- Trial name
- NCT07389889
- Testing
- Robot, CT scan
- Volunteers
- 116 people
- Sponsor
- Fujian Medical University Union Hospital
Solitary Pulmonary Nodules
Near Infrared Fluorescence Imaging With Indocyanine Green
This research study will evaluate how Near Infrared Fluorescence imaging (NIFI) with indocyanine green (ICG) contrast dye can assist in the identification and diagnosis of lung nodules during surgery.
- Trial name
- NIFI-ICG (NCT02851368)
- Testing
- near infrared fluorescence imaging (NIFI), Indocyanine Green
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Pittsburgh
High-risk Lung Nodules
Immunoprevention for High-risk Lung Lesions
The main purpose of this study is to assess nadunolimab as an immunoprevention strategy for high-risk lung nodules in participants who are current or former tobacco smokers. The study may last up to 5 years for each participant.
- Trial name
- NCT07284485
- Testing
- Nadunolimab
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Robert Samstein
AI (Artificial Intelligence), Pulmonary Nodule, Solitary
DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution
This study is a multi-centre prospective observational cohort study recruiting patients with 5-30mm solid and part-solid pulmonary nodules that have been detected on CT chest scans performed as part of routine practice.
- Conditions
- AI (Artificial Intelligence), Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple, Lung Cancer
- Trial name
- DOLCE (NCT05389774)
- Where
- 10 sites in United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Nottingham University Hospitals NHS Trust